• Progress in Superconductivity
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• v.10 no.2
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• pp.139-143
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• 2009

We have fabricated a low-noise 61-channel axial-type first-order gradiometer system for measuring fetal magnetocardiography(MCG) signals. Superconducting quantum interference device(SQUID) sensor was based on double relaxation oscillation SQUID(DROS) for detecting biomagnetic signal, such as MCG, magnetoencphalogram(MEG) and fetal-MCG. The SQUID sensor detected axial component of fetal MCG signal. The pickup coil of SQUID sensor was wound with 120 ${\mu}m$ NbTi wire on bobbin(20 mm diameter) and was a first-order gradiometer to reject the environment noise. The sensors have low white noise of 3 $fT/Hz^{1/2}$ at 100 Hz on average. The fetal MCG was measured from $24{\sim}36$ weeks fetus in a magnetically shielded room(MSR) with shielding factor of 35 dB at 0.1 Hz and 80 dB at 100 Hz(comparatively mild shielding). The MCG signal contained maternal and fetal MCG. Fetal MCG could be distinguished relatively easily from maternal MCG by using independent component analysis(ICA) filter. In addition, we could observe T peak as well as QRS wave, respectively. It will be useful in detecting fetal cardiac diseases.

• Journal of Environmental Science International
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• v.22 no.3
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• pp.291-301
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• 2013

Sediment from the upstream channel has been deposited near the Nakdong River Estuary Barrage (NREB) due to the mild slope and decreased velocity. The annual mechanical dredging to ensure the flood capacity has been performed to remove the deposited sediment. However, the dredging method is not considered as an effective countermeasure due to high cost and long time to operate. Therefore, many methods for sedimentation reduction have been proposed for NREB. Especially, the channel contraction method to mitigate sedimentation problem by changing the channel geometry from 2 km to 3 km upstream of NREB has been recently suggested as an effective countermeasure. However, there is the possibility that the channel contraction method induces flood level increase compared to original condition. Therefore, it is necessary to investigate quantitatively the flood level changes in the upstream and downstream section due to the channel contraction method for NREB. In this study, water level changes by 10% channel contraction of whole width has been evaluated using the HEC-RAS model and simulated with and without channel contraction for various flood discharge. As a result, water level in the section where the channel was contracted was decreased by 0.02 m and flood level at the upstream of channel contracted was increased up to 0.015 m for the 500-year flood.

• Journal of Convergence for Information Technology
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• v.7 no.3
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• pp.1-12
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• 2017

The purpose of this study is to contribute to research on dementia and policy making by reviewing research trends of dementia for 15 years and it was collected from 12,588 dementia - related research data for 15 years at Google 's scalar site. The results of this study confirm that the research on dementia, one of the most common geriatric diseases, is continuously increasing. Second, research on dementia is increasing due to social influences such as government support. Third, we suggested that dementia is changing from a viewpoint of diseases to be managed at the facility and treatment of severe dementia patients to a paradigm from the viewpoint of management of mild patients and community participation. Fourth, dementia seems to be shifting from a serious and negative awareness to a social atmosphere that is accepted as a slow but manageable disease. This is changing to a dementia-friendly social environment, which is making a very positive environmental change. This study contributes to the field research by presenting the trend of domestic research on dementia.

• Health Policy and Management
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• v.19 no.4
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• pp.98-120
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• 2009

The purpose of this study is to elicit preference for drug listing decision criteria and to estimate the ICER threshold in South Korea using the discrete choice experiment (DCE) method. To collect the data, a DCE survey was administered to a subject sample either educated in the principle concepts of pharmacoeconomics or were decision makers within that field. Subjects chose between alternative drug profiles differing in four attributes: ICER, uncertainty, budget impact and severity of disease. The orthogonal and balanced designs were determined through computer algorithm to take the optimal set of drug profiles. The survey employed 15 hypothetical choice sets. A random effect probit model was used to analyze the relative importance of attributes and the probabilities of a recommendation response. Parameter estimates from the models indicated that three attributes (ICER, Impact, Severity of disease) influenced respondents' choice significantly(p${\pm}$0.001). In addition, each parameter displayed an expected sign. The Lower the ICER, the higher the probability of choosing that alternative. Respondents also preferred low levels of uncertainty and smaller impact on health service budget. They were also more likely to choose drugs for serious diseases rather than mild or moderate ones. Uncertainty however is not statistically significant. The ICER threshold, at which the probability of a recommendation was 0.5, was 29,000,000 KW/QALY in expert group and 46,500,000 KW/QALY in industry group. We also found that those in our sample were willing to accept high ICER to get medication for severe diseases. This study demonstrates that the cost-effectiveness, budget impact and severity of disease are the main reimbursement decision criteria in South Korea, and that DCE can be a useful tool in analyzing the decision making process where a variety of factors are considered and prioritized.

