• 제목/요약/키워드: Military Hospital

검색결과 342건 처리시간 0.023초

Synergistic Increase of Oxidative Stress and Tumor Markers in PAH-Exposed Workers

  • Gao, Mei-Li;Chen, Lei;Li, Yong-Fei;Xue, Xiao-Chang;Chen, Lan;Wang, Li-Na;Shah, Walayat;Kong, Yu
    • Asian Pacific Journal of Cancer Prevention
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    • 제15권17호
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    • pp.7105-7112
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    • 2014
  • In this study, we investigated oxidative stress and tumor marker levels of polycyclic aromatic hydrocarbons (PAHs) in 136 coke oven workers and in 60 control subjects, and evaluated the correlation between oxidative stress and tumor marker levels. Questionnaires on basic demographic information were also administered. Significant differences in employment time and percentages of alcohol drinkers were observed between the control and exposed groups. PAH exposure was assessed using urinary 1-hydroxy-pyrene (1-OHP) levels and was found to be significantly higher in workers than in the controls. Significant differences (P<0.001) of MDA, GST, LDH, NSE, Cyfra21-1, and of SCC and TNF-a (P<0.0001 and P<0.05, P<0.001, respectively) levels were observed among controls and coke-oven workers, except for bottom coke oven workers. Associations between age and risk of increased TNF-a, smoking and increased GST activities, and drinking with increased MDA concentrations, were marginal (P=0.055, P=0.048, P=0.057, respectively). The association between smoking with MDA (P=0.004), NSE (P=0.005), SCC (P=0.004) andTNF-a (P<0.001), and drinking with TNF-a levels was significant (P=0.012). In addition, a significant positive correlation between oxidative stress and tumor markers was found in the present study. These results suggest that a synergistic increase of oxidative stress and tumor markers induced by PAHs may play a role in toxic responses for PAHs in coke oven workers.

전문대학(專門大學)의 방사선과(放射線科) 교육(敎育)에 관(關)한 조사연구(調査硏究) (Investigation on Education of Radiological Technology in Junior College)

  • 최종학;김영일;전만진
    • 대한방사선기술학회지:방사선기술과학
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    • 제5권1호
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    • pp.77-95
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    • 1982
  • The result of this study from surveying and analyzing the present situation of educational institutes of radiologic technology, educational situation of radiologic technology, and students' attitude and recognition about the education of radiologic technology, the faculty's thought of it throughout the country from October, 1981 to April, 1982 is as follows: 1. The total number of educational institutes for radiologic technology is 11, but all of them are private colleges classified by foundation and 1,414 freshmen were admitted to enter the colleges by admission quotas of students at present in March, 1982. 2. The number of male(1965-1982) is 3,046(78.0%), that of female is 856(22.0%), and total of them is 3,904 that graduated from the departments of radiologic technology in 9 junior colleges in Korea. 3. The number of the instructional staffs in radiologic technology in Korea is 32, but among them 1 professor, 1 associate professor, 16 assistant professors and 14 full-time instructors. 4. The credits for graduation are 80-96 credits and students need required liberal arts and required major studies to get the qualification for graduation. 5. In the national examination for radio-technologist license, total 7,150 persons took the examination, but only 2,796 persons passed it, therefore, the average passed rate is 39.1% from the year 1965 to 1982. 6. 61.3% of students expressed dissatisfaction about their campus lives, the reason of which is mainly poor educational facilities(26.7%), insufficient number of faculty(21.2%) and negative Recognition on junior college from society, etc. 7. About the education of their major studies of colleges, 70.9% of students answered that they were short of laboratory works and clinical trainings rather than theoretical lessons. 8. The chief problem in practice works is about facilities and equipemtns for practice (students 39.1%, faculty 68.8%), and about the fact that too many students usually work at a time(students 17.1%, faculty 21.9%), etc. 9. 87.4% of students and 93.8% of faculty answered that clinical training in school is necessary. 10. Students' viewpoints on the radiologic technologist and the attitudes on the profession as a radiologic technologist are approximately affirmative. 11. Fields of employment to advance after graduation are mainly the fields related to their major studies(hospital, clinic, health clinic, industrial companies related and military officers of medical technology, etc.), which fields arc predominant to 74.5% rather than non-related fields(enrols into 4 year colleges, etc.). 12. 85.2% of students, 87.5% of the faculty expressed their opinions that the present academic years of 2 should be lengthened more. 13. 90.7% of the faculty expressed their opinions that the present students quotas should be reduced in whole or in part.

