• Molecules and Cells
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• 제24권2호
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• pp.200-209
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• 2007

We generated gene expression data from the tissues of 50 gastric cancer patients, and applied meta-analysis and gene set analysis to this data and three other stomach cancer gene expression data sets to define the gene expression changes in gastric tumors. By meta-analysis we identified genes consistently changed in gastric carcinomas, while gene set analysis revealed consistently changed biological themes. Genes and gene sets involved in digestion, fatty acid metabolism, and ion transport were consistently down-regulated in gastric carcinomas, while those involved in cellular proliferation, cell cycle, and DNA replication were consistently up-regulated. We also found significant differences between the genes and gene sets expressed in diffuse and intestinal type gastric carcinoma. By gene set analysis of cytogenetic bands, we identified many chromosomal regions with possible gross chromosomal changes (amplifications or deletions). Similar analysis of transcription factor binding sites (TFBSs), revealed transcription factors that may have caused the observed gene expression changes in gastric carcinomas, and we confirmed the overexpression of one of these, E2F1, in many gastric carcinomas by tissue array and immunohistochemistry. We have incorporated the results of our meta- and gene set analyses into a web accessible database (http://human-genome.kribb.re.kr/stomach/).

• International Journal of Internet, Broadcasting and Communication
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• 제7권1호
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• pp.66-69
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• 2015

Recently with the development of IT technology, the medical technology have been developed in various ways. Among them, WBAN can check the state of the patient in real time. However, the data generated by these techniques have a problem that they have heterogeneous properties depending on the type of sensors and devices. In this paper, we proposed a method using meta repository as a way to provide the sensing data of WBAN for the health care system by integrating along the HL7 standard item.

• 인터넷정보학회논문지
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• 제21권4호
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• pp.97-107
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• 2020

본 연구의 목적은 빅데이터 분석기법을 활용하여 공유경제 관련 국내 학술연구 동향을 탐색하기 위해 내용분석 관점에서 종합적 메타스터디를 수행하는데 있다. 종합적 메타분석 연구방법론은 일련의 전체 연구결과물들을 역사적으로 그리고 포괄적으로 살펴봄으로써 전체 연구동향의 규칙성이나 특성을 조명하여, 이를 통해 향후 연구에 대해 방향성을 제시할 수 있다. 공유경제를 주제로 하는 국내 학술연구는 Lawrence Lessig 교수가 2008년에 공유경제의 개념을 세상에 소개한 해에 등장하였으나, 본격적인 연구는 2013년부터 진행되었다. 특히, 2006~2008년 사이에 국내 공유경제 관련 학술연구는 양적으로 급격히 증가하였다. 본 연구는 2013년부터 현재까지 약 8년간의 논문들을 분석 논문으로 선정하고, 전자저널의 학술논문검색 및 원문서비스를 이용하여 제목, 키워드, 초록을 중심으로 텍스트 데이터를 수집하였다. 수집된 데이터를 정제, 분석, 시각화의 순서로 빅데이터 분석을 실시하여, 추출된 핵심어들을 통해 연도별 및 문헌 유형별 연구동향 및 인사이트를 도출하였다. 데이터 전처리 및 텍스트 마이닝, 메트릭스 빈도분석을 위해 Python3.7과 Textom 분석도구를 활용하였고, 핵심어 노드 간의 구조적 연관성을 파악하기 위해 UCINET6/NetDraw, Textom 프로그램 기반의 N-gram 차트, 중심성 및 소셜네트워크 분석, 그리고 CONCOR 클러스터링 시각화를 통해 8개로 군집화 한 키워드들을 토대로 연구동향의 유형별 특성을 발견하였다. 아직까지 사회과학적 관점에서 공유경제 관련 학술연구 동향에 관한 조사가 이루어진 바가 없기 때문에, 본 연구의 결과물은 선행연구로서 후속 연구들에게 이론적 고찰 및 향후 연구방향에 대해 유용한 정보를 제공하는 초석의 역할을 기대할 수 있다.

• 한국임상보건과학회지
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• 제4권1호
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• pp.504-509
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• 2016

Purpose. This study aims to present basic data to develop programs suitable to the characteristics of elderly people through a meta-analysis of effectiveness of variables related to psychological effects of programs of elderly people conducted in past 15 years. Methods. The analysis subjects are total 229 articles related to the psychological effects of programs for elderly people and submitted for master or doctor degrees or published in academic journals. CMA2 is used for the analysis. Results. The results of this study shows lower variables of the psychological effect promoting factor group that are highly effective for Life Satisfaction, Self-Efficacy, Self-Respect and Self-Integration and lower variables of suppressing factor group that are highly effective for Loneliness, Tension, Weakness, Anger and Depression. For the effect scale of psychological effect promoting factors, Arts is shown to be the highest followed by Exercise, Consultation, Recollection, Others and Recreation in order. For the effect scale of suppressing factors, Consultation is shown to be the highest followed by Recollection, Arts, Exercise, Others and Recreation) in order. Conclusions. This study has its own meaning for establishing integrated factors of psychological effects of programs for elderly people and presenting realistic data for planing programs suitable for various desires of elderly people.

• 시스템엔지니어링학술지
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• 제11권1호
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• pp.25-31
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• 2015

Under the relevant regulations, it is required to develop a system architecture for the research and development of the information and communication infra system ; however, the national defense architecture development guides and MND-AF, which provide the instructions on the development and utilization of a system architecture, are still limited to the ITA level and merely providing the guidelines for developing the information system centric architecture. Thus, it is evident that we need a suitable architecture development methodology that corresponds to the growing needs for the communication infra system architecture, as well as the general weapon system architecture. Improving a meta-model is the core of improving a architecture framework. It determines a contents of a architecture and it influences a efficiency and a effectiveness of a architecture. The meta-model of the architecture framework must reflect concerns of various stakeholders and provide a traceability among them. Also, it should be easy to develop and use the architecture by securing the feasibility of the logical relationships and eliminating the duplication of the data inside the architecture. It is implemented through the development of the data-centric architecture and achieved through the "Fit-for-purpose" concept.

