• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.719-724
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• 2012

This study aimed to investigate the clinical significance of expression and amplification of decoy receptor 3 (DcR3) in pancreatic carcinomas (PC). mRNA expression was detected by PQ-PCR, and amplification was determined. DcR3 protein expression was detected by immunohistochemistry and ELISA. Correlations between DcR3 expression and clinical pathological factors were analyzed. The relative amount of DcR3 in PC tissues and non-cancerous tissues showed a statistically significant difference, 21 cases displaying more than two fold DcR3 amplification, while no such amplification was found in normal pancreatic tissues. DcR3 positive cell staining was located in the cytoplasm. The positive rate of DcR3 in PC and non-cancerous tissues showed a significant difference. DcR3 mRNA expression was correlated with clinical staging, size of the tumor, lymph node metastasis and histological staging, while protein expression was correlated with clinical data like tumor size. DcR3 gene amplification only correlated with tumor size. The level of DcR3 in serum of the PC resectable group before operation was $72.2{\pm}10.2$ pg/ml, showing a significant difference compared to gallbladder carcinoma group (GC) or pancreatic benign tumor (PBT) group (P < 0.01). In conclusion, DcR3 amplification is correlated with DcR3 expression in PC tissues, especially those clinical pathological factors which reflect tumor progression. Assessment of DcR3 level in sera of PC patients may be helpful for the early diagnosis and prognostic judgement.

• 대한한의학원전학회지
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• 제25권2호
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• pp.25-41
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• 2012

Objective : Neijingshiyifanglun with additions and emendations was written by Liu Yude, a doctor who lived during Ming period. I researched the origin of the book, and analyzed the features of it as well. I also approximated his birth date and death date. In doing this, I gained a better understanding the practice of medicine in ancient China. Method : I researched the book by comparing its contents, including the causes of diseases, the descriptions of symptoms, the transmissions of diseases, and treatments, with other sources that he had referenced. Result : In understanding Hwangdineijing, Liu Yude was influenced by many medical scholars such as, Wang Bing, Ma Shi, and Wu Kun, but his opinion is most similar to that of Zhang Jiebin. In the field of the Chinese Medical Theory, he was deeply influenced by 'JinYuan-Sidaijia's theories, particularly Li Gao and Zhu Zhenheng. In fanglun, he was greatly influenced by Yifangkao. He concluded that 'aggregationaccumulation' was a disease of stuffiness, and suggested its cure in through 'yangjingzezichu' and 'treatment of blood aspect'. He recognized the disease of 'reversal of qi' as the disease of 'jiaoqi'. He also indicated that the word of 'qi' is not 'rough' but 'tears' or 'yingfengliulei'. Conclusion : 1. He was an excellent medical practitioner and scholar in the history of oriental medicine. 2. He found and corrected errors in the opinions of Wang Bing, Ma Shi, and Wu Kun. 3. He frequently practiced Taipinghuiminhejijufang, and considered Spleen-Stomach, yin-blood, and fire-heat important. 4. He captured the spirit of Huangdisuwenxuanminglunfang, Neijingshiyifanglun, Yifangkao in views of remedy and theory. 5. Neijingshiyifanglun with additions and emendations is the most comprehensive book about fanglun because of its thorough analysis of the Hwangdineijing and its connection to the treatment of ancient diseases in Oriental Medical History.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2837-2840
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• 2012

We investigated whether IFN-${\beta}$ inhibits the growth of human malignant glioma and induces glioma cell apoptosis using the human IFN-${\beta}$ gene transfected into glioma cells. A eukaryonic expression vector ($pSV2IFN{\beta}$) for IFN-${\beta}$ was transfected into the glioma cell line SHG44 using liposome transfection. Stable transfection and IFN-${\beta}$ expression were confirmed using an enzyme-linked immunosorbent assay (ELISA). Cell apoptosis was also assessed by Hoechst staining and electron microscopy. In vivo experiments were used to establish a SHG44 glioma model in nude mice. Liposomes containing the human IFN-${\beta}$ gene were injected into the SHG44 glioma of nude mice to observe glioma growth and calculate tumor size. Fas expression was evaluated using immunohistochemistry. The IFN-${\beta}$ gene was successfully transfected and expressed in the SHG44 glioma cells in vitro. A significant difference in the number of apoptotic cells was observed between transfected and non-transfected cells. Glioma growth in nude mice was inhibited in vivo, with significant induction of apoptosis. Fas expression was also elevated. The IFN-${\beta}$ gene induces apoptosis in glioma cells, possibly through upregulation of Fas. The IFN-${\beta}$ gene modulation in the Fas pathway and apoptosis in glioma cells may be important for the treatment of gliomas.

