• Journal of Korean Society of Industrial and Systems Engineering
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• v.33 no.3
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• pp.63-70
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• 2010

Based on the known results of the expected busy periods for the triadic Min (N, T, D) and Max (N, T, D) operating policies applied to a controllable M/G/1 queueing model, a relation between them is constructed. Such relation is represented in terms of the expected busy periods for the simple N, T and D, and the dyadic Min (N, T), Min (T, D) and Min (N, D) operating policies. Hence, if any system characteristics for one of the two triadic operating policies are known, unknown corresponding system characteristics for the other triadic operating policy could be obtained easily from the constructed relation.

• Korean Journal of Microbiology
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• v.46 no.3
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• pp.233-239
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• 2010

Four genes (yqfR, yfmL, ydbR, deaD) were identified as putative DEAD-box RNA helicase genes in the genomic sequence of Bacillus subtilis by homology search. To understand the function of these genes, each of the genes was deleted and the constructed strains were tested for their growth charateristics at different temperatures. The growth rate of ydbR deletion mutant ($T_d$=53 min) was a little bit reduced at $37^{\circ}C$ as compared to that of wild type strain (CU1065). But the growth rate of other three (yqfR, yfmL, deaD) deletion mutants ($T_d$=30-40 min) is nearly equal to the growth rate of wild type ($T_d$=32 min). On the other hands, the growth rate of deletion mutants were reduced at $22^{\circ}C$ in order of yqfR ($T_d$=151 min), yfmL ($T_d$=214 min), ydbR ($T_d$=343 min), which showed cold-sensitive phenotype. The deletion mutant of deaD ($T_d$=109 min) grew equally as compared to the growth rate ($T_d$=102 min) of the wild type at $22^{\circ}C$ and did not show cold-sensitive growth. Double, triple and quadruple deletion mutants of these genes were constructed, and growth rate of these mutants were measured at various temperature conditions ($22^{\circ}C$, $37^{\circ}C$, $42^{\circ}C$) using LB broth. Multiple deletion mutations showed more severe cold-sensitive growth than single deletion mutations, and double deletion of ydbR and yfmL ($T_d$=984 min) showed most cold-sensitive growth than any other double mutants. Such a cold-sensitive growth of these mutations is quite similar to the result of csdA or srmB deletion in E. coli and suggested that physiological role of ydbR and yfmL is related with ribosome assembly.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.33 no.2
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• pp.97-104
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• 2010

Using the known result of the expected busy period for the triadic Min (N, T, D) operating policy applied to a controllable M/G/1 queueing model, its upper and lower bounds are derived to approximate its corresponding actual value. Both bounds are represented in terms of the expected busy periods for the dyadic Min (N, T), Min (N, D) and Min (T, D) and simple N, T and D operating policies. All three input variables N, T and D are equally contributed to construct such bounds for better approximations.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.36 no.1
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• pp.58-63
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• 2013

Using the known result of the expected busy period for the triadic Med (N, T, D) operating policies applied to a controllable M/G/1 queueing model, its upper and lower bounds are derived to approximate its corresponding actual values. Both bounds are represented in terms of the expected busy periods for the dyadic Min (N, T), Min (N, D) and Min (T, D) or Max (N, T), Max (N, D) and Max (T, D) with the simple N, T and D operating policies without using any other types of triadic operating policies such as Min (N, T, D) and Max (N, T, D) policies. All three input variables N, T and D are equally contributed to construct such bounds for estimation of the expected busy period.

• Toxicological Research
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• v.6 no.1
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• pp.75-88
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• 1990