• Journal of the Korean Data and Information Science Society
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• 제21권4호
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• pp.651-667
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• 2010

항-고지혈 효과에 대한 연관 측도로 효과 인자를 고려한 헤지의 표준화된 평균차를 이용하였다. 고정효과모형을 적용하여 메타분석을 시행하였다. 그 결과 변의 콜레스테롤 농도와 총 콜레스테롤 농도 그리고 트리글리세리드 농도에서 통계적으로 유의한 감소를 보였으며, 고농도지단백 콜레스테롤 농도에서 통계적으로 유의한 증가를 보였다. 다음으로 연구 간 분산을 고려하지 않고 고정효과모형을 가정하여 분석한 모든 변수들에 대해 동질성 검정을 실행하여 연구 간의 이질성의 존재를 확인하였다. 그 결과 신장의 무게, 간의 무게, 고농도지단백 콜레스테롤, 저농도지단백 콜레스테롤, 총 콜레스테롤, 트리글리세리드 농도에서 동질성을 만족하지 않았다.

• Journal of the Korean Data and Information Science Society
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• 제21권3호
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• pp.447-459
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• 2010

본 연구는 메타분석에서 헤지의 표준화된 평균차를 이용하여 당뇨에 걸린 쥐들에게 프로폴리스를 투여하여 체중, 혈당량, 콜레스테롤, 트리글리세리드의 평균비교를 통해 프로폴리스의 항-당뇨 효과에 대해 알아보았다. 고정효과모형을 적용시킨 결과 혈당량의 감소, 콜레스테롤 농도의 감소, 트리글리세리드 농도의 감소에 대해 유의한 효과를 보였고, 동질성 검정을 통해 동질성을 만족하지 않은 모든 변수에 대해 랜덤효과모형을 적용시킨 결과 혈당량의 감소와 트리글리세리드 농도의 감소에 대해 유의한 효과를 나타냈다. 또한 프로폴리스의 투여기간과 투여량에 대해 메타회귀분석을 실시한 결과, 투여기간이 체중, 혈당량, 콜레스테롤에 유의한 변수로 나타났다.

• 임상간호연구
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• 제17권2호
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• pp.163-175
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• 2011

Purpose: This study was to analyze the characteristics and effect size of intervention studies applied to cancer-related fatigue in Korea. Methods: For meta-analysis, a total of 963 studies were retrieved from search engines. And 19 studies with a total of 721 participants published from 1990 to 2010 were selected upon their satisfaction with the inclusion criteria. Two authors independently extracted data from the selected studies and assessed the methodological quality. The data was analyzed by the RevMan 5.0 program of Cochrane library. Results: Intervention studies included 4 studies on foot-reflexo-massage (21.1%), comprehensive program (21.1%), and exercise (21.1%), respectively, 3 for hand-reflexo-massage (15.8%), and 4 for others. The effect size of the intervention studies shown higher effect size in order of exercise (d=-1.80), and foot & hand-reflexo-massage (d=-0.55). Conclusion: This study suggest that exercise can reduce the intensity of cancer-related fatigue, even though the number of intervention studies and randomized controlled trials were very few. There is limited evidence that reflexo-massage is effective in reducing cancer-related fatigue.

• 유통과학연구
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• 제20권2호
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• pp.1-9
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• 2022

Purpose: The online distribution channel has attracted the attention of retailers by potential impact on consumers' purchase intention. The objectives of this study are to provide an insight into how to encourage consumers' impulse buying behavior on commercial website as well as attempts to reveal factors that influence consumers' impulsive buying behavior in the online shopping environment. Research design, data and methodology: The research framework is based on the stimulus-organism-response (S-O-R) framework. The Meta-analysis method carried out the research, gathering data from 37 published studies. Results: The research findings suggest that intrinsic motivations such as perceived ease of use, perceived enjoyment, and online flow experience play a significant role in boosting consumers' hedonic value when buying and online. In addition, these findings help online retailers use appropriate marketing stimuli such as offering pricing incentives, promotion tactics, and improved communication effectiveness. Also, obtaining a better grasp of how to build a website to improve the consumer experience generally helps consumers feel the urge to buy impulsively and act without hesitation. Conclusions: This research confirms a direct positive relationship between marketing stimuli and hedonic shopping value, which may support an applied theoretical framework for future research and provide managerial implications for retailers in online distribution channels.

• 유통과학연구
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• 제11권6호
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• pp.13-19
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• 2013

Purpose - This study aims to predict the audit reports of listed companies on the Tehran Stock Exchange by using meta-heuristic algorithms. Research design, data, methodology - This applied research aims to predict auditors reports' using meta-heuristic methods (i.e., neural networks, the ANFIS, and a genetic algorithm). The sample includes all firms listed on the Tehran Stock Exchange. The research covers the seven years between 2005 and 2011. Results - The results show that the ANFIS model using fuzzy clustering and a least-squares back propagation algorithm has the best performance among the tested models, with an error rate of 4% for incorrect predictions and 96% for correct predictions. Conclusion - A decision tree was used with ten independent variables and one dependent variable the less important variables were removed, leaving only those variables with the greatest effect on auditor opinion (i.e., net-profit-to-sales ratio, current ratio, quick ratio, inventory turnover, collection period, and debt coverage ratio).