• Title/Summary/Keyword: Mixed-effect model

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A Study of Facial Organs Classification System Based on Fusion of CNN Features and Haar-CNN Features

  • Hao, Biao;Lim, Hye-Youn;Kang, Dae-Seong
    • The Journal of Korean Institute of Information Technology
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    • v.16 no.11
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    • pp.105-113
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    • 2018
  • In this paper, we proposed a method for effective classification of eye, nose, and mouth of human face. Most recent image classification uses Convolutional Neural Network(CNN). However, the features extracted by CNN are not sufficient and the classification effect is not too high. We proposed a new algorithm to improve the classification effect. The proposed method can be roughly divided into three parts. First, the Haar feature extraction algorithm is used to construct the eye, nose, and mouth dataset of face. The second, the model extracts CNN features of image using AlexNet. Finally, Haar-CNN features are extracted by performing convolution after Haar feature extraction. After that, CNN features and Haar-CNN features are fused and classify images using softmax. Recognition rate using mixed features could be increased about 4% than CNN feature. Experiments have demonstrated the performance of the proposed algorithm.

Modeling of the effect of current density and contact time on membrane fouling reduction in EC-MBR at different MLSS concentration (EC-MBR 공정의 MLSS, 전류밀도 및 접촉시간이 막 오염 감소에 미치는 영향 모델링)

  • Kim, Wan-Kyu;Chang, In-Soung
    • Journal of Korean Society of Water and Wastewater
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    • v.33 no.2
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    • pp.111-119
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    • 2019
  • Electro-coagulation process has been gained an attention recently because it could overcome the membrane fouling problems in MBR(Membrane bio-reactor). Effect of the key operational parameters in electro-coagulation, current density(${\rho}_i$) and contact time(t) on membrane fouling reduction was investigated in this study. A kinetic model for ${\rho}_i$ and t required to reduce the membrane fouling was suggested under different MLSS(mixed liquor suspended solids) concentration. Total 48 batch type experiments of electro-coagulations under different sets of current densities(2.5, 6, 12 and $24A/m^2$), contact times(0, 2, 6 and 12 hr) and MLSS concentration(4500, 6500 and 8500mg/L) were carried out. After each electro-coagulation under different conditions, a series of membrane filtration was performed to get information on how much of membrane fouling was reduced. The membrane fouling decreased as the ${\rho}_i$ and t increased but as MLSS decreased. Total fouling resistances, Rt (=Rc+Rf) were calculated and compared to those of the controls (Ro), which were obtained from the experiments without electro-coagulation. A kinetic approach for the fouling reduction rate (Rt/Ro) was carried out and three equations under different MLSS concentration were suggested: i) ${\rho}_i^{0.39}t=3.5$ (MLSS=4500 mg/L), ii) ${\rho}_i^{0.46}t=7.0$ (MLSS=6500 mg/L), iii) ${\rho}_i^{0.74}t=10.5$ (MLSS=8500 mg/L). These equations state that the product of ${\rho}_i$ and t needed to reduce the fouling in certain amounts (in this study, 10% of fouling reduction) is always constant.

Anti-inflammatory and Anti-gastritis Effect of Sogunjung-tang Mixed Soft Extract (소건중탕 혼합단미연조엑스의 항염증 및 항위염 효과)

  • Kim, Myoung-Jin;Choi, Hye-Min;Nam, Won-Hee;Kim, Se-Jin;Son, Su-Mi;Kim, Jung-Ok
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.35 no.6
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    • pp.235-241
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    • 2021
  • Sogunjung-tang (SGJT) is traditional herbal prescriptions used to treat abdominal pain. In this study, we evaluated the effect on inflammation and gastritis through SGJT formulation development. SGJT composition herbal medicine was boiled in water at 95~100℃ for 3 hours and then concentrated. Sogunjung-tang mix soft extract (STM) was prepared using pharmaceutical excipients such as purified water, sodium benzoate, β-cyclodextrin and CMC-Na. Anti-inflammatory experiment was conducted using STM and lipopolysaccharide (LPS) in RAW 264.7 cells. Cell survival was measured by MTT method. Nitric oxide (NO) was measured using griess reagents, and pro inflammatory cytokines were measured by enzyme-linked immunosorbent assay and RT-PCR. Also, we verified STM validity in acute gastritis using the ICR mouse. STM was administered oral for three days. And 150 mM HCl in 60% ethanol was oral administered 0.5 mL one hour after the last drug administration. Mice were sacrificed 1 hour after 150 mM HCl in 60% ethanol administration. The gastric mucosa was visually observed. STM were not toxic in RAW 264.7 cells. Treatment of STM inhibited the production of NO and inflammatory cytokine at the protein and mRNA levels. Also, in the acute gastritis model with the mouse, the treatment of STM improved gastric mucosal bleeding and edema. In summary, it was confirmed that the treatment of STM exerts anti-inflammatory and anti-gastritis effects. Therefore, we suggest that STM may provide a preclinical evidence for the prevention and treatment of inflammatory and gastritis diseases.

