• 대한의용생체공학회:의공학회지
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• 제25권1호
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• pp.77-82
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• 2004

다양한 한국인의 표준 뇌를 완성하기 위해 영상 획득의 기준을 마련하고, 획득된 한국인의 뇌 영상 데이터들과 피검자들의 개인 정보들을 저장하고 관리하는 데이터베이스 관리 시스템의 개발이 본 연구의 목적이다. 해부학적 영상 획득을 위해 SNR과 CNR이 우수하고 영상획득시간도 줄일 수 있는 3D MP-RAGE 기법을 선택하였고, 최적의 영상 획득을 손잡이 검사, 상태-특성 불안척도 검사, A 유형 성격 검사, 자기평가 우울척도 검사, 사상체질 검사 간이정신 진단검사, 지능진단 검사, 성격요인 검사를 질문지로 수행한 후 그 결과를 저장하고 관리 할 수 있도록 하였다. 또한 본 시스템은 피검자의 영상 정보 및 개인 정보의 저장, 삽입, 삭제, 검색, 출력 기능뿐만 아니라 Access 권한 기능, ODBC와의 연결 설정도 자동으로 수행되도록 개발하였다. 개발된 시스템은 다양한 한국인의 영상 정보와 개인 정보를 저장, 관리 할 수 있기 때문에 다양한 한국인의 표준뇌를 완성하는데 큰 기여를 할 수 있을 것이다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제17권11호
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• pp.2924-2944
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• 2023

Alzheimer's disease (AD) is a neurological condition that is recognized as one of the primary causes of memory loss. AD currently has no cure. Therefore, the need to develop an efficient model with high precision for timely detection of the disease is very essential. When AD is detected early, treatment would be most likely successful. The most often utilized indicators for AD identification are the Mini-mental state examination (MMSE), and the clinical dementia. However, the use of these indicators as ground truth marking could be imprecise for AD detection. Researchers have proposed several computer-aided frameworks and lately, the supervised model is mostly used. In this study, we propose a novel 3D Convolutional Neural Network Multilayer Perceptron (3D CNN-MLP) based model for AD classification. The model uses Attention Mechanism to automatically extract relevant features from Magnetic Resonance Images (MRI) to generate probability maps which serves as input for the MLP classifier. Three MRI scan categories were considered, thus AD dementia patients, Mild Cognitive Impairment patients (MCI), and Normal Control (NC) or healthy patients. The performance of the model is assessed by comparing basic CNN, VGG16, DenseNet models, and other state of the art works. The models were adjusted to fit the 3D images before the comparison was done. Our model exhibited excellent classification performance, with an accuracy of 91.27% for AD and NC, 80.85% for MCI and NC, and 87.34% for AD and MCI.

• Journal of Preventive Medicine and Public Health
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• 제32권3호
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• pp.306-316
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• 1999

Objectives: In Korea, as in most countries, there will be a sharp increase in the number of dementia patients in the near future. However basic data on dementia prevalence, which is important in defining epidemiologic characteristics and in implementing preventive strategy, are limited. This study was conducted to estimate the prevalence rate of dementia in the urban elderly aged 65 or older in Kwangmyung, Korea. Methods: A two phase design was used for case finding and case identification. In phase I, a representative sample aged 65 or older was selected and interviewed by door-to-door survey with a Korean version of the Mini-Mental State Examination (K-MMSE). In phase II, Of the 946 subjects interviewed in phase 1,356 elderly were randomly selected disproportionately according to K-MMSE score. Of these elderly, 223 (61.5%) underwent standardized clinical evaluations, including psychiatric interview, neurological examination, and neuropsychological assessment. Dementia was diagnosed by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. The diagnosis of Alzheimer's disease (AD) was made by National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and feinted Disorders Association(NINCDS-ADRDA) criteria and vascular dementia (VD) by DSM-IV. Results: The overall weighted prevalence rate of all dementia among Kwangmyung residents aged 65 or older was 12,8%(age-adjusted rate: 13,0%, 95% Confidence Interval[CI]: 10.6-15.3%). Women had much higher prevalence rate than men even when age was controlled(15.9%[95% CI 12.6-19.2%] vs 7.5%[95% CI 4.0-10.4%]), The rates of dementia were 5.2%, 12.2%, 17.0%, and 34.3% for the age groups of 65-69, 70-74, 75-79 and 80 and over, respectively. The rate of AD appeared to be slightly higher than that of VD(5.2% vs 4.8%), though not statistically significant. Most of the cases(69%) were mild dementia according to CDR(<1) in these subjects. Conclusions : These results showed that the prevalence rate of dementia among urban elderly in Korea appears to be higher than those of other Asian countries.

