• JSTS:Journal of Semiconductor Technology and Science
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• 제16권4호
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• pp.436-442
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• 2016

An electroencephalogram (EEG)-connectome processor to monitor and diagnose mental health is proposed. From 19-channel EEG signals, the proposed processor determines whether the mental state is healthy or unhealthy by extracting significant features from EEG signals and classifying them. Connectome approach is adopted for the best diagnosis accuracy, and synchronization likelihood (SL) is chosen as the connectome feature. Before computing SL, reconstruction optimizer (ReOpt) block compensates some parameters, resulting in improved accuracy. During SL calculation, a sparse matrix inscription (SMI) scheme is proposed to reduce the memory size to 1/24. From the calculated SL information, a small world feature extractor (SWFE) reduces the memory size to 1/29. Finally, using SLs or small word features, radial basis function (RBF) kernel-based support vector machine (SVM) diagnoses user's mental health condition. For RBF kernels, look-up-tables (LUTs) are used to replace the floating-point operations, decreasing the required operation by 54%. Consequently, The EEG-connectome processor improves the diagnosis accuracy from 89% to 95% in Alzheimer's disease case. The proposed processor occupies $3.8mm^2$ and consumes 1.71 mW with $0.18{\mu}m$ CMOS technology.

• 생물정신의학
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• 제7권2호
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• pp.115-122
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• 2000

The development of molecular biology has brought many changes in psychiatry. Molecular biology makes us possible to know the cause of mental disorders that provide the way to prevent the disorders, and to develop various accurate diagnostic and treatment methods for mental disorders. The author discusses the concept, cause, and treatment of mental disorders in the aspect of molecular biology. Importing the methods of molecular biology into psychiatry, we can anticipate to get a number of the goals of psychiatric genetics, including identification of specific susceptibility genes, clarification of the pathophysiological processes whereby these genes lead to symptoms, establishment of epigenetic factors that interact with these genes to produce disease, validation of nosological boundaries that more closely reflect the actions of these genes, and development of effective preventive and therapeutic interventions based on genetic counseling, gene therapy, and modification of permissive or protective environmental influences. In addition to their capacity to accelerate the discovery of new molecules participating in the nervous system's response to disease or to self-administered drugs, molecular biological strategies can also be used to determine how critical a particular gene product may be in mediating a cellular event with behavioral importance. Molecular biology probably enables us discover the environmental factors of mental disorders and allow rational drug design and gene therapies for mental disorders, by isolation of gene products that facilitate a basic understanding of the pathogenesis of these disorders. A specific genetic linkage may suggest a novel class of drugs that has not yet been tried. With respect to gene therapy, the hypothetical method would use a gene delivery system, most likely a modified virus, to insert a functional copy of a mutant gene into those brain cells that require the gene for normal function.

• 한국임상보건과학회지
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• 제1권1호
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• pp.75-82
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• 2013

Purpose : The aim of this study was to identify the relation of cognition and visuospatial perception in stoke patients. Methods : A total of 16 stroke patients recruited from two hospital located in Donghae, Kang-won participated in this study(Right hemiplegia : twelve, Left hemiplegia : four). All participants scored higher than 20 point on the MMSE-K. To assess the cognitive function, we performed the Korean version of Mini Mental State Examination(MMSE-K), spatial perception domain of Lowenstein Occupational Therapy Cognition Assessment(LOTCA), Figure Color Copy(FCC), Linebisection Test(LBT) and Albert's test in stoke patients. Results: The Korean version of Mini Mental State Examination and spatial perception domain of Lowenstein Occupational Therapy Cognition Assessment were the highest points in sixty ages, Figure Color Copy is difference between Right hemiplegia and Left hemiplegia. Linebisection Test(LBT) and Albert's test had much relation, visuospatial perception had not relationship. Conclusion: Aging was cognition function and visuospatial perception had an interrelationship. visuospatial perception according to affected side in brain had an interrelationship but cognition function and visuospatial perception had not any interrelationship.

