• Journal of Korean Port Research
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• v.8 no.2
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• pp.37-56
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• 1994

The effects of wave energy focusing by a submerged berm type of structure is examined. The fundamental idea is based on the phenomenon of refraction by a lens-shaped crescent structure which results in the focusing of wave energy on the center line of the structure. The shape of the submerged structure is a complex curve combining circular with elliptical elements. Based on the design procedure, a special configuration of structure(termed herein as a triple crescent structure) is introduced. Next, some hydraulic model tests are performed to confirm the wave focusing effect in laboratory. In addition, in order to interpret the wave focusing performance behind the structure, a numerical procedure by the hybrid element method is used on the basis of the conventional mild slope equation but modified and extended to allow for steeper bottom slopes and higher curvature. The modified refraction and diffraction provide additional mechanism for wave height amplification and the maximum amplification for triple crescent structure is presented. It also allows for the possibility of wave energy scattering with the change of the incident wave direction. Comparisons with previous theoretical results involving a submerged crescent shape structure are described.

• The Korean Journal of Physiology
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• v.17 no.2
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• pp.119-124
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• 1983

The in vivo and in vitro buffer capacities of true plasma and tissue buffer capaciies were compared on dogs. Intracellular pH was determined on skeletal muscle by a modification of the method of Schloerb and Grantham using $C^{14}$ DMO. The in vivo curve for plasma or extracellular fluid has a much lower slope than the in vitro curve. The in vivo slope of skeletal muscle in the dog is approximately 20 sl. The slope for skeletal muscle in vivo falls between the in vitro and in vivo slopes of true plasma. It appears that intracellular hydrogen ion varies linearly with extracellular hydrogen ion when $CO_2$ tension is changed. Both hydrogen ion gradient and Hi/He ratio vary in skeletal muscle, with an increase in $CO_2$ tension. Infusion of 0.3N HCl gave two distinct patterns, the $H_i-H_e$ gradient decreased; and it would appear that very little hydrogen ion as such penetrated to the inside of the cells during the time of observation. Although lactic acid presumably enters the cell and the same of larger load was given as was used for hydrochloric acid, only very mild intracellular acidosis resulted, ostensibly due to metabolism of this substrate. Gluconic acid produced a more severe acidosis, both intracellularly and extracellularly, but with both of these acids the hydrogen ion gradient decreased and the $H_i/H_e$ ratio also decreased. The experiments on the dogs with hemorrhagic shock the hydrogen ion increase producing the acidosis originates inside the cells. Even so, the hydrogen ion gradient increased only very slightly in the acute experiments. This may suggest that even over short intervals of time skeletal muscle cells have a capacity to pump out hydrogen ions at a rate which maintains approximately the normal $H_i/H_e$ gradient when the source of the hydrogen ion is in the interior of the cell.

• Tuberculosis and Respiratory Diseases
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• v.52 no.1
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• pp.24-36
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• 2002

Background: Bronchial reactivity is known to be a component of airway hyperresponsiveness, a cardinal feature of asthma, with bronchial sensitivity, and is increments in response to induced doses of bronchoconstrictors as manifested by the steepest slope of the dose-response curve. However, there is some controversy regarding methods of measuring bronchial reactivity and clinical impact of such measurements. The purpose of this study was to evaluate the clinical significance and assess the clinical use by analyzing the relationship of the bronchial sensitivity, the clinical severity and the changes in pulmonary function with bronchial reactivity. Method: A total of 116 subjects underwent a methacholine bronchial provocation test. They were divided into 3 groups : mild intermittent, mild persistent, moderate and cough asthma. Severe patients were excluded. Methacholine PC20 was determined from the log dose-response curve and PC40 was determined by one more dose inhalation after PC20. The steepest slope of log dose-response curve, connecting PC20 with PC40, was used to calculate the bronchial reactivity. Body plethysmography and a single breath for the DLCO were done in 43 subjects before and after methacholine test. Results: The average bronchial reactivity was 38.0 in the mild intermittent group, 49.8 in the mild persistent group, 61.0 in the moderate group, and 41.1 in the cough asthma group. There was a weak negative correlation between PC20 and bronchial reactivity. A heightened bronchial reactivity tends to produce an increased clinical severity in patients with a similar bronchial sensitivity and basal spirometric pulmonary function. There were significant correlations between the bronchial reactivity and the initial pulmonary function before the methacholine test in the order of sGaw, Raw, $FEV_1$/FVC, MMFR. There were no correlations between the bronchial sensitivity and the % change in the pulmonary function parameters after the methacholine test. However, there were significant correlations between the bronchial reactivity and the PEF, $FEV_1$, DLCO. Conclusion: There was weak significant negative correlation between the bronchial reactivity and the bronchial sensitivity, and the bronchial reactivity closely reflected the severity of the asthma. Accordingly, measuring both the bronchial sensitivity and the bronchial reactivity can be of assistance in assessing of the ongoing disease severity and in monitoring the effect of therapy.

