• YAKHAK HOEJI
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• v.44 no.5
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• pp.440-447
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• 2000

Microspheres of felodipine, which is one of the calcium channel blocker using a mixture of Eudragi $t^{R}$ RL, L, E, and cellulose on the base of Eudragi $t^{R}$ RS were investigated. Cremopho $r^{R}$ was added to each preparation of polymers in order to increase the release of felodipine from microspheres. Felodipine-loaded microspheres were prepared by a solvent evaporation method, which is based on dispersion of methylene chloride containing felodipine and polymers in 0.5 w/v % polyvinyl alcohol solution. The average diameter based on the size distribution of the felodipine-loaded microspheres was observed to be ca. 40-55 ${\mu}{\textrm}{m}$. A good and smooth surface were showed in all types of the microspheres. The amount of felodipine loaded was over 90 w/w % in all types of microspheres. The dissolution profiles of felodipine from microspheres were similar with each type of polymer, and about a 60 w/w % of the total amount of felodipine loaded to microsphere was released within 7 hours. Dissolution rate of felodipine from the microsphere was increased by addition of Cremophor. After oral administration of the felodipine-loaded microspheres in PVA solution and felodipine alone in PEG solution to rats, respectively, the pharmacokinetic study revealed that the Tmax values of the microspheres were observed in the range of 0.67~l.0 hr while that of the felodipine solution was obtained 0.33 hr. In addition, the AUC of the microspheres at 0 to 7 hr was remarkably increased in comparison to that of felodipine solution. These results revealed that the microspheres based on Eudragit RS could be a good candidate for the controlled release drug delivery system for felodipine.e.e.e.

• Journal of ILASS-Korea
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• v.23 no.4
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• pp.192-204
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• 2018

In this study, a 3D CFD analysis method for the combustion process was established for a low calorific value syngas-diesel dual-fuel engine operating under very lean fuel-air mixture condition. Also, the accuracy of computational analysis was evaluated by comparing the experimental results with the computed ones. To simulate the combustion for the dual-fuel engine, a new dual-fuel chemical kinetics set was used that was constituted by merging two verified chemical kinetic sets: n-heptane (173 species) for diesel and Gri-mech 3.0 (53 species) for syngas. For dual-fuel mode operations, the early stage of combustion was dominated by the fuel burning inside or near the spray plume. After which, the flame propagated into the syngas in the piston bowl and then proceeded toward the syngas in the squish zone. With the baseline injection system and piston shape, a significant amount of unburned syngas was discharged. To solve this problem, effects of the injection parameters and piston shape on combustion characteristics were analyzed by calculation. The change in injection variables toward increasing the spray plume volume or the penetration length were effective to cause fast burning in the vicinity of TDC by widening the spatial distribution of diesel acting as a seed of auto-ignition. As a result, the unburned syngas fraction was reduced. Changing the piston shape with the shallow depth of the piston bowl and 20% squish area ratio had a significant effect on the combustion pattern and lessened the unburned syngas fraction by half.

• The Plant Pathology Journal
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• v.34 no.6
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• pp.499-505
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• 2018

Huanglongbing (HLB, Citrus greening disease) is one of the most devastating diseases that threaten citrus production worldwide. Although HLB presents systemically, low titer and uneven distribution of these bacteria within infected plants can make reliable detection difficult. It was known loop-mediated isothermal amplification (LAMP) method has the advantages of being highly specific, rapid, efficient, and laborsaving for detection of plant pathogens. We developed a new LAMP method targeting gene contained tandem repeat for more rapid and sensitive detection of Candidatus Liberibacter asiaticus (CLas), putative causal agent of the citrus huanglongbing. This new LAMP method was 10 folds more sensitive than conventional PCR in detecting the HLB pathogen and similar to that of real-time PCR in visual detection assay by adding SYBR Green I to mixture and 1% agarose gel electrophoresis. Positive reactions were achieved in reaction temperature 57, 60 and $62^{\circ}C$ but not $65^{\circ}C$. Although this LAMP method was not more sensitive than real-time PCR, it does not require a thermocycler for amplification or agarose gel electrophoresis for resolution. Thus, we expect that this LAMP method shows strong promise as a reliable, rapid, and cost-effective method of detecting the CLas in citrus and can be applied for rapid diagnosis is needed.

