• 한국컴퓨터정보학회논문지
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• 제27권10호
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• pp.195-202
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• 2022

이 연구는 한국 노인들에서 심혈관질환의 위험인자에 대한 태극권의 효과를 알아보고자 시도되었다. 68명의 노인참가자를 실험군과 대조군으로 나눈 후, 실험군 34명에게 6주 동안 일주일에 5번씩, 하루 60분 동안 태극권운동을 하게 했다. 심혈관질환 위험인자로 알려진 것 중 체질량지수, 공복혈당, 중성지방, 고밀도 콜레스테롤, 저밀도 콜레스테롤을 6주간의 운동 전후에 측정하였다. 결과는 태극권운동군에서 체질량지수, 공복혈당, 중성지방, 저밀도 콜레스테롤이 유의미하게 감소하였고, 고밀도콜레스테롤은 유의미한 증가를 보였다. 이 연구결과는 태극권운동이 노인들에게 심혈관질환 예방에 효과적이라는 것을 보여주었다. 그러므로, 노인센터나 지역보건소에서 노인을 위한 건강프로그램에 태극권운동을 적용해 보는 것을 제안한다.

• 한국융합학회논문지
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• 제13권1호
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• pp.161-166
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• 2022

HIF-2α는 저산소 조건에서 활성화되는 전사인자로 암, 대사증후군, 관절염, 간염 등의 발병 기전에서 핵심 역할을 한다고 보고된 바 있다. 이에 HIF-2α 저해제를 도출하고자 기존 약리활성 구조를 도입한 N'-arylisonicotinolyhydrazide를 골격으로 설정하고 화합물 라이브러리로부터 해당 화합물들을 선택하여 HIF-2α 저해활성을 측정하였다. 이를 위해 HRE-luciferase를 HTB-94세포에 transfection하고 아데노바이러스를 이용하여 HIF-2α를 세포 내로 도입하여 luciferase reporter gene assay를 수행하였다. 2-hydroxy-1-naphthyl 기를 포함한 화합물에서 저해활성이 발견됨에 따라 이 구조를 포함하는 골격을 다시 설정하고 해당 화합물들을 선정하여 활성을 측정하였다. 그 결과 HIF-2α 저해활성과 위양성 시험을 통하여 2 종의 HIF-2α 저해제를 도출하였다. 본 연구는 생물학과 화학의 융합연구로 수행되었으며 도출된 저해제는 후속 저해제 탐색 연구와 HIF-2α의 기능 연구에 활용될 수 있고 관련 질환의 치료제 개발에도 기여 할 것으로 사료된다.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2021년도 제64차 하계학술대회논문집 29권2호
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• pp.333-335
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• 2021

Gallbladder polyps (GBPs) may be a cause of gallbladder cancer. The known risk factors for GBPs are male gender, obesity, metabolic syndrome, and dyslipidemia. Especially, male gender has been known that it strongly affects on the prevalence of GBPs. Therefore, this study aimed to investigate risk factors affecting the prevalence of GBPs among adults on Jeju Island according to genders. We examined 5,574 subjects who visited a single health-screening center in Jeju between January 2015 and December 2019. Univariate and multiple logistic regression analysis were performed to identify risk factors affecting the prevalence of GBPs. The prevalence of GBPs were 8.9% in male subjects and 8.1% in female subjects, respectively. Multivariate analysis revealed that ≥60 year age (odds ratio [OR] 0.659; P=0.027) and aspartate aminotransferase >32 IU/L (OR 0.658; P=0.009) in male subjects and high-density lipoprotein-cholesterol ≥60 mg/dL (OR 0.514; P=0.013) in female subjects were independent factors affecting the prevalence of GBPs. The prevalence of GBPs in men (8.9%) is comparable to that in women (8.1%) on Jeju Island. Age <60 years and the high level of aspartate aminotransferase in men and the greater level of high-density lipoprotein-cholesterol in women were independent risk factors of GBPs on Jeju Island.

