• Korean Journal of Occupational Health Nursing
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• v.14 no.1
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• pp.71-82
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• 2005

Purpose: This study analyzed domestic articles that studied job-stress of nurses using Meta Analysis to evaluate the responses resulted from job-stress and the factors affecting them. Method: To conduct this study, data were collected primarily from database of "richis" and additionally from 8 nursing journals and 5 theses for a degree on job-stress of clinical nurses. Result: As a result of Meta Analysis casual factor of job-stress, the result represented that two reasons; personal factor was the age, occupational factor were ward, duration of employment and position. By the result of analysis of effect of job-stress, satisfaction of the job, exhaustion, health status and immersion of the job were strongly related to job-stress. According to the general solution against job-stress that referred from job-stress related theses, there are several; Imagination Therapy, Assertive Training and Value Clarification Training could bring significant result. Conclusion: This study showed that because job-stress of clinical nurses had nothing to do with personal factors, job-stress management plans for nurses are needed to focus on occupational factors. Also the study suggested that various coping skills that proved to be effective are needed to be used to relieve job-stress and that's responses on nurses.

• Journal of Korean Elementary Science Education
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• v.40 no.1
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• pp.13-21
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• 2021

This study analyzed the effects of 'online biology learning using E-learning system' on elementary school students' science-related attitudes. Samples of the study were composed of 95 sixth-grade students of N elementary school in Seoul, Korea. The learning was conducted for 11 times over a month. The main results of this study are as follows. First, for the paired t-test, a statistically significant difference between the pre and post scores of science-related attitudes was found. After conducting the online biology learning science related attitudes scores of students generally declined. "The boredom caused by simply watching online biology contents" is the decisive cause of the decline in science-related attitude scores analyzed through interviews. Second, in ANCOVA, according to 'levels of meta-cognition'. there was no statistically significant difference in scores of science-related attitudes. but, there was statistically significant difference in science-related attitudes according to 'adoption of scientific attitudes'. Students of high meta-cognition type showed a greater decline in scores than students of low meta-cognition type. Based on the results of this study, implications for research of online biology education and elementary science education are discussed.

• Journal of Life Science
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• v.25 no.5
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• pp.515-522
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• 2015

Treculia africana Decne, a breadfruit species, is native to many parts of West and Tropical Africa. The breadfruit belongs to the family Moraceae and is one of the four members of the genera Treculia. The crude extract of T. africana has been used in folk medicine as an anti-inflammatory agent for various ailments, such as whooping cough. In this study, we evaluated the anti-oxidative and anti-cancer activities of the methanol extract of T. africana Decne (META) and the molecular mechanisms of its anti-cancer effects in human colon carcinoma HT29 cells. The META exhibited anti-oxidative activity through a DPPH radical scavenging capacity and inhibited cell growth in a dose-dependent manner in HT29 cells. META treatment induced apoptosis of HT29 cells, showing an increase in the percentage of both SubG1 cells and Annexin V-positive cells and the formation of apoptotic bodies in a dose-dependent manner. META-mediated apoptosis was associated with the up-regulation of the death receptor FAS and Bax and a decrease in the Bcl-2 expression. META-treated HT29 cells also showed the release of cytochrome c from the mitochondria into the cytosol, activation of caspase-3, caspase-8, and caspase-9, and proteolytic cleavage of poly ADP-ribose polymerase (PARP). These findings suggest META may exert an anti-cancer effect in HT29 cells by inducing apoptosis through both intrinsic and extrinsic pathways.

• Journal of Digital Convergence
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• v.18 no.7
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• pp.331-337
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• 2020

The purpose of this study was to meta-synthesize the results of qualitative research that explored the experiences of nursing care in a domestic nurse to understand the phenomenon. The research method was a qualitative meta-synthesis study, which was analyzed using Thomas and Harden's methods. This was analyzed by searching for quality assessments for individual studies, extracting data for analysis, and meta-synthesizing the results. As a result of the study, it appeared as five synthetic themes. 1) Disaster nursing that begins with anxiety and fear, 2) Disaster nursing process: An atmosphere that feels even loneliness and burden in isolation and disconnection, 3) Disaster nursing process: Being in a poor and diverse environment, 4) Disaster nursing process: Although exhausted Endure and overcome. 5) After disaster care: A leap forward for development beyond mission and self-esteem. Conclusion, this study is expected to be a useful basic data for the development and application of nurse's disaster nursing programs and educational programs in the future.

