• Progress in Superconductivity
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• 제14권2호
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• pp.87-91
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• 2012

Metallic magnetic calorimeters (MMCs) are one of the most competitive low temperature detector (LTD) readout sensors. They have the advantages of high time resolution, no heat dissipation, and a wide range of operating temperature. We apply MMCs to our neutrinoless double beta decay ($0v{\beta}{\beta}$) search experiment. A $CaMoO_4$ crystal was employed as both a source of $0v{\beta}{\beta}$ and an energy absorber. The crystal was thermally connected to a MMC sensor. We set a simple thermal model for this detector and measured pulse shapes are compared with a numerical solution of the thermal model.

• Journal of Periodontal and Implant Science
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• 제24권3호
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• pp.607-617
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• 1994

To determine the effect of tenascin on forming periodontal pocket and pseudopocket, the ginival tissues were surgically obtained from the patients with adult periodontitis(10) and non-inflammatory phenytoin-associated gingival hyperplasia(5). The excised tissue specimens were fixed in neutral formalin for $6{\sim}24$ hours, embedded with paraffin, sectioned at 4-6m in thickness, mounted on glass slides coated with 3-aminopropyltriethoxysilane(Sigma Chemical Co., St. Louis, MO, U.SA.) and immunohistochemically processed by Avidin-Biotin peroxidase complex method for the localization of tenascin, using monoclonal mouse anti-human tenascin antiboday(Chemicon-International Inc., Temecula, CA, U.S.A., 1: 5,000) as the primary antibody. Regardless of periodontal pocket and pseudopocket, tenascin was localized along the connective tissue subjacent to basement membrane of gingival epithelium, and strong positive reactivity was obviously noted in the papillary projections of gingival connective tissue. The results suggest that tenascin may affect the development of papillary projections and the proliferation of epithelial cells.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2001년도 The 6th International Symposium of East Asian Resources Recycling Technology
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• pp.325-330
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• 2001

Shizhuyuan W-Mo-Bi-Ca $F_2$polymetallic ore is classified to the refractory one due to its complex property, fine dissemination and close association of minerals. Through several years of researches, in line with GY new mineral processing technology developed by Guangzhou Research Institute of Nonferrous Metals, in sulfide flotation circuit, an iso-flotability flowsheet is used to replace original overall bulk flotation flowsheet, and in tungsten flotation circuit, a new chelating type-GY reagent and a special pulp-conditioning system and a new technology of wolframite slime flotation are used to replace the traditional "Caustic Soda Method"$_{［1］}$, the metallurgical performance is greatly improved. Besides, GY New Method has created a favorable condition for comprehensive recovery of fluoride from tungsten flotation tailings. Notable economic benefit has been achieved.d.

• Journal of Nutrition and Health
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• 제14권3호
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• pp.146-150
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• 1981

미강으로부터 추출한 lipase의 몇가지 효소 화학적 성질을 알아 보았다. 반응시간에 따른 유리 지방산의 생성율은 $35^{\circ}C$에서 30분후에 가장 높았다. 효소의 활성화 에너지는 1.83kca1/mo1e이였으며, olive oil emulsion을 기질로 사용하였을때 Km값은 $0.8{\times}10^{-3}mol/{\ell}$였다. 효소 활성은 Ca++이온에 의해 보다 촉진되었다. 미강의 효율적 이용 및 찰의 저장에 대한 이들 효소화학적 성질의 응용성이 토의 되었다.

• 대한기계학회논문집B
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• 제25권9호
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• pp.1149-1156
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• 2001

The objective of the present study is to investigate the performance of electronic scale mitigation unit(ESMU), which reduces the amount of scale in a heat exchanger. The circular tube with diameter of 19mm and plate-and-frame heat exchangers with 20 thermal plates were used for the tests. In order to accelerate the rate of scale in a laboratory test, artificial hard water of 1000ppm(as CaCO$_3$) was recirculated at a flow rate of 5 lpm, 7 lpm, and 9 lpm throughout the tests. The effect of ESMU on the scale thickness and overall heat transfer coefficients was examined. The test results showed that the ESMU could reduce the scale deposits even in the acceleated test.