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개 심장사상충을 진단하기 위한 중합연쇄반응검사 (PCR)의 진단적 특성 평가 (Evaluation of Diagnostic Performance of a Polymerase Chain Reaction for Detection of Canine Dirofilaria immitis)

  • 박선일;김두
    • 한국임상수의학회지
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    • 제24권2호
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    • pp.77-81
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    • 2007
  • 본 연구는 개에서 심장사상충을 검출하기 위하여 표준검사를 적용하지 않은 상황에서 중합연쇄반응검사 (PCR)의 진단 능력을 평가하였다. 효소면역검사법 (ELISA)과 PCR 검사를 동시에 사용한 경우 PCR 검사의 민감도와 특이도는 두 검사의 조건부 독립을 가정한 상태에서expectation-maximization (EM) 알고리즘을 이용한 최대우도법과 Bayesian 기법으로 두 집단 검사 모형으로 분석하였다 2002-2004년 기간 중 심장사상충검사 결과를 기록한 의무기록에서 무작위로 266개 결과를 추출하여 133개씩 2회의 시험으로 배치하였다. 2회의 분석결과를 종합할 때 EM 알고리즘에서 PCR 검사의 민감도와 특이도는 각각 96.4-96.7%와 97.6-98.8%, Bayesian기법에서는 94.4-94.8h와 97.1-98%로 추정되었다. PCR 검사는 심장사상충을 스크리닝하는 도구로 유용하며, 표준검사를 적용하지 않은 상황에서 진단검사의 특성을 추론하는 방법으로 Bayesian 기법은 매우 유용함을 확인하였다.

The Up-Regulation of miR-199b-5p in Erythroid Differentiation Is Associated with GATA-1 and NF-E2

  • Li, Yuxia;Bai, Hua;Zhang, Zhongzu;li, Weihua;Dong, Lei;Wei, Xueju;Ma, Yanni;Zhang, Junwu;Yu, Jia;Sun, Guotao;Wang, Fang
    • Molecules and Cells
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    • 제37권3호
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    • pp.213-219
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    • 2014
  • MicroRNAs (miRNAs) represent a class of small non-coding regulatory RNAs that play important roles in normal hematopoiesis, including erythropoiesis. Although studies have identified several miRNAs that regulate erythroid commitment and differentiation, we do not understand the mechanism by which the crucial erythroid transcription factors, GATA-1and NF-E2 directly regulate and control differentiation via miRNA pathways. In this study, we identified miR-199b-5p as a key regulator of human erythropoiesis, and its expression was up-regulated during the erythroid differentiation of K562 cells. Furthermore, the increase of miR-199b-5p in erythroid cells occurred in a GATA-1- and NF-E2-dependent manner during erythrocyte maturation. Both GATA-1 and NF-E2 bound upstream of the miR-199b gene locus and activated its transcription. Forced expression of miRNA-199b-5p in K562 cells affected erythroid cell proliferation and maturation. Moreover, we identified c-Kit as a direct target of miR-199b-5p in erythroid cells. Taken together, our results establish a functional link among the erythroid transcription factors GATA-1/NF-E2, miR-199b-5p and c-Kit, and provide new insights into the coupling of transcription and post-transcription regulation in erythroid differentiation.

