• Asian Pacific Journal of Cancer Prevention
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• 제15권14호
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• pp.5673-5679
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• 2014

Background: Previous published data on the association between CYP1A2 rs762551, rs2069514, rs2069526, and rs2470890 polymorphisms and lung cancer risk have not allowed a definite conclusion. The present meta-analysis of the literature was performed to derive a more precise estimation of the relationship. Materials and Methods: 8 publications covering 23 studies were selected for this meta-analysis, including 1,665 cases and 2,383 controls for CYP1A2 rs762551 (from 8 studies), 1,456 cases and 1,792 controls for CYP1A2 rs2069514 (from 7 studies), 657 cases and 984 controls for CYP1A2 rs2069526 (from 5 studies) and 691 cases and 968 controls for CYP1A2 rs2470890 (from 3 studies). Results: When all the eligible studies were pooled into the meta-analysis for the CYP1A2 rs762551 polymorphism, significantly increased lung cancer risk was observed in the dominant model (OR=1.21, 95 % CI=1.00-1.46). In the subgroup analysis by ethnicity, significantly increased risk of lung cancer was observed in Caucasians (dominant model: OR=1.29, 95%CI=1.11-1.51; recessive model: OR=1.33, 95%CI=1.01-1.75; additive model: OR=1.49, 95%CI=1.12-1.98). There was no evidence of significant association between lung cancer risk and CYP1A2 rs2069514, s2470890, and rs2069526 polymorphisms. Conclusions: In summary, this meta-analysis indicates that the CYP1A2 rs762551 polymorphism is linked to an increased lung cancer risk in Caucasians. Moreover, our work also points out the importance of new studies for rs2069514 associations in lung cancer, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the rs2069514 polymorphism in lung cancer development.

• 소성∙가공
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• 제29권5호
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• pp.241-250
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• 2020

In this study, the methodology of the springback prediction of automotive parts applied 3rd generation AHSS was investigated using the response surface model analysis based on a regression model, and the meta model analysis based on a Kriging model. To design the learning data set for constructing the springback prediction models, and the experimental design was conducted at three levels for each processing variable using the definitive screening designs method. The hat-shaped member, which is the basic shape of the member parts, was selected and the springback values were measured for each processing type and processing variable using the finite element analysis. When the nonlinearity of the variables is small during the hat-shaped member forming, the response surface model and the meta model can provide the same processing parameter. However, the accuracy of the springback prediction of the meta model is better than the response surface model. Even in the case of the simple shape parts forming, the springback prediction accuracy of the meta model is better than that of the response surface model, when more variables are considered and the nonlinearity effect of the variables is large. The efficient global optimization algorithm-based Kriging is appropriate in resolving the high computational complexity optimization problems such as developing automotive parts.

• 디지털융복합연구
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• 제15권4호
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• pp.317-326
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• 2017

본 연구는 간호대학생의 메타인지와 자기효능감 및 임상수행능력의 정도를 파악하고 임상수행능력에 영향을 주는 요인을 파악하고자 시도된 서술적 조사연구이다. 간호대학생 153명을 대상으로 자기보고형 설문지를 통해 2015년 9월1일부터 9월30일까지 자료를 수집하였다. SPSS/Win 18.0 프로그램을 이용하여, 빈도와 백분율, 평균과 표준편차, Pearson's Correlation coefficient, t-test, One-way ANOVA, 다중회귀분석을 사용하였다. 본 연구결과 메타인지와 자기효능감이 임상수행능력과 양의 상관관계가 있었다. 대상자의 특성 중 전공만족과 임상실습만족을 포함시켰을 때는 임상수행능력의 7%를 설명하였다(F=2.76, p=.030). 메타인지를 추가적으로 투입하였을 때는 임상수행능력이 25%의 설명력을 나타내었으며 자기효능감을 추가적으로 투입하였을 때는 임상수행능력이 27%의 설명력이 나타났다. 결론적으로 스스로의 문제해결능력이 강조되고 있는 간호현장의 상황을 고려할 때 임상수행능력 향상을 위해서는 체계적인 교육과정의 개발 및 다양한 교수학습방법의 활성화가 필요할 것으로 사료된다.