• 동의생리병리학회지
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• 제19권2호
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• pp.412-415
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• 2005

This study was carried out to investigate the solubility of the bilestone in the solutions of the traditional oriental medicine prescriptions. The cholesterol and the calcium carbonate($CaCO_3$) were chosen as the ingredients of the bilestone. Three prescriptions were studied for the bilestone. The cholesterol had showed under 5% solubility in all solutions of the traditional oriental medicine prescriptions, but the calcium carbonate had showed the 30-50% solubility in all solutions of the traditional oriental medicine prescriptions.

• Asian Pacific Journal of Cancer Prevention
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• 제16권11호
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• pp.4603-4608
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• 2015

Background: To determine the potential value of serum tumor markers in predicting pCR (pathological complete response) during neoadjuvant chemotherapy. Materials and Methods: We retrospectively monitored the pro-, mid-, and post-neoadjuvant treatment serum tumor marker concentrations in patients with locally advanced breast cancer (stage II-III) who accepted pre-surgical chemotherapy or chemotherapy in combination with targeted therapy at Fudan University Shanghai Cancer Center between September 2011 and January 2014 and investigated the association of serum tumor marker levels with therapeutic effect. Core needle biopsy samples were assessed using immunohistochemistry (IHC) prior to neoadjuvant treatment to determine hormone receptor, human epidermal growth factor receptor 2(HER2), and proliferation index Ki67 values. In our study, therapeutic response was evaluated by pCR, defined as the disappearance of all invasive cancer cells from excised tissue (including primary lesion and axillary lymph nodes) after completion of chemotherapy. Analysis of variance of repeated measures and receiver operating characteristic (ROC) curves were employed for statistical analysis of the data. Results: A total of 348 patients were recruited in our study after excluding patients with incomplete clinical information. Of these, 106 patients were observed to have acquired pCR status after treatment completion, accounting for approximately 30.5% of study individuals. In addition, 147patients were determined to be Her-2 positive, among whom the pCR rate was 45.6% (69 patients). General linear model analysis (repeated measures analysis of variance) showed that the concentration of cancer antigen (CA) 15-3 increased after neoadjuvant chemotherapy in both pCR and non-pCR groups, and that there were significant differences between the two groups (P=0.008). The areas under the ROC curves (AUCs) of pre-, mid-, and post-treatment CA15-3 concentrations demonstrated low-level predictive value (AUC=0.594, 0.644, 0.621, respectively). No significant differences in carcinoembryonic antigen (CEA) or CA12-5 serum levels were observed between the pCR and non-pCR groups (P=0.196 and 0.693, respectively). No efficient AUC of CEA or CA12-5 concentrations were observed to predict patient response toward neoadjuvant treatment (both less than 0.7), nor were differences between the two groups observed at different time points. We then analyzed the Her-2 positive subset of our cohort. Significant differences in CEA concentrations were identified between the pCR and non-pCR groups (P=0.039), but not in CA15-3 or CA12-5 levels (p=0.092 and 0.89, respectively). None of the ROC curves showed underlying prognostic value, as the AUCs of these three markers were less than 0.7. The ROC-AUCs for the CA12-5 concentrations of inter-and post-neoadjuvant chemotherapy in the estrogen receptor negative HER2 positive subgroup were 0.735 and 0.767, respectively. However, the specificity and sensitivity values were at odds with each other which meant that improving either the sensitivity or specificity would impair the efficiency of the other. Conclusions: Serum tumor markers CA15-3, CA12-5, and CEA might have little clinical significance in predicting neoadjuvant treatment response in locally advanced breast cancer.

• 재활치료과학
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• 제9권4호
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• pp.69-81
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• 2020