The characteristics of dopamine uptake, D-1 and D-2 receptors after acute and subacute cocaine administration were determind in striatum from WKY and SHR. Cocaine was administered either acutely (40 mg/kg, s.c.) or twice daily (20 mg/kg, s.c.) for 3 and 7 days in 9-wk old WKY and SHR. Rats were sacrificed 30 min, 2 or 24 h after the single injection and 18 h after the last administration to the subacutely treated group. The changes in dopamine uptake, dopamine uptake sites, D-1 and D-2 receptors were determined using $(^3H)$dopamine, $(^3H)$-GBR-12935, $(^3H)$SCH-23390 and $(^3H)$sulpiride, respectively. In acutely treated rats, significant increases in $V_{max}$of dopamine uptake were observed 30 min after the cocanine injection in both strains without changes in $K_m$ values. The in vitro $IC_{50}$for cocaine was significantly decreased 30 min in WKY and 2 h in SHR. However, that for in vitro GBR-12909 was significantly increased 30 min and 2 h in both strains. Also densities of $(^3H)$-GBR-12935 binding sites were significantly increased 30 min and 2 h without changes in their $K_d$. Significant increases in D-2 receptor density were observed 30 min, 2 or 24 h after acute injection in both strains without changes in their affinities. The density of D-1 receptor was significantly decreased 30 min after the injection in WKY, but not in SHR. In subacutely treated rats, a significant increase in $K_m$ of dopamine uptake was observed in 7-day treated SHR. The in vitro $IC_{50}$fot GBR-12909 was significantly increased in 3-day treated WKY. The density of D-1 receptors was significantly increased in 3- and 7-day treated WKY, but not in SHR. The affinity of both binding sites remained unchanged. The results suggest that cocanine administration alters dopamine uptake, characteristics of dopamine uptake sites and dopamine receptor binding characteristics in rat brain. Furthermore, D-1 and D-2 dopamine receptors appear to be differently regulated.

• Proceedings of the Korea Information Processing Society Conference
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• 2022.05a
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• pp.702-704
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• 2022

자율주행 시뮬레이터를 위한 대체재로 게임 엔진을 통한 가상 환경 모의 연구가 수행되고 있다. 하지만 게임 엔진에서는 자율 주행에 필요한 센서를 기기에 맞게 사용자가 직접 모델링을 해줘야 하기 때문에 개발 비용이 크게 작용된다. 특히, Ray 를 활용한 3D LIDAR 는 GPU(Graphics Processing Unit) 사용량이 많은 작업이기 때문에 저비용 시뮬레이터를 위해서는 저비용 3D LIDAR 모의가 필요하다. 본 논문에서는 낮은 컴퓨터 연산을 사용하는 C++ 기반 3D LIDAR 모의 프레임 워크를 제안한다. 제안된 3D LIDAR 는 다수의 언덕으로 이루어진 비포장 Map 에서 성능을 검증 하였으며, 성능 검증을 의해 본 논문에서 생성된 3D LIDAR 로 간단한 LPP(Local Path Planning) 생성 방법도 소개한다. 제안된 3D LIDAR 프레임 워크는 저비용 실시간 모의가 필요한 자율 주행 분야에 적극 활용되길 바란다.

• Toxicological Research
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• v.13 no.1_2
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• pp.117-125
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• 1997

In order to assess the possibility whether CYP2D is involved in caffeine metabolism, we have purified and characterized the rat liver microsomal cytochrome P4502D1 (CYP2D1), equivalent to CYP2D6 in human liver, and have utilized the reconstituted CYP2D1 in the metabolism of 4 primary caffeine (1, 3, 7-trimethylxanthine) metabolites such as paraxanthine (1, 7-dimethylxanthine), 1, 3, 7-trimethylurate, theophylline (1, 3-dimethylxanthine) and theobromine (3, 7-dimethylxanthine). Rat liver CYP 2D1 has been purified to a specific content of 8.98 nmole/mg protein (13.4fold purification, 1.5% yield) using $\omega$-aminooctylagarose, hydroxlapatite, and DE52 columns in a sequential manner. As judged from sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), the purified CYP2D1 was apparently homogeneous. Molecular weight of the purified CYP2D1 was found to be 51, 000 Da. Catalytic activity of the purified and then reconstituted CYP2D1 was confirmed by using bufuralol, a known subsFate of CYP2D1. The reconstituted CYP2D1 was found to produce to 1-hydroxylbufuralol at a rate of 1.43$\pm$0.13 nmol/min/nmol P450. The kinetic analysis of bufuralol hydroxylation indicated that Km and Vmax values were 7.32$\mu M$ and 1.64 nmol/min/nmol P450, respectively. The reconstituted CYP2D1 could catalyze the 7-demethylation of PX to 1-methylxanthine at a rate of 12.5 pmol/min/pmol, and also the 7- and 3- demethylations of 1, 3, 7-trimethylurate to 1, 3-dimethylurate and 1, 7-dimethylurate at 6.5 and 12.8 pmol/min/pmol CYP2D1, respectively. The reconstituted CYP2D1 could also 3-demethylate theophylline to 1-methylxanthine at 5 pmol/min/pmol and hydroxylate the theophylline to 1, 3-dimethylurate at 21.8 pmol/min/pmol CYP2D1. The reconstituted CYP2D1, however, did not metabolize TB at all (detection limits were 0.03 pmol/min/pmol). This study indicated that CYP2D1 is involved in 3-and 7-demethylations of paraxanthine and theophylline and suggested that CYP2D6 (equivalent to CYP2D1 in rat liver) present in human liver may be involved in the secondary metabolism of the primary metabolites of caffeine.