• Journal of Korean Public Health Nursing
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• v.36 no.1
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• pp.5-19
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• 2022

Purpose: The purpose of this systematic review and the meta-analytic study was to examine the effectiveness of the interventions for smartphone addiction problems in youth on alleviating their levels of anxiety, depression, impulsiveness, self-control, self-esteem, and smartphone addiction. Methods: Relevant literature was searched from six electronic databases, and studies were searched by rigor PICOS framework. A total of 31 studies were included for the meta-analysis, which met the inclusion criteria of this study. Comprehensive Meta-Analysis 2.0 was used for analysis. Results: Overall effect size of the intervention was Hedges' g 1.02 (95% CI: 0.86~1.17), which was a large effect size with a statistical significance. The effect sizes of the outcome variables were significant. Self-control showed the largest effect sizes (g=1.73), followed by smartphone addiction (g=1.49), self-esteem (g=0.99), impulsiveness (g=0.82), anxiety (g=0.77), and depression (g=0.67). Interventions targeting smaller groups showed a higher effect size than larger groups. Conclusion: This study indicates that the interventions targeting Korean youths can reduce anxiety, depression, impulsiveness, self-control, self-esteem, and smartphone addiction of Korean youth. This study can provide evidence for further interventions to prevent smartphone addiction and related programs in Korean youths.

• Journal of The Korean Society of Integrative Medicine
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• v.10 no.3
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• pp.37-52
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• 2022

Purpose : The purpose of this meta-analysis was to evaluate the effects of electrical stimulation on patients with non-specific low back pain. Methods : Domestic databases were gathered from studies that conducted clinical trials associated with electrical stimulation and its impact on pain of non-specific low back patients. A total of 681 studies were identified, with 12 studies satisfying the inclusion data. The studies consisted of patient, intervention, comparison, outcome, and study design (PICO-SD). The search outcomes were items associated with low back pain. Cochrane risk of bias 2 (RoB 2) was used to evaluate the quality of 12 randomized controlled trials. Effect sizes (Hedges's g) in this study were computed as the corrected standard mean difference (SMD). A random-effect model was used to analyze the effect size because of the high heterogeneity among the studies. Egger's regression and 'trim-and-fill' tests were carried out to analyze the publication bias. Cumulative meta-analysis and sensitivity analysis were conducted to analyze the effect according to the sample size and the consistency of the effect size. Results : The following factors had a large overall effect size (Hedges's g=1.28, 95 % CI=.20~2.36) involving electrical stimulation on non-specific low back pain. The subgroup analysis all showed a statistical difference in the types of study design, electrical stimulation, and assessment tool. No statistically significant difference was found in the meta-regression analysis. Publican bias was found in the data. Conclusion : The findings in this study indicate that electrical stimulation interventions have a positive effect on patients with non-specific low back pain. However, due to the low quality of studies and publication bias, the results of our study should be interpreted cautiously.

• Journal of Oriental Neuropsychiatry
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• v.34 no.4
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• pp.403-420
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• 2023

Objectives: This study investigated the effectiveness of herbal medicine for generalized anxiety disorder (GAD) based on recent clinical studies. Methods: Studies were searched through four databases. Clinical research studies on herbal medicine treatment for GAD patients were included. The studies were analyzed according to study design, diagnostic criteria, population, and intervention. A risk of bias assessment was performed to assess the quality of the included randomized controlled trials (RCT). If the intervention applied to the treatment and control groups was the same and two or more studies were reporting the same items as outcome indicators, a meta-analysis was performed. Results: A total of 19 studies, including 12 RCTs were selected. The most common pattern identification was 'Phlegm fire disturbing upward' (痰熱上擾), and the most used herb for therapeutic purposes was 'Rhizome of Poria cocos' (茯苓). Meta-analysis results of three studies showed that there were no significant differences in effectiveness between the herbal medicine intervention and the Western medicine intervention. Meta-analysis results of five studies showed that the Hamilton Anxiety Rating Scale was significantly reduced in the case of herbal medicine intervention compared to Western medicine intervention. Conclusions: The results of our study demonstrated that herbal medicine treatment for GAD is effective in alleviating anxiety symptoms and chief symptoms of GAD. However, this study has several limitations; there was a lack of placebo-controlled RCT and an absence of objective diagnostic criteria in case reports. Therefore, further well-designed clinical studies, conducted based on the results of this study, are recommended.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6863-6869
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• 2014