목적 : 본 연구의 목적은 인지기능저하 노인을 선별할 수 있는 이중과제를 활용한 노인인지기능 선별검사를 개발하는 것이다. 연구방법 : 2019년 5월부터 8월까지 경기도 및 충청도에 있는 지역사회 기관에서 60세 이상 노인 229명을 대상으로 개발된 Y-DuCog(Yonsei Dual Task Cognitive Screening Test)의 신뢰도 및 타당도 검증과 인지기능저하 노인의 분류 기준점을 확인하였다. 결과 : MMSE-K, MoCA-K와 Y-DuCog와의 상관분석을 실시한 결과 Y-DuCog의 이중과제 효과와 이중과제 초당 정답 수에서 상관관계를 보였다. 내적 일치도 분석 결과 이중과제 효과와 이중과제 초당 정답 수의 Cronbach's-α 값은 각각 .848(p<.01), .916(p<.01)의 신뢰도를 보였고, 검사-재검사 신뢰도는 ICCs가 .969~.996으로 높게 나타났다. 선별기준점은 총 수행시간 DTE에서 31.76초를 기준으로 88.7%의 민감도와 83.5%의 특이도를, 총 이중과제 CRR에서 0.38개를 기준으로 84.5%의 민감도와 76.6%의 특이도를 보였다. 결론 : 본 연구를 통해 Y-DuCog의 신뢰도 및 타당도가 검증되었다. Y-DuCog는 기존 지필 평가의 제한점인 교육수준과 문자에 영향을 받지 않으며 간편하고 빠르게 검사를 시행할 수 있어 노인의 인지기능 평가 및 중재 방법에 대한 효과성 검증 시 사용될 수 있을 것으로 기대한다.

• 대한본초학회지
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• 제31권1호
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• pp.7-15
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• 2016

Objectives : Polygalae Radix (POL) has an ameliorating effect on learning and memory impairment caused by cerebral hypoperfusion. In regard to POL's action mechanism, this study was carried out to investigate the effects of POL on oxidative damage and neuronal apoptosis induced by cerebral hypoperfusion in rats.Methods : The cerebral hypoperfusion was induced by permanent bilateral common carotid artery occlusion (pBCAO) in Sprague-Dawley rats. POL was administered orally once a day (130 mg/kg of water-extract) for 28 days starting at 4 weeks after the pBCAO. Superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in the brain tissue were measured using ELISA method. Expressions of 4-hydroxynonenal (4HNE) and 8-hydroxy-2'- deoxyguanosine (8-OHdG) were observed using immunohistochemistry. In addition, neuronal apoptosis was evaluated with Cresyl violet staining, TUNEL labeling, and immunohistochemistry against Bax and caspase-3.Results : POL treatment significantly increased SOD activities and significantly reduced MDA levels in the cerebral cortex. The up-regulations of 4HNE and 8-OHdG expression caused by pBCAO in the CA1 of hippocampus were significantly attenuated by POL treatment. POL treatment also restored the reduction of CA1 thickness and CA1 neurons caused by pBCAO and significantly attenuated the apoptotic markers including TUNEL-positive cells, Bax, and caspase-3 expression in the CA1 of hippocampus.Conclusions : The results show that POL attenuated the oxidative damage in brain tissue and neuronal apoptosis in the hippocampus caused by the cerebral hypoperfusion. It suggests that POL can be a beneficial medicinal herb to treat the brain diseases related to cerebral hypoperfusion.

• 한국식품저장유통학회지
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• 제9권4호
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• pp.391-395
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• 2002

솎은 과실의 일반성분은 완숙과실 보다 조단백질, 조지방, 회분함량이 높았으나 탄수화물 함량은 낮았다. 무기물 함량은 Ca> Mg＞ P＞ Na＞ K＞ B 순이었다. 중금속 중 As, Cd, Cr, Hg는 검출되지 않았고 Ge, Mo, Ni, Pb 등은 극 미량이었다. 유기산은 tartaric acid, citric acid, malic acid, succinic acid 등이 검출되었으나 솎은 배는 citric acid가 검출되지 않았다. 유리당은 glucose, fructose, sucrose 등이 검출되었으나 솎은 사과는 sucrose 가 검출되지 않았다. 식이섬유 함량은 불용성 식이섬유가 수용성 식이섬유 보다 높았다. DPPH법에 의한 항산화 효과는 사과 추출액이 RC$_{50}$ 81.2~85.2 ${\mu}\ell$/mL로 가장 활성이 높았고 아질산염 소거능은 반응 pH 1.2에서 솎은 사과와 배 추출액이 각각 80%와 63%로 우수한 효과가 있었으며, tyrosinase 저해 활성은 배 추출액이 61.0~89.4%로 가장 높았다.다.