• 대한치과마취과학회지
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• 제12권2호
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• pp.75-91
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• 2012

Background: Dental sedation reduces fear and phobia during dental treatment and helps patients get quality treatment by inducing adequate consciousness control. Propofol has recently grabbed the spotlight, but no meta-analysis for efficacy and safety of propofol in dentistry has yet been performed. Thus, the purpose of this study was to perform meta-analysis to verify the efficacy and safety of propofol for use in dental sedation. Methods: Articles published between 1980 and 2010 were searched in the web sites, journals and medical database including The Cochrane Library, MEDLINE and EMBASE. And a total of 22 studies were selected among the randomized controlled trials (RCTs) that compared the use of propofol with other sedatives (control group). The data was collected from these studies and meta-analysis for efficacy and safety was performed using Comprehensive Meta-Analysis 5.0 (CMA 5.0). Results: The patient recovered significantly faster and discharged significantly earlier in the propofol group (SMD = -1.442, P < 0.001). The satisfaction of patient and that of operator was higher in the propofol group (P < 0.05). The incidence of arrhythmia and apnea/ hypoventilation was significantly lower in the propofol group (OR = 0.071, P < 0.05), and there was no significant difference in the other side effects. On the level of sedation, although the sedation score was significantly lower in the propofol group (SMD = -0.430, P < 0.05). Conclusions: The present analysis showed that the use of propofol resulted in high satisfaction levels on the part of the patients and operators, a shorter recovery time, and faster hospital discharge. The incidence of complications, however, was lower in the propofol groups or not much different between the propofol and control groups. Thus, the adequate use of propofol in dentistry is believed to be helpful for the effective and safe sedation of the patients.

• Journal of Korean Neurosurgical Society
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• 제62권4호
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• pp.389-397
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• 2019

Objective : Mechanical thrombectomies with balloon-guide catheters (BGC) are thought to improve successful recanalization rates and to decrease the incidence of distal emboli compared to thrombectomies without BGC. We aimed to assess the effects of BGC on the outcomes of mechanical thrombectomy in acute ischemic strokes. Methods : Studies from PubMed, EMBASE, and the Cochrane library database from January 2010 to February 2018 were reviewed. Random effect model for meta-analysis was used. Analyses such as meta-regression and the "trim-and-fill" method were additionally carried out. Results : A total of seven articles involving 2223 patients were analyzed. Mechanical thrombectomy with BGC was associated with higher rates of successful recanalization (odds ratio [OR], 1.632; 95% confidence interval [CI], 1.293-2.059). BGC did not significantly decrease distal emboli, both before (OR, 0.404; 95% CI, 0.108-1.505) and after correcting for bias (adjusted OR, 1.165; 95% CI, 0.310-4.382). Good outcomes were observed more frequently in the BGC group (OR, 1.886; 95% CI, 1.564-2.273). Symptomatic intracranial hemorrhage and mortality did not differ significantly with BGC use. Conclusion : Our meta-analysis demonstrates that BGC enhance recanalization rates. However, BGC use did not decrease distal emboli after mechanical thrombectomies. This should be interpreted with caution due to possible publication bias and heterogeneity. Additional meta-analyses based on individual patient data are needed to clarify the role of BGC in mechanical thrombectomies.

• 디지털융복합연구
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• 제19권7호
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• pp.427-440
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• 2021

본 연구는 여대생을 대상으로 한 식이 행동 중재프로그램의 효과를 조사하기 위한 체계적인 검토 및 메타분석이다. 분석 대상 논문은 2015년부터 2020년 2월 29일까지의 연구로, PRISMA에 따라 체계적으로 수집되었다. 메타분석을 위해 총 9편의 논문이 최종 선정되었고, 효과 크기를 추정하기 위해 Comprehensive Meta-Analysis 3.0을 사용하여 분석하였다. 여대생을 대상으로 적용된 식이 행동 중재프로그램 연구의 전체적인 효과 크기는 큰 것으로 나타났고, 문제 식이 행동 여대생을 대상으로 한 6편의 연구에서 효과 크기가 더 큰 것으로 확인되었다. 전체 여대생과 문제 식이행동 여대생 모두 식이 행동 관련 변수 및 심리사회적 관련 변수에서 유의한 효과 크기를 나타냈다. 그러므로 본 연구결과는 향후 여대생을 대상으로 차별화 된 식이 행동 중재프로그램을 개발하는 기초자료로써 연구의 의의가 있다.

