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http://dx.doi.org/10.7314/APJCP.2016.17.5.2719

Downregulated MicroRNA-133a in Gastric Juice as a Clinicopathological Biomarker for Gastric Cancer Screening  

Shao, Juan (Key Laboratory of Gerontology, Medical College, Yangzhou University)
Fang, Peng-Hua (Key Laboratory of Gerontology, Medical College, Yangzhou University)
He, Biao (Key Laboratory of Gerontology, Medical College, Yangzhou University)
Guo, Li-Li (Key Laboratory of Gerontology, Medical College, Yangzhou University)
Shi, Ming-Yi (Key Laboratory of Gerontology, Medical College, Yangzhou University)
Zhu, Yan (Department of Endocrinology, Clinical Medical College, Yangzhou University)
Bo, Ping (Key Laboratory of Gerontology, Medical College, Yangzhou University)
Zhang, Zhen-Wen (Key Laboratory of Gerontology, Medical College, Yangzhou University)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.17, no.5, 2016 , pp. 2719-2722 More about this Journal
Abstract
Circulatory miR-133a is a marker shared by several types of cancer. In this study we evaluated the feasibility of using miR-133a levels in gastric juice to screen for gastric cancer. A total of 204 samples of gastric juice and mucosa from gastric cancer, atrophic gastritis, gastric ulcer, superficial gastritis and healthy cases were collected by gastroscopy. The results showed that miR-133a levels in gastric juice and carcinoma tissues of patients with gastric cancer were significantly downregulated and positively correlated. Moreover, miR-133a in gastric juice has high operability, high reliability, high sensitivity, high specificity and relative stability, fit for clinical diagnosis of gastric cancer.
Keywords
MicroRNA-133a; down-regulation; gastric juice; gastric cancer;
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