• 대한한방내과학회지
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• 제21권2호
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• pp.193-201
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• 2000

Objective : In western medicine, many medication therapies and non-medication therapies have been treated for dementia. But these methods did no more than symptomatic therapies, not basic treatment, which just can better subordinate symptoms. In fact, care or control became the very point of treatment of dementia. So, to try to find oriental medical treatments for Dementia, a clinical analysis was carried out for 84 patients who were diagnosed as Dementia through MMSE-K and treated in Dong-shin Oriental Medicine Kwangju Hospital and Karitaas Sanatorium from 10. Jan. 1998 to 20. May. 2000. Methods : Regardless of patterns of Dementia, the basic treatment(本治) is to supplement encephalon deficiency(腦髓不足). And the external treatment(標治) must be accompanied by through diagnosis according to symptoms(辨證). All patients were given Yukmi-jihwanghwan gami and acupuncture treatment. Results : Dementia of cerebral vascular type shows a high distribution(51 patients, 60.7%). Women also are distributed more widely(62명, 73.8%). In Age distribition, 70-79 years-32 patients(38.1%), over 80 years-21 patients(25%), 60-69 years-17 patients(20.2%), 50-59 years-13 patients(15.5%) and under 49 years-1 patient(1.2%). From this, Dementia occurs well over 60 years and the rate of occurrence of Dementia is high as people grow older. In past history of people with Dementia, hypertension is associated much(50 patients, 64.1%). Distribution of mental state by MMSE-K examination declined in orientaion, mathmatical faculty, memory faculty and composition faculty. In therapeutic effect by treatment duration, 14 patients(93.3%) out of 15 in sanatorium show a significant effect. And 52 patients(75.4%) out of 69 in the hospital show the same result. Especially, 11 patients with Alzheimer type in sanatorium showed an good effect when treated over 4 months. 40 patients(83.3%) with cerebral vascular type out of 48 in the hospital showed the stage of betterment. Conclusions : The basic treatment(本治) for Dementia is to supplement encephalon deficiency(腦髓不足). For promoting encephalon through supplementing kindney(補腎健腦), All patients were given Yukmi-jihwanghwan gami. And the external treatment(標治) through diagnosis according to symptoms(辨證) were be accompanied by. The result is quite effective. We consider there must be more research based on this study.

• 보건교육건강증진학회지
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• 제23권3호
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• pp.99-119
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• 2006

Objectives: This study intends to understand the difference within group of social support level and the effect of social support to health behaviors and health status of the elderly by selecting the old of local society as target. Methods: Data were obtained from self-administered questionnaire of 8,688 persons, older than 65 years, living in a community. We measured the sociodemographic characteristics, social support(family support, other support, quality of support), physical health state(subjective health status, number of chronic disease), physical function state(activities of daily living; ADL, instrumental activities of daily living; IADL), cognition state(mini-mental state examination-Korean; MMSE-K) and depression state(short form of geriatric depression scale; SGDS), health behaviors(smoking, drinking, exercise, eating habit). Univariate, multinominal logistic regression and covariance structure analysis were employed to analyze factors affecting on the social support of the elderly. Results: When considering the degree of social support by the sociodemographic characteristics of the older adults, the family support, other support and quality of support is better when the old is male, young, high education and self-reported living status is good and it has significance statistically. When considering the relation between social support and health status, the family support, other support and quality of support is better when the old's subjective and objective physical health status is good. The family support, other support and quality of support is better when the old's subjective health status is better. The other support and quality of support is better when the old's ADL(activities of daily living) and IADL(instrumental activities of daily living) are good. The family support, other support and quality of support is better when the old's cognitive function and depression state is better. When considering the relation between social support and health behaviors, in case of smoking and drinking, the quality of support, family support and other support is better when the old smokes and drinks rather than the old does not. In case of exercise and eating habit, the family support, other support and quality of support is better when the old exercises and eats regularly rather than the old does not. It has significance statistically. From the result of performing covariance structure analysis by structural equation modeling(SEM) with two endogenous variable(health behaviors and health status) and one exogenous variable(social support), factor loading of health status is 0.74 and factor loading of health behaviors is 0.05. The social support explains health status of 55.4% and health behaviors of 2.9%. Conclusions: This study has the meaning that it finds the difference of social support generating from inside of the group for the old residing in city and country and specifies the effect that the difference of social support influences to health status and health behaviors. From now on, in the development of health improvement strategy of the olds, it is necessary to approach from inclusive aspect while considering psychosocial factor such as social support and social economical factor as well as health status.

• Journal of Korean Biological Nursing Science
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• 제15권3호
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• pp.107-114
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• 2013

Purpose: This study was aimed to describe the level of medication adherence and to identify the impact of cognitive function and self-efficacy on medication adherence of elderly patients with chronic disease. Methods: The descriptive study included 303 patients over 65 years with chronic diseases from two medical centers in Cheonan city. Data were collected from July to November 2011. A questionnaire including questions on the Korean version of mini-mental state examination (MMSE-K), self-efficacy and medication adherence were completed by the subjects. Data were analyzed using the SPSS/WIN 20.0 program. Results: The mean score of medication adherence was $1.4{\pm}1.6$. In univariate analysis, exercise (t=2.85, p=.005), type of disease (F=3.91, p=.001) and self-efficacy (r=-.57, p<.001) were the significant factors related to medication adherence. Linear regression analysis demonstrated that self-efficacy (${\beta}$=-.57, p<.001) was a significantly associated factor with medication adherence. Self-efficacy explained about 33% of the total variance of the medication adherence in elderly patients. Conclusion: The results suggest that self-efficacy to medication can be a facilitator to medication adherence in elderly patients. However, these results indicate that there remains much work to be done in identifying other predictors of medication adherence of elderly patients with chronic diseases.

