• Polymer(Korea)
• /
• v.38 no.2
• /
• pp.220-224
• /
• 2014

Protein adsorption kinetics was studied with the amount of proteins adsorbed to contact lens hydrogels over time scales. Hydroxyethylmethacrylate (HEMA) and silicone hydrogels were dipped in protein solutions (albumin or IgG) and adsorption amounts were measured over time scales. The amount of protein adsorbed to both hydrogel types increased rapidly in 10 min, and remained consistently in 90 min. Decreasing interfacial energetics was taken slowly up to an hour in spite of rapid diffusion of protein molecules. This is due to the fact that water deprivation from three dimensional interphase initially formed by protein diffusion took over an hour. Interpretation of adsorption kinetics on contact lens hydrogels was discussed with understanding of relationship between surface energy and protein adsorption capacity.

• Molecules and Cells
• /
• v.25 no.4
• /
• pp.494-503
• /
• 2008

Many therapeutic glycoproteins have been successfully generated in plants. Plants have advantages regarding practical and economic concerns, and safety of protein production over other existing systems. However, plants are not ideal expression systems for the production of biopharmaceutical proteins, due to the fact that they are incapable of the authentic human N-glycosylation process. The majority of therapeutic proteins are glycoproteins which harbor N-glycans, which are often essential for their stability, folding, and biological activity. Thus, several glyco-engineering strategies have emerged for the tailor-making of N-glycosylation in plants, including glycoprotein subcellular targeting, the inhibition of plant specific glycosyltranferases, or the addition of human specific glycosyltransferases. This article focuses on plant N-glycosylation structure, glycosylation variation in plant cell, plant expression system of glycoproteins, and impact of glycosylation on immunological function. Furthermore, plant glyco-engineering techniques currently being developed to overcome the limitations of plant expression systems in the production of therapeutic glycoproteins will be discussed in this review.

• Journal of Hospice and Palliative Care
• /
• v.23 no.2
• /
• pp.39-43
• /
• 2020

This paper aims to explore how to help terminally ill patients and their families find meaning in their suffering from the logotherapeutic perspective, which is the essence of palliative care. For this purpose, this paper examines the main concepts and principles of logotherapy, and specific approaches based on the logotherapeutic perspective to help terminally ill patients and their families find meaning in life are presented. Emphasizing the will to meaning as the primary motive to explain human behaviors and based on its unique perspective of the human being, which is called the dimensional ontology, logotherapy considers the human being to consist of the body, the mind, and the spirit. The dimensional ontology implies that the human being "has" the body and the mind, but the human being "is" the spirit itself. Therefore, even though a human being can be sick physically or psychologically, Accordingly, it is essential to help these patients realize that they are not their illnesses, but just have them, and to rise above themselves to reach out toward something meaningful or someone to love; despite their suffering, they can still do something meaningful, even in a small way. Above all, the most important thing for these patients is to acknowledge that they have already lived a meaningful life and to believe that their meaningful work has been safely preserved in the past and nothing can take it from them, for as spiritual beings, their lives have been meaningful unconditionally.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.10 no.5
• /
• pp.917-922
• /
• 2009

This paper presents a technique to generate road surface profiles in a spatial domain using a power spectral density function. A single track power spectral density function is proposed to describe a road surface profile, which is also applicable for multi-track vehicle response analysis. The roads in lateral direction makes the relation between the coherence of the lateral tracks. The derived road surfaces are compared to ISO(International Organization for Standardization) standards. Generated road profiles are in good agreements with the target road PSD shape and measured coherence relation.

• Korean Journal of Human Ecology
• /
• v.21 no.4
• /
• pp.715-728
• /
• 2012

This research aims at examining the relationships between mother-toddler interaction and its related variables. A total of 49 toddlers and their mothers were participated and observed in the child lab during free play. The main results of this study are as follows. First, among the mother-toddler interaction, 'involvement' was frequently used in comparison with the 'rejection' was the hardly used in their interaction. Second, the mothers' sensitivity, parenting stress, and the mother-toddler interaction had no significant difference by the mothers' job status or gender of toddlers. However, their parenting stress was lower in working mothers or mothers who have girls. Third, mother-toddler interaction was significantly correlated with the mothers' sensitivity, parenting stress, parenting style, and the temperament of toddlers. On the basis of this results, the implication related to the variables influencing mother-toddler interaction was discussed.

