• 한국약용작물학회지
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• 제18권5호
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• pp.338-344
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• 2010

Our paper shows the results of 302 samples of herb medicines about fungal contamination at Yakyeang markets in Seoul. The sample medicines were treated VICAM pretreatment and analysed by post column derivatisation procedure(PHRED-HPLC) with a fluorescence detector. Aflatoxin B1 was founded from 50.3% of samples, aflatoxin B2 was 39.7%, aflatoxin G1 was 21.2% and aflatoxin G2 was 23.5%. The detected ranges of aflatoxin B1, B2, G1 and G2 were from 0.1 to $57.2\;{\mu}g/kg$, 0.1 to $42.6\;{\mu}g/kg$, 0.1 to $23.5\;{\mu}g/kg$ and 0.1 to $9.5\;{\mu}g/kg$ respectively. Among total samples, 26 samples contained aflatoxin B1 violated the regulation (less than 10 ug/kg) for aflatoxin B1 of KFDA. From the result, we could presumed that more than a half of samples were contaminated by aflatoxins. Therefore, it seems to be necessary that the new safety giudeline will be established aflatoxin B2, G1 and G2 from herb medicines as aflatoxin B1.

• 한국약용작물학회지
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• 제18권5호
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• pp.345-360
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• 2010

This study was conducted to investigate the content of sulfur dioxide residues in medicinal herbs in Seoul in 2009. Sulfur dioxide in the samples were determined by Monnier-Williams's modified method. A total of 1,821 samples of 205 different types of herbs were collected from Kyung-Dong Herb markets and Oriental medicine hospitals in Seoul. Of these samples, 642 samples were domestic, and 1,179 samples were imported. Of the 1,821 samples, 61 (3.3%, 31 types) failed to meet the regulations for sulfur dioxide residues of KFDA in medicinal herbs. Among these 61 unsuitable samples, 17 (7 types) were domestic, and 44 samples (26 types) were imported. The content of sulfur dioxide in the domestic medicinal herbs ranged from 0 to 809 mg/kg, while those in imported medicinal herbs ranged from 0 to 4,481 mg/kg. Approximately 84.6% of the samples contained less than 10 mg/kg of sulfur dioxide and about 10.0% of samples contained more than 30 mg/kg of sulfur dioxide.

• Annals of Surgical Treatment and Research
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• 제95권5호
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• pp.240-248
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• 2018

Purpose: This study aimed to validate the synergistic effect of ABT-737 on docetaxel using MDA-MB-231, a triple negative breast cancer (TNBC) cell line overexpressing B-cell lymphoma-2 (Bcl-2). Methods: Western blot analysis was performed to assess expression levels of Bcl-2 family proteins and caspase-related molecules. Cell viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell cycle distribution was determined by flow cytometry analysis. Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (z-VAD-fmk) was used for pretreatment to assess the role of caspases. Results: Cell viability of MDA-MB-231 after combination treatment with ABT-737 and docetaxel was significantly lower than that after docetaxel or ABT-737 monotherapy based on MTT assay (both P < 0.001), with a combination index of 0.41. The proportion of sub-G1 population after combination treatment was significantly higher than that after docetaxel or ABT-737 monotherapy (P = 0.001, P = 0.003, respectively). Pretreatment with z-VAD-fmk completely restored cell viability of MDA-MB-231 from apoptotic cell death induced by combination therapy (P = 0.001). Although pro-caspase-8 or Bid did not show significant change in expression level, pro-casepase-9 showed significantly decreased expression after combination treatment. Cleaved caspase-3 showed increased expression while poly (ADP-ribose) polymerase cleavage was induced after combination treatment. However, hypoxia-inducible factor 1-alpha and aldehyde dehydrogenase 1 totally lost their expression after combination treatment. Conclusion: Combination of ABT-737 with docetaxel elicits synergistic therapeutic effect on MDA-MB-231, a TNBC cell line overexpressing Bcl-2, mainly by activating the intrinsic pathway of apoptosis. Therefore, adjunct of ABT-737 to docetaxel might be a new therapeutic option to overcome docetaxel resistance of TNBCs overexpressing Bcl-2.