• 한국식생활문화학회지
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• 제25권2호
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• pp.109-116
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• 2010

Ramyen and Korean noodles (guksu) are popular foods in Korea and around the world. Since 1998, rice consumption in Korea has gradually decreased, whereas consumption of noodles has continuously increased. The purpose of this study is to assess the consumption of ramyen and Korean noodles of Koreans, using data from the Korean National Health and Nutrition Examination Survey (KNHANES) of 2007. Korean adults (>20) were selected to examine the associations between noodle consumption and food and nutrient intake and health status. SAS 9.1 and SUDAAN 9.1 were used for the data analysis. 10.3% of Korean adults consumed ramyen, and 15.4% consumed Korean noodles. The consumption of ramyen and Korean noodles were higher in men than in women, in lunch than in other meals, and in the lowest income quartile than the highest quartile. Ramyen and Korean noodle consumer groups consumed more grain products, seasonings, and oils than the nonconsumer group. The noodle group showed significantly lower systolic blood pressure than the non-consumer group. The noodle groups showed lower rates of hypertension and metabolic syndrome than the non-consumer group. From these results, we conclude that ramyen and Korean noodles may have positive health effects. More studies on the association between noodles and the health of Koreans and those in other countries should be done in the future.

• 대한영양사협회학술지
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• 제29권4호
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• pp.230-247
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• 2023

This study aimed to investigate the association between awareness of having a chronic disease with food habits and dietary quality among 320 male manufacturing workers in their 40s. Participants were categorized into groups. The first group comprised workers who were aware of having chronic diseases (ACD, n=160) and had been diagnosed with any one or more of the following major chronic diseases: Metabolic syndrome, hyperlipidemia, hypertension, obesity, and cardiovascular disease. The second group comprised those who had experienced none of the above diseases were classified as a group of people who were a ware of not having chronic diseases (ANCD, n=160). The mean age of the subjects was 44.2 years. The mean weight (P<0.001) and body mass index (BMI; P<0.01) were significantly higher in the ACD than in the ANCD group. The frequency of alcohol consumption and the number of current smokers were not significantly different between the two groups. Dietary attitudes were not significantly different between the two groups. The frequency of egg consumption was significantly higher in the ACD group (P<0.05). Picky eating, vegetable intake, checking nutrition labels, and healthy eating behavior were not significantly different between the two groups. The frequency of exercise was significantly lower in the ACD group compared to the ANCD group (P<0.05). The mean nutrition quotient (NQ) score was 51.9, with no significant difference between the two groups. Based on these results, the awareness of suffering from chronic diseases was not significantly related to dietary attitudes, food habits, and overall dietary quality among production workers. Therefore, there is a need to develop and implement nutrition education programs to inculcate an awareness of health status that can lead to dietary changes.

• Clinical Nutrition Research
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• 제12권1호
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• pp.21-28
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• 2023

Studies indicate an association between hyperuricemia (HUA) and metabolic syndrome risk factors. On the other hand, obesity is a major modifiable and independent risk factor for HUA and gout. However, evidence concerning the effects of bariatric surgery on serum uric acid levels is limited and not completely clarified. This retrospective study was carried out with 41 patients who underwent sleeve gastrectomy (n = 26) and Roux-en-Y gastric bypass (n = 15) from September 2019 to October 2021. Anthropometric, clinical, and biochemical data, including uric acid blood urea nitrogen and creatinine fasting blood sugar (FBS), serum triglyceride (TG), and serum cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), were measured preoperatively and postoperative 3, 6 and 12 months. From baseline to 6 and 12 months, bariatric surgery resulted in a significant decrease in serum uric acid of patients with severe obesity (p < 0.001). The decreases in serum FBS, TG, and cholesterol of patients were significant during 6 and 12 months of follow-up (p < 0.05). However, the HDL increase of patients was not statistically significant in 6 and 12 months (p > 0.05). Besides, although patients' serum level of LDL decreased significantly during the 6 months of follow-up (p = 0.007), it was not significant after 12 months (p = 0.092). Bariatric surgery significantly reduces serum uric acid levels. Therefore, it may be an effective supplementary therapy for lowering serum uric acid concentrations in morbidly obese patients.

