• The Journal of the Korea institute of electronic communication sciences
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• v.12 no.5
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• pp.791-796
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• 2017

In this study, we investigated the influence of the fabrication process of stacked capacitors on the cell capacitance by using Load Lock (L/L) LPCVD system for dielectric thin film of DRAM capacitor. As a result, it was confirmed that the capacitance difference of about 3-4 fF is obtained by reducing the effective thickness of the oxide film by about $6{\AA}$ compared to the conventional non-L/L device. In addition, Cs was found to be about 3-6 fF lower than the calculated value, even though the measurement range of the thickness of the nitride film as an insulating film was in a normal management range. This is because the node poly FI CD is managed at the upper limit of the spec, resulting in a decrease in cell surface area, which indicates a Cs reduction of about 2fF. Therefore, it is necessary to control the thickness of insulating film and CD management within 10% of the spec center value in order to secure stable Cs.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.5
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• pp.1418-1425
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• 2004

The water extract of Chongmyung-tang has been traditionally used for treatment of memory-disorder in oriental medicine. This study was designed to investigate the protective mechanisms of Chongmyung-tang on β-amyloid or H₂O₂-induced cytotoxicity in Neuro 2A cells. The water extract of Chongmyung-tang significantly reduced both β-amyloid or H₂O₂-induced cell death and apoptotic characteristics through reduction of intracellular peroxide generation. Also, it inhibited the mitochondrial dysfunction including the disruption of mitochondria membrane permeability transition(MPT) and the modulation in expression of Bcl-2 family proteins in H₂O₂-treated H9c2 cells. Furthermore, pretreatment of quercetin inhibited the activation of caspase-3, in turn, degradation of ICAD/DFF45 were completely abolished in H₂O₂-treated cells. Taken together, that data suggest that the protective effects of the water extract of Chongmyung-tang against β-amyloid induced oxidative injuries may be achieved through modulation of mitochondrial dysfunction.

• Korean Journal of Medicinal Crop Science
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• v.14 no.2
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• pp.70-76
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• 2006

Paeoniae radix has been widely used for its anti-allergic, anti-inflammatory and analgesic effects, and demonstrated to have anticonvulsant, memory enhancing and anxiolytic activities. The present study was performed to examine the protective effect of methanol extract of Paeoniae radix (PR) from Paeoniae Japonica Miyabe et Takeda (Paeoniaceae) on hydrogen peroxide $(H_2O_2)-induced$ neurotoxicity using cultured rat cerebral cortical neuron. $H_2O_2$ produced a concentration-dependent reduction of neuronal viability, PR, over a concentration range of 10 to $100\;{\mu}g/ml$ showed concentration-dependent decrease of the $H_2O_2$$(100\;{\mu}M)-induced$ neuronal cell death, as assessed by a 3-[4,5-dimethylthiazol-2-yl]-2,5-di-phenyl-tetrazolium bromide assay and the number of apoptotic nuclei, evidenced by Hoechst 33342 staining. PR $(100\;{\mu}g/ml$ inhibited $100\;{\mu}M$ $H_2O_2-induced$ elevation of the cytosolic $Ca^{2+}$ concentration $([Ca^{2+}]_c)$, which was measured by a fluorescent dye, flue-4 AM. PR $(50\;{\mu}g/ml$ inhibited glutamate release into medium induced by $100\;{\mu}M$ $H_2O_2$, which was measured by HPLC, and generation of reactive oxygen species (ROS). These results suggest that PR may mitigate the $H_2O_2-induced$ neurotoxiciy by interfering with the increase of $[Ca^{2+}]_c$, and then inhibiting glutamate release and generation of ROS in cultured neurons.

• The KIPS Transactions:PartA
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• v.11A no.7 s.91
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• pp.489-498
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• 2004

VLIW processor is considered to be an appropriate processor for the embedded system, provided with high performance and low power con-sumption due to its simple hardware structure. Unfortunately, the VLIW processor often suffers from high memory access latency due to the variable length of I-packets, which consist of independent instructions to be issued in parallel. It is because of the variable I-packet length that some I-packets must be placed over two cache blocks, which are called straddle I-packets, so that two cache accesses are required to fetch such I-packets. In this paper, an expansion buffer cache is proposed to improve not only the instruction fetch bandwidth, but also the power consumption of the I-cache with moderate hardware cost. The expansion buffer cache has a small expansion buffer containing a fraction of a straddle packet along with the main cache to reduce the additional cache accesses due to the straddle I-packets. With a great reduction in the cache accesses due to the straddle packets, the expansion buffer cache can achieve $5{\~}9{\%}$improvement over the conventional I-caches in the $Delay{\cdot}Power{\cdot}Area$ metric.

• Proceedings of the Korean Society for Cognitive Science Conference
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• 2005.05a
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• pp.151-153
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• 2005

We investigated the brain substrate of repetition priming on the implicit memory taskusing low-resolution electromagnetic tomography (LORETA) with high-density 128 channel EEG and individual MRI as a realistic head model. Thirteen right-handed, healthy subjects performed a word/nonword discrimination task, in which the words and nonwords were presented visually,and some of the words appeared twice with a lag of one or five items. All of the subjects exhibited repetition priming with respect to the behavioral data, in which a faster reaction time was observed to the repeated word (old word) than to the first presentation of the word (new word). The old words elicited more positive-going potentials than the new words, beginning at 200 ms and lasting until 500 ms post-stimulus. We conducted source reconstruction using LORETA at a latency of 400 ms with the peak mean global field potentials and used statistical parametric mapping for the statistical analysis. We found that the source elicited by the old words exhibited a statistically significant current density reduction in the left inferior frontal gyrus. This is the first study to investigate the generators of repetition priming using voxel-by-voxel statistical mapping of the current density with individual MRI and high-density EEG.