• 대한지역사회작업치료학회지
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• 제2권1호
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• pp.37-47
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• 2012

목적 : 본 연구는 요양원에서 휠체어를 타고 생활하고 있는 노인에게 ROM dance가 인지 기능과 신경정신 행동에 어떠한 영향을 미치는지 알아보는 것이다. 연구방법 : 본 연구는 대전 ${\bigcirc}{\bigcirc}$요양원에 거주하고 휠체어를 사용하는 15명을 대상으로 하였으며, 2010년 3월부터 2010년 8월까지 주 1회 총 18회 실시하였다. 평가도구는 인지기능을 알아보기 위해서 Mini-Mental State Examination-Korean(MMESE-K)를 사용하였고, 신경정신행동을 알아보기 위해서 Neuropsychiatric Inventory-Questionnaire(NPI-Q)를 사용하였다. 결과 : MMSE-K 검사 결과 초기평가에서는 14.6점에서 ROM dance를 한 후에 16.3점으로 향상되었으며, 특히 MMSE-K의 항목 중 시간에 대한 지남력에서 유의미한 차이가 있었다(p<.05) NPI-Q검사에서는 초기평가에서 88점에서 64점으로 감소되었음을 볼 수 있었으며, 수면/야간행동, 무감동/무관심 영역에서 유의미하게 차이가 있었다(p<.05). 결론 : 본 연구의 결과 휠체어를 이용하는 노인에게 ROM dance는 인지기능 향상과 신경 정신 행동의 감소에 긍정적인 영향을 미치는 것을 볼 수 있었다. 향후 휠체어를 사용하는 노인 뿐만 아니라 많은 노인에게 적용하여 그 효과가 검증된다면 임상에서 유용하게 활용 될 수 있을 것이다.

• 셀메드
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• 제7권3호
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• pp.13.1-13.10
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• 2017

Nutrition is one of the factors influencing cognitive functions. But, the role of nutrition on cognitive functions within the elderly is recognized to a lesser degree. The aim of this academic endeavor was to analyze the affiliation between nutritional status and cognitive functions of the elderly in Korea. 316 subjects, of 114 male and 201 female aged above 65 years, were gathered from university hospital clinics, Elderly Welfare Centers, and Health Welfare Centers located in the district of Seoul, Gyeonggi province, and Incheon in Korea. The cognitive function was tested by the Korean-Mini Mental State Examination (K-MMSE) questionnaire. Nutrition intake was assessed by a 24-hour recall, a food frequency questionnaire (FFQ). Nutrition adequacy and quality were assessed by the Nutrition Screening Initiative (NSI) checklist, the nutritional adequacy ratio (NAR), and the mean adequacy ratio (MAR). The elderly with normal cognitive function status displayed significantly higher levels of calcium, riboflavin, thiamin, folate, vitamin C, vitamin E, vitamin B6, phosphorous, potassium, iron, niacin, zinc, animal fat, animal protein, polyunsaturated fatty acids, total protein, vegetable oil, vegetable protein, fiber than levels of the elderly with moderate cognitive impairment. The K-MMSE score positively correlated with of high consumption of pork, white radish, sea mustard, tomato, tangerine, grape, apple, and ice cream, and K-MMSE was negatively associated with high intake of potato, anchovy, fish cake, and mushroom. The findings suggest that nutritional status is affiliated with cognitive function within the elderly of Korea. The consumption of variety of foods and nutrients ensures adequate cognitive function in the Korean elderly.

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2008년도 제49회 학술심포지움 및 국제학술대회
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• pp.28.1-28.1
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• 2008

• Molecules and Cells
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• 제45권11호
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• pp.781-788
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• 2022

Proline plays a multifaceted role in protein synthesis, redox balance, cell fate regulation, brain development, and other cellular and physiological processes. Here, we focus our review on proline metabolism in neurons, highlighting the role of dysregulated proline metabolism in neuronal dysfunction and consequently neurological and psychiatric disorders. We will discuss the association between genetic and protein function of enzymes in the proline pathway and the development of neurological and psychiatric disorders. We will conclude with a potential mechanism of proline metabolism in neuronal function and mental health.

• 한국콘텐츠학회논문지
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• 제19권9호
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• pp.308-320
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• 2019

본 연구는 가족돌봄자가 노인의 정신질환을 주로 어떤 증상을 통해 발견하였는지를 알아보는 한편, 가족돌봄자를 중심으로 노인의 정신건강서비스를 이용하게 이끄는 주된 원인이 무엇인지를 실증적으로 검증하고자 하였다. 이를 위해 정신건강문제를 갖고 지역사회에 거주하는 노인을 돌보는 가족돌봄자를 대상으로 설문조사를 실시하였으며 이를 통해 수집된 324명의 자료로 이항 로지스틱 회귀분석을 실시하였다. 연구결과를 보면 첫째, 가족돌봄자가 노인 환자의 정신건강질환을 의심하게 된 주된 증상은 기억력 저하와 다른 인지기능 저하가 가장 많은 것으로 확인되었다. 둘째, 노인이 노인 정신건강서비스를 이용하는데 영향을 미치는 요인으로는 노인의 장기요양등급, 가족돌봄자의 나이, 노인을 돌본 기간, 가족돌봄자가 느끼는 돌봄 스트레스의 수준, 가족 돌봄자의 노년기 정신질환에 대한 이해, 가족돌봄자의 지역사회 정신건강서비스에 대한 인지도가 영향을 미치는 것으로 확인되었다. 이러한 연구결과를 토대로 노인 가족돌봄자의 관점에서 노인 정신건강문제 조기 발견과 대응 및 관련서비스 이용을 위한 정책적 실천적 함의를 제시하였다.

