• Clinical Endoscopy
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• 제57권1호
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• pp.36-47
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• 2024

Background/Aims: Scissor-type endoscopic submucosal dissection (ST-ESD) knives can reduce the adverse events associated with ESDs. This study aimed to compare ST-ESD and non-scissor-type (NST)-ESD knives. Methods: We identified ten studies that compared the performance characteristics and safety profiles of ST-ESD and NST-ESD knives. Fixed- and random-effects models were used to calculate the pooled proportions. Heterogeneity was assessed using the I² test. Results: On comparing ST-ESD knives to NST-ESD knives, the weighted odds of en bloc resection was 1.61 (95% confidence interval [CI], 0.90-2.90; p=0.14), R0 resection was 1.10 (95% CI, 0.71-1.71; p=0.73), delayed bleeding was 0.40 (95% CI, 0.17-0.90; p=0.03), perforation was 0.35 (95% CI, 0.18-0.70; p<0.01) and ESD self-completion by non-experts was 1.89 (95% CI, 1.20-2.95; p<0.01). There was no heterogeneity, with an I² score of 0% (95% CI, 0%-54.40%). Conclusions: The findings of reduced odds of perforation, a trend toward reduced delayed bleeding, and an improvement in the rates of en bloc and R0 resection with ST-ESD knives compared to NST-ESD knives support the use of ST-ESD knives when non-experts perform ESDs or as an adjunct tool for challenging ESD procedures.

• Tuberculosis and Respiratory Diseases
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• 제87권3호
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• pp.261-281
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• 2024

Cardiovascular comorbidity is common in individuals with chronic obstructive pulmonary disease (COPD). This factor interferes with pharmacological treatment. The use of β-blockers has been proposed for their known cardioprotective effects. However, due to their adverse reactions, and the risk of causing bronchospasm, there is reluctance to use them. To summarize existing evidence on the effects of β-blocker use in COPD associated with cardiovascular comorbidities in relation to disease severity, exacerbation, and mortality outcomes. EMBASE, Medline, Lilacs, Cochrane Library, and Science Direct databases were used. Observational studies that evaluated the effects of β-blockers on individuals with COPD and cardiovascular comorbidities, and related disease severity, exacerbations, or mortality outcomes were included. Studies that did not present important information about the sample and pharmacological treatment were excluded. Twenty studies were included. Relevance to patient care and clinical practice: The use of β-blockers in individuals with COPD and cardiovascular disease caused positive effects on mortality and exacerbations outcomes, compared with the results of individuals who did not use them. The severity of the disease caused a slight change in forced expiratory volume in 1 second. The odds ratio for mortality was 0.50 (95% confidence interval [CI], 0.39 to 0.63; p<0.00001), and for exacerbations, 0.76 (95% CI, 0.62 to 0.92; p=0.005), being favorable to the group that used β-blockers. Further studies are needed to study the effect of using a specific β-blocker in COPD associated with a specific cardiovascular comorbidity.

• 셀메드
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• 제14권10호
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• pp.10.1-10.6
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• 2024

Background and Objectives: As per the available data, 75% peri and postmenopausal women experience hot flashes having negative effect on their quality of life. Using herbal medicines are stepping forward to alleviate hot flashes as the available hormonal medications have been reported the presence of side effects. This study was planned with the intention to investigate the effect of Asparagus racemosus root in the treatment of postmenopausal hot flashes in comparison to the placebo. Methods: This prospective patient blinded clinical trial randomly assigned 40 postmenopausal women with symptoms of hot flashes to receive either test drug (n=20) comprising Asparagus racemosus tablet of 1g in the dosage of 2 tablet thrice in a day for the duration of 60 days continuously or to receive placebo tablet prepared from roasted wheat flour in the same dosage and duration as test drug. The efficacy was determined by reduction in the frequency and intensity of hot flashes assessed by daily diary along with the improvement in quality of life assessed through Hot Flash-Related Daily Interference Scale. Statistical analysis was accomplished by student t test and Chi-square/Fisher Exact test. Results: Test drug significantly (p <0.001) reduced the intensity and frequency of hot flashes as well as improved the quality of life without showing any side effect. Discussion & Conclusion: According to Unani scriptures, the treatment is to treat the underlying cause, such as aberrant temperament and psychological and environmental issues. Unani drugs have emmenagogue, anti-inflammatory, analgesic, and neuroprotective qualities that can help alleviate premenstrual symptoms. Unani herbs such as C. sativus, Vitex, agnus castus, P. vulgare, N. Jatamansi, M. officinalis, and Z. officinalis have been clinically demonstrated to be effective in PMS. Thus, traditional knowledge authentication and conservation are vital for future research and appreciated for application in the modern day. Furthermore, randomised controlled trials, comprehensive reviews, and meta-analyses are suggested.

