• Clinical and Experimental Pediatrics
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• v.64 no.5
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• pp.208-222
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• 2021

The publication of genetic epidemiology meta-analyses has increased rapidly, but it has been suggested that many of the statistically significant results are false positive. In addition, most such meta-analyses have been redundant, duplicate, and erroneous, leading to research waste. In addition, since most claimed candidate gene associations were false-positives, correctly interpreting the published results is important. In this review, we emphasize the importance of interpreting the results of genetic epidemiology meta-analyses using Bayesian statistics and gene network analysis, which could be applied in other diseases.

• Journal of the military operations research society of Korea
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• v.23 no.2
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• pp.85-102
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• 1997

There have been several research efforts to support interoperability among multiple databases. In integrating multiple databases, we must resolve schema conflicts due to the heterogeneity in databases. To resolve these conflicts, not only meta-data for database schemas but also general knowledge expressing the real world meanings associated with the database schemas are required. This paper presents a uniform representation method for relational schema and general knowledge base that is composed, among other things, of concept hierarchy and thematic roles in relationship, using the knowledge representation language Lk. This representation method has a flexible descriptive power which facilitates concepts to be expressed at different levels of granularity and can describe knowledge expressed in Lk are used for input of the next step, such as conflict resolution and query processing of multiple database.

• Journal of the Korea Computer Industry Society
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• v.5 no.9
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• pp.873-882
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• 2004

Multimedia database system can be improve data transferring efficiency by consulting catalogue database which is storing the object and serving multimedia meta-database and perform the pre-scheduling for data transferring and by delaying of transferring to reduce the responding timeand reordering the data by various method of transferring. By Introducing these techniques we can enhance the server resources utilizing, minimizing the users responding time and can decrease failure at the scheduling itself and easily search and transfer the information that the user wanted. Like this, the importance of multimedia information treating skill and efficient management are widely recognized and expected lots of research and development to form a butter efficient multimedia database syst

• Proceedings of the Korea Information Processing Society Conference
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• 2002.11c
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• pp.1887-1890
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• 2002

새롭게 발견되는 단백질의 구조와 기능 예측에 사용되는 모티프는 단백질 원시 데이터가 빠르게 증가함에 따라 그 중요성 역시 나날이 증가하고 있으며 이러한 모티프에 대한 다양한 서열 메소드들과 데이터베이스들이 개발되었다. 그러나, 이러한 모티프 데이터베이스들은 각각 이질적인 데이터 구조를 지니고 독자적으로 개발, 개발되어 왔기 때문에 서로 다른 형태의 검색 결과를 제공한다. 따라서 사용자는 각 데이터베이스에서 사용하는 데이터 구조들에 대한 전반적인 지식을 습득해야 하며 모티프 데이터베이스들 각각에 대해 중복된 반복 검색 작업들을 수행하여야 한다. 따라서 이 논문에서는 이러한 문제 해결을 위해, 각각의 모티프 데이터베이스들에서 제공하는 자원을 분해하고, 합병하는 과정을 거쳐 하나의 통합된 모티프 데이터베이스를 구축하였고, 기존의 데이터베이스에서 지원하지 못했던 단백질 3차 구조정보, 분류 정보의 지원을 가능케 하였고, 각 멤버 데이터베이스 검색 메소드의 장점을 그대로 적용할 수 있는 메타 엔진을 설계하여 사용자 편의적 검색 환경을 제공한다.

• Journal of Korean Academy of Nursing
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• v.43 no.3
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• pp.341-351
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• 2013

Purpose: This study was done to analyze the effects of Tai Chi on fall-related risk factors through meta-analysis of randomized clinical trials published in English and Korean between 2000 and 2010. Methods: Using health related database and hand search of references and Google, 28 randomized studies were collected from doctoral dissertation and published peer reviewed articles. The Comprehensive Meta-analysis version 2.0 was used for the analysis. Results: The effect sizes for Tai Chi for 3 months were significant with ES=0.54 for static balance, ES=0.24 for dynamic balance, ES=0.69 for balance measured by scale, and ES=0.40 for flexibility, ES=0.48 for muscle strength, ES=0.71 for ADL, and ES=0.37 for fear of falling. Also, the effect sizes of Tai Chi for 6 months were significant for most fall-related variables. The 6 month data for flexibility was not analyzed since only one study was published. Conclusion: The analysis of studies of randomized clinical trials indicate that Tai Chi is effective in improving balance, flexibility, muscle strength, activities of daily living, and fear of falling when applied for 3 or 6 months. The findings provide the objective evidence to apply Tai Chi as a fall preventive intervention.

• The Journal of the Korea Contents Association
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• v.9 no.12
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• pp.572-581
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• 2009

Study on the class using XMI Meta model and XML MetaDats has significant difference from the method of Data creation which is widely used. Most of MXL System are focusing on the editor funcition, Database connection and Generation of Markup language. Unlikelly, however, this study has focused on the creation of Markup language of Class MetaData which are extracted from MXI data modedl. In addition to that, the attribute of unit element within the class and the relationship between the classes within the model were set to be given and expressed respectively. For the generation of Markup language, XML schema was used to declare the detail data type.