Effect of Training Types Using Recumbent Cycle Ergometer on Ankle Strength in Healthy Male Subjects

  • Ryu, Ho-Youl;Jeon, In-Cheol;Kim, Ki-Song
    • The Journal of Korean Physical Therapy
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    • v.33 no.6
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    • pp.292-296
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    • 2021
  • Purpose: The purpose of this study was to investigate the exercise effect of two types of training with a recumbent cycle ergometer on ankle muscle strength (dorsiflexor strength, DFS; dorsiflexor strength/weight, DFS/kg; plantar flexor strength, PFS; and plantar flexor strength/weight, PFS/kg) in healthy male subjects. Methods: Twenty-three healthy males (27.91±8.66 yr) were randomly allocated into two groups (high-intensity interval training (HIIT), and aerobic exercise training (AET) after the first measurement. The subjects were trained for 24 sessions (40 min/rep, three times/week) and ankle strength was measured for a second time. Two-way mixed model analysis of variance (ANOVA) was used to identify significant differences between changes in ankle muscle strength between before and after training (within factors) in the HIIT and AET groups (between factors). The statistical significance level was set at α=0.05. Results: In both HIIT and AET groups, all variables of ankle muscle strength were significantly increased after training compared to before training (p=0.001). However, there were no differences in all variables of ankle strength between the HIIT and AET group (p>0.05). Conclusion: Both types (HIIT and AET) of recumbent cycle exercise training could be effective training methods to increase ankle muscle strength in healthy individuals, and the HIIT type with high intensity and low frequency pedaling could be recommended more to strengthen ankle muscles.

Comparison of the bite force and occlusal contact area of the deviated and non-deviated sides after intraoral vertical ramus osteotomy in skeletal Class III patients with mandibular asymmetry: Two-year follow-up

  • Kwon, Hyejin;Park, Sun-Hyung;Jung, Hoi-In;Hwang, Woo-Chan;Choi, Yoon Jeong;Chung, Chooryung;Kim, Kyung-Ho
    • The korean journal of orthodontics
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    • v.52 no.3
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    • pp.172-181
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    • 2022
  • Objective: The objectives of this study were to compare the time-dependent changes in occlusal contact area (OCA) and bite force (BF) of the deviated and non-deviated sides in mandibular prognathic patients with mandibular asymmetry before and after orthognathic surgery and investigate the factors associated with the changes in OCA and BF on each side. Methods: The sample consisted of 67 patients (33 men and 34 women; age range 15-36 years) with facial asymmetry who underwent 2-jaw orthognathic surgery. OCA and BF were taken before presurgical orthodontic treatment, within 1 month before surgery, and 1 month, 3 months, 6 months, 1 year, and 2 years after surgery. OCA and BF were measured using the Dental Prescale System. Results: The OCA and BF decreased gradually before surgery and increased after surgery on both sides. The OCA and BF were significantly greater on the deviated side than on the non-deviated side before surgery, and there was no difference after surgery. According to the linear mixed-effect model, only the changes in the mandibular plane angle had a significant effect on BF (p < 0.05). Conclusions: There was a difference in the amount of the OCA and BF between the deviated and non-deviated sides before surgery. The change in mandibular plane angle affects the change, especially on the non-deviated side, during the observation period.