• Journal of the Korean Geographical Society
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• v.43 no.4
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• pp.495-510
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• 2008

Vaccinium vitis-idaea or lingonberry, a typical arctic-alpine plant, is common on the circumpolar regions and alpine belts of the Northern Hemisphere, and also occurs on the alpine and subalpine belts of the Korean Peninsula, including Mt. Sorak and Hongchon. Vaccinium vitis-idaea at the elevation of c. 350m a.s.l. of Hongchon is found on the wind hole area with cool summer, and mild winter. Vaccinium vitis-idaea at Hongchon is regarded as the glacial relict of the Pleistocene period, and shows a disjunctive distribution, along with the alpine and subalpine belts of the northern and central Korea since the Holocene period. Present vertical range of Vaccinium vitis-idaea between Mt. Sorak and Hongchon might indicates that the temperatures during the glacial epoch was colder than today, down to -6 to $-7^{\circ}C$ Vaccinium vitis-idaea at this fragile wind hole site could be endanger if current global warming trends continues, and anthropogenic activities become serious.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2008.05a
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• pp.35-41
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• 2008

Qualitative enhancement of dwelling life has changing the recognition for the environment friendly wood which is being highlighted for its usage as an interior materials. This trend may prove the excellent performance of wood whose inherent characteristics has its comfortable, mild feeling of material, sound resistance and stabilities and the market of interior woods including floor, moulding and wooden panel as finishing interior materials is growing sustainably. However, since this materials is vulnerable to humidity and flame, waterproofing and flame retarding stability, an essential condition for interior materials, together with maintenance, are the main topics to be resolved. From the above-mentioned results, as a result of waterdrop contact angle, wood absorption volume and water content percentage test and the performance test of the processed materials after flame retardant, though there was some submerging time changes among types of woods for ensuring waterproofing performance improvement but as time passes, similar tendency was noticed to be formulated. As the submerging time is increased, so does the absorption volume and accordingly optimal level of range is judged to be drawn in order to ensure excellent performance, taking optimal economy into consideration. Therefore, it is considered that above-mentioned woods could be utilized for waterproof and flame retardant processed interior materials using uniform microwave and in order to put this technology into practical application, a research by way of diversified performance proving is required to be carried out.

• The Plant Pathology Journal
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• v.18 no.3
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• pp.121-125
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• 2002

This study was conducted to determine the causal virus that naturally infected hollyhock (Althaea rosea) plant showing mild mosaic symptom in 1999. Flexuous virus particles were found in the cytoplasm of plant tissue from infected hollyhock under transmissible electron microscopy. A virus from the genus Potyvirus under the family Potyviridae was isolated and was maintained on Chenopodium quinoa for three passages. Chlorotic local legions were used to inoculate 20 species of indicator plants. The virus infected all the tested cucurbit plants, but failed to infect Nicotiana benthamiana. Based on the host range test and RT-PCR analysis, the potyvirus was identified as a strain of Zucchini yellow mosaic virus-A (ZYMV-A), one of the major pathogens of cucurbits. Infectivity analysis showed that ZYMV-A induced faster systemic symptom than ZYMV-Cu on squash and other cucurbit plants, suggesting that ZYMV-A was a more severe strain. To better characterize ZYMV-A, Western blot assay was carried rout to the coat protein (CP) of the virus using ZYMV-specific antiserum with ZYMV-Cu and other potyviruses. The CP of the virus reacted strongly with the antiserum against ZYMV, and other tested antisera did not react with the CP of ZYMV-A. Results strongly suggest that the potyvirus infecting hollyhock was a novel strain of ZYMV. This is the first report on ZYMV as the causal virus infecting hollyhock in Korea.