• 한국입자에어로졸학회지
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• 제17권4호
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• pp.115-123
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• 2021

The emission gas from meat grilled restaurants has unpleasant odor and sticky particulate matters (PM) in form of oil mist. This affects the residents living nearby. In oder to decrease the odor and PM, electrostatic precipitators (ESP) were installed at several restaurants by support of Seoul metropolitan government and emission characteristics of PM and odor were investigated. The removal efficiency of odor and PM at before- and after-ESP was that total hydrocarbon (THC), NH₃, H₂S, acetaldehyde, butyraldehyde were not much decreased. Total suspended particles (TSP) emitted from the vent was below the value of 7 mg/m³ regardless of the concentration of before-ESP and removal efficiency was in the range of 64 ~ 86%. The ratio of PM_1.0 to PM₁₀ of emission gas was over 0.9. So it was revealed that most PM of emission gas was PM1.0. The PM concentration in the air of the street near the vent was higher than another street due to the emission gas and the PM of indoor air of restaurant grilling meats was measured very high compared to outdoor air. So it needs more powerful ventilation of indoor air.

• 웰빙융합연구
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• 제5권4호
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• pp.19-31
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• 2022

Purpose: This study was conducted to identify indoor air quality in various living spaces using sensors that can measure noise, vibration, fine dust, and odor in real time and to propose optimal indoor air quality maintenance management using Internet of Things(IoT). Research design, data and methodology: Using real-time sensors to monitor physical factors and environmental air pollutants that affect the comfort of the residential environment, Noise, Vibration, Atmospheric Pressure, Blue Light, Formaldehyde, Hydrogen Sulfide, Illumination, Temperature, Ozone, PM10, Aldehyde, Amine, LVOCs and TVOCs were measured. It were measured every 1 seconds from 4 offices and 4 stores on a small scale from November 2018 to January 2019. Results: The difference between illuminance and blue light for each measuring point was found to depend on lighting time, and the ratio of blue light in total illumination was 0.358 ~ 0.393. Formaldehyde and hydrogen sulphide were found to be higher than those that temporarily attract people in an indoor office space that is constantly active, requiring office air ventilation. The noise was found to be 50dB higher than the office WHO recommendation noise level of 35 ~ 40dB. The most important factors for indoor environmental quality were temperature> humidity> illumination> blue light in turn. Conclusions: Various factors that determine the comfort of indoor living space can be measured with real-time sensors. Further, it is judged that the use of IoT can help maintain indoor air quality comfortably.

• 농약과학회지
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• 제18권4호
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• pp.269-277
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• 2014

HPLC-UVD를 이용하여 diflubenzuron이 다종농약다성분 분석법 제2법에 적합한지를 검증하고자 본 연구를 수행하였다. 유효성을 검증하기 위하여 농약이 검출되지 않은 시금치, 엇갈이배추, 가지, 애호박, 청피망, 오이, 참외 등 7종 농산물을 대상으로 직선성, 특이성, 검출한계, 정량한계, 정확성, 정밀성을 확인하였다. Diflubenzuron 표준용액을 0.05-5 mg/kg 농도로 희석하여 분석한 표준검량선의 직선성은($R^2=0.99999$)은 매우 만족할 만한 수준이었다. 검출한계는 0.008 mg/kg, 정량한계는 0.02 mg/kg 이며 회수율은 77.5-105.6%, 상대표준편차는 최대 20% 미만, 정밀도는 intra-day test에서 0.4-1.9%, inter-day test에서 0.7-1.9%를 나타내어 잔류농약분석법에서 허용하는 회수율 기준 70-120% 범위와 상대표준편차 20% 이하의 기준에 적합하였다. LC-MSD를 이용한 재확인 과정을 통해 잔류결과의 신뢰성을 확보하였다. 따라서 유통농산물 중 diflubenzuron의 일상적 검사법으로 빠르고 간편한 다종농약다성분 제2법을 적용할 수 있을 것으로 판단된다.

