• 생물정신의학
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• 제13권2호
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• pp.117-120
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• 2006

Localized amnesia is characterized by a failure to recall events that occurred during a circumscribed period of time. Localized amnesia is the most common type of dissociative amnesia. It is assumed that this is a disorder of memory retrieval. Recent neuroimaing studies reported that posterior cingulate cortex may play a important role in memory(autobiographical) retrieval. The authors reported a case of localized amnesia with mass on left posterior cingulate cortex.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제15권3호
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• pp.993-1014
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• 2021

This paper proposes a new image retrieval method called the 3D integrated multi-index to fuse SIFT (Scale Invariant Feature Transform) visual words with other features at the indexing level. The advantage of the 3D integrated multi-index is that it can produce finer subdivisions in the search space. Compared with the inverted indices of medium-sized codebook, the proposed method increases time slightly in preprocessing and querying. Particularly, the SIFT, contour and colour features are fused into the integrated multi-index, and the joint cooperation of complementary features significantly reduces the impact of false positive matches, so that effective image retrieval can be achieved. Extensive experiments on five benchmark datasets show that the 3D integrated multi-index significantly improves the retrieval accuracy. While compared with other methods, it requires an acceptable memory usage and query time. Importantly, we show that the 3D integrated multi-index is well complementary to many prior techniques, which make our method compared favorably with the state-of-the-arts.

• 대한한방소아과학회지
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• 제15권1호
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• pp.77-104
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• 2001

The effects of the oriental herbal medicine Saenghyetang(SHT, 生慧湯), which consists of Rehmanniae Radix (熟地黃 九蒸: was made by 9th steam) 40g, Corni Fructus(山茱黃) 16g, Polygalae Radix(遠志) 8g, Zizyphi Spinosae Semen(酸棗仁) 2g, Biotae Semen(柏子仁 去油: oil ingredient was removed) 20g, Poria Cocos(茯笭) 12g, Ginseng Radix(人蔘) 12g, Acori Graminei Rhizoma(石菖蒲) 2g, Sinapis Semen(白芥子) 8g, on learning ability and memory were investigated. Hot water extract(HWE) and ethanol extract(EE) from SHT were used for the studies. Learning ability and memory are related to modifications of synaptic strength among neurons that interactive. Enhanced synaptic coincidence detection leads to improved learning ability and memory. If the NMDA receptor, a synaptic coincidence detector, acts as a graded switch for memory formations, enhanced signal detection by NMDA receptors should enhance learning ability and memory. It was shown that NR2B was increased in the forebrains of oriental medicine-administrated mice, leading to enhanced activation of NMDA receptors and facilitating synaptic potentiation in response to stimulation at 10-100 Hz. These HWE-SHT treated mice exhibited that superior ability in learning and memory when performing various behavioral tasks, showing that NR2B is enhanced by HWE-SHT treatment and also is critical in gating the age-dependent threshold for plasticity and memory formation. NMDA receptor-dependent modifications, which were mediated in part by HWE administration, of synaptic efficacy, therefore, represent a mechanism for associative learning ability and memory. Results suggest that oriental medical enhancement of NR2B contributes to increase intelligence and memory in mammals On the other hand, to examine the effects of EE-SHT on the learning ability and memory in experimental mice, EE-SHT was tested on passive and active avoidance responses. The EE-SHT ameliorated the memory retrieval deficit induced by ethanol in mice, but not other memory impairments. EE-SHT(10, 20mg/100 g, p.o.) did not affect the passive avoidance responses of normal mice in the step through and step down tests, the conditioned and unconditioned avoidance responses of normal mice in the shuttle box, lever press performance tests and the ambulatory activity of normal mice in a normal condition. However, EE-SHT at 20 mg/kg significantly decrease the spontaneous motor activity during the shuttle box test, and also to extend the sleeping time induced by pentobarbital in mice. These results suggest that SHT has an ameliorating effect on memory retrieval impairments and a weak tranquilizing action.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2006년도 한국컴퓨터종합학술대회 논문집 Vol.33 No.1 (A)
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• pp.34-36
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• 2006

