• 제목/요약/키워드: Mig

검색결과 228건 처리시간 0.033초

Production of Plasma Leptin and Expression of Interferon-γ Inducible Protein-10 (IP-10), Monokine Induced by Interferon-γ (Mig) and Interleukin-8 (IL-8) mRNA in Kawasaki Disease

  • Lee, Young-Hwan;Kim, Won-Duk;Kim, Hee-Sun
    • IMMUNE NETWORK
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    • 제2권4호
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    • pp.202-207
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    • 2002

  • Background: Kawasaki disease is an acute febrile illness with systemic vasculitis which primarily affects children, We examined the production of leptin in plasma and gene expressions of CXC chemokines in peripheral blood mononuclear cells from patients with Kawasaki disease. Methods: Consecutive 39 samples from 13 patients according to the different clinical stages (acute, subacute, convalescent) of Kawasaki disease were collected. The plasma leptin levels according to clinical stages of Kawasaki disease were examined by ELISA and the expression of IP-10, Mig and IL-8 mRNAs in 39 samples (13 samples of each stage) from 13 cases were examined by RT-PCR. Results: There were not significant changes of plasma leptin levels according to the clinical stages of Kawasaki disease. The mean values of plasma leptin concentrations during each of the stages (n=13, p>0.05, pg/ml) were $335.8{\pm}549.0$ in acute, $358{\pm}347.6$ in subacute, and $443.6{\pm}645.9$ in convalescent stage. The mRNAs of IP-10, Mig, and IL-8 were expressed in 13/13 (100%), 2/13 (15%), 9/13 (69%) during acute stage, 13/13 (100%), 6/13 (46%), 13/13 (100%) during subacute stage, and 13/13 (100%), 4/13 (31%), 10/13 (77%) during the convalescent stage, respectively. In three patients, the production of leptin and expression of IP-10 mRNA were dramatically decreased according to the process of the clinical stages. In five patients with prominent cervical lymphadenopathy, the expression of IL-8 mRNA during the subacute stage was more elevated than the acute and convalescent stages. Conclusion: This data suggests that the production of leptin and the gene expressions of IP-10, Mig and IL-8 seem to have no significant correlation to the clinical stages of Kawasaki disease. However, expression patterns of IP-10, Mig and IL-8 mRNA may be related to the specific clinical manifestations, and the expression of IP-10 may also be correlated to leptin levels with pericardial involvement.

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MigAgent를 이용한 Seamless 게임에서의 부하 분산 (Load Balancing in Seamless Game with MigAgent)

  • 김법균;장행진;유강수
    • 인터넷정보학회논문지
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    • 제7권6호
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    • pp.51-62
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    • 2006

  • 기존의 다른 어떤 종류의 게임보다도 큰 부하와 거대한 하나의 가상월드가 MMORPG(Massively Multiplayer Online Role-Playing Game)의 중요한 특징이다. 이러한 Seamless 환경에서는, 독립된 게임 서버들이 관리하는 하위의 공간들을 모아 하나의 거대한 가상 월드로 구축한다. 게임 개발자들의 노력에도 불구하고 게이머들은 여전히 클라이언트와 서버, 필드 서버들 간의 상호작용에서 비롯된 과다한 메시지 트래픽에 대해 불만을 가지고 있다. 본 논문에서는 메시지 트래픽을 줄이기 위해 MigAgent를 이용한 새로운 게임 서버 구조를 제안한다. 일반적으로 PC(Player Character)가 다른 필드 서버로 이동할 때 발생하는 메시지 트래픽이 최고조에 이른다. MigAgent는 이런 PC들을 처리하고 예기치 못한 상황에 대처하기 위한 에이전트 역할을 수행한다. 관심영역과 인접 셀의 크기 비율에 따라 그 효과를 분석함으로써 이 시스템의 효과를 분석한다.

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