• The Korean Journal of Physiology and Pharmacology
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• v.8 no.2
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• pp.101-110
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• 2004

Voltage-sensitive release mechanism was pharmacologically dissected from the $Ca^{2+}-induced\;Ca^{2+}\;release$ in the SR $Ca^{2+}$ release in the rat ventricular myocytes patch-clamped in a whole-cell mode. SR $Ca^{2+}$ release process was monitored by using forward-mode $Na^+-Ca^{2+}$ exchange after restriction of the interactions between $Ca^{2+}$ from SR and $Na^+-Ca^{2+}$ exchange within micro-domains with heavy cytosolic $Ca^{2+}$ buffering with 10 mM BAPTA. During stimulation every 10 s with a pulse roughly mimicking action potential, the initial outward current gradually turned into a huge inward current of $-12.9{\pm}0.5\;pA/pF$. From the inward current, two different inward $I_{NCX}s$ were identified. One was $10\;{\mu}M$ ryanodine-sensitive, constituting $14.2{\pm}2.3%$. It was completely blocked by $CdCl_2$ (0.1 mM and 0.5 mM) and by $Na^+-depletion$. The other was identified by 5 mM $NiCl_2$ after suppression of $I_{CaL}$ and ryanodine receptor, constituting $14.8{\pm}1.6%$. This latter was blocked by either 10 mM caffeine-induced SR $Ca^{2+}-depletion$ or 1 mM tetracaine. IV-relationships illustrated that the latter was activated until the peak in $30{\sim}35\;mV$ lower voltages than the former. Overall, it was concluded that the SR $Ca^{2+}$ release process in the rat ventricular myocytes is mediated by the voltage-sensitive release mechanism in addition to the $Ca^{2+}-induced-Ca^{2+}\;release$.

• The Journal of Engineering Geology
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• v.4 no.1
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• pp.29-42
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• 1994

Discrimination studies between microearthquakes and underground explosions are carried out in the pure-continental path of north-south within the Korean Peninsula. The characteristic waveforms for explosions and microearthquakes are investigated in the light of observation and synthetic seismograms. The characteristic waveform generation is minnly a function of source mechanism and ray-path and former influences more strongly than the latter.A double-couple source mechanism for microeatthquakes and a single-couple(force) mechanism for explosions are presented in this study. It is found for very shallow events to have outstanding of $L_g$ waves in the transverse components that pass through the upper crust with period of 1 - 6 seconds and fundamental modes of Rayleigh waves, $R_g$ in the vertical component with period 8-12 seconds. Furthermore it is pointed out that the first arrival amplitudes of SH waves for explosions are always srnall regardless of azimuth of stations since there is non-existence of nodal lines for the explosion mechanism. Theoretical seismograms for explosions show the first motions of compression with short wavelengths as well as mostly fundamental modes of Rayleight waves, $R_g$ waves and $L_g$ waves, whereas those of micro-earthquakes give either compression or dilatation according to the ack azimuth epicenter to stations and poor or non $R_g$ waves and complicated $L_g$ waves, depending on the focal depth.

• Journal of Preventive Medicine and Public Health
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• v.39 no.3
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• pp.249-254
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• 2006

Objectives: This study was conducted to examine the factors related to the perceived peer smoking prevalence for adolescents. Methods: A self-administrated questionnaire was administered to 352 students in a technical high school in Kangwon Province in May, 2002. The questions included in the questionnaire were concerned with the estimated number of smokers among ten students of the same grade in their school, the sociodemographic characteristics, the smoking-related behaviors and attitudes, and the smoking-related environments. All the students had their expiratory carbon monoxide level measured with EC50 Micro-Smokerlyzer? to verify their smoking status. Multiple regression analysis was applied for data analysis using Windows SPSS 11.5. Results: The former and current smokers overestimated the peer smoking prevalence. Multiple regression analysis for estimating the peer smoking prevalence for the male showed that the perceived smoking prevalence was higher in the female students than in the male students, higher in those students whose mothers had a higher educational level, who had smoked more frequently, who had more best friends smoking, and who had a higher actual smoking rate of the class. For estimating the peer smoking prevalence for the female, the perceived smoking prevalence was higher in the female students than in the male students, higher in those who smoked more frequently, whose five best friends smoked, who had higher actual smoking rate of the class, and who had smoking siblings. Conclusions: This study showed that a higher perceived peer smoking rate is related with their own smoking history and smoking frequency, the smoking related environment, and gender. Smoking prevention and smoking cessation programs need to focus on correcting the falsely perceived smoking prevalence.