• 비만대사연구학술지
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• 제3권1호
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• pp.1-8
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• 2024

Background: This study investigated the association between obesity and cardiometabolic disease clusters in Korean adults aged 19-39 years. Methods: We included 3,785 participants (1,767 men and 2,018 women) aged 19-39 years who participated in the Korea National Health and Nutrition Examination Survey (2020-2022). The risk factors for cardiometabolic disease were defined as follows: high blood pressure; hypertriglyceridemia; hyperuricemia; and high low-density lipoprotein cholesterol, low high-density lipoprotein cholesterol, high fasting plasma glucose, elevated alanine aminotransferase levels. Results: The prevalence of participants with ≥ 1, ≥ 2, and ≥ 3 cardiometabolic disease risk factors was 95.2%, 84.2%, and 65.6% in men and 90.0%, 70.5%, and 43.0%, in women with class 2-3 obesity, respectively. Compared to those for young adults with underweight/normal weight, the odds ratios (ORs) and 95% confidence intervals (CIs) for the clustering of cardiometabolic risk factors were 17.26 (8.32-35.80) for ≥ 1; 19.43 (12.18-31.00) for ≥ 2; and 22.93 (14.15-37.15) for ≥ 3 factors in men with class 2-3 obesity and 14.67 (8.00-26.91) for ≥ 1; 20.88 (12.15-35.88) for ≥ 2; and 36.26 (20.20-65.09) for ≥ 3 factors in women with class 2-3 obesity. Conclusion: Although the patients were young, the prevalence and ORs for cardiometabolic disease risk factor clusters in young adults with obesity were prominently high. Prevention and management of obesity in young Korean adults are urgently needed at both individual and public levels.

• 대한한방내과학회지
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• 제29권4호
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• pp.970-978
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• 2008

Objectives : This study aimed to clarify the relationship between the Oriental medical diagnosis and arteriosclerosis by measuring carotid-ankle vascular index(CAVI) in acute cerebral infarction patients. Method : One hundred thirty-one subjects were recruited from the patients admitted to the Internal Medical Department at Kyunghee University Oriental Medical Center from April 2007 to August 2008. We sorted cerebral infarction patients and assessed one hundred fourteen patients' CAVI data. We diagnosed dampness-phlegm by Oriental medical diagnosis and evaluated stroke type by single or multiple infarctions. then, we analyzed their characteristics with type of stroke, risk factor, lifestyle, metabolic syndrome and dampness-phlegm diagnosis. Result : 1. On the demographic variables of the patients, age, hypertension, hyperlipidemia, multiple infarction group and metabolic syndrome and dampness-phlegm group were significantly higher in the high CAVI score group than in the control. 2. According to the significant difference in the dampness-phlegm group, we analyzed dampness-phlegm related index for pattern identifications by CAVI score. As a result, dark circles, insomnia, headache, white coating tongue. slippery pulse, and rough pulse were significantly higher in the high CAVI score group then in the control. 3. In multivariate analysis, age, hypertension, multiple infarction and dampness-phlegm groups showed a close relationship with the high CAVI score group. Conclusions : According to the analysis, significance between dampness-phlegm diagnosed patients group and high CAVI score were clarified. Moreover, multiple location infarctions also have a relationship with high CAVI score in cerebral infarction patients. These results can be utilized in the future as a basis material.

• 대한방사선기술학회지:방사선기술과학
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• 제37권4호
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• pp.287-294
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• 2014