Prevalence and associates of obesity and overweight among school-age children in a rural community of Thailand

  • Nonboonyawat, Teechaya;Pusanasuwannasri, Wuttipat;Chanrat, Nattanon;Wongthanavimok, Natta;Tubngern, Danutanut;Panutrakul, Piengkwan;Mungthin, Mathirut;Nivesvivat, Thirapa;Hatthachote, Panadda;Rangsin, Ram;Piyaraj, Phunlerd
    • Clinical and Experimental Pediatrics
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    • 제62권5호
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    • pp.179-186
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    • 2019
  • Purpose: Information about overweight and obesity among students in rural areas of Thailand is limited. Therefore, we aimed to determine overweight and obesity prevalences and associated factors among school-aged children in a rural community of Thailand. Methods: We selected 9 public schools through cluster sampling in 2 provinces located in central Thailand in 2016. Anthropometric measurements were measured using standard techniques, classified as overweight (>1 standard deviation [SD]) and obese (>2 SD) with respect to their age and sex using 2007 World Health Organization reference charts. Standardized questionnaires on risk factors were sent to parents to be completed together with their child. Results: Among 1,749 students, 8.98% had overweight and 7.26% had obesity. Mean age (range) was 11.5 years (5-18 years). Independent factors associated with overweight and obesity included primary school student (reference as secondary school) (adjusted odds ratio [aOR], 2.25; 95% confidence interval [CI], 1.24-4.08; P=0.07), mother's body mass index (aOR, 1.07; 95% CI, 1.02-1.12; P=0.001), self-employed father (aOR, 1.99; 95% CI, 1.12-3.55; P=0.018), number of siblings (aOR, 0.61; 95% CI, 0.47-0.81; P=0.001), having sibling(s) with obesity (aOR, 1.82; 95% CI, 1.20-2.77; P=0.005), more than one (aOR, 7.16; 95% CI, 2.40-21.32; P<0.001), consuming 2-3 ladles of rice/meal (aOR, 2.14; 95% CI, 1.38-3.32; P=0.001), consuming >3 ladles of rice/meal (aOR, 2.69; 95% CI, 1.11-6.46; P=0.27), watching <2 hours of television/day (aOR, 2.18; 95% CI, 1.19-4.01; P=0.012), and watching >2 hours of television/day (aOR, 2.60; 95% CI, 1.36-4.96; P=0.004). Conclusion: Many sociodemographic, dietary, and behavioral factors were related to overweight and obesity among school-aged children not only in urban but also rural communities of Thailand.

의료능력을 고려한 대량전상자 환자분류 강화학습 모델 (Reinforcement Learning Model for Mass Casualty Triage Taking into Account the Medical Capability)

  • 박병호;조남석
    • 한국재난정보학회 논문집
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    • 제19권1호
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    • pp.44-59
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    • 2023
  • 연구목적: 대량전상자 발생 시 신속하고 정확한 환자분류가 진행되어야 최대한 많은 환자를 회복시켜 전장으로 돌려보낼 수 있다. 그러나 복잡한 전투현장에서 적은 의료인력으로 대량전상자의 환자분류를 시행하기란 임무는 과다하고 환경은 불확실하다. 따라서, 전투현장에서 의료인력을 보조하고 대체할 수 있는 인공지능 모델에 대해 논의하고자 한다. 연구방법:인공지능의 한 분야인 강화학습을 활용하여 환자분류 모델을 제시한다. 모델의 학습은 무작위로 설정된 환자의 상태와 병원시설의 의료능력을 고려하여 최대 다수의 환자가 치료받을 수 있는 정책을 찾도록 진행된다. 연구결과:강화학습 모델이 정상적으로 학습되었음은 누적 보상 값 등을 통하여 확인하였고, 학습된 모델이 정확하게 환자를 분류하는 것은 생존자 수를 통해 확인하였다. 또한, 규칙 기반 모델과 비교하여 성능을 검증하였으며, 강화학습 모델이 규칙 기반 모델에 비해 약 10%만큼 더 많은 환자를 생존시킬 수 있었다. 결론:강화학습을 이용한 환자분류 모델은 의료인력의 대량전상자 환자분류 의사결정을 보조하고 대체하는 대안으로 활용 가능하다.