• Journal of Preventive Medicine and Public Health
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• v.49 no.2
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• pp.129-133
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• 2016

Objectives: The systematic review (SR) is a research methodology that aims to synthesize related evidence. Updating previously conducted SRs is necessary when new evidence has been produced, but no consensus has yet emerged on the appropriate update methodology. The authors have developed a new SR update method called 'adaptive meta-analysis' (AMA) using the 'cited by', 'similar articles', and 'related articles' citation discovery tools in the PubMed and Scopus databases. This study evaluates the usefulness of these citation discovery tools for updating SRs. Methods: Lists were constructed by applying the citation discovery tools in the two databases to the articles analyzed by a published SR. The degree of overlap between the lists and distribution of excluded results were evaluated. Results: The articles ultimately selected for the SR update meta-analysis were found in the lists obtained from the 'cited by' and 'similar' tools in PubMed. Most of the selected articles appeared in both the 'cited by' lists in Scopus and PubMed. The Scopus 'related' tool did not identify the appropriate articles. Conclusions: The AMA, which involves using both citation discovery tools in PubMed, and optionally, the 'related' tool in Scopus, was found to be useful for updating an SR.

• Journal of Korean Academy of Nursing
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• v.41 no.6
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• pp.821-833
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• 2011

Purpose: The purpose of this study was to evaluate the effectiveness of foot reflexology on fatigue, sleep and pain. Methods: A systematic review and meta-analysis were conducted. Electronic database and manual searches were conducted on all published studies reporting the effects of foot reflexology on fatigue, sleep, and pain. Forty four studies were eligible including 15 studies associated with fatigue, 18 with sleep, and 11 with pain. The effects of foot reflexology were analyzed using Comprehensive Meta-Analysis Version 2.0. The homogeneity and the fail-safe N were calculated. Moreover, a funnel plot was used to assess publication bias. Results: The effects on fatigue, sleep, and pain were not homogeneous and ranged from 0.63 to 5.29, 0.01 to 3.22, and 0.43 to 2.67, respectively. The weighted averages for fatigue, sleep, and pain were 1.43, 1.19, and 1.35, respectively. No publication bias was detected as evaluated by fail-safe N. Foot reflexology had a larger effect on fatigue and sleep and a smaller effect on pain. Conclusion: This meta-analysis indicates that foot reflexology is a useful nursing intervention to relieve fatigue and to promote sleep. Further studies are needed to evaluate the effects of foot reflexology on outcome variables other than fatigue, sleep and pain.

• Journal of Korean Medicine Rehabilitation
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• v.27 no.3
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• pp.71-79
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• 2017

Objectives To determine the effectiveness of Tuina for temporomandibular joint disorder. Methods We searched 10 electronic databases (Pubmed, CNKI, EMBASE, Cochrane Library, KISS, KISTI, NDSL, RISS, KMBASE, DBpia) up to May 2017. We included randomized controlled trials (RCTs) using Tuina for temporomandibular joint disorder. The methodological quality of each RCT was assessed by the Cochrane risk of bias tool. Results 14 RCT studies were eligible in our review. 14 studies were divided into 4 groups, and meta-analysised. The meta-analysis of 6 studies showed favorable results for the use of Tuina. High risk of bias were observed in 9 studies. Conclusions Although there are favorable results with meta-analysis, our systematic review are highly dependent on the single source of Chinese electrical database, CNKI. Now limited evidence is available to support Tuina for temporomandibular joint disorder and further well-designed RCTs should be encouraged.

• Korean Journal of Adult Nursing
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• v.29 no.1
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• pp.51-62
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• 2017

Purpose: The purpose of this study was to provide data about the risk factors related to falls among elderly patients with dementia using meta-analysis. Methods: Key words used for search through electronic database (CINAHL, PubMed, Ovid-MEDLINE, RISS, KISS, DBPIA, National Assembly Library) included 'dementia', 'Alzheimer', 'fall'. Twenty studies met the inclusion criteria for the meta-analysis and 'R' version 3.2.2 was used to analyze the correlated effect size. Results: Study results showed that risk factors related to falls were identified as the demographic (age, gender, education), dementia-related (disease duration, cognition), physical (body mass index, walking, balance, activity of daily living, use of walking aids, number of medications including psychotropic drugs, musculoskeletal problems, parkinsonism, comorbidity), psychological (neuropsychiatric symptom, depression), environmental (Physical environment), and fall-related (fall history, high risk group of fall) factors. The effect size of risk factors such as high risk group of fall (r=.35), use of walking aids (r=.33), depression (r=.31), psychotropic drugs (r=.27), Musculoskeletal problems (r=.25) were higher than the other risk factors. Conclusion: Based on the findings of this study, strategies to improve elderly patient's depression, intensive care for high risk group of fall, and adequate training with walking aids are needed for prevention of falls in elderly patients with dementia.