• 대한의생명과학회지
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• 제25권4호
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• pp.293-301
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• 2019

Combination chemotherapy is more effective than mono-chemotherapy and is widely used in clinical practice for enhanced cancer treatment. In this study, we investigated the potential synergistic effects of acetaminophen, a common component in many cold medicines, and romidepsin, a histone deacetylase (HDAC) inhibitor, in the A549 non-small cell lung cancer (NSCLC) cell line. The combination of acetaminophen and romidepsin also exerted significant cytotoxicity and apoptosis induced by activation of caspase-3 on tumor cells in vitro. Moreover, combination therapy significantly induced increased production of chemokines that stimulate migration of activated T-cells into tumor cells. This mechanism can lead to active T-cell mediated anti-tumor immunity in addition to the direct cytotoxic chemotherapeutic effect. Activated T-cells led to enhanced cytotoxicity in drug-treated A549 cells through interaction with tumor cells. These results suggested that the interaction between the two drugs is synergistic and significant. In conclusion, our data showed that the use of romidepsin and low concentrations acetaminophen could induce effective anti-tumor effects via enhanced tumor immune and direct cytotoxic chemotherapeutic responses. The combination of acetaminophen with romidepsin should be considered as a promising strategy for the treatment of lung cancer.

• 한국컴퓨터정보학회논문지
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• 제22권11호
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• pp.89-96
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• 2017

This study analyzed how mental health affects stress in adolescents. The subjects of the study were data of about 60,000 middle and high school students living in the country, using cross-tabulation data and chi - square test to analyze the relationship between stress and mental health of adolescents. As a result of the research, it was found that the adolescents exposed to the excessive stress showed a poor correlation with the recovery of the fatigue, while the adolescents with relatively low stress showed the good recovery of fatigue. In the case of mental illness, depression or despair, the students who answered that they were stressed showed a lot of experience. In the case of suicide ideation, suicide attempt, and suicide attempt, the number of attempts to commit suicide was high when the level of perceived stress was high similar to the result of previous analysis. This finding confirms that stress is an important factor in the quality of life in adolescent mental health. It can be used as a strategy and business to prevent the problem of youth suicide in modern society in advance by stress management.

• 한국기록관리학회지
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• 제7권1호
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• pp.145-170
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• 2007

종이기록과 달리 특정 하드웨어와 소프트웨어의 조합에 의해서만 접근 가능한 전자기록은 그들의 생산에 이용된 저장매체, 하드웨어와 소프트웨어, 포맷의 수명보다 훨씬 더 길뿐만 아니라 시간이 흐르면 퇴화되거나 노후화되기 때문에 이에 대한 대비가 철저하게 이루어져야만 디지털정보의 장기보존과 접근, 미래 특정시점에서의 재현성을 보장할 수 있다. 이에 본 연구에서는 전자기록의 장기보존과 장기 접근성 유지에 근간이 되는 기술정보요소를 지속적으로 수집 관리하여 마이그레이션이나 에뮬레이션과 같은 보존 전략을 효율적으로 지원하는 포맷등록시스템 개발 방안을 제안하였다.

• International Journal of Computer Science & Network Security
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• 제22권3호
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• pp.252-258
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• 2022

Globalization, development of the information society, intensification of migration processes, and internationalization of education in recent years have significantly affected the international labour market and increased competition between professionals in various fields. Academic, research and teaching staff are currently facing rapid changes and growing demand for quality educational services. Under such conditions, educational institutions around the world pay particular attention to improving the quality of the educational process in order for their graduates to be able to compete in the international labour market. The study of the experience of teachers' professional training in advanced countries opens new opportunities for improving the system of pedagogical training in Ukraine in order to adapt it to the requirements of the European educational space. The progressive achievements of countries demonstrating a high level of teachers' professional training in accordance with international standards, having rich historical educational traditions are of considerable scientific interest; consequently, this contributes to their leadership in science and education at the regional and global levels. The purpose of the present academic paper lies in analysing the latest trends in exploring teaching experience in the European countries and performance review of passing by students and teachers of the program on studying of pedagogical practice and experience of teaching in the countries of Europe. Methodology. Analytical and empirical (questionnaire) methods were used in the research process. Results. According to the obtained results of the research, the advantages, the most common areas of educational programs and the wishes of the participants regarding the practical implementation of the experience were identified.