• Journal of Biomedical Engineering Research
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• v.32 no.1
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• pp.55-60
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• 2011

Although sound intensity is considered as one of important factors in auditory processing, its neural mechanism in auditory neurons with limited dynamic range of firing rates is still unclear. In this study, we examined the effect of sound intensity adaptation on the change of glucose metabolism in a rat brain using [F-18] micro positron emission tomography (PET) neuroimaging technique. In the experiment, broadband white noise sound was given for 30 minutes after the [F-18]FDG injection in order to explore the functional adaptation of rat brain into the sound intensity levels. Nine rats were scanned with four different sound intensity levels: 40 dB, 60 dB, 80 dB, 100 dB sound pressure level (SPL) for four weeks. When glucose uptake during the adaptation of a high intensity sound level (100 dB SPL) was compared with that during adaptation to a low intensity level (40 dB SPL) in the experiment, the former induced a greater uptake at bilateral cochlear nucleus, superior olivary complexes and inferior colliculi in the auditory pathway. Expectedly, the metabolic activity in those areas linearly increased as the sound intensity level increased. In contrast, significant decrease interestingly occurred in the bilateral auditory cortices: The activities of auditory cortex proportionally decreased with higher sound intensities. It may reflect that the auditory cortex actively down-regulates neural activities when the sound gets louder.

• Journal of Korean Library and Information Science Society
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• v.47 no.1
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• pp.1-20
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• 2016

Humanities is one of the largest buzzword in Korea. Humanities programs are being provided indiscriminately in public authorities, universities, life-long education institutions, cultural centers, the media, museums, libraries etc. Among them, the public library is the base camp for spreading and popularizing the humanities. Nevertheless, there is also a critical views for the humanities program of public library. The purpose of this study is to discuss the discourse of the humanities banquet in theoretical positions and practical aspects. The former discussed the humanities banquet in terms of academic axioms, global macro and micro discourse, social and economic wave, the spirit cultural evolution. The latter discussed the humanities banquet at the axiom and identity of the library and humanities, pitfalls and limitations in terms of reason, paradox and the dilemma on the linkage side, inconvenient truth at the destination aspect, weaknesses and challenges in the content aspect.

• Journal of the Korean Society for information Management
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• v.23 no.3 s.61
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• pp.187-204
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• 2006

The main purpose of the archives is to maintain a history of the organization's functions and activities. Selecting valuable records for the permanent archives through objective appraisal from among many records that reflects the activities of organization is very important but also very difficult. The quantity and complexity of comtemporary records has rapidly expanded because of electronic storage, and with the information environment, and it is now possible to manage and control the records an entire lifetime. In this study, it is proposed the appraisal methods based on a business analysis that is combined the macro-appraisal factor and micro-appraisal factor; The former is functions and organizations as the objective guideline of selecting valuable records from the beginning and the latter is a contents appraisal (evidential value) of the individual records.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.11a
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• pp.753-756
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• 2008