• Journal of Korean Neurosurgical Society
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• 제66권5호
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• pp.525-535
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• 2023

Objective : We performed an expanded multi-ethnic meta-analysis to identify associations between inflammation-related loci with intracranial aneurysm (IA) susceptibility. This meta-analysis possesses increased statistical power as it is based on the most data ever evaluated. Methods : We searched and reviewed relevant literature through electronic search engines up to August 2022. Overall estimates were calculated under the fixed- or random-effect models using pooled odds ratio (OR) and 95% confidence intervals (CIs). Subgroup analyses were performed according to ethnicity. Results : Our meta-analysis enrolled 15 studies and involved 3070 patients and 5528 controls including European, Asian, Hispanic, and mixed ethnic populations. Of 17 inflammation-related variants, the rs1800796 locus (interleukin [IL]-6) showed the most significant genome-wide association with IA in East-Asian populations, including 1276 IA patients and 1322 controls (OR, 0.65; 95% CI, 0.56-0.75; p=3.24#x00D7;10^-9) under a fixed-effect model. However, this association was not observed in the European population (OR, 1.09; 95% CI, 0.80-1.47; p=0.5929). Three other variants, rs16944 (IL-1β), rs2195940 (IL-12B), and rs1800629 (tumor necrosis factor-α) showed a statistically nominal association with IA in both the overall, as well as East-Asian populations (0.01<p<0.05). Conclusion : Our updated meta-analysis with increased statistical power highlights that rs1800796 which maps on the IL-6 gene is associated with IA, and in particular confers a protective effect against occurrence of IA in the East-Asian population.

• Asia pacific journal of information systems
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• 제7권2호
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• pp.163-183
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• 1997

As object models and hybrid knowledge are increasingly used in current information systems development, Is-a structures need to be more formally defined, and subsequently subsumption related anomalies need to be detected with minimal declaration of meta knowledge. This paper extends a metagraph in the hybrid environments and demonstrates its utilities for detecting such anomalies that can occur from semantics and dynamics unique to the hybrid knowledge and data structure.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2013년도 춘계학술발표대회
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• pp.833-834
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• 2013

진료데이터는 진료를 보면서 축척된 데이터로서 다양한 병명들에 대한 의사들의 진료행위를 추적해 볼 수 있는 유용한 정보가 될 수 있으며, 진료에 재활용함으로써 환자들에 대한 진료행위를 표준화하는데 사용될 수 있다. 본 연구에서는 다양한 상황에서 환자를 진료한 근거자료인 진료데이터를 이용하여 병원에서 활용 가능한 임상진료데이터를 추출하기 위한 방법에 대한 연구를 진행하였다.

• Journal of the Korean Data and Information Science Society
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• 제26권2호
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• pp.355-365
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• 2015

지난 수 십년간 전 지구적인 기후가 극적으로 변화함에 따라 가장 중요한 문제 중 하나로 인식되고 있는 식량 안보에 대하여 기후 변화의 영향을 평가하는 연구가 활발하게 진행되어 왔다. 본 연구에서는 메타분석을 이용하여 기후변화가 국내 농업에 미치는 영향을 분석하였다. 특히, 국내 농업에서 큰 비중을 차지하는 쌀에 대하여 이산화탄소 농도와 두 적응방안(파종시기 변경과 품종 변경)에 대한 효과를 추정하였다. 관심있는 효과에 대한 요약통계량을 이용하는 기존의 일반적인 메타분석 방법과는 달리, 다양한 온실가스 배출 시나리오와 대순환 모형을 사용하여 쌀 생산량을 예측한 6개의 개별 연구로부터 자료를 통합하여 메타분석을 수행하였다. 모델링 접근법으로써 쌀 생산량의 변화율을 종속변수로 설정하고, 이산화탄소 농도와 적응방안의 주 효과와 상호 작용 효과를 독립변수로 설정하여 회귀분석 실시하였다. 결과적으로 적응방안이 고려되지 않을 경우 이산화탄소 농도의 증가는 쌀 생산량을 감소시키나, 적응방안이 고려된다면 이산화탄소 농도의 증가는 쌀 생산량을 증가시키는 것으로 나타났다. 추가로 파종시기 변경 방안보다 품종 변경 방안이 쌀 생산량을 더 증가시키는 것을 알 수 있었다. 본 연구 결과는 향후 기후변화 대응책을 수립하는데 정량적 자료로 활용될 것으로 기대된다.