• Composites Research
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• v.12 no.3
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• pp.55-65
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• 1999

In this paper, the thermal buckling and postbuckling behaviour of composite beam with embedded shape memory alloy (SMA) wires are investigated experimentally and analytically. The results of thermal buckling tests on uniformly heated, clamped, composite beam embedded with SMA wire actuators are presented and discussed in consideration of geometric imperfections, slenderness ratio of beam and embedding position of SMA wire actuators. The shape recovery force can reduce the thermal expansion of composite laminated beam, which result in increment of the critical buckling temperature and reduction of the lateral deflection of postbuckling behaviours. It is presented quantitatively on the temperature-load-deflection behaviour records how the shape recovery force affects the thermal buckling. The cross tangential method is suggested to calculate the critical buckling temperature on the temperature-deflection plot. Based on the experimental analysis, the new formula is also proposed to describe the critical buckling temperature of a laminated composite beam with embedded SMA wire actuators.

• The Korean Journal of Physiology and Pharmacology
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• v.9 no.5
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• pp.263-268
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• 2005

Striatum has important roles in motor control, habitual learning and memory. It receives glutamatergic inputs from neocortex and thalamus, and dopaminergic inputs from substantia nigra. We examined effects of dopamine (DA) on the corticostriatal synaptic transmission using in vitro extracellular recording technique in rat brain corticostriatal slices. Synaptic responses were elicited by stimulation of cortical glutamatergic inputs on the corpus callosum and recorded in the dorsal striatum. Corticostriatal population spike (PS) amplitudes were decreased ($39.4{\pm}7.9$%) by the application of $100{\mu}M$ DA. We applied receptor subtype specific agonists and antagonists and characterized the modulation of corticostriatal synaptic transmission by different DA receptor subtypes. $D_2$ receptor agonist (quinpirole), antagonist (sulpiride), and $D_1$ receptor antagonist (SKF 83566), but not $D_1$ receptor agonist (SKF 38393), induced significantly the reduction of striatal PS. Pretreatment neither with SKF 83566 nor sulpiride significantly affected corticostriatal synaptic inhibition by DA. However, the inhibition of DA was completely blocked by pretreatment with mixed solution of both SKF 83566 and sulpiride. These results suggest that DA inhibits corticostriatal synaptic transmission through both $D_1$ and $D_2$ receptors in concert with each other.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.3
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• pp.2192-2200
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• 2015

In this paper, we propose an efficient vehicle image compensation algorithm based on Histogram Equalization. The proposed a vehicle image compensation algorithm was elimination to the vehicle image shake using motion compensation and motion estimation. And, algorithm was calculated the histogram of pixel values from each sub-image by dividing the image as the constant size areas in order to image enhancement. Also, it had enhancement to the image by adjusting the gradient. The proposed algorithm was evaluate the difference between of performance and time, image by applied to the IP, and were confirmed the image enhancement with removing of vehicle camera image shake. In this paper, the proposed vehicle image enhancement algorithm was demonstrated effectiveness when compared to existing vehicle image stabilization, because the elimination of shake for the vehicle images used real-time processing without using a memory. And it was obtained the reduction effect of the computation time by the calculated through block matching, and obtained the better restoration result for naturalness of the image with the lowest noise.

• Journal of Advanced Navigation Technology
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• v.20 no.1
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• pp.79-85
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• 2016

Network traffic is increased rapidly, due to mobile and social network, such as smartphones and facebook, in recent web environment. In this paper, we improved web response time of existing system using direct buffer of NIO and DMA. This solved the disadvantage of JAVA, such as CPU performance reduction due to the blocking of I/O, garbage collection of buffer. Key values circulated many data due to priority change put on a hash map operated easily and apply a priority modification algorithm. Large response data is separated and stored at a fast direct buffer and improved performance. This paper showed that the proposed method using NIO was much improved performance, in many test situations of cache hit and cache miss.

• Journal of KIISE:Computing Practices and Letters
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• v.16 no.4
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• pp.427-431
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• 2010

Multidimensional scaling (MDS) is a widely used method for dimensionality reduction, of which purpose is to represent high-dimensional data in a low-dimensional space while preserving distances among objects as much as possible. MDS has mainly been applied to data visualization and feature selection. Among various MDS methods, the classical MDS is not readily applicable to data which has large numbers of objects, on normal desktop computers due to its computational complexity. More precisely, it needs to solve eigenpair problems on dissimilarity matrices based on Euclidean distance. Thus, running time and required memory of the classical MDS highly increase as n (the number of objects) grows up, restricting its use in large-scale domains. In this paper, we propose an efficient approximation algorithm for the classical MDS based on divide-and-conquer and CUDA. Through a set of experiments, we show that our approach is highly efficient and effective for analysis and visualization of data consisting of several thousands of objects.