• Journal of the Korean Society of Propulsion Engineers
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• v.22 no.6
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• pp.84-93
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• 2018

Three-dimensional (3D) numerical simulations have been carried out to study how coolant injection conditions influence the cooling efficiency and projectile ejection performance in a mixture-gas ejection system (or gas-steam launch system). The 3D single-phase computational model was verified using a 1D model constructed with reference to the previous research and then a two-phase flow computation simulating coolant injection on to hot gas was performed using a DPM (Discrete Phase Model). As a result of varying the coolant flow rate and number of injection holes, cooling efficiency was improved when the number of injection holes were increased. In addition, the change of the coalescence frequency and spatial distribution of coolant droplets caused by the injection condition variation resulted in a change of the droplet diameter, affecting the evaporation rate of coolant. The evaporation was found to be a critical factor in the design optimization of the ejection system by suppressing the pressure drop while the temperature decreases inside the breech.

• Korean Journal of Metals and Materials
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• v.46 no.3
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• pp.182-188
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• 2008

Carbon nanotubes(CNTs) have outstanding mechanical, thermal, and electrical properties. Thus, by placing nanotubes into appropriate matrix, it is postulated that the resulting composites will have enhanced properties. Cold spray can produce thick metal-based composite coatings with very high density, low oxygen content, and phase purity, which leads to excellent physical properties. In this study, we applied cold spray coating process for the consolidation of Cu/CNT composite powder. The precursor powder mixture, in which CNTs were filled into copper particles, was prepared to improve the distribution of the CNT in copper matrix. Pure copper coating was also conducted by cold spraying as a reference. Annealing heat treatment was applied to the coating to examine its effect on the properties of the composite coating. The hardness of Cu/CNT composite coating represented similar value to that of pure copper coating. It was importantly found that the electrical conductivity of the Cu/CNT composite coating significantly increased from 53% for the standard condition to almost 55% in the optimized condition, taking annealed ($500^{\circ}C/1hr$.) copper coating as a reference (100%). The thermal conductivity of Cu/CNT composite coating layer was higher than that of pure Cu coating. It was also found that the electrical and thermal conductivities of Cu/CNT composite could be improved through annealing heat treatment. The microstructural evolution of Cu/CNT coating was also investigated and related to the macroscopic properties.

• Environmental and Resource Economics Review
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• v.29 no.4
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• pp.443-468
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• 2020

Broad effects of fuel-transition in all type of ground transportation have occurred with the help of the advances in electric vehicle (EV) technologies and the increases in EV supply. This research estimates the economic benefit of air environmental improvements, which results from the fuel-transition of high-mileage business cars(taxies) in metropolis. If we consider power production sector for EV operation, some air pollutants will be produced. In this respect, this research takes both the mixture of power sources in power production level and the driving pattern of business cars into account when investigating the economic benefit in air environment resulted from the fuel-transition of business cars(taxies). According to our results, the business cars' fuel transition from LPG to electricity brings about 21.5￦/km (8.6million won/year) of economic benefit in air environment. These results emphasize the necessity and appropriateness of public polices for expanding power production with renewable energies and facilitating EV distribution.

• Nuclear Engineering and Technology
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• v.54 no.9
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• pp.3516-3525
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• 2022

The high capture cross-section (𝜎_c) of Gadolinium (Gd-155 and Gd-157) causes reactivity penalty and swing at the initial stage of fuel burnup in Pressurized Water Reactor (PWR). The present study is concerned with the feasibility of the combination of mixed burnable poison with both low and high 𝜎_c as an approach to minimize these effects. Two considered reference designs are fuel assemblies with 24 IBA rods of Gd₂O₃ and Er₂O₃ respectively. Models comprise nuclear fuel with a homogeneous mixture of Er₂O₃, AmO₂, SmO₂, and HfO₂ with Gd₂O₃ as well as the coating of PaO₂ and ZrB₂ on the Gd₂O₃ pellet's outer surface. The infinite multiplication factor was determined and reactivity was calculated considering 3% neutron leakage rate. All models except Er₂O₃ and SmO₂ showed expected results namely higher values of these parameters than the reference design of Gd₂O₃ at the early burnup period. The highest value was found for the model of PaO₂ and Gd₂O₃ followed by ZrB₂ and HfO₂. The cycle burnup, discharge burnup, and cycle length for three batch refueling were calculated using Linear Reactivity Model (LRM). The pin power distribution, energy-dependent neutron flux and Fuel Temperature Coefficient (FTC) were also studied. An optimization of model 1 was carried out to investigate effects of different isotopic compositions of Gd₂O₃ and absorber coating thickness.

