• The Journal of Korean Institute of Communications and Information Sciences
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• v.34 no.10C
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• pp.983-991
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• 2009

While H.264/AVC is in wide use for multimedia applications such as DMB and IPTV service, we have limited usage cases for embedded real-time applications due to its high computational demand. The paper provides judicious guide line for optimization method selection, by presenting the detailed experiments data through the development process of a real time H.264 software encoder on embedded DSP. The experimental analysis includes an intensive profiling analysis, fast algorithm application, optimal memory assignment, and intrinsic-based instruction selection. We have realized a real-time software that encodes CIF resolution videos 15 fps on TMS320DM64x processors.

• BMB Reports
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• v.55 no.8
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• pp.380-388
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• 2022

The B cell translocation gene 1 (BTG1) and BTG2 play a key role in a wide range of cellular activities including proliferation, apoptosis, and cell growth via modulating a variety of central biological steps such as transcription, post-transcriptional, and translation. BTG1 and BTG2 have been identified by genomic profiling of B-cell leukemia and diverse lymphoma types where both genes are commonly mutated, implying that they serve as tumor suppressors. Furthermore, a low expression level of BTG1 or BTG2 in solid tumors is frequently associated with malignant progression and poor treatment outcomes. As physiological aspects, BTG1 and BTG2 have been discovered to play a critical function in regulating quiescence in hematopoietic lineage such as Hematopoietic stem cells (HSCs) and naive and memory T cells, highlighting their novel role in maintaining the quiescent state. Taken together, emerging evidence from the recent studies suggests that BTG1 and BTG2 play a central anti-proliferative role in various tissues and cells, indicating their potential as targets for innovative therapeutics.

• KIPS Transactions on Computer and Communication Systems
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• v.6 no.9
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• pp.377-384
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• 2017

The performance improvement of a single core processor has reached its limit since the circuit density cannot be increased any longer due to overheating. Therefore, the multicore and manycore architectures have emerged as viable approaches and parallel programming becomes more important. Haskell, a purely functional language, is getting popular in this situation since it naturally supports parallel programming owing to its beneficial features including the implicit parallelism in evaluating expressions and the monadic tools supporting parallel constructs. However, the performance of Haskell parallel programs is strongly influenced by the performance of the run-time system including the garbage collector. Though a memory profiling tool namely GC-tune has been suggested, we need a more systematic way to use this tool. Since GC-tune finds the optimal memory size by executing the target program with all the different possible GC options, the GC-tuning time takes too long. This paper suggests a basic divide-and-conquer method to reduce the number of GC-tune executions by reducing the search area by one-quarter for every searching step. Applying this method to two parallel programs, a maximally independent set and a K-means programs, the memory tuning time is reduced by 7.78 times with accuracy 98% on average.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.1
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• pp.43-50
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• 2016

NAND flash based storage devices adopts multi-channel and multi-way architecture to improve performance using parallel operation of multiple NAND devices. However, multiple NAND devices consume higher current and peak power overlap problem influences on the system stability and data reliability. In this paper, current waveform is measured for erase, program and read operations, peak current and model is defined by profiling method, and estimated probability of peak current overlap among NAND devices. Also, system level TLM simulator is developed to analyze peak overlap phenomenon depending on various simulation scenario. In order to remove peak overlapping, token-ring based simple power management method is applied in the simulation experiments. The optimal peak overlap ratio is proposed to minimize performance degradation based on relationship between peak current overlapping and system performance.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.22 no.5
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• pp.49-54
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• 2022

With the recent widespread adoption of general-purpose GPUs (GPGPUs) in cloud systems, maximizing the resource utilization through multitasking in GPGPU has become an important issue. In this article, we show that resource allocation based on the workload classification of computing-bound and memory-bound is not sufficient with respect to resource utilization, and present a new thread block scheduling policy for GPGPU that makes use of fine-grained resource utilizations of each workload. Unlike previous approaches, the proposed policy reduces scheduling overhead by separating profiling and scheduling, and maximizes resource utilizations by co-locating workloads with different bottleneck resources. Through simulations under various virtual machine scenarios, we show that the proposed policy improves the GPGPU throughput by 130.6% on average and up to 161.4%.

• Korean Journal of Biological Psychiatry
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• v.12 no.1
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• pp.42-61
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• 2005

Objectives:The ginsenoside Rg1 and Rb1, the major components of ginseng saponin, have neurotrophic and neuroprotective effects including promotion of neuronal survival and proliferation, facilitation of learning and memory, and protection from ischemic injury and apoptosis. In this study, to investigate the molecular basis of the effects of ginsenoside on neuron, we analyzed gene expression profiling of SH-SY5Y human neuroblastoma cells treated with ginsenoside Rg1 or Rb1. Methods:SH-SY5Y cells were cultured and treated in triplicate with ginsenoside Rg1 or Rb1($80{\mu}M$, $40{\mu}M$, $20{\mu}M$). The proliferation rates of SH-SY5Y cells were determined by MTT assay and microscopic examination. We used a high density cDNA microarray chip that contained 8K human genes to analyze the gene expression profiles in SH-SY5Y cells. We analyzed using the Significance Analysis of Microarray(SAM) method for identifying genes on a microarray with statistically significant changes in expression. Results:Treatment of SH-SY5Y cells with $80{\mu}M$ ginsenoside Rg1 or Rb1 for 36h showed maximal proliferation compared with other concentrations or control. The results of the microarray experiment yielded 96 genes were upregulated(${\geq}$3 fold) in Rg1 treated cells and 40 genes were up-regulated(${\geq}$2 fold) in Rb1 treated cells. Treatment with ginsenoside Rg1 for 36h induced the expression of some genes associated with protein biosynthesis, regulation of transcription or translation, cell proliferation and growth, neurogenesis and differentiation, regulation of cell cycle, energy transport and others. Genes associated with neurogenesis and neuronal differentiation such as SCG10 and MLP increased in ginsenoside Rg1 treated cells, but such changes did not occur in Rb1-group. Conclusion:Our data provide novel insights into the gene mechanisms involved in possible role for ginsenoside Rg1 or Rb1 in mediating neuronal proliferation or cell viability, which can elicit distinct patterns of gene expression in neuronal cell line. Ginsenoside Rg1 have more broad and strong effects than ginsenoside Rb1 in gene expression and related cellular physiology. In addition, we suggest that SCG10 gene, which is known to be expressed in neuronal differentiation during development and neuronal regeneration during adulthood, may have a role in enhancement of activity dependent synaptic plasticity or cytoskeletal regulation following treatment of ginsenoside Rg1. Further, ginsenoside Rg1 may have a possible role in regeneration of injured neuron, promotion of memory, and prevention from aging or neuronal degeneration.