• 제목/요약/키워드: Microsporum gypseum

검색결과 34건 처리시간 0.031초

부산 해운대 백사장에서 분리한 각질친화성 피부사상균의 분포 (A Distribution of Keratinophilic Fungi Isolated from the Soil of Haeundae Beach in Korea)

  • 김소진;김수정
    • 대한임상검사과학회지
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    • 제48권4호
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    • pp.343-347
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    • 2016
  • 각질친화성 진균(keratinophilic fungi)은 대부분 토양에 분포하면서 사람이나 동물의 피부에 감염되어 상재균으로 존재하고, 각질에 침입하여 백선이라는 피부질환을 유발하기도 한다. 전세계적으로 광범위하게 분포되어 있으나 발생 양상은 기후나 지리적인 요건 등에 뚜렷한 차이를 보인다. 이 균주들은 피부나 손톱, 모발 등에 풍부한 케라틴을 분해하면서 영양분을 공급받으며 증식한다. 이 논문에서는 우리나라 여름철 휴가지로 가장 많은 인파가 몰리는 해운대를 선택하게 되었으며 매년 많은 사람들이 모이는 해운대 백사장에 피부사상균의 존재와 검출되는 균의 종에 대해 조사하고 고찰하였다. 토양시료는 무작위로 총 100개를 채취하였고 채취된 검체는 hair-baiting technique을 이용하여 분석하였으며 100개 시료 중 21곳의 모래시료에서 23종의 피부사상균이 검출되었다. 검출된 균들은 Microsporum gypseum (43%), Chrysosporium spp. (35%), Trichophyton ajelloi (13%), Microsporum cookie (9%) 순이었다. 본 연구를 통해 많은 사람들이 모이는 해변 모래사장에 다양한 병원성 진균들이 분포함을 확인하였다. 향후 지속적인 자료수집을 통해 각질친화성 피부사상균의 분포 추이를 조사할 수 있을 것으로 사료된다.

Efficacy of the Rhinacanthus nasutus Nees Leaf Extract on Dermatophytes with Special Reference to Trichophyton mentagrophytes var. mentagrophytes and Microsporum canis

  • Darah, I.;Jain, K.
    • Natural Product Sciences
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    • 제7권4호
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    • pp.114-119
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    • 2001
  • The effect of Rhinacanthus nasutus leaf extract on the growth of dermatophytes had been investigated. In vitro the extract exhibited high activity against various species of dermatophytes (Trichophyton mentagrophytes var. mentagrophytes, T. mentagrophytes var. interdigitale, T. rubrum, Microsporum canis and M. gypseum). The minimal inhibitory concentration (MIC) values of the extract revealed that all the dermatophytes tested had MIC values of 13.6 mg/ml. The extract exhibited fungistatic activity at lower concentrations $({\leq}13.6\;mg/ml\;or\;below\;the\;MIC\;value)$ and fungicidal activity at higher concentrations $({\geq}13.6\;mg/ml$\;or\;above\;the\;MIC\;value)$. The results suggested that the extract acted on the cell wall of the dermatophytes which subsequently leading to the formation of cytopathological and membrane structural degeneration and finally leading to cell lysis and death.

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3-D QSAR Studies on Thiazole and Triazole Antifungal Agents by CoMFA and CoMSIA

  • Thai, Khac-Minh;Tran, Thanh-Dao;Park, Hyun-Ju
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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    • pp.249.2-250
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    • 2003
  • 3D-QSAR analyses by CoMFA and CoMSIA were conducted on a series of thiazole and triazole analogues with respect to their antifungal activities against Microsporum gypseum. A total of twenty analogues were used for the derivation of the 3D-QSAR models (training set). Thesuperposition of the compounds was performed by applying the FlexS with shape-based screening method. (omitted)

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버섯 중 항균물질의 검색 및 개발에 관한 연구 -곰팡이에 대한 항균물질의 검색 (1보)- (Study on the Screening and Development of Antibiotics in the Mushrooms -The Screening of Fungal Antibiotics in Basidomycetes (I)-)