Objectives: Several preclinical and observational studies have shown that anti-diabetic medications (ADMs) may modify the risk of lung cancer. We performed a systematic review and meta-analysis evaluating the effect of metformin, sulfonylureas (SUs), thiazolidinediones (TZDs), and insulin on the risk of lung cancer in patients with diabetes mellitus (DM). Materials and Methods: We conducted a systematic search of Pubmed and Web of Science, up to August 20, 2013. We also searched the Conference Proceedings Citation Index (CPCI) and China National Knowledge Infrastructure (CNKI) for abstracts from major meetings. Fixed or random effect pooled measures were selected based on heterogeneity among studies, which was evaluated using Q test and the I2 of Higgins and Thompson. Meta-regression was used to explore the sources of between-study heterogeneity. Publication bias was analyzed by Begg's funnel plot and Egger's regression test. Associations were assessed by odds ratios (ORs) with 95% confidence intervals (CIs). Results: A total of 15 studies (11 cohort, 4 case-control) were included in this meta-analysis. In observational studies no significant association between metformin (n=11 studies; adjusted OR=0.99, 95%CI: 0.87-1.12), SUs (n=5 studies; adjusted OR=0.98, 95%CI: 0.79-1.22), or TZDs (n=7 studies; adjusted OR=0.92, 95%CI: 0.75-1.13), insulin (n=6 studies; adjusted OR=1.13, 95%CI: 0.79-1.62) use and risk of developing lung cancer was noted. There was considerable inherent heterogeneity between studies not explained by study design, setting, or location. Conclusions: Meta-analysis of existing studies does not support a protective or harmful association between ADMs use and risk of lung cancer in patients with DM. There was considerable heterogeneity across studies, and future, well-designed, prospective studies would be required for better understanding of any association.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.42 no.10
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• pp.884-892
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• 2014

In this paper, a meta model using neural network substituting for the simulator aerodynamic database is proposed to improve simulation fidelity near the critical flight area and real-time performance. It is shown that the accuracy of the meta model is relatively higher than the existing table lookup methods for arbitrary nonlinear database and the calculation speed is also improved for a specific F-16 maneuver simulation. The increase in the number of hidden nodes in the meta model for better accuracy of database representations causes a delay in function generation due to increased time required for computing exponential functions. In order to make up this drawback, we additionally study the fast exponential function method.

• Journal of Korean Academy of Nursing
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• v.44 no.5
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• pp.459-470
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• 2014

Purpose: The purpose of this study was to evaluate the quality of meta-analysis regarding exercise using Assessment of Multiple Systematic Reviews (AMSTAR) as well as to compare effect size according to outcomes. Methods: Electronic databases including the Korean Studies Information Service System (KISS), the National Assembly Library and the DBpia, HAKJISAand RISS4U for the dates 1990 to January 2014 were searched for 'meta-analysis' and 'exercise' in the fields of medical, nursing, physical therapy and physical exercise in Korea. AMSTAR was scored for quality assessment of the 33 articles included in the study. Data were analyzed using descriptive statistics, t-test, ANOVA and ${\chi}^2$-test. Results: The mean score for AMSTAR evaluations was 4.18 (SD=1.78) and about 67% were classified at the low-quality level and 30% at the moderate-quality level. The scores of quality were statistically different by field of research, number of participants, number of databases, financial support and approval by IRB. The effect size that presented in individual studies were different by type of exercise in the applied intervention. Conclusion: This critical appraisal of meta-analysis published in various field that focused on exercise indicates that a guideline such as the PRISMA checklist should be strongly recommended for optimum reporting of meta-analysis across research fields.