• Journal of Korean Neurosurgical Society
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• v.61 no.5
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• pp.539-547
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• 2018

Traumatic spinal cord injury (SCI) research has recently focused on the use of rat and mouse models for in vivo SCI experiments. Such small rodent SCI models are invaluable for the field, and much has been discovered about the biologic and physiologic aspects of SCI from these models. It has been difficult, however, to reproduce the efficacy of treatments found to produce neurologic benefits in rodent SCI models when these treatments are tested in human clinical trials. A large animal model may have advantages for translational research where anatomical, physiological, or genetic similarities to humans may be more relevant for pre-clinically evaluating novel therapies. Here, we review the work carried out at the University of British Columbia (UBC) on a large animal model of SCI that utilizes Yucatan miniature pigs. The UBC porcine model of SCI may be a useful intermediary in the pre-clinical testing of novel pharmacological treatments, cell-based therapies, and the "bedside back to bench" translation of human clinical observations, which require preclinical testing in an applicable animal model.

• Journal of Korean Tunnelling and Underground Space Association
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• v.22 no.1
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• pp.91-105
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• 2020

This study is the basic study for improving the range of influence and potency of mixing bars in the chamber of Shield TBM. Currently, there are many studies on disk cutters, cutter bits and segments in the study of the domestic Shield TBM. However, studies that mix soil and rocks that come from the membrane during the Shield TBM excavation and scatter them with screw conveyors are not as good as those abroad. In this study, the existing Shield TBM Chamber was manufactured as a miniature and the experiment. Inside the chamber, different sizes (4 mm, 6 mm, 8 mm, 10 mm) and colors (black, white, red, and blue) were used to form layers. This experiment was carried out by different shapes and sizes of RPM and mixing bars. In addition, the difference between a miniature model and a reclining one was checked to determine the effect of the direction of gravity on the mixing efficiency. This was done in the same way for all other conditions other than differences in the direction of gravity. Through this experiment, we identified the orientation of the chamber model, the size and shape of the mixing bar inside, and the mixing effect and torque depending on RPM. A comparative review of the mixing effect and torque confirmed that the shape and size of the mixing bar affect the mixing of samples, and that the direction of gravity affects torque.

• Restorative Dentistry and Endodontics
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• v.34 no.3
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• pp.199-207
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• 2009

The objective of this study was to evaluate the effect of color measuring instrument by measuring the color of dental composite resins. Nine shade light cured composite resin disks were prepared (diameter : 15 mm, thickness : 4 mm). CIE $L^*a^*b^*$ color scale of each disk was measured with 3 different types of spectrophotometer [MiniScan XE plus (Model 4000S, Hunter Lab, USA), CM-3500d (Minolta, Japan) and Specbos 2100 Miniature VIS Reflection spectrometer (Serial No: 319416, JETI Technishe VIS Instrumentic GmbH. Germany)]. Miniscan XE Plus and CM-3500d using identical measuring geometry with different size of viewing aperture. But Specbos 2100 using different measuring geometry. Within the limitation of this study, there were color difference (${\Delta}E^*$) from 2.4 to 7.8 between Miniscan XE Plus and CM-3500d, but $L^*$, $a^*$, $b^*$ values showed the high correlation. However, there were great color difference (${\Delta}E^*$) in the extent of about 20 between instruments with the different measuring geometry. Therefore, color scale measured by color measuring instrument should be used as a relative value rather than an absolute value in the field of dentistry.

• Journal of the Korean Geotechnical Society
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• v.21 no.2
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• pp.5-16
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• 2005

Tn this study, model soil deposits are prepared in large test chambers to minimize the scale effects. Also, slurry of mixture containing 50 percent kaolin clay and 50 percent silica has been consolidated to simulate the process of natural soil deposit formation and to reduce the consolidation time. To provide a more detailed description of varying soil properties along the soil profile of model clay deposits and to compare the in-situ test results with those from prototype tests, miniature in-situ tests, including vane shear, piezoprobe, and cone penetration tests were conducted in each of the clay deposits. The current results indicate that consistent soil deposits were prepared for the current and previous test programs. Also, reasonable predicting methods of prototype behavior based on model in-situ test results were suggested in this study by examining differences between the test results from both the model and prototype tests.

• The Plant Pathology Journal
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• v.23 no.4
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• pp.239-244
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• 2007

MicroTom is a miniature tomato plants with various properties that make it as a model system for experiments in plant molecular biology. To extend its utility as a model plant to study a plant - bacterial wilt system, we investigated the potential of the MicroTom as a host plant of bacterial wilt caused by Ralstonia solanacearum. We compared the disease progress on standard tomato and MicroTom by two inoculation methods, root dipping and soil drenching, using a race 1 strain GMI1000. Both methods caused the severe wilting on MicroTom comparable to commercial tomato plant, although initial disease development was faster in root dipping. From the diseased MicroTom plants, the same bacteria were successfully reisolated using semiselective media to fulfill Koch's postulates. Race specific and isolate specific virulence were investigated by root dipping with 10 isolates of R. solanacearum isolated from tomato and potato plants. All of the tested isolates caused the typical wilt symptom on MicroTom. Disease severities by isolates of race 3 was below 50 % until 15 days after inoculation, while those by isolates of race 1 reached over 50% to death until 15 days. This result suggested that MicroTom can be a model host plant to study R. solanacearum - plant interaction.