  • 이갑득;서연찬;박상신;민태진
    • 한국균학회지
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    • 제23권1호통권72호
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    • pp.37-45
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    • 1995
  • 석유에테르, 80% 에탄올 및 물로 추출하여 얻은 204개의 추출물 각각에 대해서 8종류의 곰팡이에 대한 항균활성을 검색하였다. 그 결과 Abortiporus DGU-L6 버섯의 석유에테르 추출물은 Microsporum gypseum균에 대하여 항균활성을 나타내었고, Cortinarius DGU-L51 버섯의 알콜추출물에서는 A. niger, Marasminus DGU-L67 버섯의 알콜 추출물 및 물 추출물에서는 A. niger(KCTC 2118)과 A. versicolor(KCTC 2120) 균에 대해서 항균활성을 나타내었다. 그리고 Hetero DGU-L25 버섯의 석유에테르 추출물은 8종류의 곰팡이에 대해서 모두 항균활성을 나타내었고, 이중 특히 모창을 유발하는 균에 대해서는 40 mg/ml의 아주 낮은 최소억제농도 값을 나타내었다.

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Purification, Structure Determination and Biological Activities of 20(29)-lupen-3-one from Daedaleopsis tricolor(Bull.ex Fr.)Bond.et Sing.

  • 김은미;정해룡;민태진
    • Bulletin of the Korean Chemical Society
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    • 제22권1호
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    • pp.59-62
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    • 2001
  • The dried fruit-body of Daedaleopsis tricolor was extracted by the petroleum ether. The extracts were purified by liquid-liquid extraction, column chromatography, and recrystallization. The purified compound was a colorless orthorhombic crystal form. Its melting point, molecular weight and molar extinction coefficient $(\varepsilon)$ were estimated $168-170^{\circ}C$, 424 and 3,935 at 208 nm, respectively. Its structure was elucidated to be 20(29)-lupen-3-one by UV-Vis, FT-IR, NMR and X-ray crystallographic analysis. It showed antifungal activities against Saccharomyces cerevisiae and Microsporum gypseum, and antibacterial activities against Escherichia coli, Proteus vulgaris, Pseudomonas pyocyanea, Bacillus subtilis, and Staphylococcus aureus. In addition, this compound showed an antioxidative activity on lipid-peroxidation by 6.4%.

Hexachlorophene의 Mannich Bases 합성 및 항미생물작용에 관한 연구 (Studies on the Synthesis of Mannich Bases of Hexachlorophene and their Antimicrobial Activities)

  • 김종호;배무;이계준
    • 한국미생물·생명공학회지
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    • 제1권1호
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    • pp.43-50
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    • 1973
  • 34종의 Hexachlorophene유도체가 합성되었으며 그 각각의 화합물에 대하여 항균성시험이 행해졌다. 검정균은 세종류의 세균과 무좀균(백성균)을 포함한 5종류의 진균류이다. 시험결과는 1. 2,2'-Methylene bis [$\alpha$-(3,4,6-trichlorophenoxy)-$\beta$-(N,N-diethylamino) propionic acid] 및 2,2'-methylene bis [$\alpha$-3,4,6-trichlorophenoxy)-$\beta$-(N,N-dimethylamino) propionic acid] 는 Sta. aureus와 B.subtilis에 대해 강한 항균작용을 나타냈다. 2. 2,2'-methylene bis [$\alpha$-(3,4,6-trichlorophenoxy)-$\beta$-(m-hydroxy-p-carbozyphenylarnino ) propionic acid]는 특히 진균류의 생장저해작용이 강하며 Trichophyton rubrum 및 Microsporum gypseum에는 2 $\mu\textrm{g}$/$m\ell$의 농도에서 항균성을 가지며, Epidermophyton floccosum Aspergillus niger 및 Aspergillus oryzae에 대해서는 1 $\mu\textrm{g}$/$m\ell$의 농도에서 항균성을 나타냄으로서 Hexachlorophene 항균성의 10배 내지 50배의 항균력을 가진다. 3. 34종류의 합성물질중 원 Hexachlorophene에 비해 5종류의 진균류에 대해 부분적으로나마 강한 항균력을 나타내는 물질은 23종류였고 3종류의 세균에 대해선 13종류였다.