• Molecules and Cells
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• v.19 no.3
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• pp.382-390
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• 2005

Calcium-binding proteins are thought to play important roles in calcium buffering. The present study investigated the effects of ischemia and reperfusion on calbindin D28K, calretinin, and parvalbumin immunoreactivity in the ganglion cell layer of the rabbit. Rabbits were administered ischemic damage by increasing the intraocular pressure. After 60 and 90 min of ischemia, reperfusion (7 d) was allowed to occur. The b-wave of the electroretinogram (ERG) was reduced by more than 50% and almost 80% in retina given ischemia for 60 and 90 min, respectively. The oscillatory potential (OPs) wave was reduced approximately 50% at 60 min ischemia and 70% at 90 min ischemia. In both normal and ischemic-treated retina, calcium-binding protein immunoreactivity was seen in many cells in the ganglion cell layer. In eyes subjected to 60 min ischemia, there was a decrease of the density of calbindin D28K- (8.29%), calretinin- (14.44%), and parvalbumin- (26.83%) immunoreactive (IR) cells compared to the control retina. In eyes subjected to 90 min ischemia, there was a higher decrease of the density of calbindin D28K- (18.48%), calretinin- (33.59%), and parvalbumin- (54.26%) IR cells than at 60 min. Some calcium-binding protein-IR neurons, especially calretinin-IR neurons, showed aggregations that were abnormally packed together in retina subjected to ischemia for 90 min. The results show that calbindin D28K-, calretinin-, and parvalbumin-IR cells in the ganglion cell layer are susceptible to ischemic damage and reperfusion. The degree of reduction varied among different calcium-binding proteins and ischemic damage times. These results suggest that calbindin D28K-containing neurons are less susceptible to ischemic damage than calretinin- and parvalbumin-containing neurons in the ganglion cell layer of rabbit retina.

• Journal of Environmental Science International
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• v.23 no.11
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• pp.1843-1850
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• 2014

PS-D2EHPA beads were prepared by immobilizing di-2-ethylhexyl-phosphoric acid (D2EHPA) with polysulfone (PSf). The removal experiments of Cu(II) and Pb(II) by the prepared PS-D2EHPA beads were conducted batchwise. The removal efficiency of Cu(II) and Pb(II) by PS-D2EHPA beads was increased with increasing pH of solution. The removal rate of Cu(II) and Pb(II) was well described by the pseudo-second-order kinetic model. The maximum removal capacity of Cu(II) and Pb(II) obtained from Langmuir isotherm were 2.58 mg/g and 12.63 mg/g, respectively. External mass transfer coefficients for the removal of Cu(II) and Pb(II) by PS-D2EHPA beads were obtained $0.61{\times}10^{-2}{\sim}5.87{\times}10^{-2}/min$ and $1.55{\times}10^{-2}{\sim}8.53{\times}10^{-2}/min$, respectively and diffusion coefficients were obtained $1.32{\times}10^{-4}{\sim}3.98{\times}10^{-4}cm^2/min$ and $1.80{\times}10^{-4}{\sim}2.28{\times}10^{-4}cm^2/min$, respectively.

• ETRI Journal
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• v.38 no.4
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• pp.612-621
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• 2016

A new time-domain decoder for Reed-Solomon (RS) codes is proposed. Because this decoder can correct both errors and erasures without computing the erasure locator, errata locator, or errata evaluator polynomials, the computational complexity can be substantially reduced. Herein, to demonstrate this benefit, complexity comparisons between the proposed decoder and the Truong-Jeng-Hung and Lin-Costello decoders are presented. These comparisons show that the proposed decoder consistently has lower computational requirements when correcting all combinations of ${\nu}$ errors and ${\mu}$ erasures than both of the related decoders under the condition of $2{\nu}+{\mu}{\leq}d_{\min}-1$, where $d_{min}$ denotes the minimum distance of the RS code. Finally, the (255, 223) and (63, 39) RS codes are used as examples for complexity comparisons under the upper bounded condition of min $2{\nu}+{\mu}=d_{\min}-1$. To decode the two RS codes, the new decoder can save about 40% additions and multiplications when min ${\mu}=d_{min}-1$ as compared with the two related decoders. Furthermore, it can also save 50% of the required inverses for min $0{\leq}{\mu}{\leq}d_{\min}-1$.