• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.2115-2120
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• 2012

The presence of lung cancer cells in anoxic zones is a key cause od chemotherapeutic resistance. Thus, it is necessary to enhance the sensitivity of such lung cancer cells. However, loss of efficient gene therapeutic targeting and inefficient objective gene expression in the anoxic zone in lung cancer are dilemmas. In the present study, a eukaryotic expression plasmid pUC57-HRE-JAB1 driven by a hypoxia response elements promoter was constructed and introduced into lung cancer cell line A549. The cells were then exposed to a chemotherapeutic drug cis-diamminedichloroplatinum (C-DDP). qRT-PCR and western blotting were used to determine the mRNA and protein level and flow cytometry to examine the cell cycle and apoptosis of A549 transfected pUC57-HRE-JAB1. The results showed that JAB1 gene in the A549 was overexpressed after the transfection, cell proliferation being arrested in G1 phase and the apoptosis ratio significantly increased. Importantly, introduction of pUC57-HRE-JAB1 significantly increased the chemotherapeutic sensitivity of A549 in an anoxic environment. In conclusion, JAB1 overexpression might provide a novel strategy to overcome chemotherapeutic resistance in lung cancer.

• 한국방사선학회논문지
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• 제15권2호
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• pp.191-199
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• 2021

본 연구의 목적은 경량 연자성 소재의 방사선 차폐 효과를 분석하여 군사시설에 대한 적용 가능성을 확인하는 것이다. 연자성 물질은 EMP 차폐에 효과적인 것으로 알려져 있다. 이 물질이 방사선 차폐에도 효과적이라면 군 방호에 효과적으로 적용이 가능할 것으로 예상된다. 이에 본 연구에서는 감마선 차폐 효과를 확인하기 위해 Cs-137 및 Co-60 선원을 사용하여 실험을 수행하였으며, 중성자 차폐 효과를 평가하기 위해 Monte Carlo N-Particle (MCNP) 모델링을 적용하였다. 그 결과 연자성 소재의 두께가 증가함에 따라 감마선과 중성자의 선형 감쇠 법칙에 의한 차폐성능이 향상됨을 확인할 수 있었다. 따라서 연자성 소재를 군사용 구조물 등에 적용할 경우에 방사선 차폐에 효과적이라는 것을 확인하였다.

• 산업경영시스템학회지
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• 제4권5호
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• pp.65-71
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• 1981

The Marketing strategy is basic to the marketing plan for a firm. It encompasses the art and science of employing the means for achieving established marketing goals. The use of the word "strategy" in reference to the performance of marketing operations has been accepted in general usage during the last twenty years by both business practitioners and educators. It has been borrowed from the military vocabulary where it refers to the art and science of employing the armed strength of a belligerent force to secure the objectives of war. A marketing strategy consists of two distinct and yet interrelated parts: 1. A target market ${\cdots}{\cdots}$a fairly homogeneous group of customers to whom a company wishes to appeal. 2. A marketing mix ${\cdots}{\cdots}$ the controllable variables which the company combines to satisfy this target group.get group.

• 한국전자거래학회지
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• 제3권2호
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• pp.161-178
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• 1998

We followed the below procedure to establish the development strategy of CITIS standard. At first, we investigated Military CITIS and Commercial CITIS to establish the concept of CITIS and examined several implemented examples. And using the previous analysis, We analyzed the structure of the functions, the technologies and the standards. To establish the development strategy of CITIS standard, we divided CITIS standards into three category, These are infrastrucure standard, data standard and process standard. In the process standard, we analyzed how we develop a formulated process and which item we select to make formulated official documents. And finally, We explained the implementation plan and extension strategy of government-enterprise and inter-enterprise CITIS respectively.

• Strategy21
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• 통권37호
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• pp.32-64
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• 2015

This paper examines the types and trends of North Korea's military provocations and regional maritime threats against South Korea, and is focusing on the Republic of Korea's naval development and modernizations by the Republic of Korea Navy (ROKN) on future actions, what directions of the ROKN has taken thus far in response, as well as an examination of how the ROKN might respond to vulnerabilities identified throughout modern history. Importantly, this paper does not consider the domestic, bilateral, multilateral, regional and global political dimensions of the situation on the Korean Peninsula; nor does it consider the North Korea's transitional power politics, but including North Korea's nuclear program and submarine-launched ballistic missile developments, as a caveat, this paper is based on open sources in Korean and English language, and thus information concerning provocations is indicative only.