• Journal of Environmental Health Sciences
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• v.43 no.4
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• pp.247-256
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• 2017

Objectives: The deaths of Korean victims exposed to the disinfectant CMIT/MIT have remained unresolved. This is mainly due to a lack of concordance between the few available toxicity tests and the abundant epidemiological data, making it difficult to establish a cause-and-effect relationship. Therefore, this study was carried out to investigate any potential associations between CMIT/MIT exposure and death. Methods: Groups of experimental and control C57BL/6 mice were instilled (in the trachea) with chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) using a visual instillobot. CMIT/MIT was instilled over a period of three days and eight weeks, respectively, to achieve acute and chronic exposures. A threshold dose-response model was applied for estimating the threshold level as one line of evidence for a causal association between CMIT/MIT and death. Results: An acute exposure of 1.2 mg ai/kg/day of CMIT/MIT was estimated to reflect the threshold for death. The dose-response curve with this threshold showed a very steep slope and a narrow range of CMIT/MIT exposures. The narrow range of CMIT/MIT exposures, in particular, indicated an evident boundary between survival and death, thus implicating a strong causal association. A similar threshold dose-response relationship observed following acute exposure was also seen following chronic exposure to CMIT/MIT. Airborne disinfectant exposure was visible as minimal or mild lung damage with no fibrosis, as shown by histopathological tests. However, many observations are considered to be functional respiratory tract or lung failure due to death, as observed in necropsies of the mice that died due to CMIT/MIT exposures. Conclusions: There are two strong lines of evidence for a causal association between death and CMIT/MIT exposure: 1) The threshold dose-response curve, with a very steep slope and a narrow range of CMIT/MIT exposures showing a visible boundary between survival and death; and 2) many cases of functional respiratory or lung failure.

• Journal of Korean Society of Forest Science
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• v.102 no.1
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• pp.113-121
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• 2013

It has been known that edges of forest fire areas play significant roles in post-fire change of forest ecosystem and recovery process. The purpose of this study was to analyze the relationships between edge formation of burned forests and landscape characteristics with consideration on spatial autocorrelation. Samcheok fire site burned in 2000 was selected as the study area. Seven hundred fifty three of 500 $m^2$ grid cells were generated for measuring landscape characteristics. This study used the topographic variables including slop, elevation, topographic wetness index, solar radiation index and proportions of fuel and land use types. In delineating landscape characteristics correlation analysis with modified t-test were performed for exploring the relationships between edge formation and landscape characteristics. The results indicated that edge formation of burned forests was positively correlated with most variables including TWI, SRI, water, paddy, developed, farm, grass, bare soil, and negatively related with elevation, slope and all fuel types. Especially TWI (r=0.437) showed a strong positive correlation with edge formation. According to the results, edge of burned forests were likely formed when proportions of heterogeneous land use types were high with mild slope and low elevation.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.4 no.4
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• pp.208-218
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• 1992

Analytic solutions for the gradient of surface elevation and vertical profiles of velocity driven by the wind stress in the one-dimensional rectangular basin were obtained under the assumption of steady-state. The approach treats the bottom frictional stress $\tau$$_{b}$ as known and includes vertically varying eddy viscosity $textsc{k}$$_{M}$, which is constant, linear and quadratic of water depth. When the $\tau$$_{b}$ is param-terized with surface stress, depth averaged velocity and bottom velocity, the result shows the relation of the no-slip bottom velocity condition and the bottom frictional stress $\tau$$_{b}$. The results of a mode splitted, (x-$\sigma$) coordinate, numerical model were compared with the derived analytic solutions. The comparison was made for the case such that $textsc{k}$$_{M}$ is the constant, linear and quadratic function of water depth. In the case of constant $textsc{k}$$_{M}$, the gradient of surface elevation and vertical profiles of velocity are discussed for a uniform depth, a mild slope and a relatively steep slope. When $textsc{k}$$_{M}$ is a linear and quadratic function of water depth, the vertical structures of velocities are discussed for various $\tau$$_{b}$. The result of the comparison shows that the vertical structure of velocities depends not only on the value of $textsc{k}$$_{M}$ but also on the profile of $textsc{k}$$_{M}$ and bottom stress $\tau$$_{b}$. Model results were in a good agreement with the analytic solutions considered in this study.his study.y.his study.