Integration and Reanalysis of Four RNA-Seq Datasets Including BALF, Nasopharyngeal Swabs, Lung Biopsy, and Mouse Models Reveals Common Immune Features of COVID-19

  • Rudi Alberts;Sze Chun Chan;Qian-Fang Meng;Shan He;Lang Rao;Xindong Liu;Yongliang Zhang
    • IMMUNE NETWORK
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    • 제22권3호
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    • pp.22.1-22.25
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    • 2022
  • Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndromecoronavirus-2 (SARS-CoV-2), has spread over the world causing a pandemic which is still ongoing since its emergence in late 2019. A great amount of effort has been devoted to understanding the pathogenesis of COVID-19 with the hope of developing better therapeutic strategies. Transcriptome analysis using technologies such as RNA sequencing became a commonly used approach in study of host immune responses to SARS-CoV-2. Although substantial amount of information can be gathered from transcriptome analysis, different analysis tools used in these studies may lead to conclusions that differ dramatically from each other. Here, we re-analyzed four RNA-sequencing datasets of COVID-19 samples including human bronchoalveolar lavage fluid, nasopharyngeal swabs, lung biopsy and hACE2 transgenic mice using the same standardized method. The results showed that common features of COVID-19 include upregulation of chemokines including CCL2, CXCL1, and CXCL10, inflammatory cytokine IL-1β and alarmin S100A8/S100A9, which are associated with dysregulated innate immunity marked by abundant neutrophil and mast cell accumulation. Downregulation of chemokine receptor genes that are associated with impaired adaptive immunity such as lymphopenia is another common feather of COVID-19 observed. In addition, a few interferon-stimulated genes but no type I IFN genes were identified to be enriched in COVID-19 samples compared to their respective control in these datasets. These features are in line with results from single-cell RNA sequencing studies in the field. Therefore, our re-analysis of the RNA-seq datasets revealed common features of dysregulated immune responses to SARS-CoV-2 and shed light to the pathogenesis of COVID-19.

The Survey of Dentists: Updated Knowledge about Basic Life support and Experiences of Dental Emergency in Korea

  • Cho, Kyoung-Ah;Kim, Hyuk;Lee, Brian Seonghwa;Kwon, Woon-Yong;Kim, Mi-Seon;Seo, Kwang-Suk;Kim, Hyun-Jeong
    • 대한치과마취과학회지
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    • 제14권1호
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    • pp.17-27
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    • 2014
  • Background: Various medical emergency situations can occur during dental practices. Cardiac arrest is known to comprise approximately 1% of emergency situation. Thus, it is necessary for dentists to be able to perform cardiopulmonary resuscitation (CPR) to increase the chance of saving patient's life in emergency situation. In this paper, we conducted a survey study to evaluate to what extent dentists actually understood CPR practice and if they had experience in handling emergency situations in practice. Method: The survey was done for members of the Korean Dental Society of Anesthesiology (KDSA), who had great interest in CPR and for whom survey-by-mail was convenient. We had selected 472 members of the KDSA with a dental license and whose office address and contact information were appropriate, and sent them a survey questionnaire by mail asking about the degree of their CPR understanding and if they had experience of handling emergency questions before. Statistical analyses -frequency analysis, chi-square test, ANOVA, and so on- were performed by use of IBM SPSS Statistics 19 for each question. Result: Among 472 people, 181 responded (38.4% response rate). Among the respondents were 134 male and 47 female dentists. Their average age was $40.4{\pm}8.4$. In terms of practice type, there were 123 private practitioners (68.0%), 20 professors (11.0%), 16 dentists-in-service (8.8%), 13 residents (specialist training) (7.2%) and 9 military doctors (5%). There were 125 dentists (69.1%) who were specialists or receiving training to be specialist, most of whom were oral surgeon (57, 31.5%) and pediatric dentists (56, 30.9%). There were 153 people (85.0%) who received CPR training before, and 65 of them (35.9%) were receiving regular training. When asked about the ratio of chest pressure vs mouth-to-mouth respiration when conducting CPR, 107 people (59.1%) answered 30:2. However, only 27.1% of them answered correctly for a question regarding CPR stages, C(Circulation)- A(Airway)- B(Breathing)- D(Defibrillation), which was defined in revised 2010 CPR practice guideline. Dentists who had experience of handling emergency situations in their practice were 119 (65.6%). The kinds of emergency situations they experienced were syncope (68, 37.6%), allergic reactions to local anesthetic (44, 24.3%), hyperventilation (43, 23.8%), seizure (25, 13.8%), hypoglycemia (15, 8.3%), breathing difficulty (14, 7.8%), cardiac arrest (11, 6.1%), airway obstruction (6, 3.3%), intake of foreign material and angina pectoris (4, 2.2%), in order of frequency. Most respondents answered that they handled the situation appropriately under the given emergency situation. In terms of emergency equipment they had blood pressure device (70.2%), pulse oximetry (69.6%), Bag-Valve-Mask (56.9%), emergency medicine (41.4%), intubation kit (29.8%), automated external defibrillator (23.2%), suction kit (19.3%) and 12 people (6.6%) did not have any equipment. In terms of confidence in handling emergency situation, with 1-10 point scale, their response was $4.86{\pm}2.41$ points. The average point of those who received regular training was $5.92{\pm}2.20$, while those who did not was $4.29{\pm}2.29$ points (P<0.001) Conclusion: The result showed they had good knowledge of CPR but the information they had was not up-to-date. Also, they were frequently exposed to the risk of emergency situation during their dental practice but the level of confidence in handling the emergency situation was intermediate. Therefore, regular training of CPR to prepare them for handling emergency situation is deemed necessary.