담석은 담도계의 가장 흔한 질환으로 최근 우리나라에서 콜레스테롤 담석의 비율이 증가하고 있으며 그 대표적인 위험인자로는 연령, 여성, 비만 등이 거론되고 있다. 본 연구는 건강검진자를 대상으로 최근 3년간의 담석의 유병률 및 위험인자를 알아보고자 하였다. 2011년 1월에서 2013년 12월까지 대구지역 종합검진전문병원에서 건강검진을 받은 4,696명을 대상으로 성별과 연령별 분표를 조사하고 키와 몸무게, 공복혈당과 간기능 및 기본 지질 검사를 하였고, 초음파 검사를 통해 담낭의 담석을 진단하였다. 체질량 지수에 따라 저체중, 정상체중, 과다체중, 비만 집단으로 나누었고, 공복혈당 수치는 미국 당뇨 협회에서 제시한 당뇨병의 진단 기준에 따라 분류하였다. 간기능 수치는 본원에서 사용하는 간기능 정상치를 참조하여 대상군을 나누고 지질 수치는 NCEP APTIII에 따라 분류하였다. 분석결과 담석이 발견된 경우는 148명(3.15%)으로 남자 84명(1.79%), 여자 64명(1.36%)으로 남자에서 더 높았으나 성별 간 유병률은 차이는 없었다. 연령별 유병률은 40대 이하 1.84%, 40대 3.38%, 50대 이상 4.66%로 담석이 없는 집단에 비해서 유의하게 높았다(p<0.003). 또한 담낭 담석으로 판명된 대상자의 신체검사 상 고지혈분류 항목에서 비정상군은 Total-cholesterol 52명으로 가장 많았고, LDL-cholesterol 39명, Triglyceride가 36명, HDL-cholesterol 19명이였다. 단변량 분석을 시행한 결과 연령, 공복혈당, 체질량지수는 담석의 유병률과 의미 있는 상관관계를 보였고, 다중 로지스틱 회귀분석에서도 연령, 체질량지수가 담석증의 독립적인 위험인자로 선정되었다. 결론적으로 비록 담석이 대사증후군과의 관계에서 나타나지 않았지만 이를 규명하기 위해서는 건강검진 대상자뿐만 아니라 일반 국민을 대상으로 한 추가적인 연구가 필요하다고 사료된다.

• Journal of Nutrition and Health
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• 제42권6호
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• pp.559-566
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• 2009

본 연구에서 직장 남성 근로자 739명 (39세 이하 그룹: 240명, 40대 그룹: 276명, 50대 그룹: 223명)을 대상으로 e-mail 영양교육이 신체계측치, 체구성 및 심혈관 질환 위험인자에 미치는 영향을 조사하고자 하였다. 검진 시 1회, 약 10분의 면대면 영양상담 후 15개 주제의 영양교육자료를 월 1회, 10회에 걸쳐 e-mail을 통해 제공하였으며, 그 결과를 요약하면 다음과 같다. 1) 1년간의 e-mail 영양교육 후, 전체 연구대상자의 체지방률 (p < 0.001), 복부지방률 (p < 0.001), 총 콜레스테롤(p < 0.01), 수축기 혈압 (p < 0.01), 이완기 혈압 (p < 0.05)이 유의적으로 감소하였다. 2) 연령 그룹별로 살펴보면, 체지방률과 수축기 혈압은 세군 모두에서 유의적으로 감소하였고, 총 콜레스테롤은 39세 이하 그룹에서만 유의적으로 감소하였다 (p < 0.01). 3) 영양교육 전, 39세 이하 그룹의 대사증후군 유병률은 25%, 40대 그룹은 27.2%, 50대 그룹은 36.3%의 분포를 보였다. E-mail 영양교육 후, 39세 이하 그룹의 대사증후군 유병률은 18.3%, 40대 그룹은 27.5%, 50대 그룹은 35.4%로 교육 전에 비해 영양교육 후 39세 이하 그룹에서의 대사증후군 유병률이 유의적으로 감소하였다 (p < 0.05). 이상과 같이 본 연구에서 e-mail교육 프로그램은 직장인들에게 신체계측치 및 심혈관 질환 위험인자 감소에 효과가 있음이 확인되었다. 따라서 종합검진 후 1년의 자기관리를 위한 e-mail 영양교육 자료를 개발하여 적용했다는데 본 연구의 의의가 있다고 본다. 본 연구의 결과를 토대로 e-mail 교육 프로그램의 효과를 평가하기 위한 확대연구와 효과의 지속기간에 대한 장기적인 추적연구를 통해 직장인의 건강증진 및 사내 복지향상과 의료비 절감을 위해 회사 지원 하에 질환에 따른 적절한 영양관리 프로그램으로 적용 될 수 있기를 기대한다.