• 아태비즈니스연구
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• 제15권2호
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• pp.53-70
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• 2024

Purpose - The purpose of this paper is to examine whether firms use social media to disseminate good news to various stakeholders thereby enhancing corporate social performance (CSP). Design/methodology/approach - This study collected data from various databases such as Korea Economic Justice Institute (KEJI) Index, VALUESearch, and TS2000, and such social media platforms as Instagram and Meta (formerly known as facebook). The sample of this study includes 3,474(firm-year) observations from 799 unique Korean firms between 2013-2022. This study conducts fixed effect panel regression analysis to test the hypotheses. Findings - First, we found both corporate use of social media, and the number of uploaded corporate news on social media were positively related to CSP. We also found that positive user reactions to the news on social media were positively related to CSP. Second, we examine the moderating roles of firm age in the relationships described above. The results show that firm age strengthens both the relationship between number of uploaded news on social media and CSP, and the relationship between positive user reactions to news on social media and CSP. Research implications or Originality - This study extends the social media research in the management literature by investigating how corporate use of social media, number of uploaded corporate news on social media, and the user reactions on the news on social media affect corporate social performance. For a practical implication, our results allow the stakeholders to better predict corporate future CSP. They suggest that ceteris paribus, firms that use social media actively, vis-a-vis firms that do not use social media actively, are more likely to get good CSP scores. They also suggest that such beneficial effects of social media will become more prominent as companies get older.

• Clinics in Shoulder and Elbow
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• 제27권2호
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• pp.160-168
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• 2024

Background: Recurrent anterior shoulder dislocation (RASD) in cases of seizure disorders (SDs) total 50%-80% of all SD-associated shoulder instabilities. Based on the extent of bone loss, treatment options include bony and soft-tissue reconstructions, arthroplasty, and arthrodesis. The primary objective of this paper was to review the treatment options for RASD in SDs. Methods: Several bibliographic databases were searched for RASD treatment options in SD patients. The demographic outcome measures, the failure rate (defined as the relative risk of recurrence of dislocation postoperation), and the postoperative seizure recurrence rate were recorded. Results: We pooled 171 cases (187 shoulders) from 11 studies. Of these, one, five, two, two, and one reports studied Bankart's operation with remplissage (27 cases/29 shoulders), the Latarjet procedure (106/118), bone block operation (21/23), arthroplasty (11/11), and arthrodesis (6/6), respectively, in treating SD-associated RASD. The relative risk of failure between SD and non-SD patients was 3.76 (1.36-10.38) after the Latarjet operation. The failure rates were 17% and 13% for Bankart's operation with remplissage and the Latarjet procedure in SD patients, respectively, but 0% each for bone block operation, arthroplasty, and arthrodesis. The total rate of seizure recurrence after operation was 33% of the pooled cases. Conclusions: SD recurrence in the postoperative period, the size of the bone block, and the muscular attachments to a small coracoid autograft are the determinants of failure among various reconstructive operations in SD-associated RASD.

• 한국과학교육학회지
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• 제35권3호
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• pp.403-417
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• 2015