한국에서 방사선 관련 종사자들의 개인피폭선량 실태에 관한 연구 (Radiation Exposure Dose on Persons Engaged in Radiation-related Industries in Korea)

  • 임봉식
    • 대한방사선기술학회지:방사선기술과학
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    • 제29권3호
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    • pp.185-195
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    • 2006
  • 목 적: 방사선 관련종사자들의 1995년 1월 6일 "진단용 방사선 발생장치의 안전관리에 관한 규칙"을 제정한 이후 방사선 노출로 인한 개인피폭선량의 실태를 조사 분석하여, 해당 의료기관과 방사선 관련종사자들에게 방사선피폭에 대한 경각심을 고취시키고, 안전관리에 도움을 주고자 한다. 조사대상 및 방법: 2000년 1월 1일부터 2004년 12월 31일까지 5년 동안 전국에 있는 검사기관, 교육기관, 군부대, 병원, 보건소, 산업체, 연구기관, 의원에서 근무하였거나 근무하고 있는 방사선종사자들의 개인 피폭선량 측정결과 판독기관에 등재(登載)된 대상자 57,136명에 대한 분기별 피폭선량 자료 149,205건을 대상으로 하여 판독수행기관에 직접 방문 하거나, 전화를 통하여 책임자에게 연구의 목적을 설명하고 긴밀한 협조를 얻어 수집하였다. 자료를 분석하는데 있어 SPSS ver 12.0을 이용하였으며, 분석방법으로는 연도별 분기별 성별 연령별 직종별 근무부서별 업종별로 심부선량과 표면선량으로 나누어 분석하였다. 빈도분석 one-way ANOVA two-way ANOVA를 시행하였다. 결 과: 5년간의 평균 피폭선량에서 심부선량과 표면선량의 평균값이 해마다 낮아지는 것으로 조사되었고, 성별 평균 피폭선량은 심부선량과 표면선량에서 남자가 여자보다 높게 나타났으며 연령별 평균 피폭선량에서 심부선량과 표면선량은 높은 연령군보다 낮은 연령군에서 높게 나타났고, 직종별 평균 피폭선량은 심부선량과 표면선량 모두에서 방사선사가 가장 높게 나타났으며 근무 부서별 평균 피폭선량은 심부선량과 표면선량에서 핵의학과가 가장 높게 나타났고, 업종별 평균 피폭선량은 심부선량과 표면선량에서 병 의원이 높게 나타난 것으로 조사되었다. 결 론: 이상의 결과에서 볼 때 최근 5년간 전국 지역에 있는 병원 의원 기타 등에서 근무하는 방사선 종사자들의 방사선 평균 피폭선량은 국제방사선방어위원회(ICRP)에서 권고하는 허용선량 기준치(20 mSv/년)를 초과하지 않는 범위의 피폭을 받고 있는 것으로 나타났다. 그러나 그것은 평균적인 수치이지 개인적으로 피폭선량에 있어 그 범위의 피폭을 초과하는 종사자들이 있는 것으로 나타나 상당히 우려가 되고 있는 실정이다. 따라서 방사선 관련종사자들이 각자가 개인별 관리에 더욱더 철저를 기하고 방사선으로 인한 피폭을 최소화 시키는데 있어 체계적인 교육 및 안전 불감증에 대한 지도가 지속적으로 유지되어야 할 것이다.