• 대한한의학원전학회지
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• 제31권2호
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• pp.83-103
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• 2018

Objectives: The Qing Dynasty experienced a development in Yunqi even greater than in the Ming Dynasty. Popularization and universalization of Yunqi theory led to many books on the subject published, especially with weights on Warm Heat Disease and Pestilence, also giving birth to new Yunqi theories. A study into this development has a great significance in the study of the traditional medicine in Qing. Methods: The paper studies the Yunqi books published in the Qing dynasty to find out the unique characters of those books. To understand the direction which the Yunqi theory in the Qing period took, the paper also reviewed the positions of different groups, those who were favorable, those who compromised, and those who were unfavorable. Results: Four directions were taken by the study of Yunqi in the Qing period. First is the systemic study and composition of Neijing's chapter of Yunqi. This direction was taken by Liumaoxiu's NeiJingYunQiBingShi) and $N{\grave{e}}ijingyunqibiao$, Xuefuchen's Suwenyunqitushuo, Zhuenhua's Suwenyunqiqianshuo, an unknown person's Su wen yunqi chao, Weigeliu's Neijingqihuapian. The second direction is the study of Yunqi in relation with the Warm Heat Disease and Pestilence, which was taken by Mayin lin's Wuyunliuqiwenyifayuan, Lumaoxiu's Suwenyipianbìngshi, Litianchi's Shiyiwenbingqìyunzhengyan lun, and Wangxun's Cihangsanyuanfujifang. The third direction deals with a new Yunqi theory. The Fourthis the explanation of Yunqi in the form of Songs, which was taken by Wuqian's Yunqiyaojue, and Wengzao's Yunqiyaojue. Conclusions: Ludanchen published Yunqibian, and explained that Haizichouyinmaochen, which is the eclipse's south latitude, becomes Nanzheng, and Southern government, which is the eclipse's north latitude, becomes Northern government. Lumaoxiu revealed that the Liuqidasitian, founded by Wangpuzhuang, his great grandfather on the mother's side, is in alignment with the theory of Dashitian, used by Liushozhen, Lidongyuan, Zhudanxi, and Zhangjingyue. The representative figure in the favorable view of Yunqi in the Qing period is Wuyang, that of those who compromised is Fengzhaozhang, and that of opposition is Zhangzhuo.

• 한국의사학회지
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• 제18권2호
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• pp.137-187
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• 2005