본 연구는 특정 사물을 계속 접하면서 그 사물에 대한 기억 강도가 의식적 노력 없이도 점점 강화되는 암묵적 기억 인출과정 associative memory retrieval의 DNA 연산 가능성을 논한다. 예를 들어 한 표적 단어에 대한 노출이 이를 관찰하는 시스템에게 그 단어의 기억 강도를 강화시키는 반면, 그와 유사한 다른 단어는 천천히 감소되고 나머지 가장 다른 단어는 일찍 잊혀지는 현상을 생각할 수 있다. 이들 단어들과 알파벳 철자들을 DNA 염기서열로 표현하고 simulated annealing을 통하여 결합 결과를 얻는다. Ridge regression 형태의 supervised 학습을 통하여 한 가지 표적 단어가 많이 생성되도록 DNA 조각들의 개수 분포를 변화시켜 진행한다. 실험 예로 'tic' 'tac' 'toe' 세 가지 단어를 그 아이템으로 정하여 계속 자극받는 표적 단어의 갯수가 증가함을 DNA annealing 시뮬레이션을 통하여 확인할 수 있다. 또한 'tac' 과 't' 와 'c'를 공유하는 'tic' 의 감소 점도가 't'만을 공유하는 'toe' 보다 느림을 확인할 수 있다. 위의 실험들을 통해 연합기억associative memory의 암묵적 인출과정을 분자 층위에서 표현할 수 있음을 확인 할 수 있다.

• 생물정신의학
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• 제14권1호
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• pp.61-67
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• 2007

Objectives : The purpose of this study was to test stage model in Traumatic Brain Injury(TBI) patients. According to the stage model, attention deficits which is basic stage in information processing lead to memory disturbance and subsequently affect higher-order cognitive function such as memory, decision-making, abstract thinking, and judgement related to executive function. Therefore, it was hypothesized that attention affect recall(retrieval efficacy) related to executive function mostly relative to other cognitive function, in TBI patients with low executive function. Methods : Participants were referred to a TBI clinic and then was rated on K-WAIS and Executive Intelligence Test(EXIT). Participants were divided into two groups according to Executive IQ(EIQ) score, which of high function group(N=67) was more than 80(above low average) and of low function group(N=52) was under 80 (under borderline). To test the stage model, using hierarchical regression analysis, recall(retrieval efficacy) was regressed on 3 subscales(attention, verbal, visuospatial scale) after controlling for IQ according to each group. Furthermore, the mediation effect of attention between retrieval efficacy and verbal, visuospatial score was analyzed. Results : In the low function group, only attention area predicted significantly recall(retrieval efficacy), indicating that lower attention were related to lower EIQ after controlling for IQ. In the high function group, no area predicted significantly retrieval efficacy. In the low function group, verbal and visuospatial scale did not predicted significantly retrieval efficacy, indicating that there was no evidences supporting the mediation model. Conclusion : Only attention affect retrieval efficacy in TBI patients with low executive function. But, the mediation effect of attention between retrieval efficacy and verbal and visuospatial scale was not tested in the low function group. These results implied that stage model was tested partially. In treating cognitive deficit in TBI patients, it is necessary to develop cognitive rehabilitation program based on stage model. Furthermore, it is necessary to necessary to test mediation model in the future study.

• 수면정신생리
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• 제4권1호
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• pp.29-38
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• 1997

치매는 기억력을 포함한 다양한 영역의 인지기능의 손상을 특징으로 하는 질병군으로 정의된다. 그러므로 현재 치매진단을 위하여 사용되고 있는 대부분의 진단기준들은 치매의 진단에 있어 기억 장애를 필수요소로 포함하고 있다. 기억력의 감퇴는 노화과정의 결과로서 나타날 수 있다. 치매와는 달리 노화에서의 기억력의 감퇴는 노화에 따른 정상으로 간주되며 사회적 그리고 직업적 기능의 영역에서 심각한 어려움이나 손상을 초래하지 않는다. 우울증 또한 기억장애를 동반할 수 있다. 하지만 치매와는 달리 우울증에서는 언어성 지연회상과 재인기억의 감소는 나타내지 않는다. 치매환자들에서의 기억장애도 병소의 위치에 따라 다른양상으로 나타날 수 있다. 피질성치매에서의 기억장애는 정보의 부호화와 기억강화과정의 이상에 의해 초래된 것인데, 피질하치매에서의 기억장애는 인출의 장애에 의한 것이다.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2002년도 제7차 학술대회 초록집
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• pp.111-111
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• 2002

Purpose： This study is to compare the distinct brain activation between implicit and explicit memory retrieval tasks using a non-invasive blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging(fMRI). Materials ＆ Methods： We studied seven right-handed, healthy volunteers aged 21-25 years(mean；22 years) were scanned under a 1.5T Signa Horizon Echospeed MR imager(GE Medical Systems, Milwaukee, U.S.A.). During the implicit and explicit memory retrieval tasks of previously teamed words under the conceptual processing, we acquired fMRI data using gradient-echo EPI with 50ms TE, 3000ms TR, 26cm${\times}$26cm field-of-view, 128${\times}$128 matrix, and ten slices(6mm slice thickness, 1 mm gap) parallel to the AC-PC(anterior commissure and posterior commissure) line. By using the program of statistical parametric mapping(SPM99), functional activation maps were reconstructed and quantified.