• BMB Reports
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• 제46권6호
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• pp.316-321
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• 2013

Gastric cancer remains the main cause of cancer death all around the world, and upregulated activation of the nonreceptor tyrosine kinase c-SRC (SRC) is a key player in the development. In this study, we found that expression of Src is also increased in clinical gastric cancer samples, with the protein level increased more significantly than that at the RNA level. Further study revealed that miR34a and miR203, two tumor suppressive miRNAs, inversely correlate with the expression of Src. Restoration of miR34a and miR203 decreased Src expression in gastric cancer cell lines, which in turn inhibited cell growth and cell migration. In summary, our study here revealed that posttranscriptional regulation of Src contributes to the deregulated cell growth and metastasis in gastric cancer, and targeting Src by miR34a or miR203 mimics would be a promising strategy in therapy.

• 문화기술의 융합
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• 제8권1호
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• pp.291-298
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• 2022

대규모 재난이 전 세계적으로 발생하여 막대한 사회·경제적 피해가 발생하고 있다. 군은 오래전부터 위기·재난관리를 위한 법령제정, 조직정비, 시스템 구축 등을 수행하였으나, 대규모 재난으로 군 핵심기능 중단 상황은 고려하지 않았다. 미군은 9.11 테러를 계기로 모든 위기상황에서 군의 핵심기능 지속을 목적으로 하는 기능연속성전략을 발전시켰으며, 중단없는 안보기능을 보장하여 국가연속성에 이바지하고 있다. 우리 군은 위기 및 재난관리시스템을 구축하였으나, 재난과 위기상황을 관리하고 통제하는데 중점을 두고 있다. 군의 관리능력을 벗어난 대규모 위기상황에서도 군 핵심기능 보장을 위한 제도가 필요하다. 본 연구에서는 ISO22301 국제표준, 미국 정부 및 군, 일본 정부COOP 지침을 비교·검토하였다. 그리고 ISO22301을 기준으로 미군 연속성 지침을 참고하여 군사분야 COOP전략지침안(案)을 개발하였다. 본 연구에서 개발한 지침은 미(美) 육·해·공군 지침의 장점을 취합하여 군사적 특성을 기존 표준에 적용·발전시킨 국내 최초 COOP계획 관련 지침이다. 기존 위기 / 재난관리매뉴얼과 정책으로 대응이 제한되는 위기상황에서 군 핵심기능 유지를 위한 제도도입 및 계획수립의 참고자료로 활용될 수 있을 것으로 기대한다.

• 한국건축시공학회지
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• 제13권3호
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• pp.263-271
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• 2013

Change orders have been widespread in both the private and public construction sectors. In particular, in the case of G2B (Government to Business) contracts, adjustment of contract price and/or schedule extension is a frequent occurrence due to change orders. To uncover the causes of change orders and suggest an appropriate strategy, this study analyzed 296 cases of change orders in military facility construction projects from 2008 to 2010. The analysis revealed that the major causes of change orders are users' additional requirements (28.38%), a change of finishing materials (23.99%), and change of footing type (17.57%), in that order. Building on the results of this analysis, the authors suggest plans for practical improvements. Specific recommendations include 1) reflect user requirements at the early stage, 2) minimize the use of additional budget due to change orders, and 3) reduce the process and time for contract amendment, among others. The results of this study may provide significant implications to those involved in military construction projects, particularly project owners (i.e., the Ministry of Defense) and contractors.

• Journal of Information Technology Applications and Management
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• 제20권1호
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• pp.1-17
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• 2013

It has been found that users' characteristics are important variables that explain information systems adoption. These user groups, which are called COIs (Community Of Interests), might show different behaviors to each other to the same information system. We study differences in MDM (master data management) system adoption between military users and SI developers using TAM (Technology Acceptance Model). In case of military users, the perceived usefulness of an MDM system does not have impacts on intention to use an MDM system. Only the ease of use of an MDM system has impacts on intention to use an MDM system. However, in case of SI developers, both the perceived usefulness and the ease of use of an MDM system have impacts on intention to use an MDM system, which are similar to findings in previous studies. These results might be interpreted that users do not pay much attention to the usefulness in adopting a new information system in a centralized organization. They are obligated to use an information system whether it is useful or not. Thus the ease of use has more impacts on users than the usefulness.

• 한국경영과학회지
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• 제39권2호
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• pp.1-19
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• 2014

Recently, one of the core keywords in information technology (IT) as well as areas such as business management is big data. Big data is a term that includes technology, personnel, and organization required to gather/manage/analyze collection of data sets so large and complex that it becomes difficult to manage and analyze using traditional tools. The military has been accumulating data for a long period due to the organization's characteristic in placing emphasis on reporting and records. Considering such characteristic of the military, this study verifies the possibility of improving the performance of the military organization through use of big data and furthermore, create scientific development of operation, strategy, and support environment. For this purpose, the study organizes general status and case studies related to big data, traces back examples of data utilization by Korean's national defense sector through US military data collection and case studies, and proposes the possibility of using and applying big data in the national defense sector.