This thesis study of the medical concept Qiu Zheng Lu (求正錄) is discussed in the Lei Jing Fu Yi (類經附翼), a book authored by Zhang Jie Bin (張介賓) a medical doctor during the Chinese Ming (明) dynasty (1368-1683). The meaning of Qiu Zheng Lu (求正錄) is "searching for the rightness." In his book Zhang Jie Bin (張介賓) intended to clarify Qiu Zheng Lu (求正錄) by delineating the concept into four categories. These are: Sanjiao Baoluo Mingmen Bian (三焦包絡命門 辨) the theory of the triple warmer, the Pericardium, the Gate of Life ; Da Bao Lun (大寶論) the theory of the great treasure of the human body; Zhen Yin Lun (眞陰論) the theory of true-yin fluid; and Shi Er Zang Mai Hou Bu Wei Lun (十二臟脈候部位論) the theory of the part of the pulse and its condition in regards to the twelve viscera. Sanjiao Baoluo Mingmen Bian (三焦包絡命門辨), the theory of the triple warmer, the Pericardium, the Gate of Life. The triple warmer (三焦: Sanjiao) is composed of three parts: the upper, middle, and lower. This concept is also connected with the functions and roles of the vital organs. The upper burner is related to the heart and lungs. The middle burner is related to the liver and spleen. Whereas, the lower burner is related to the kidneys. Bao-Luo (包絡) is the Pericardium, the envelope of the heart, serving as the protector of the heart. Ming-Men (命門) is the Gate of Life, reffering to the vitals of life. It functions as kidney-yang which is considered as the origin of yang-energy of the human body, and serves partly as the function of cortico-adrenal gland in modern medicine. Zhang Jie Bin (張介賓) discussed the Da Bao Lun (大寶論) as the most important function in the human body because the Da Bao (大寶/great treasure) is the true-yang (眞陽) which is the affective force for physiological functions, and as the source of energy for life activities. Moreover, true-yang (眞陽) functions both as a heater and thermometer that warms the human body and indicates vitality by levels of body warmth respectively. The Zhen Yin Lun (眞陰論) theory states that if true-yang (眞陽) is energy, then true-yin (眞陰) is the source of energy. This can be likened to a tree with roots which absorbs nutrients from the ground (source), and spreads the nutrients (energy) through its branches. Thus, true-yin (眞陰) is the root cause for later functional activities of true-yang (眞陽). In Shi Er Zang Mai Hou Bu Wei Lun (十二臟脈候部位論) the theory of the pulse (脈 /Mai) and its condition in regards to the twelve viscera, Zhang Jie Bin (張介賓) insisted that when a diagnoses by the pulse is made the five vital organs and the six viscera (五臟六腑) of a human body should be harmoniously arranged in accordance with its respective part of the pulse. Furthermore, Zhang Jie Bin (張介賓) supported his theory with evidence from earlier Chinese medical doctors. And, by stating that human beings must cultivate and preserve their true-yin (眞陰) and true-yang (眞陽) energies he therefore created four new prescriptions called: Zuoguiyin (左歸飮), Youguiyin (右歸飮), Zuoguiwan (左 歸丸), Youguiwan (右歸丸). To further clarify his theory Zhang Jie Bin (張介賓) considered that the function of true-yang (眞陽) and true-yin (眞陰) is expressed by Ming-Men (命門). This theory is that for humans to be spiritually and physically healthy they must live in accord with natural law. Also, within the framework of natural law, astronomical and geographical factors must be considered for complete, holistic, health. Thus, Ming-Men is the basis for healthy living in the modern world.

• 동양고전연구
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• 제56호
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• pp.35-73
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• 2014