• The Journal of Internal Korean Medicine
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• v.10 no.1
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• pp.105-123
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• 1989

Yuk Gi (六氣) in oriental medicine have influence on the body and, the body which adapt itself to the change of Yuk Gi, can maintain the activity of life, so five vital organs of the body have relation to Yuk Gi. The relation between Lung and Jo (燥) is well described from Whang Jae Nai Kyung (黃帝內經), the oldest book in oriental medicine, to the old books of Chung (淸) dynasty and modern documents. By the way, when autumn has come and the environment become dry, clear and mild ability of lung is losed. It's because dryness evil (燥邪) occured the trouble of Lung. The following results were obtained according to these facts which is considreed peviodically and bibliographically. 1. According to flourishing the functional activities of dryness (燥氣), as reducing the functional activities of water (水氣) of upper portion of the body cavity (上焦), Kidny Water (腎水) is not nutrited and Fire-Heat (火熱) is activiting, which is evoking the disease of Lung. 2. In the disease of Lung, there are many diseases because of dryness evil (燥邪), thinking that, which methods of treatment are the principal one of 'Clear up the lung and moisten dryness (淸肺潤煥)'. I found that Lung and Jo (燥) have the relation of intimacy. 3. Creating the vital essence of the kidney (腎水) to the functional activities of the lung (肺氣) is in prosperous condition, the functional activities of fire (火氣) stabilize the function of Lung become normal condition which wear said in the literary.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.13 no.1
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• pp.48-53
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• 2013

Tyrosinemia I (fumarylacetoacetate hydrolase deficiency) is an autosomal recessive inborn error of tyrosine metabolism that produces liver failure in infancy or a more chronic course of liver disease with cirrhosis, often complicated by hepatocellular carcinoma in childhood or early adolescence. We studied a 37-year-old woman with tyrosinemia I whose severe liver disease in infancy and rickets during childhood were resolved with dietary therapy. From 14 years of age, she resumed unrestricted diet with the continued presence of the biochemical features of tyrosinemia, yet maintained normal liver function. In adult years, she accumulated only a small amount of succinylacetone. Despite this evolution to a mild biochemical and clinical phenotype, she eventually developed hepatocellular carcinoma. Her fumarylacetoacetate hydrolase genotype consists of a splice mutation, IVS6-1G>T, and a novel missense mutation, p.Q279R. Studies of resected liver revealed the absence of hydrolytic activity and immunological expression of fumarylacetoacetate hydrolase in tumour. In the non-tumoral areas, however, 53% of normal hydrolytic activity and immunologically present fumarylacetoacetate hydrolase were found. This case demonstrates the high risk of liver cancer in tyrosinemia I even in a seemingly favorable biological environment. In this study of tyrosinemia I, Case 2 with negative succinylacetone accumulation and the recovery of acute liver failure was compared with Case 1. Diet restriction and NTBC treatment are crucial to prevent hepatocellular carcinoma until liver transplant can take place and cure the condition. Further studies are needed to examine cases where liver cancer did not result despite clinical symptoms/signs of tyrosinemia type I.

• Journal of the korean academy of Pediatric Dentistry
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• v.26 no.4
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• pp.623-629
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• 1999

The definition of fascial spaces are latent spaces between fascial planes. If infections which spread from dental origin to soft tissue are mild, they are restricted by fascial planes. But, when infections are severe, fascial spaces are often used as a natural pathway which spread to the deep cervical region. If they are not treated at early stage, they may result in the fatal complications as followings; airway obstruction, septicemia, cerebral abscess, and thrombophlebitis etc. The early treatment of fascial space abscess is very important for young children. These case reports present the successful result of fascial space abscess treatment through intracanal drainage without surgical excision. It is proven that the treatment through intracanal drainage has some benefits to the surgical excision, which are as follows: 1) It is economic to the patients or their parents avoiding admission. 2) The treatment procedure is more simple. 3) Childrens can avoid the fearful environment.