• Korean Journal of Biological Psychiatry
• /
• v.16 no.2
• /
• pp.121-126
• /
• 2009

Objectives : The serotonin transporter gene(SLC6A4) is one of the most widely studied candidate genes in autism spectrum disorder(ASD), but there have been conflicting results from studies into the association between SLC6A4 and ASD. The aim of this study was to evaluate the association between single nucleotide polymorphisms(SNPs) in the SLC6A4 gene and ASD in the Korean population. Methods : We selected 12 SNPs in SLC6A4 and observed the genotype of 151 Korean ASD trios. We tested the family-based association for each individual polymorphism and haplotype by using the standard TDT method in Haploview(http://www.broad.mit.edu/mpg/haploview/). Results : Through transmission-disequilibrium testing and haplotype analysis, we could not find any statistically significant transmitted allele or haplotype. In addition, a case-control association test with Korean HapMap data did not reveal any statistical significance. Conclusion : Although serotonin-related genes must be considered candidate genes for ASD, we suggest that common SNPs of SLC6A4 are not important markers for associations with Korean ASD.

• 한국전산유체공학회:학술대회논문집
• /
• 2002.05a
• /
• pp.8-15
• /
• 2002

For the large scale computation of turbulent flows around an arbitrarily shaped body, a parallel LES (large eddy simulation) code has been recently developed in which domain decomposition method is adopted. METIS and MPI (message Passing interface) libraries are used for domain partitioning and data communication between processors, respectively. For unsteady computation of the incompressible Wavier-Stokes equation, 4-step splitting finite element algorithm [1] is adopted and Smagorinsky or dynamic LES model can be chosen fur the modeling of small eddies in turbulent flows. For the validation and performance-estimation of the parallel code, a three-dimensional laminar flow generated by natural convection inside a cube has been solved. Then, we have solved the turbulent flow around MIRA (Motor Industry Research Association) model at $Re = 2.6\times10^6$, which is based on the model height and inlet free stream velocity, using 32 processors on IBM SMP cluster and compared with the existing experiment.

• The Journal of Korean Association of Computer Education
• /
• v.5 no.1
• /
• pp.109-115
• /
• 2002

Nowadays, Web-based bulletin board system is widely used for e-learning because of its effectiveness in communicating and information sharing. But harmful or irrelevant contents are frequently posted and these affect students in learning community based on Web-boards and the ill effect of Web-board is revealed. Some Web-boards provide features that allow users can filter specific words to resolve this problem but those features have shortcomings. Using these features the content that contains harmful words is always removed even if the whole meaning of it isn't harm and user who uses harmful words habitually cannot have an opportunity of having his/her bad habit be corrected. In this paper, we proposed new way of dealing with harmful words that overcomes those shortcomings.

• Journal of the Korea Society of Computer and Information
• /
• v.22 no.6
• /
• pp.123-129
• /
• 2017

In this paper, we proposed a smart multiple-tap system which a remote user with smartphone can control multiple-taps in order to reduce standby-power consumption more conveniently when plugged-in electric appliances are turned-off. Recently, several researches of smart multiple-tap using IoT technology has reported. However, in these researches, an additional device like as a server computer is necessary, or multiple-taps could be only remotely controlled by smartphone and not directly controlled by on/off switch. The proposed smart multiple-tap system does not need any additional device only if it has a WiFi router, and it can be used for user as well as remote control using smartphone application and physically direct control using contact switches like existing multiple-taps. Our approach is to develop a smart multiple-tap device capable of WiFi communication can each serve as a server or a client, and can be operated by the hybrid switch combining the on/off contact switch and the relay switch. We implemented the prototype of the proposed system composed of the smart multiple-tap device and the smartphone application, and the test of the prototype validates the proposed system.

• Molecules and Cells
• /
• v.37 no.5
• /
• pp.365-371
• /
• 2014

Recent findings, notably on adipokines and adipose tissue inflammation, have revised the concept of adipose tissues being a mere storage depot for body energy. Instead, adipose tissues are emerging as endocrine and immunologically active organs with multiple effects on the regulation of systemic energy homeostasis. Notably, compared with other metabolic organs such as liver and muscle, various inflammatory responses are dynamically regulated in adipose tissues and most of the immune cells in adipose tissues are involved in obesity-mediated metabolic complications, including insulin resistance. Here, we summarize recent findings on the key roles of innate (neutrophils, macrophages, mast cells, eosinophils) and adaptive (regulatory T cells, type 1 helper T cells, CD8 T cells, B cells) immune cells in adipose tissue inflammation and metabolic dysregulation in obesity. In particular, the roles of natural killer T cells, one type of innate lymphocyte, in adipose tissue inflammation will be discussed. Finally, a new role of adipocytes as antigen presenting cells to modulate T cell activity and subsequent adipose tissue inflammation will be proposed.