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Antifungal Activities of the Essential Oils in Syzygium aromaticum (L.) Merr. Et Perry and Leptospermum petersonii Bailey and their Constituents against Various Dermatophytes

  • Park, Mi-Jin;Gwak, Ki-Seob;Yang, In;Choi, Won-Sil;Jo, Hyun-Jin;Chang, Je-Won;Jeung, Eui-Bae;Choi, In-Gyu
    • Journal of Microbiology
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    • 제45권5호
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    • pp.460-465
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    • 2007
  • This study was carried out in order to investigate the potential of using plant oils derived from Leptospermum petersonii Bailey and Syzygium aromaticum L. Merr. Et Perry as natural antifungal agents. The antifungal effects of essential oils at concentrations of 0.05, 0.1, 0.15, and 0.2 mg/ml on the dermatophytes Microsporum canis (KCTC 6591), Trichophyton mentagrophytes (KCTC 6077), Trichophyton rubrum (KCCM 60443), Epidermophyton floccosum (KCCM 11667), and Microsporum gypseum were evaluated using the agar diffusion method. The major constituents of the active fraction against the dermatophytes were identified by gas chromatography-mass spectrometry and high-performance liquid chromatography analysis. The antifungal activities of S. aromaticum oil (clove oil) against the dermatophytes tested were highest at a concentration of 0.2mg/ml, with an effectiveness of more than 60%. Hyphal growth was completely inhibited in T. mentagrophytes, T. rubrum, and M. gypseum by treatment with clove oil at a concentration of 0.2 mg/ml. Eugenol was the most effective antifungal constituent of clove oil against the dermatophytes T. mentagrophytes and M. canis. Morphological changes in the hyphae of T. mentagrophytes, such as damage to the cell wall and cell membrane and the expansion of the endoplasmic reticulum, after treatment with 0.11 mg/ml eugenol were observed by transmission electron microscopy (TEM). At a concentration of 0.2 mg/ml, L. petersonii oil (LPO) was more than 90% effective against all of the dermatophytes tested, with the exception of T. rubrum. Geranial was determined to be the most active antifungal constituent of L. petersonii oil. Taken together, the results of this study demonstrate that clove and tea tree oils exhibited significant antifungal activities against the dermatophytes tested in this study.

전주근교의 토양에서 분리된 호각화질성 진균의 오염에 관한 조사 (The Isolation of Keratinophilic Fungi from Soils in Chon-ju Area)

  • 허인;이주묵;윤창모
    • 한국임상수의학회지
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    • 제7권2호
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    • pp.489-495
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    • 1990
  • The purpose of this study was to investigate the contamination rates of Keratinophilic fungi in soils In Chonju. From september to November 1986, 98 soil samples were collected at the school and children's play ground, dog barn, pig barn, cow barn, horse barn and fowl barn( total 33 sites ). The samples were collected at the different depths(0~2cm, 30cm, 50cm ) in each of the sites, respectively. Each sample was cultured at 25$^{\circ}C$ according to Modified hair baiting method by using horse mane hair as a bait. The results obtained were summerized as follows ; 1. Eighty one of the 98 soil samples were found to be positive for Keratinophilic fungi. 2. In the examination of keratinophilic fungi in 98 soil samples, the organisms isolated weie as follows; Microsporum gypseum 20, Trichophyton ajelloi 15, Chrysosporium tropicum 40, C. Keratinophilum 24, C. tuberculatum 6 and Chrysosporium spp. like organism 4 strains. 3. The positive rates of keratinophilic fungi in each of the depths were 87.9%(29/33) in surface layer, 90.9%(30/33) in middle layer and 68.8%(22/32) in deep layer. 4. The positive rates of Keratinophilic fungi in each of the sites were 100%(3/3) in horse barn 91.7% (l1/12) in dog barn, 88.9%(16/18) in pig barn, 86.7%(13/15) in cow barn, 76.2%(16/21) in fowl barn and 75.9%(22/29) in school and children's play ground. 5. The isolation rates of M. gypseum, Pathogenic fungi for human and animals, were as follows ; 58.3% in dog barn(surface layers 100%, middle layers 50%, deep layers 25%) and 16.7% in pig barn(surface 33.3%, middle 16.7%, deep 0%). In the cow barn, the isolation rates were 13.3%(surface 40.0%, middle 0%, deep 0%) and 10% in horse barn(surface l00%, middle 100%, depp 100%). In the fowl barn, the isolation rates was 19.1%(surface 28.8%, middle 14.3%, deep 14.3%) and 3.5% in school and children's play ground(surface 0%, middle 0%, deep 11.1%).