• Journal of the Korean Chemical Society
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• v.36 no.4
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• pp.552-557
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• 1992

Chloramphenicol was studied by differential pulse polarography (DDP). A reduction peak which is dependent on pH of the solution appeared in the voltage range between zero and -1.50 volt vs. Ag/AgCl (sat. KCl) reference electrode. A plot of peak potentials (Ep) measured at room temperature (20$^{\circ}C$) vs. pH of the chloramphenicol solutions showed linear relationship changing slope (Ep/pH) at pH 8.9. The slope was -59.7 mV/pH in pH 2.7∼8.9 and -24.3 mV/pH in pH 8.9∼11.2, respectively. A log plot of peak currents (ip) vs. concentrations showed a linearity at the concentrations between 4.8 ${\times}$ 10$^{-7}$ M and 6.2 ${\times}$ 10$^{-5}$ M (0.16 ppm∼20 ppm) chloramphenicol in pH 8.0 ammonium buffer. Between the DPP method and the reference method measuring absorbance at 278 nm, the correlation coefficient was 0.996, which means an excellent linearity. The DPP method was able to detect degradation products of chloramphenicol in mild alkaline solution (pH = 8.0) more distinctly than the spectrophotometric method.

• Ecology and Resilient Infrastructure
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• v.7 no.4
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• pp.327-335
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• 2020

The method of selecting an existing flood hazard area via a numerical model requires considerable time and effort. In this regard, this study proposes a method for selecting flood vulnerable areas through topographic analysis based on a surface runoff mechanism to reduce the time and effort required. Flood vulnerable areas based on runoff mechanisms refer to those areas that are advantageous in terms of the flow accumulation characteristics of rainfall-runoff water at the surface, and they generally include lowlands, mild slopes, and rivers. For the analysis, a digital topographic map of the target area (Seoul) was employed. In addition, in the topographic analysis, eight topographic factors were considered, namely, the elevation, slope, profile and plan curvature, topographic wetness index (TWI), stream power index, and the distances from rivers and manholes. Moreover, receiver operating characteristic analysis was conducted between the topographic factors and actual inundation trace data. The results revealed that four topographic factors, namely, elevation, slope, TWI, and distance from manholes, explained the flooded area well. Thus, when a flood vulnerable area is selected, the prioritization method for various factors as proposed in this study can simplify the topographical analytical factors that contribute to flooding.

• Earthquakes and Structures
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• v.4 no.4
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• pp.397-428
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• 2013

This paper examines whether the "effective period" of bilinear isolation systems, as defined invariably in most current design codes, expresses in reality the period of vibration that appears in the horizontal axis of the design response spectrum. Starting with the free vibration response, the study proceeds with a comprehensive parametric analysis of the forced vibration response of a wide collection of bilinear isolation systems subjected to pulse and seismic excitations. The study employs Fourier and Wavelet analysis together with a powerful time domain identification method for linear systems known as the Prediction Error Method. When the response history of the bilinear system exhibits a coherent oscillatory trace with a narrow frequency band as in the case of free vibration or forced vibration response from most pulselike excitations, the paper shows that the "effective period" = $T_{eff}$ of the bilinear isolation system is a dependable estimate of its vibration period; nevertheless, the period associated with the second slope of the bilinear system = $T_2$ is an even better approximation regardless the value of the dimensionless strength,$Q/(K_2u_y)=1/{\alpha}-1$, of the system. As the frequency content of the excitation widens and the intensity of the acceleration response history fluctuates more randomly, the paper reveals that the computed vibration period of the systems exhibits appreciably scattering from the computed mean value. This suggests that for several earthquake excitations the mild nonlinearities of the bilinear isolation system dominate the response and the expectation of the design codes to identify a "linear" vibration period has a marginal engineering merit.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.4 no.1
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• pp.34-44
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• 1992

A numerical model using Hybrid Element Method(HEM) is presented for the prediction of wave agitations in a harbor which are induced by the intrusion and transformation of incident short-period waves. A linear mild-slope equation including bottom friction is used as the governing equation and a partial absorbing boundary condition is used on solid boundaries. Functional derived in the present paper is based on the Chen and Mei(1974)'s concept which uses finite element net in the inner region and analytical solution of Helmholtz equation in the outer region. Final simultaneous equations are solved using the Gaussian Elimination Method. The model appears to be reasonably good from the comparison of numerical calculation with hydraulic experimental results of short-wave diffraction through a breakwater gap(Pos and Kilner, 1987). The problem of requring large computational memory could be overcome using 8-noded isoparametric elements.