Transverse variability of flow and sediment transport in estuaries with an estuarine dam

  • Steven Figueroa;Minwoo Son
    • Proceedings of the Korea Water Resources Association Conference
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    • 2023.05a
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    • pp.125-125
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    • 2023
  • Estuarine dams are dams constructed in estuaries for reasons such as securing freshwater resources, controlling water levels, and hydroelectric power generation. These estuarine dams alter the flow of freshwater to the coastal ocean and the tidal properties of the estuaries which has implications for the estuaries' circulation and sediment transport. A previous study has analyzed the effect of estuarine dams on 1D (along-channel) circulation and sediment transport. However, the effect of estuarine dams on the transverse variability of along-channel and across-channel circulation and sediment transport has not been studied and is not known. In this study, a coupled hydrodynamic-sediment dynamic numerical model (COAWST) was used to analyze the transverse variability of along-channel and across-channel flow and sediment transport in estuaries with estuarine dams. The estuarine dam was found to change the 3D structure of circulation and sediment transport, and the result was found to depend on the estuarine type (i.e., strongly stratified (SS) or well-mixed (WM) estuary). The SS estuary had inflow in the channel and outflow over the shoals, consistent with estuarine circulation. Longer discharge interval reduced the estuarine circulation. The WM estuary had inflow over the shoals and outflow in the channel, consistent with tide-induced circulation. As the estuarine dam was located nearer to the estuary mouth, the tide-induced circulation was reduced and replaced with estuarine circulation. The lateral circualtion was the greatest in the tide-dominated estuaries. It was reduced and changed direction due to differential advection change as the dam was located nearer the mouth. Overall, the WM estuary transverse flow structure changed the most. Lateral sediment flux was important in all estuaries, particularly for transporting sediments to the tidal flats.

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Effect of remimazolam and propofol anesthesia on autonomic nerve activities during Le Fort I osteotomy under general anesthesia: blinded randomized clinical trial

  • Yuto Tsuji;Kyotaro Koshika;Tatsuya Ichinohe
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.24 no.4
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    • pp.273-283
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    • 2024
  • Background: This study evaluated the effect of remimazolam and propofol on changes in autonomic nerve activity caused by surgical stimulation during orthognathic surgery, using power spectrum analysis of blood pressure variability (BPV) and heart rate variability (HRV), and their respective associations with cardiovascular fluctuations. Methods: A total of 34 patients undergoing Le Fort I osteotomy were randomized to the remimazolam (Group R, 17 cases) or propofol (Group P, 17 cases) groups. Observables included the low-frequency component of BPV (BPV LF; index of vasomotor sympathetic nerve activity), high-frequency component of HRV (HRV HF; index of parasympathetic nerve activity), balance index of the low- and high-frequency components of HRV (HRV LF/HF; index of sympathetic nerve activity), heart rate (HR), and systolic blood pressure (SBP). Four observations were made: (1) baseline, (2) immediately before down-fracture, (3) down-fracture, and (4) 5 min after down-fracture. Data from each observation period were compared using a two-way analysis of variance with a mixed model. A Bonferroni multiple comparison test was performed in the absence of any interaction. One-way analysis of variance followed by Tukey's multiple comparisons test was performed when a significant interaction was observed between time and group, with P < 0.05 indicating statistical significance. Results: Evaluation of autonomic nerve activity in comparison with baseline during down-fracture showed a significant increase in BPV LF (P < 0.001), an increasing trend in HRV LF/HF in Group P, and an increasing trend in HRV HF in Group R. There were no significant differences in HR or SBP between the two groups. Conclusion: During down-fracture of Le Fort I osteotomy, sympathetic nerve activity was predominant with propofol anesthesia, and parasympathetic nerve activity was predominant with remimazolam anesthesia.

Development of whitening mouth rinses formulated with mushroom residues and their effect on enamel's physical properties