본 연구의 목적은 통합교육의 효과와 관련된 국내 연구결과에 대한 메타분석을 통하여 연구 변인에 따른 효과크기를 비교하고, 이를 통해 추후 통합교육 연구와 관련된 시사점을 도출하는 것이다. 이를 위하여 2012년부터 최근 3년간 통합교육의 효과를 분석한 161편의 논문으로부터 총 236개의 효과크기를 산출하고, 연구의 종속변인인 창의성, 문제해결력, 학업성취도, 과학탐구능력, 창의적 인성, 과학적 태도, 흥미와 연구의 중재변인인 학습자 특성, 집단크기, 수업 운영방식, 중심교과, 출판유형(학술지/석사학위논문/박사학위논문)에 따라 효과크기에 어떤 차이가 있는지를 분석하였다. 연구결과 통합교육의 전체 효과크기는 0.88(U3=81.06%)로 Cohen(1988)의 해석준거에 따르면 큰 효과크기를 나타냈다. 종속변인에 따른 효과크기를 분석한 결과, 과학적 태도의 효과크기가 가장 큰 것으로 나타났으나 모든 종속변인이 중간크기 이상의 효과크기를 갖는 것으로 분석되었다. 학교급 별 효과크기 분석에서는 유치원을 대상으로 한 연구의 효과 크기가 가장 큰 것으로 나타났으며 일반학생과 영재학생의 구분에서는 영재학생을 대상으로 한 연구의 효과크기가 더 큰 것으로 나타났다. 집단크기 별 효과크기는 30명 이하의 소집단을 대상으로 한 연구가 가장 컸으며, 정규교과 시간보다 방과 후 활동을 비롯한 교과 외 시간에 시행한 연구의 효과크기가 더 큰 것으로 분석되었다. 통합교육 설계의 중심이 되는 교과 별로 효과크기를 분석한 결과, 예체능 교과의 효과크기가 가장 컸으나 모든 교과에서 중간 크기 이상의 효과크기가 나타났다. 마지막으로 출판 유형에 따른 효과크기의 차이를 분석한 결과 박사학위 논문의 효과크기가 가장 컸으며 학술지 논문과 석사학위 논문의 효과크기는 비슷한 것으로 나타났다. 본 연구에서 얻은 결과를 바탕으로 추후 통합교육 관련 연구를 위한 시사점을 제안하였다.

• Genomics & Informatics
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• 제9권2호
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• pp.52-58
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• 2011

Osteoporotic fracture (OF), along with bone mineral density (BMD), is an important diagnostic parameter and a clinical predictive risk factor in the assessment of osteoporosis in the elderly population. However, a genome-wide association study (GWAS) on OF has not yet been clarified sufficiently. To identify OF-associated genetic variants and candidate genes, we conducted a GWAS in a population-based cohort (Korean Association Resource [KARE], n=1,427 [case: 288 and control: 1139]) and performed a de novo replication study in hospital-based individuals (Asan and Catholic Medical Center [ACMC], n=1,082 [case: 272 and control: 810]). In a combined meta-analysis, a newly identified genetic locus in an intergenic region at 10p11.2 (near genes FZD8 and ANKRD30A ) showed the most significant association (odd ratio [OR] = 2.00, 95% confidence interval [CI] = 1.47~2.74, p=$1.27{\times}10^{-6}$) in the same direction. We provide the first evidence for a common genetic variant influencing OF and genetic information for further investigation in bone metabolism.

• 한방안이비인후피부과학회지
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• 제34권3호
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• pp.27-54
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• 2021

Objectives : This review was conducted to validate the effectiveness and safety of herbal medicine combined with conventional therapy for rosacea. Methods : Randomized controlled trials(RCTs) reporting the effects of herbal medicine treatment on rosacea were searched through eight electronic databases from 2016 to March 17, 2020. This study collection and data extraction were performed by two independent reviews. The Cochrane risk-of-bias tool was used for the evaluation of the risk of bias in all included RCTs. Mean differences(MD) and Risk ratio(RR) of 95% Confidence intervals(Cls) were calculated and data synthesis was conducted using Review Manager(RevMan, ver.5.4) Results : Eighteen RCTs were included and all trials compared the combined therapy of herbal medicine with conventional western therapy to conventional therapy alone. The effective rate of the combination of herbal medicine with western medicine(RR 1.20, 95% CI : 1.13-1.28, p<0.00001, I²=0%), the effective rate of the combination of herbal medicine with laser-based therapy(RR 1.12, 95% CI : 1.04-1.21, p=0.004, I²=18%) and the effective rate of the combination treatment group using herbal medicine, western medicine and external drugs were all statistically higher that of the control group(RR 1.19, 95% CI : 1.11-1.28, p<0.00001, I²=0%). The score of non transient erythema(MD -0.36, 95% CI : -1.01 0.29, p=0.27, I²=93%), flushing(MD -0.69, 95% CI : -0.97, 0.41, p<0.00001, I²=32%), papules or pustules(MD 0.10, 95% CI : -0.15, 0.35 p=0.44, I²=0%) were also seen in the herbal medicine and western medicine combination group. The overall risk of bias of the included studies was some concerns. No serious adverse effects were observed. Conclusions : This review found the safety and effectiveness of the combined therapy of herbal medicine with conventional western therapy for rosacea.