• Journal of Audiology & Otology
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• 제25권4호
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• pp.217-223
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• 2021

Background and Objectives: In cochlear implant (CI) surgery, the results and causes of revision and reimplantation may guide surgeons in establishing surgical protocols for revision surgery with safe audiological outcomes. The aim of this study was to review our experience in terms of etiology, surgical strategy, and hearing outcomes in pediatric patients who underwent CI removal and reimplantation. Subjects and Methods: All patients received implants of the same brand. Pre and postoperative Categories of Auditory Performance score and aided free-field pure tone audiometry thresholds were noted. In vivo integrity tests were performed for each patient and the results of ex vivo tests of each implant were obtained from manufacturer. Results: A total of 149 CIs were placed in 121 patients aged <18 years. The revision rate in children was 6.7% (10/121 children). Six patients had a history of head injury leading to a hard failure. The causes of reimplantation in others were soft failure (n=1), electrode migration (n=1), infection (n=1), and other (n=1). All patients showed better or similar postreimplantation audiological performance compared with pre-reimplantation results. Conclusions: It is very important to provide a safe school and home environment and educate the family for reducing reimplantation due to trauma. Especially for active children, psychiatric consultation should be continued postoperatively.

• Molecules and Cells
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• 제45권9호
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• pp.631-639
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• 2022

Breast cancer is the leading cause of cancer-related death in women worldwide, despite medical and technological advancements. The RhoBTB family consists of three isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. RhoBTB1 and RhoBTB2 have been proposed as tumor suppressors in breast cancer. However, the roles of RhoBTB3 proteins are unknown in breast cancer. Bioinformatics analysis, including Oncomine, cBioportal, was used to evaluate the potential functions and prognostic values of RhoBTB3 and Col1a1 in breast cancer. qRT-PCR analysis and immunoblotting assay were performed to investigate relevant expression. Functional experiments including proliferation assay, invasion assay, and flow cytometry assay were conducted to determine the role of RhoBTB3 and Col1a1 in breast cancer cells. RhoBTB3 mRNA levels were significantly up-regulated in breast cancer tissues as compared to in adjacent normal tissues. Moreover, RhoBTB3 expression was found to be associated with Col1a1 expression. Decreasing RhoBTB3 expression may lead to decreases in the proliferative and invasive properties of breast cancer cells. Further, Col1a1 knockdown in breast cancer cells limited the proliferative and invasive ability of cancer cells. Knockdown of RhoBTB3 may exert inhibit the proliferation, migration, and metastasis of breast cancer cells by repressing the expression of Col1a1, providing a novel therapeutic strategy for treating breast cancer.

• 대한청각학회지
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• 제25권4호
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• pp.217-223
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• 2021

Background and Objectives: In cochlear implant (CI) surgery, the results and causes of revision and reimplantation may guide surgeons in establishing surgical protocols for revision surgery with safe audiological outcomes. The aim of this study was to review our experience in terms of etiology, surgical strategy, and hearing outcomes in pediatric patients who underwent CI removal and reimplantation. Subjects and Methods: All patients received implants of the same brand. Pre and postoperative Categories of Auditory Performance score and aided free-field pure tone audiometry thresholds were noted. In vivo integrity tests were performed for each patient and the results of ex vivo tests of each implant were obtained from manufacturer. Results: A total of 149 CIs were placed in 121 patients aged <18 years. The revision rate in children was 6.7% (10/121 children). Six patients had a history of head injury leading to a hard failure. The causes of reimplantation in others were soft failure (n=1), electrode migration (n=1), infection (n=1), and other (n=1). All patients showed better or similar postreimplantation audiological performance compared with pre-reimplantation results. Conclusions: It is very important to provide a safe school and home environment and educate the family for reducing reimplantation due to trauma. Especially for active children, psychiatric consultation should be continued postoperatively.