• Journal of Veterinary Science
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• v.24 no.4
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• pp.53.1-53.12
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• 2023

Background: Mammalian orthoreovirus type 3 (MRV3), which is responsible for gastroenteritis in many mammalian species including pigs, has been isolated from piglets with severe diarrhea. However, the use of pig-derived cells as an infection model for swine-MRV3 has rarely been studied. Objectives: This study aims to establish porcine intestinal organoids (PIOs) and examine their susceptibility as an in vitro model for intestinal MRV3 infection. Methods: PIOs were isolated and established from the jejunum of a miniature pig. Established PIOs were characterized using polymerase chain reaction (PCR) and immunofluorescence assays (IFAs) to confirm the expression of small intestine-specific genes and proteins, such as Lgr5, LYZI, Mucin-2, ChgA, and Villin. The monolayered PIOs and three-dimensional (3D) PIOs, obtained through their distribution to expose the apical surface, were infected with MRV3 for 2 h, washed with Dulbecco's phosphate-buffered saline, and observed. Viral infection was confirmed using PCR and IFA. We performed quantitative real-time reverse transcription-PCR to assess changes in viral copy numbers and gene expressions linked to intestinal epithelial genes and antiviral activity. Results: The established PIOs have molecular characteristics of intestinal organoids. Infected PIOs showed delayed proliferation with disruption of structures. In addition, infection with MRV3 altered the gene expression linked to intestinal epithelial cells and antiviral activity, and these effects were observed in both 2D and 3D models. Furthermore, viral copy numbers in the supernatant of both models increased in a time-dependent manner. Conclusions: We suggest that PIOs can be an in vitro model to study the infection mechanism of MRV3 in detail, facilitating pharmaceutical development.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.47 no.3
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• pp.51-58
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• 2010

Since Augmented Reality (AR) enables users to experience computer-generated content embedded in real environments, AR agents can be visualized among physical objects in the environments where the users exist, and directly interact with them in real-time. We model perceptual attention for autonomous agents in AR environments where virtual and physical objects coexist. Since such AR agents must adaptively perceive and attend to surrounded objects relevant to their goals, our model allows the agents to determine currently visible objects from the description of what virtual and physical objects are configured in the camera's viewing area. A degree of attention is assigned to each perceived object based on its relevance to achieve agents' goals. The agents can focus on a reduced set of perceived objects with respect to the estimated degree of attention. To demonstrate the effectiveness of our approach, we implemented an animated character that was overlaid over a miniature version of campus and that attended to buildings relevant to their goals. Experiments showed that our model could reduce the character's perceptual loads even when surroundings change.

• Transactions of the Korean Society of Mechanical Engineers
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• v.18 no.12
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• pp.3185-3194
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• 1994

In this study, an impact model and impact response analysis method was suggested for the impacts between arbitrary shaped bodies. Unlike the impacts between geometrically simple structures, there is no rules to analyze the impacts between general elastic structures First of all, it has been attempted to explain the impoot between arbitrary elastic structures as the elastic deformation of a virtual contact spring in the vicinity of contact points. The contact stiffness and the exponent are determined from the Hertz's contact theory and F. E. analysis. In order to evaluate the validities and limitations of the proposed methods, an impact tester and the miniature of container, missile and isolators have been provided and tested experimentally. All the experiments were performed with various impact conditions. The results obtained by the proposed methods were directly compared with the measured values in terms of maximum contract force, contact duration, the shape of contact force and the structure responses. The computed contact force and responses, using this proposed methods, were very close to the measured results, unless any plastic deformations were presented.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.20 no.9
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• pp.2812-2818
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• 1996

A cantilever beam with a mass and a spring at the end can be use to model a miniature flexible arm. It is necessary to know the natural frequencies and mode shapes to discuss its free vibration, especially when modal analysis is employed. A beam is clamped-free. In this paper we look at the lateral vibration of beams that have step changes in the properties of their cross sections. The frequency equation is derived by Bernoulli-Euler formulation and is sloved by the separation of variable. The parameters of the beam, 'mass and spring stiffness' are defined as nondimensionalized parameters for wide application of the results. According to the change of eigenvalues and mode shape are presented for this beam. The results presented are the eigenvalues and the natural frequencies for the first three modes of vibration. Results show that the parameters have a significant effect on the natural frequency.

• ETRI Journal
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• v.43 no.6
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• pp.957-965
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• 2021

A miniaturized wideband band-pass filter with a 3-dB fractional bandwidth of 109.3% (1.53 GHz to 5.22 GHz), high out-of-band attenuation greater than 25 dB, and wide upper stopband up to 14 GHz is proposed. The design consists of a dual-composite right/left handed resonator, embedded open-circuited stub, and a pair of quarter-wavelength short-circuited stubs. These elements are coupled in the near distance to form a miniature filter with a compact occupied area of 0.21 λ_g×0.19 λ_g (≈ 0.013 cm²). The optimized filter has multitransmission poles in the passband, substantially improving the return loss and insertion loss characteristics. The behavior of the passband and stopband is verified against the results of a lumped element model and matrix analysis with a full-wave moment-based analysis and actual measurements. The results of this verification and a comparison with the performance of filters in other references indicate that the proposed filter is very efficient and applicable to compact microwave systems.