• 한국산학기술학회논문지
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• 제13권10호
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• pp.4612-4618
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• 2012

본 연구는 지역사회에 거주하는 뇌졸중 클라이언트에서 생산과제의 세 가지 방법을 모두 이용하고 Freedman 등의 양적 채점 방법을 사용하여 인지 손상 선별 검사로서 CDT(Clock Drawing Test)의 신뢰도 및 타당도를 분석하였다. 2010년 11월 부터 2011년 8월 까지 지역사회에 거주하는 뇌졸중 클라이언트 51명을 대상으로 CDT와 K-MMSE(Korean Version of Mini Mental State Examination)를 검사하였다. 스피어맨 순위 상관계수 분석으로 CDT의 검사-재검사 신뢰도, 검사자간 신뢰도, 동시타당도를 분석하였고, 맨 휘트니 유 검정을 사용하여 구성타당도를 분석하였다. 검사재검사 신뢰도, 검사자간 신뢰도, 구성타당도, 동시타당도 분석 모두에서 통계학적으로 유의하였다(p<.01). 본 연구의 결과에서 생산과제 방법을 이용하고 Freedman 등의 양적 채점 방법을 사용한 CDT는 인지손상을 선별하는 검사로서 지역사회에 거주하는 뇌졸중 클라이언트에게 적용될 수 있을 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7321-7326
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• 2015

As the essence of health in humans, spiritual health is a fundamental concept for discussing chronic diseases such as cancer and a major approach for improving quality of life in patients is through creating meaningfulness and purpose. The present descriptive analytical study was conducted to assess the relationship between spiritual health and quality of life in 210 patients with cancer admitted to the Cancer Institute of Iran, selected through convenience sampling in 2014. Data were collected using Spiritual Health Questionnaire and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC-QLQ). Patients' performance was assessed through the Karnofsky Performance Status Indicator and their cognitive status through the Mini-Mental State Examination (MMSE). Data were analyzed in SPSS-16 using descriptive statistics and stepwise linear regression. The results obtained reported the mean and standard deviation of the patients' spiritual health scoreas $78.4{\pm}16.1$ and the mean and standard deviation of their quality of life score as $58.1{\pm}18.7$. The stepwise linear regression analysis confirmed a positive and significant relationship between spiritual health and quality of life in patients with cancer (${\beta}$=0.688 and r=0.00). The results of the study show that spiritual health should be more emphasized and reinforced as a factor involved in improving quality of life in patients with cancer. Designing care therapies and spiritual interventions is a priority in the treatment of these patients.

• 대한한방내과학회지
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• 제38권2호
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• pp.138-145
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• 2017

Objectives: The purpose of this case study is to describe the effect of Korean medicine on a patient with delirium caused by a left middle cerebral artery infarct. Methods: The patient was treated with Sopungbosimdodam-tang, acupuncture, and moxibustion. The Korean version of the Delirium Rating Scale (K-DRS), Neelon and Champagne (NEECHAM) Confusion Scale, and Korean Version of the Mini-Mental State Examination (MMSE-K) were used to evaluate the effect of the treatment. Results: After 50 days of treatment with Sopungbosimdodam-tang, the patient's K-DRS score decreased from 16 to 8. The NEECHAM Confusion Scale also improved from 17 to 23, and the MMSE-K score improved from 1 to 7. Conclusion: This clinical study suggested that Korean medicine could contribute greatly to the treatment of delirium caused by a left middle cerebral artery infarct.

• 대한한방내과학회지
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• 제38권2호
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• pp.217-225
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• 2017

Objectives: This case study evaluated the effectiveness of Chengsimyeonja-tang-gamibang (Gamicheongsim-tang and Cheongsimsunhwal-tang) in a patient with a pontine hemorrhage and quadriparesis, dysarthria, and dysphagia. Methods: A patient diagnosed with a pontine hemorrhage was treated with Chengsimyeonja-tang-gamibang (Gamicheongsim-tang and Cheongsimsunhwal-tang) acupuncture, and moxibustion. The manual muscle test (MMT), modified Barthel index (MBI), National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS), Mini Mental State Examination-Korea (MMSE-K), and Articulatory Functional Ability of Achievement Scale were administered. Results: Improvements in the MMT, MBI, NIHSS, mRS, and K-MMSE were observed after the treatment. The MMT grade increased from Rt. 3/3- and Lt. 3/3- pretreatment to Rt. 4/4 and Lt. 4+/4+ post-treatment. The MBI increased from 10 to 50 post-treatment. The NIHSS decreased from 24 to 6 post-treatment, and the mRS fell from 5 to 4 post-treatment. Finally, the MMSE-K increased from 0 to 24 post-treatment. The Articulatory Functional Ability of Achievement Scale also improved. Conclusion: This study shows that Chengsimyeonja-tang-gamibang can be used to treat the symptoms of patients with a pontine hemorrhage.