• Acta Via Serica
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• 제8권1호
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• pp.101-120
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• 2023

In March 1245, Pope Innocent IV authorized three missions to the Mongols, seeking information about this menace from the East and summoning Eastern Christian support against an anticipated Mongol onslaught. Only one of the missions, led by John of Plano Carpini, reached Mongolia-the first-known Western European party to reach East Asia by a land route. Traveling along the Silk Road's new "Grasslands Route," John and his companion Benedict reached the camp of Güyüg Khan, where they witnessed his installation as the Great Khan. Upon their return to the papal court in 1247, they delivered Güyüg's letter demanding the submission of the pope and all the West's princes. John also presented a detailed report on what he and Benedict had learned. A close reading of it reveals a master intelligence operative at work. In addition to presenting an overview of Mongol history and culture, Friar John's report provides detailed information on the Mongols' grand strategy, their military organization and armaments, and their battle tactics. Turning from intelligence gathering to military operations, he offered practical advice on how to meet and defeat the coming Mongol onslaught, an attack that, providentially for the West, never came. What did occur was a modest but significant migration of Western missionaries and merchants to East Asia in the century following this pioneering journey.

• 한국응용곤충학회지
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• 제42권4호
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• pp.367-381
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• 2003

곤충의 분산다형성이란 비상능력과 관련된 다형성으로 그 구체적 내용으로는 시다형성, 비상근다형성 그리고 비상행동변이성 등과 이들과는 별개로 개체군 밀도의존적인 상변이성이 있다. 분산다형성은 시간적으로나 공간적으로 이질적인 서식처 환경에 대응하기 위하여 이동형인 “유시형이나 장시형”과 정주형인 “무시형이나 단시형”을 생활사에 적절히 짜넣은 적응적 형질이다. 점변태곤충류에서는 유충과 성충의 생태학적지위가 중복되여 있어 유충과 성충이 생활공간과 그 밖의 요구조건을 달리하고 있는 완전변태류나 반변태류에 비하여 분산다형성의 예가 대단히 많다. 무시형 또는 단시형곤충은 같은 종의 유시형 또는 장시형곤충에 비하면 초산연령이 빠르고 총산란수도 많은 것이 보통이여서 자연증가율(r)이 크다. 단시형과 관련된 환경요인으로는 서식처의 시간적 영속성이나 공간적 이질성, 먹이조건, 개체군밀도, 온도, 일장 기타 여러 가지가 알려지고 있다 서식처의 환경조건에 대한 분산다형성발현상은 종에 따라 다를 뿐 아니라 암수간에도 차가 있고 같은 종에서도 계통간에 차가 있는 극히 탄력적인 현상이다. 분산다형성의 문제는 생리학, 유전학 그리고 생태학등에 걸친 폭넓은 학문분야로 특히 생태유전학이나 정량유전학분야치 연구는 분산다형성의 유전적본질 구명에 중요하다 하겠다.

• 한국응용곤충학회지
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• 제55권4호
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• pp.483-487
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• 2016

최근 감귤에서 볼록총채벌레의 피해가 증가하고 있다. 볼록총채벌레의 발생시기 및 피해증상에 관한 연구는 진행되었으나 주변 기주식물과의 관계에 관한 연구는 미흡한 실정이다. 본 연구는 볼록총채벌레 기주식물 150여 가지 중 제주도에 넓은 면적으로 재배되고 있는 망고, 키위 등의 1차 기주식물과 2차 기주식물인 감귤에서의 볼록총채벌레 발생의 유연관계를 구명하기 위해 수행되었다. 그 결과 1차 기주식물과원과 인접 감귤원의 볼록총채벌레 발생양상의 경우 밀도의 차이가 있을 뿐 발생 시기는 거의 동일하거나 감귤원에서의 발생이 약 1주일 가량 지연되어 나타났다. 1차 기주식물과원과 인접 감귤원의 트랩설치간격별 발생밀도의 경우 트랩설치간격이 짧을수록 총채벌레 포획수가 유의미하게 많았으며 과실 피해도 또한 유의미하게 높았다. 이는 1차 기주식물인 망고, 키위, 녹차 등이 인접 감귤원의 볼록총채벌레 발생에 직접적인 영향을 주고 있는 것을 나타내며 이는 추후 감귤원의 볼록총채벌레 방제연구에 기초자료로 활용 될 수 있을 것으로 생각된다.