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동물친화성 피부사상균 감염의 역학적 연구 (Epidemiologic Study on Zoophilic Dermatophytes)

  • 방용준;김쌍용
    • 대한임상검사과학회지
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    • 제37권2호
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    • pp.118-122
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    • 2005
  • An epidemiological study was performed on zoophilic dermatophytes. The number of patients with zoophilic dermatophytes diagnosed on clinical findings and culture at the Catholic Dermatological Clinic in Daegu City were 1,339 for 10 years from January 1995 to December 2004. Species of zoophilic dermatophytes isolated from 47,925 patients with dermatophytes were as follows; Trichophyton(T.) rubrum was isolated from 43,702 (91.2%), T. interdigitale 2,660 (5.6%), Epidermophyton(E.) floccosum 43 (0.1%), T. tonsurans 131 (0.3%), T. mentagrophytes 625 (1.3%), T. verrucosum 56 (0.2%), Microsporum(M.) canis 658 (1.4%), and M. gypseum 50 (0.1%). Zoophilic dermatophytes infections were chiefly Tinea facial in the cases of T. mentagrphytes and Tinea corporis in the cases of T. verrucosum, but Tinea capitis in the cases of M. canis. Number of patients with zoophilic dermatophytes by site and age were as follows; Most patients with infected scalps were young people under 15 years old. Infection of the trunk area (neck,chest,back) and extremities (arms, legs, hands, feet) were relatively high in those patients over 15 years old. M. canis were most frequently isolated in autumn and winter, and T. mentagrophyts and T. verrucosum were mostly in spring and winter.

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실험용 설치류의 피부사상균 보균실태와 albino rat에서 분리한 Trichophyton mentagrophytes의 완전형 (Asymptomatic carrier state of dermatophytes on laboratory rodents and the perfect state of Trichophyton mentagrophytes isolated from albino rats)

  • 이헌준;최원필;전무형
    • 대한수의학회지
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    • 제30권1호
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    • pp.59-64
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    • 1990
  • The present study was conducted in order to elucidate the asymptomatic carrier state of dermatophytes on the laboratory rodents in Korea during the period from August 1986 to April 1987. A total of 988 laboratory rodents, comprising 393 albino rats, 285 albino mice, 238 guinea pigs and 72 hamsters, were randomly selected for the isolation of dermatophytes from 6 research institutes and 2 breeding farms. And the mating experiments were performed to identified the perfect states of Trichophyton mextagrophytes isolated from albino rats. Dermatophytes were recovered from 94 of 393(23.9%) albino rats and from 3 of 5 colonies. Isolation rate of each colony was 38.4%, 32.0% and 9.8%, respectively, and the albino rats over 2 months old(28.2%) were higher than below 2 months old(2.9%) in the isolation rate of dermatophytes. Among 94 strains of dermatophytes isolated from albino rats, all the strains were identified T mentagrophytes, except 1 strain of Microsporum gypseum, and its perfect states were Arthroderma $vanbreuseghemii^+$.

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