  • Julliana Andrade da Silva;Dayse Alexia de Carvalho de Brito;Debora Alves Nunes Leite Lima;Juliano Lemos Bicas;Gislaine Ricci Leonardi
    • Restorative Dentistry and Endodontics
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    • v.49 no.3
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    • pp.27.1-27.13
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    • 2024
  • Objectives: This study aimed to develop whitening mouth rinses formulated with industrial mushrooms and compare them with over-the-counter whitening mouth rinses. Materials and Methods: Formulations with black shimeji mushrooms, mushroom substrates, and mushroom stalks were developed. Bovine enamel/dentin samples were divided into 7 groups (n = 10): Colgate Luminous White, Listerine Whitening Extreme (LWE), Listerine Cool Mint (LC), mushroom extract rinse (MEC), mushroom substrate rinse (MSB), mushroom stalk rinse (MTC), and artificial saliva. Samples were stained with black tea for 6 days, and then were immersed in 100 mL of each mouth rinse twice daily for 14 days. Color parameters (CIELAB [ΔE*], CIEDE2000 [ΔE00], whiteness index for dentistry [ΔWID]) and microhardness (Knoop hardness number [KHN]) were analyzed at T1 (initial), T2 (24 hours), and T3 (7 days). Mouth rinse pH was measured, and enamel was examined using a scanning electron microscope. Data were analyzed using generalized linear models, and KHN with the generalized linear mixed model for repeated measures (p ≤ 0.05). Results: ΔE* was higher in LW and MSB groups. No significant differences were found for ΔE00 (p = 0.0982) and ΔWID (p = 0.2536). Experimental mouth rinses did not promote enamel whitening based on ΔE00 and ΔWID. LWE and LC reduced KHN and had a more acidic pH, while MEC had higher KHN at T2. MEC, MSB, and MTC had alkaline pH, not altering the tooth surface. Conclusions: Black shimeji mushrooms are promising for mouth rinse development due to their alkaline pH and non-altering effect on surface microhardness.

Detorque values of abutment screws in a multiple implant-supported prosthesis (다수 임플란트 지지 보철물에서 지대주 나사의 풀림 토크값에 대한 연구)

  • Lee, Ju-Ri;Lee, Dong-Hwan;Hwang, Jae-Woong;Choi, Jung-Han
    • The Journal of Korean Academy of Prosthodontics
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    • v.48 no.4
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    • pp.280-286
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    • 2010
  • Purpose: This study evaluated the detorque values of screws in a multiple implant-supported superstructure using stone casts made with 2 different impression techniques. Material and methods: A fully edentulous mandibular master model and a metal framework directly connected to four implants (Br${\aa}$nemark $System^{(R)}$; Nobel Biocare AB) with a passive fit to each other were fabricated. Six experimental stone casts (Group 1) were made with 6 non-splinted impressions on a master cast and another 6 experimental casts (Group 2) were made with 6 acrylic resin splinted impressions. The detorque values of screws ($TorqTite^{(R)}$ GoldAdapt Abutment Screw; Nobel Biocare AB) were measured twice after the metal framework was fastened onto each experimental stone cast with 20 Ncm torque. Detorque values were analyzed using the mixed model with the fixed effect of screw and reading and the random effect of model for the repeated measured data at a .05 level of ignificance. Results: The mean detorque values were 7.9 Ncm (Group 1) and 8.1 Ncm (Group 2), and the mean of minimum detorque values were 6.1 Ncm (Group 1) and 6.5 Ncm (Group 2). No statistically significant differences between 2 groups were found and no statistically significant differences among 4 screws were found for detorque values. No statistically significant differences between 2 groups were also found for minimum detorque values. Conclusion: In a multiple external hexagon implant-supported prosthesis, no significant differences between 2 groups were found for detorque values and for minimum detorque values. There seems to be no significant differences in screw joint stability between 2 stone cast groups made with 2 different impression techniques.

BMDL of blood lead for ADHD based on two longitudinal data sets (주의력 결핍 과잉 행동장애를 종점으로 하는 혈중 납의 벤치마크 용량 하한 도출: 두 동집단 자료의 병합)

  • Kim, Si Yeon;Ha, Mina;Kwon, Hojang;Kim, Byung Soo
    • The Korean Journal of Applied Statistics
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    • v.31 no.1
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    • pp.13-28
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    • 2018
  • The ministry of Environment of Korea initiated two follow-up surveys in 2005 and 2006 to investigate environmental effect on children's health. These two cohorts, referred to as the 2005 Cohort and 2006 Cohort, were followed up three times every two years. This data set was referred to as the Children's Health and Environmental Research (CHEER) data set. This paper reproduces the existing research results of Kim et al. (Journal of the Korean Data and Information Science Society, 25, 987-998, 2014) and Lee et al. (The Korean Journal of Applied Statistics, 29, 1295-1310, 2016) and derive a benchmark dose lower limit (BMDL) for blood lead level for attention deficit hyperactivity disorder (ADHD) after pooling two cohort data sets. The different ADHD rating scales were unified by applying the conversion formula proposed by Lee et al. (2016). The random effect model and AR(1) model were built to reflect the longitudinal characteristics and regression to the mean phenomenon. Based on these models the BMDLs for blood lead levels were derived using the BMDL formula and the simulation. We obtained a hight level of BMDLs when we pooled two independent cohort data sets.