• 대한간호학회지
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• 제27권4호
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• pp.943-952
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• 1997

This study was done to analyze the effects of prompted voiding therapy on urinary incontinence in elderly patients in an elderly care hospital. Specifically, this study looks to evaluate the effects of prompted voiding as an intervention for improving independent voiding and also identified the relationship of urinary continence to cognitive, emotional, and physical factors. The study was based on a pre-experimental design used to evaluate the effects of prompted voiding therapy on an experimental group without a control group. An experimental group of 143 patients was selected through convenience sampling from patients in an elderly care hospital. The data was collected from November 4 to December 14, 1996. Prompted voiding therapy is a behavioral therapy for managing incontinence and it is applied to patients who are cognitively impaired and dependent. In this study, the patients were asked at each designated time whether or not they had to urinate. If they answered yes, they were either given a bedpan or were assisted to the bathroom, and if the patient answered no, their diaper was checked to determine whether or not it was wet. The results were then recorded on the patients urinary voiding record. The urinary voiding score based on the model presented by Burton(1984), Burke and Walsh(1992), Chenitz, Stone & Salisbury(1991) was modified and used as a tool in this study. After forty six out of the total of 143 patients were selected for interviews through random sampling the levels of cognitive functions, mental depression and ADL(activities of dally life) within the given time frame were measured. In this study, the cognitive function was measured using the scale developed by Kabhn, Goldfarb, Pollack & Peck(1960), elderly mental depression, using the tool developed by Sheikh & Yesavage(1986), and the ADL(activities of dally living), through the Barthel Index. The data was analyzed through SPSS windows for descriptive statistics, repeated measured ANOVA and Pearson's correlation. According to the results of the study, the application of the prompted voiding therapy can improve the voiding pattern of patients. It was shown especially that incontinence could be controlled by the intervention developed according to the individual voiding pattern. In terms of the relationship between cognitive function, mental depression and ADL and the voiding function score, a close correlation was not found. It was shown that urinary incontinence can be improved through therapy even though patients have problems nth their cognitive, mental and physical functions.

• 한국산학기술학회논문지
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• 제13권12호
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• pp.5976-5985
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• 2012

본 연구는 장기요양서비스의 질 제고를 위해 장기요양서비스 이용 노인들의 신체적 및 정신적 기능 상태를 평가해 보고, 그에 영향을 미치는 관련 요인을 규명하고자 시도하였다. 조사대상은 대전지역에 거주하는 65세 이상 노인 중 장기요양서비스 이용자 350명(재가급여 178명, 시설급여 172명)으로 하였으며, 자료 수집은 2011년 2월 16일부터 3월 31일까지의 기간 동안에 표준화된 무기명식 면접조사용 설문지를 사용하여 면접조사를 통해 이루어졌다. 연구결과, 재가급여 노인의 IADL과 MMSE-K는 시설급여 노인보다 유의하게 높았으나 ADL과 CES-D는 유의한 차이를 보이지 않았다. ADL, IADL, CES-D 및 MMSE-K 상호 간의 상관관계를 보면, 재가 및 시설급여 이용노인 모두 ADL은 IADL 및 MMSE-K와 양의 상관관계를 보인 반면, CES-D와는 음의 상관관계를 나타내었다. IADL은 MMSE-K와 양의 상관관계를 보인 반면, CES-D와는 음의 상관관계를 나타내었다. 다중회귀분석 결과 재가 및 시설 급여 이용 노인 모두 ADL과 IADL에 유의하게 영향을 미치는 변수로는 건망증 증상 유무, 규칙적 운동 및 MMSE-K가 선정되었다. 또한 CES-D와 MMSE-K는 주관적 건강상태, 건망증 증상 유무 및 IADL이 유의하게 영향을 주는 것으로 나타났다. 이상과 같은 결과는 장기요양서비스 이용 노인들의 신체적 및 정신적 기능은 개인의 건강상태나 건강관련행위 특성과 밀접한 관련성이 있음을 시사하고 있다.