• IMMUNE NETWORK
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• v.14 no.4
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• pp.201-206
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• 2014

IL-33 is a member of the IL-1 cytokine family and plays a role in the host defense against bacteria, viruses, and fungi. In this study, we investigated the function of IL-33 and its receptor in in vitro macrophage responses to Candida albicans. Our results demonstrate that pre-sensitization of isolated peritoneal macrophages with IL-33 enhanced their pro-inflammatory cytokine production and phagocytic activity in response to C. albicans. These macrophage activities were entirely dependent on the ST2-MyD88 signaling pathway. In addition, pre-sensitization with IL-33 also increased ROS production and the subsequent killing ability of macrophages following C. albicans challenge. These results indicate that IL-33 may increase anti-fungal activity against Candida through macrophage-mediated resistance mechanisms.

• Proceedings of the KSAR Conference
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• 2004.06a
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• pp.210-210
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• 2004

Equinechorionic gonadotropin(eCG) is a member of the glycoprotein hormone family which includes FSH, hCG, TSH. These hormone family is characterized by a heterodimeric structure composed a common α-subunit noncovalently linked to a hormone specific β-subunit. To determine a and β-subunits can be synthesized as a single polypeptide chain (tethered-eCG) and also display biological activity, the tethered-molecule by fusing the carboxyl terminus of the eCG β-subunit to the amino terminus of the α-subunit was constructed and transfected into chinese hamster ovary (CHO-K1) cells. (omitted)

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.05a
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• pp.774-777
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• 2002

There are various methods to join mechanical structures together. They typically include welding, mechanical joints by bolts and other processes depending on specific needs. Analyses of joints in the mechanical structures are essential in understanding the dynamic characteristics of the structures. In this research an impulse technique is applies to investigate the dynamic behavior of joints produced by bolts. The length overlap in the joints was varied as the number of the bolts in the joins was changed. Also, the torque applied to the bolts were adjusted. Resonance frequencies were determined for the joints to evaluate the relationship between the increase in the applied torque and the increase in the number of bolts used in the joints. The results have demonstrated that the resonance frequencies of the joints increase with the increasing torque.

• Journal of the Korean Society for Precision Engineering
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• v.16 no.1 s.94
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• pp.125-131
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• 1999

For linkage mechanisms driven by a cam, cam profile is the major design factor and is determined by the cam follower motion. If a cam mechanism has additional kinematic linkage besides cam and follower then the follower motion should be specified from the motion of end linkage member so that cam would be able to generate the desired end linkage motion. In this paper, a cam-linkage mechanism is constructed with the combinations of modular linkage elements including cam and follower and as a result, a planar cam-linkage mechanism design software with the cam profile optimization function is developed and presented.

• Proceedings of the Korean Society of Toxicology Conference
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• 2001.05a
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• pp.167-167
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• 2001

Peroxisome proliferator-activated receptors(PPARs) are member of the neuclear hormone receptor superfamiliy of ligand-dependent transcription factors that heterodimerizes with the retinoid X receptor to function as a transcriptional regulator. They are divided into three subtypes(PPAR-$\alpha$, $\beta$ and ${\gamma}$).(omitted)

• Journal of Microbiology and Biotechnology
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• v.18 no.6
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• pp.1090-1094
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• 2008

In this article, we show that the orf slr1471 from Synechocystis sp. PCC 6803 codes for a functional member of the YidC/Alb3/Oxa1 protein family, and the encoded protein has a transmembrane topology with a common core structure. Using specific antibodies raised against the Synechocystis YidC homologous protein, we further show that the Synechocystis YidC protein appears to be predominantly localized in the cyanobacterial cytoplasmic membrane. The impact of the described findings for synthesis of membrane proteins and for protein sorting within cyanobacterial cells is discussed.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• v.12 no.2
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• pp.81-95
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• 2008

In this paper, the negative Polya-Eggenberger distribution has been introduced by compounding negative binomial distribution with beta distribution of I-kind which generates a number of univariate contagious or compound (or mixture of) distributions as its particular cases. The distribution is unimode, over dispersed and all of its positive and negative integer moments exist. The difference equation of the proposed model shows that it is a member of the Ord's family of distribution. Some of its interesting properties have been explored besides different methods of estimation been discussed. Finally, the parameters of the proposed model have been estimated by using a computer programme in R-software. Application of the proposed model to some data, available in the literature, has been given and its goodness of fit demonstrated.

• Journal of the Korean Operations Research and Management Science Society
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• v.23 no.4
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• pp.171-186
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• 1998

While one main stream of research in GDSS (Group Decision Support System) is to investigate how GDSS affects decision-making performances of groups according to task types, support features, meeting facilitation modes and meeting environments. little study h3s been done about how group characteristics affect group decision processes and outcomes depending upon GDSS is provided or not. So far, most GDSS research has considered group characteristics (e.g. personality homogeneity) as given and did not include it as control variables in experiments. Therefore, the objective of this study is to investigate how members of two different groups perceive the use of GDSS in group meetings through lab experiments. The two groups are homogeneous and heterogeneous groups in terms of members' personality mix. This research found that the effect of GDSS is a function of groups' personality homogeneity in regards of the satisfaction on decision process and the communication thoroughness. The support of GDSS and the group homogeneity are proved to influence participant's perception about some dependent variables such as satisfaction on decision process.

• Structural Engineering and Mechanics
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• v.8 no.4
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• pp.401-410
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• 1999

A method of optimum design based on reliability for antenna structures is presented in this paper. By constructing the equivalent event, the formula is derived for calculating the reliability of reflector accuracy of antenna under the action of random wind load. The optimal model is developed, in which the cross sectional areas of member are treated as design variables, the structure weight as objective function, the reliability of reflector accuracy and the strength or stability of structural elements as constraints. The improved accelerated convergence gradient algorithm developed by the author is used. The design results show that the method in this paper is feasible and effective.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2006.11a
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• pp.312-315
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• 2006

Overlay Multicast is a promising approach to overcome the implementation problem of IP multicast. Real time services like internet broadcasting are provided by overlay multicast technology due to the complex nature of IP multicast and the high cost to support multicast function. Since multicast members can dynamically join or leave their multicast group, it is necessary to keep a reliable overlay multicast tree to support real time service without delay. In this paper, we consider path level reliability that connects each member node. The problem is formulated as a binary integer programming which maximizes the reliability of multicast tree. Tabu search based algorithm is presented to solve the NP-hard problem.