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 NEW STRATEGY FOR DRUG DEVELOPMENT IN POST-GENOMIC ERA(대한약학회)
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• pp.196.1-196.1
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• 2000

• 한국디지털정책학회:학술대회논문집
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• 한국디지털정책학회 2005년도 춘계학술대회
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• pp.215-229
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• 2005

The purpose of this study is to analyses 7 metropolitan cites on the urban facility data rather than application systems including water, sewer, and roads and to present the best way to reconfigure of the geospatial data in Korea. Data were mainly compiled from the 2nd NGIS(National Geographic Information Systems: 95-00) because the GIS data of this study is relatively important to generate favorable results due to their data precisely examinate by the 1st NGIS evaluated results. In results, GIS data and invested budget of the Seoul metropolitan government were not only covered 25 distracted areas of the fields, but also were overwhelming other six metropolitan government invested budget. Relatively the Daejeon metropolitan government had least invested budget resulted in Jess geospatial data than others. In particularly there were serious geospatial data error occurred even though geospatial data of the urban infrastructures like water, sewer, and roads including the national infrastructure like elec., comm., heat, oil pipes, and gas were facilitated with human habitants, gas and elec. had very high error data nearly two times high than the permitted error in 30cm. Therefore, this paper exhibited a LiDAR technology to regenerate high accuracy geospatial data of the metropolitan governments because of the new technology's extremely accuracy in 20cm in horizontal scale in fields.

• 농약과학회지
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• 제17권3호
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• pp.162-167
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• 2013

GC-NPD를 이용하여 pencycuron의 다종농약다성분 분석법을 확립하고자 본 연구를 수행하였다. 제시된 분석법의 검증을 위해 예비 실험을 거쳐 농약이 검출되지 않은 상추, 시금치, 엇갈이배추, 근대, 아욱, 배추를 대상으로 실험하였다. Pencycuron 표준용액을 0.02-2 mg/kg의 농도로 희석하여 분석한 검량선의 직선성($r^2$ = 0.9999)은 우수하였다. 검출한계는 0.005 mg/kg이고 정량한계는 0.02 mg/kg이며 회수율은 79.6-112.1%, 분석오차는 최대 4.9%미만으로 잔류농약 분석법에서 허용되는 회수율 기준 70-120% 범위와 분석오차 20% 이하의 기준에 적합하였다. 정밀도는 intra-day test에서 1.6-3.0%, inter-day test에서 5.3-11.5%를 나타내어 다종농약다성분 분석법을 통해 pencycuron의 직선성, 검출한계, 정량한계, 회수율과 정밀도를 검증하고 정확성을 증명하였다. 오랜 시간이 걸려 추출, 정제, 유도체화 과정을 거치는 분석법보다 빠르고 간편한 실험법인 다종농약다성분 분석법이 pencycuron의 분석시에 유용한 분석법으로 활용될 수 있을 것으로 판단된다.

• 한국식품위생안전성학회지
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• 제29권3호
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• pp.211-216
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• 2014

본 실험은 2012년부터 2013까지 4,318건의 다양한 식품으로부터 155건의 B. cereus를 분리하고 그 중 140건에 대하여 $25^{\circ}C$와 $70^{\circ}C$의 추출온도에 따라 마늘, 계피, 생강, 녹차 추출물의 항균력 시험을 실시하였다. 식품유형별 균분리율은 고춧가루(48.65%), 농산물(31.08%), 김치류(25.61%)가 높았으며 식중독원인으로 의심되었던 식품접객업소 조리식품에서는 1.17%가 분리되었다. 항균성 시험에서는 $25^{\circ}C$ 마늘 추출물과 $25^{\circ}C$와 $70^{\circ}C$ 녹차 추출물에서만 140개의 모든 분리주에서 억제환이 나타났다. 억제환의 크기는 $25^{\circ}C$에서 마늘 > 녹차 > 계피의 순으로 $70^{\circ}C$에서는 녹차 > 마늘 > 계피의 순으로 나타나 온도에 따른 항균성의 차이가 있음을 알 수 있었다. 각 추출물들의 상관관계 분석에서 $25^{\circ}C$에서는 마늘과 녹차, 계피와 녹차가 유의적인 차이를 나타내었고 $70^{\circ}C$에서는 마늘과 녹차만이 유의적인 차이를 나타내었다.