• Journal of Ginseng Research
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• v.46 no.2
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• pp.296-303
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• 2022

Background: Skin microbiota is important for maintenance of skin homeostasis; however, its disturbance may cause an increase in pathogenic microorganisms. Therefore, we aimed to develop a red ginseng formulation that can selectively promote beneficial bacteria. Methods: The effects of red ginseng formulation on microorganism growth were analyzed by comparing the growth rates of Staphylococcus aureus, S. epidermidis, and Cutibacterium acnes. Various preservatives mixed with red ginseng formulation were evaluated to determine the ideal composition for selective growth promotion of S. epidermidis. Red ginseng formulation with selected preservative was loaded into a biocompatible polymer mixture and applied to the faces of 20 female subjects in the clinical trial to observe changes in the skin microbiome. Results: Red ginseng formulation promoted the growth of S. aureus and S. epidermidis compared to fructooligosaccharide. When 1,2-hexanediol was applied with red ginseng formulation, only S. epidermidis showed selective growth. The analysis of the release rates of ginsenoside-Rg1 and -Re revealed that the exact content of Pluronic F-127 was around 11%. The application of hydrogel resulted in a decrease in C. acnes in all subjects. In subjects with low levels of S. epidermidis, the distribution of S. epidermidis was significantly increased with the application of hydrogel formulation and total microbial species of subjects decreased by 50% during the clinical trial. Conclusion: We confirmed that red ginseng formulation with 1,2-hexanediol can help maintain skin homeostasis through improvement of skin microbiome.

• Advances in nano research
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• v.14 no.3
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• pp.211-224
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• 2023

This work presents a modified analytical model for the bending behavior of axially functionally graded (AFG) carbon nanotubes reinforced composite (CNTRC) nanobeams. New higher order shear deformation beam theory is exploited to satisfy parabolic variation of shear through thickness direction and zero shears at the bottom and top surfaces.A Modified continuum nonlocal strain gradient theoryis employed to include the microstructure and the geometrical nano-size length scales. The extended rule of the mixture and the molecular dynamics simulations are exploited to evaluate the equivalent mechanical properties of FG-CNTRC beams. Carbon nanotubes reinforcements are distributed axially through the beam length direction with a new power graded function with two parameters. The equilibrium equations are derived with associated nonclassical boundary conditions, and Navier's procedure are used to solve the obtained differential equation and get the response of nanobeam under uniform, linear, or sinusoidal mechanical loadings. Numerical results are carried out to investigate the impact of inhomogeneity parameters, geometrical parameters, loadings type, nonlocal and length scale parameters on deflections and stresses of the AFG CNTRC nanobeams. The proposed model can be used in the design and analysis of MEMS and NEMS systems fabricated from carbon nanotubes reinforced composite nanobeam.

• Journal of the Korean Geotechnical Society
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• v.23 no.8
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• pp.97-106
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• 2007

In this study, experiments are conducted to find out the effect of waste leachate on landfill clay liner system. Tensile test, hydrometer analysis and crack pattern test were conducted on sand-bentonite mixtures with different pH values of water. The tensile strength of specimen compacted with pH 9 of water is smaller than that of specimen compacted with for pH 3 and 6 of water. That is, the higher the pH value, the smaller the tensile strength, because a higher pH solution decreases flocculation phenomenon. The percent finer also increased with high pH value in particle size distribution of fine grained soil (<0.075 mm), because the velocity of particles settling decreases. This trend becomes the clearer as the content of bentonite, becomes the larger, because the higher pH value decreases flocculation structure of fine soils. The results of the crack pattern tests also showed the effect of pH values of water.