• 한국과학예술포럼
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• 제20권
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• pp.315-326
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• 2015

본 연구는 현대 철학과 예술, 문화 전반에 영향을 준현대 미학의 메타 담론중 하나인 미장아빔 기법의 개념과 특성이 현대건축에서 어떠한 방식으로 표현되어지는지에 대한 의구심으로부터 시작하였다. 미장아빔은 소설가 앙드레 지드의 소설에서 처음 도입된 이 후 누보로망 작가들에 의해 주로 사용되진 기법이다. 이는 동 시대 예술 전반에 확대 적용된 예술표현 기법이자 포스트모더니즘 이 후의 예술에 있어서 필수적으로 등장하는 메타 담론이다. 두 개의 거울 사이에 상이 끝없이 맺히는 것을 의미하는 미장아빔은 그 당시 활동하던 들뢰즈, 데리다와 같은 다양한 철학가들의 담론과 연관을 맺었다. 또한 그들의 철학에 영향을 받은 현대 건축가들에 의해서 건축이라는 언어로 표현되었다. 이러한 맥락에서 예술에서 주로 사용되는 미장아빔 기법과 건축가의 공간표현 방식간의 연계성을 가진다. 본 연구는 미장아빔 기법과 현대 건축표현 방식 간의 연계성을 기반으로 현대건축 표현 방식에서 나타나는 미장아빔적 특성에 대하여 고찰해 보았다. 또한 이를 바탕으로 비 물질화와 특이성을 건축적 언어로 사용하는 장누벨의 건축 작품을 분석하였다. 건축에서 미장아빔기법의 표현 특성은 건축물의 외관을 구성하는 표피의 소재에 의해 구현되거나 반영과 그래픽적 요소를 활용에서 표현됨을 연구를 통해 확인할 수 있었다. 본 연구를 통하여 비록 미장아빔을 표현하는 수단이 다르고 분야가 다르지만 근본이 되는 개념이 가지는 특성을 서로 공유하고 있다는 것을 분석을 통하여 확인하는 기회를 가졌다. 또한 특정한 주류가 없는 현대에 현대건축을 이해하는 하나의 척도로써 미장아빔 기법이 가지는 의의를 생각해보는 기회를 가졌다.

• 벤처혁신연구
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• 제4권3호
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• pp.125-139
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• 2021

4차산업혁명이 진전되면서 새로운 기술이나 서비스들이 탄생, 성장, 성숙해 가고 있다. 이제는 모바일 시대를 넘어 새로운 패러다임으로 metaverse에 대한 논의가 진행이다. 이에 본 연구에서는 메타버스 시대를 대비하여 새로운 기술을 소비자들이 사용하고자 할 때 어떠한 요인들이 중요하게 영향을 미치는지에 대해 분석하고자 했다. 특히 소비자들이 해당 기술을 사용하는 맥락이 B2C인지 B2B인지에 따라 어떻게 달라지는지에 초점을 두고 연구를 진행하였다. 이를 위해 연구 대상을 메타버스 시대와 연계해서 B2C 맥락에서는 증강 현실(AR)을 선정하였고, B2B 맥락에서는 스마트 팩토리를 선정하였다. 분석을 위한 연구 모형은 수정 확장된 통합기술 수용이론(Meta-UTAUT)을 기반으로 연구 대상 기술의 특성을 반영하여 공통의 영향 변인을 도출하여 설정하였다. 실증 분석을 위해 설문조사를 진행하였으며 AR 사용자 150명, 스마트 팩토리 사용자 150명을 분석의 대상으로 삼았다. 실증연구 결과는 다음과 같다. 성과기대와 사용 의도, 기술 준비도와 사용 의도 간의 관계는 AR과 스마트 팩토리 모두 유의한 정(+)의 영향을 미치는 것으로 나타났다. 반면, 노력 기대, 사회적 영향, 신뢰성은 AR에 있어서만 사용 의도에 정(+)의 영향을 미치는 것으로 나타났다. 스마트 팩토리에서만 사용 지원이 사용 의도에 정(+)의 유의한 영향을 미쳤다. 인지된 위험 역시 스마트 팩토리에서만 사용 의도에 부(-)의 유의한 영향을 미친 것으로 나타났다. 이러한 연구 결과는 학술적으로는 새로운 기술의 사용도 소비자들이 사용하는 맥락에 따라 영향 요인이 달라진다는 것을 실증적으로 검정 했다는데 의의가 있다고 할 수 있다. 또한 제공하는 기술이나 서비스가 어떠한 맥락에서 이루어지고 있는지를 판단해서 무엇에 우선적으로 집중해야 할 지를 제시한 점에서 실무적인 의의가 있다고 할 수 있다.