본고는 근대 전환기 심재(深齋) 조긍섭(曺兢燮)(1873-1933)의 시세계를 화운시(和韻詩)를 중심으로 살펴보았다. 그의 시에는 화운시 특히 두보(杜甫)와 소식(蘇軾) 시에 대한 화운시가 많다. 이것은 그가 격변의 시기에 가장 전통적인 방법으로 한시창작에 임했던 중세적 시인이었음을 가늠케 한다. 화운시를 놓고 보았을 때 그의 창작 생애는 대략 40세가 전환의 기점이 된다. 40세 이전에는 두 소뿐만 아니라 그 밖에 당(唐) 송(宋) 및 명(明) 청(淸) 대(代) 시인들, 우리나라의 이황(李滉) 등 화운의 대상이 폭넓게 나타난다. 40세 이후에는 두 소에 대한 화운은 줄어드는 대신 지역과 관련된 우리나라 인물의 시에 화운하는 예가 종종 발견된다. 연령으로는 30대에 지은 것이 가장 많다. 심재는 시재(詩才)의 온전함과 의경(意境)의 통달함을 꼽으며 두보를 '시인의 집대성(集大成)'이라 일컬었다. 그런 인식을 반영하듯이 두시 화운시도 주제와 의경이 다양하게 드러난다. 소시(蘇詩)에 대해서는 그가 따로 생각을 밝힌 바 없으나 일정한 애호를 가지고 있었던 것으로 보인다. 원시에 대한 밀착도는 두시가 소시보다 비교적 더 높게 나타난다. 거칠게 말하면 두보에 대해서는 닮고자 하면서 자기 개성을 찾아나가는 방향이라면, 소식에 대해서는 닮으려 하기보다 계기로 활용해서 자기 의사를 드러내려는 측면이 좀 더 많은 것으로 생각된다. 신중하게 보아야 할 것은 그가 화운시를 짓되 일방적인 모방에 그치지 않고 대조와 차이의 미학을 만들어 내고 있다는 점이다. 그 주제와 의경을 그대로 가져오기보다는 창작의 계기는 공유하되 시 안에 자기 뜻을 기탁해 새로운 의미를 만드는 경우가 많다. 소시 화운시는 전반적으로 원시와의 밀착력이 더 희박한 편이다. 이것은 화운이라는 제약이 많은 창작 방법을 활용하면서도 그에 전적으로 지배되지 않고 자신의 주제와 개성을 만들기 위해 노력한 흔적이라고 할 수 있다. 그런데 두 소시 화운시가 40세 이후로는 별로 지어지지 않는다는 점이 주목된다. 이것은 어쩌면 화운시 '안'에서의 노력만으로는 더 이상 감당하기 어려운 문학적 현실을 자각한 때문은 아닐까. 예컨대 그는 1919년 소식의 옥중시(獄中詩)를 차운해 4수를 짓고 다시 <구중잡제(拘中雜題)[팔수(八首)]>를 지었다. 이것저것 읊은 이 잡제에는 누구의 운에도 제약되지 않은 그의 복잡다단한 심사와 정회가 다종하게 분출되어 있다. 심재의 화운시는 근대 전환기에 한시의 아비투스가 생존했던 현실과 그 인상적인 생존 방식을 증언해 준다. 화운시 창작은 분명 그의 호고(好古)적 성향을 반영하는 것이나, 이면에는 근대적 문자 변동에 저항하는 심리가 일정하게 작용했을 것으로 판단된다. 아울러 유의할 것은 그것이 두 소시에 대한 일방적인 모습(模襲)과 같은 반동적 방향으로 내닿지는 않았다는 사실이다. 그가 한계 속에서도 자기 개성과 목소리를 내기 위해 노력했다는 점을 다시 한 번 의미 있게 새길 필요가 있다. 요컨대, 심재의 화운시는, 새로움과 기이함, '근대'라는 이름의 시도에 이목을 붙들렸던 근대 한시사에서 '접혀 있던' 한쪽 얼굴, 그 평면이 아닌 입체로서의 얼굴을 펼쳐 보게 하는 의의가 있다.

• 동양고전연구
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• 제35호
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• pp.101-133
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• 2009

청초(淸初)의 시인(詩人), 시론가(詩論家)로서 청(淸) 사대(四大) 시학(詩學) 중 하나인 신운설(神韻說)의 창도자(唱導者)로 알려진 왕사정(王士禎)은 50년 넘게 청초(淸初) 시단(詩壇)의 영수(領袖)로 활약한 인물이다. 그는 통시적(統時的)으로는 종영(鍾嶸)의 "시품(詩品)", 엄우(嚴羽)의 "시화(詩話)", 서정경(徐禎卿) 의 "담예록(談藝錄)" 등 위진(魏晉)부터 명(明)에 이르는 주요 시학(詩學)들의 성과를 통합하고 공시적(共時的)으로는 청원(淸遠)/호건(豪健), 종당(宗唐)/종송(宗宋), 완약(婉約)/호방(豪放), 북송사(北宋詞)/남송사(南宋詞)와 같은 당대(當代) 문단(文壇)의 쟁점들을 통합함으로써 자신의 통합적 시학(詩學)을 완성하였다. 이 과정에서 그의 변함없는 목표는 역시 특정한 가치에 함몰되지 않고 절대적이며 객관적인 기준 위에서 문학 본연의 가치를 구현하는 것이었다. 그 기준과 가치의 제공은 역시 신운설(神韻說)이 그 원천이 되었고 구체적으로는 '불저일자(不著一字), 진득풍류(盡得風流)', 미외지미(味外之味), 흥회(興會), 자연(自然), 아정(雅正) 등이 각각 역할을 담당했다. 또한 그의 신운설(神韻說)은 몇 가지 시품(詩品)만을 편파적으로 추켜세우는 대신, 각 시품(詩品)이 적절하고 완벽한 경지에 이르면 보편적으로 얻는 본연(本然)의 정신적 특성으로 '신운(神韻)'을 귀결지음으로써 객관적, 보편적 차원에서 그 통합성을 강화하였다. 아울러 신운설(神韻說)은 그의 시론(詩論)과 사론(詞論)을 통합하는 작용도 했다. 왕사정(王士禎)이 미학 이론으로서의 신운설(神韻說)을 성립, 발전시키는 과정에서 그의 시론(詩論)과 사론(詞論)이 상호독립적으로 윤곽을 갖추는 동시에 상호영향을 주고받았으며, 나아가 거꾸로 양자(兩者)가 신운설(神韻說)을 심화시킨 것이다. 이상과 같이 성립된 왕사정(王士禎)의 통합적 시학(詩學)은 시(詩)와 사(詞)에 대한 실제 비평에서도 특정 작가나 조대(朝代), 유파(流派)에 대한 편견에 빠지지 않고 각각의 장점을 보고 취사선택하는 객관적 감식안을 발휘하였다. 이로써 왕사정(王士禎)의 통합적 시학(詩學)은 거의 반 세기 동안 청초(淸初) 문단(文壇)을 주도하고 청(淸) 사대시학(四大詩學)의 선성(先聲)이 될 수 있었다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4441-4444
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• 2012