HPFRCC (High-Performance Fiber Reinforced Cementitious Composites), which is relatively more ductile and has the characteristic of high toughness with high fiber volume fractions, can be used in structures subjected to extreme loads and exposed to durability problems. In the case of using PVA(polyvinyl alcohol) fibers, it is noted by former studies that around 2% fiber volume fractions contributes to the most effective performance at HPFRCC. In this study, therefore, compressive and flexural tests were implemented to evaluate the compressive and flexural capacities of HPFRCC while the total fiber volume fractions was fixed at 2% and two different PVA fibers were used with variable fiber volume fractions to control the micro-crack and macro-crack with short and long fibers, respectively. Moreover, specimens reinforced with steel and PVA fiber simultaneously were also tested to estimate their behavior and finally find out the optimized mixture. In the result of these experiments, the specimen consists of 1.6% short fibers (REC 15) and 0.4% long fiber (RF4000) outperformed other specimens. When a little steel fibers added to the mixture with 2% PVA fibers, the flexural capacity was increased, however, when high steel fiber volume fractions applied, the flexural capacity was decreased.

• The Korean Journal of Zoology
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• v.13 no.3
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• pp.75-84
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• 1970

Gamma-radiolyses of oxygenated and deoxygenated glycylglycylclycine in aqueous solution and in the solid state are observed, with special regards to peptied bond rupture for elucidation of radiolytic mechanism of proteins, by means of chromatorgraphic separation of degradation products, spectrophotometric quantitation of carbonyl compounds, micro-titration of amide formation, infrared spectrophptometry, and ultraviolet spectrophotometry for evaluation of radiation damage. Essential difference of peptide bond rupture is observed in solution and in the solid state, being high in the former and negligible in the latter. On the other hand, the presence of and obsence of oxygen in solution during irradiation are not so significant with respect to peptide bond rupture, except the recombination of free-radicals produced in deoxygenated solution. Peptide bond rupture in solution is attributable to the mechanisms proposed by Garrison et al.; dehydrogenation followed by hydrolysis to yield acid amide and carbonyl function as found on the basis of radiolytic products. Peptide bond attack at $\\alpha$-carbon locus might be suggestive for irradiated solid but not significant in view of low degree of peptide bond rupture.

• Tribology and Lubricants
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• v.30 no.5
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• pp.303-310
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• 2014

In order to reduce friction and improve reliability, researchers have applied various surface texturing methods to highly sliding machine elements such as mechanical seals and piston rings. Despite extensive theoretical research on surface texturing, previous numerical results are only applicable to isothermal and iso-viscous conditions. Because the lubricant flow pattern of textured bearing surfaces is much more complicated than that for non-textured bearings, the Navier?Stokes equation is more suitable than the Reynolds equation for the former. This study carries out a thermohydrodynamic (THD) lubrication analysis to investigate the lubrication characteristics of a single micro-dimpled parallel thrust bearing cell. The analysis involves using the continuity, Navier?Stokes, energy, temperature?viscosity relation, and heat conduction equations with the commercial computational fluid dynamics (CFD) code FLUENT. This study discretizes these equations using the finite volume method and solves them using the SIMPLE algorithm. The results include finding the streamlines, pressure and temperature distributions, and variations in the friction force and leakage for various dimple radii and depths. Increasing the dimple radius and decreasing the depth causes a recirculation flow to form because of a strong vortex, and the oil temperature greatly increases compared with the non-textured case. The present numerical scheme and results are applicable to THD analysis of various surface-textured sliding bearings and can lead to further study.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.sup3
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• pp.317-321
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• 2016

Detection of micrometastasis in sentinel lymph nodes (SLNs) is a very useful tool for appropriate assessment of the clinical stage of disease in breast cancer patients. Early identification of clinically relevant disease could lead to early treatment or staging approaches for breast cancer patient. Micrometastases in SLNs of women with invasive breast cancer are of great significance in this context. In this study we examined SLN biopsies considered to have small numbers of cancerous cells by real time RT-PCR. All of the samples underwent immunohistochemical staining for cytokeratin for confirmation of the presence or absence of micrometastases. BUB1b expression assay of selected patients with and without metastasis showed overexpression in the former, but not in normal breast and lymph node tissue. Our results may be taken into account in the discussion about the merits of routine use of molecular assessment in pathogenetic studies of SLNs.