• 생물정신의학
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• 제18권2호
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• pp.80-89
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• 2011

Pavlovian fear conditioning has been extensively studied for the understanding of neurobiological basis of memory and emotion. Pavlovian fear conditioning is an associative memory which forms when conditioned stimulus (CS) is paired with unconditioned stimulus (US) once or repeatedly. This behavioral model is also important for the understanding of anxiety disorders such as posttraumatic stress disorder. Here we describe the neural circuitry involved in fear conditioning and the molecular mechanisms underlying fear memory formation. During consolidation some memories fade out but other memories become stable and concrete. Emotion plays an important role in determining which memories will survive. Memory becomes unstable and editable again immediately after retrieval. It opens the possibility for us of modulating the established fear memory. It provides us with very efficient tools to improve the efficacy of cognitive-behavior therapy and other exposure-based therapy treating anxiety disorders.

• 한국언어정보학회지:언어와정보
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• 제9권1호
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• pp.69-92
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• 2005

Pattern recognition in cognitive agents is based on (i) the uninterpreted input data (e.g. parameter values) provided by the agent's hardware devices and (ii) and interpreted patterns (e.g. templates) provided by the agent's memory. Computationally, the task consists in finding the memory data corresponding best to the input data, for any given input. Once the best fitting memory data have been found, the input is recognized by applying to it the interpretation which happens to be stored with the memorized pattern. This paper presents a fast converging procedure which starts from a few initially recognized items and then analyzes the remainder of the input by systematically checking for items shown by memory to have been related to the initial items in previous encounters. In this way, known patterns are tried first, and only when they have been exhausted, an elementary exploration of the input is commenced. Efficiency is improved further by choosing the candidate to be tested next according to frequency.

• 말소리와 음성과학
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• 제16권2호
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• pp.83-90
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• 2024

본 연구는 초등 2-3학년 난독증 아동과 읽기이해부진 아동의 음운인출과 음운기억 능력을 살펴보고자 하였다. 본 연구에는 난독증 아동 17명, 읽기이해부진 아동 17명, 일반 아동 24명이 참여하였다. 난독증 아동은 표준화된 읽기검사의 단어해독 검사에서 표준점수 85점 이하인 아동으로 선정하였으며, 읽기이해부진 아동은 단어해독 검사에서는 표준점수 90점 이상이며 읽기이해 검사에서는 표준점수 85점 이하인 아동, 그리고 일반 아동은 단어해독과 읽기이해 검사 모두에서 표준점수 90점 이상인 아동으로 선정하였다. 모든 대상자에게 음운인출 능력을 살펴보기 위해 빠른 이름대기, 음운기억 능력을 살펴보기 위해 비단어 따라말하기 검사를 실시하였다. 연구 결과 난독증 아동은 빠른 이름대기와 비단어 따라말하기에서 다른 두 집단보다 통계적으로 유의하게 수행력이 낮은 것으로 나타났다. 반면 읽기이해부진 아동과 일반 아동 간에는 차이가 나타나지 않았다. 각 집단 별로 상관 분석을 실시한 결과 난독증 아동 집단에서는 빠른 이름대기 능력이 해독 및 읽기이해와 통계적으로 상관이 있는 것으로 나타났다. 일반 아동 집단에서는 빠른 이름대기 능력이 해독 및 읽기이해와 관련이 있었으며, 비단어 따라말하기는 읽기이해와 관련이 있는 것으로 나타났다. 반면, 읽기이해부진 집단에서는 변인들간에 관련성이 나타나지 않았다. 본 연구 결과 난독증 아동은 읽기 발달의 토대가 되는 음운인출과 음운기억에서 어려움이 있는 반면, 읽기이해부진 아동은 음운처리 기술에서는 결함이 없는 것으로 나타났다. 난독증 아동의 단어해독 어려움은 음운처리 결함에 기인한 것으로 해석할 수 있다.