Background: Polymorphisms of the Taq I gene have been associated with prostate cancer risk. Methods:We applied a fixed-effects model to combine odds ratios (ORs) and 95% confidence intervals (95% CI). The Egger's test was carried out to evaluate potential publication bias. Results: A total of 10 case-control studies enrolling 1,141 prostate cancer patients and 1,685 controls were included in this meta-analysis. Compared with the T allele, the OR for the C allele was 0.81 (0.70-0.94). The ORs for CT and CC+CT genotypes were 0.86 (0.74-1.01) and 0.84 (0.73-0.97) compared to wide type genotype (homozygote TT). Conclusions: The present meta-analysis suggests that the TF gene Taq I polymorphism may reduce the prostate cancer risk in Asian populations.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2719-2722
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• 2016

Circulatory miR-133a is a marker shared by several types of cancer. In this study we evaluated the feasibility of using miR-133a levels in gastric juice to screen for gastric cancer. A total of 204 samples of gastric juice and mucosa from gastric cancer, atrophic gastritis, gastric ulcer, superficial gastritis and healthy cases were collected by gastroscopy. The results showed that miR-133a levels in gastric juice and carcinoma tissues of patients with gastric cancer were significantly downregulated and positively correlated. Moreover, miR-133a in gastric juice has high operability, high reliability, high sensitivity, high specificity and relative stability, fit for clinical diagnosis of gastric cancer.

• International Journal of Aeronautical and Space Sciences
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• 제17권1호
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• pp.29-36
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• 2016

Tensairity girder is a light weight inflatable fabric structural concept which can be used in road emergency transportation. It uses low pressure air to stabilize compression elements against buckling. With the purpose of obtaining the comprehensive target of minimum deflection and weight under ultimate load, the cross-section and the inner pressure of tensairity girder was optimized in this paper. The Variable Complexity Modeling (VCM) method was used in this paper combining the Kriging approximate method with the Finite Element Analysis (FEA) method, which was implemented by ABAQUS. In the Kriging method, the sample points of the surrogate model were outlined by Design of Experiment (DOE) technique based on Optimal Latin Hypercube. The optimization framework was constructed in iSIGHT with a global optimization method, Multi-Island Genetic Algorithm (MIGA), followed by a local optimization method, Sequential Quadratic Program (SQP). The result of the optimization gives a prominent conceptual design of the tensairity girder, which approves the solution architecture of VCM is feasible and efficient. Furthermore, a useful trend of sensitivity between optimization variables and responses was performed to guide future design. It was proved that the inner pressure is the key parameter to balance the maximum Von Mises stress and deflection on tensairity girder, and the parameters of cross section impact the mass of tensairity girder obviously.