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소음성 난청 선별검사에 HHIE-S(Hearing Handicap Inventory for the Elderly-Screening version)의 적용 (Application of HHIE-S(Hearing Handicap Inventory for the Elderly-Screening version) to screening test of noise-induced hearing loss)

  • 이미영;서석권;이충원
    • Journal of Preventive Medicine and Public Health
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    • 제29권3호
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    • pp.539-553
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    • 1996
  • 이 연구는 1994년도 5월부터 9월까지 동산병원 건강 관리과에서 소음특수건강진단을 받은 근로자 중 일부를 대상으로 하여 1차 선별 순음청력검사에 난청선별 설문지(HHIE-S)의 적용가능성을 점검해 보기 위하여 시행되었다. 대상자는 이 기간중의 특수검진 수진자들로서 총 6,700명 중 계통적 표본추출법에 의하여 매 5번째의 근로자가 추출되었다. 최종분석 대상은 자료가 미비한 14명을 제외한 1,019명으로 남자 488명, 여자 531명이었다. 소음성 난청의 1차 선별검사로 순음청력검사와 HHIE-S를 포함한 설문지검사를 실시하였다. 청력검사의 1차 선별기준은 양쪽 어느 귀의 청력손실이 4000Hz 에서 40dB이상인 자로 하였고 2차 정밀검사에서 난청의 기준은 3분법으로 계산하여 30dB 이상이면서 4000Hz에서 50dB 이상의 청력손실이 있는 자로 하였다. 설문지의 신뢰도는 0.84였다. 청력장애와 관련된 변수들의 단일변량분석에서 유의한 차이를 보인 항목은 남자에서 HHIE-S 총척도와 사회적/상황적 소척도에서 근무기간, 군복무력, 1000Hz 및 4000Hz에서의 청력역치였으며 여자에서 총척도와 소척도 모두에서 연령, 근무기간, 1000Hz 및 4000Hz에서의 청력역치였다. 다단계 다중회귀분적에서 남자에서 1000Hz및 4000Hz에서의 청력역치가 선택되었으며 여자에서는 총척도와 사회적/상황적 소척도에서 1000Hz 및 4000Hz에서의 청력 역치, 근무기간, 연령이 선택되었다. 2차 순음청력검사를 황금기준으로 하여 1차 선별청력검사와 HHIE-S점수를 기준으로 한 ROC곡선을 그린 결과, 최적의 타당도는 병행검사에서 HHIE-S점수 8을 기준으로 하였을 때였으며 민감도와 특이도가 각각 85%와 67%이었으며 위음성이 15%로 최소였다. 이러한 결과는 HHIE-S가 우리나라에서 신뢰도 및 타당도가 비교적 적절하며 소음성 난청 1차 선별검사에 순음청력검사와 함께 병행해서 사용하면 민감도를 높이고 위음성을 떨어뜨림으로써 순음청력검사의 병행검사로 적용가능성이 있음을 시사해 준다.

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