• 대한환경공학회지
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• 제33권10호
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• pp.717-722
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• 2011

현재, melamine은 레진, 내화제, 접착제, 라미네이트 등 우리 생활에 다양하게 사용되고 있다. 그로 인해 melamine이 포함된 폐수의 수계 유입 또한 증가하고 있다. EU안전지침서의 GHS에는 melamine을 암 유발 가능성이 있는 물질로 구분하고 있다. 하지만 아직까지 melamine에 대한 독성연구는 진행 중이며 어떤 영향을 주는지 아직까지 밝혀진 사실이 적다. 본 연구에서는 한강과 주변하천의 melamine 오염 정도를 HPLC/UV를 이용하여 오염 정도를 파악하였다. 그리고 활성탄을 이용한 흡착실험 및 모델링에 관한 연구를 하였다. 우선 한강수계 중 상대적으로 상류에 있는 팔당댐 근교와 그보다 하류지역인 뚝섬유원지에서 동일한 시료를 3개씩 채수하였고 한강에 유입되는 하천 중 홍릉천, 왕숙천, 청계천에서 동일하게 시료를 채수하여 정제 후 melamine 농도를 측정하였다. 그 결과 팔당댐 근교의 시료에서는 melamine이 검출되지 않았으며 그보다 상대적으로 하류인 뚝섬유원지에서는 $0.312{\mu}g/L$농도가 검출되었다. 왕숙천에는 $0.578{\mu}g/L$로 가장 높았으며 청계천과 홍릉천은 각 $0.197{\mu}g/L$, $0.325{\mu}g/L$로 검출되었다. 전체적으로 낮은 농도지만 대부분의 지점에서 melamine의 검출을 확인할 수 있었다. 1970년대에는 melamine 생산량이 200,000 ton에서 최근에는 1,400,000 ton으로 계속적인 사용의 증가로 수계오염은 심화될 것으로 보인다. 활성탄을 이용한 흡착 실험에서는 활성탄 크기에 따라 melamine흡착에 약간의 차이를 보였으나 파과모델과 어느 정도 일치함을 보였다.

• 한국수산과학회지
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• 제44권6호
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• pp.577-583
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• 2011

In 2007, pet food contaminated with melamine caused hundreds of dogs and cats to develop renal failure all over the world. In 2008, over 294,000 infants consumed infant formula and developed kidney stones in China. Further investigation revealed that fish feed also contained melamine; this raised concerns about melamine residues in edible fish tissues, which could have caused the urinary tract stone epidemic. In Korea, catfish fed with assorted feed that included cuttlefish organs that contained melamine developed whitening syndrome and fell dead in some populations in 2008. This event raised suspicions about the toxicity of melamine and all feeds containing melamine were immediately recalled. In this study, we investigated the rates of melamine accumulation and depletion in muscle and viscera of catfish to propose proper withdrawal periods. One group of catfish was fed a commercially available diet that contained 30, 100 and 300 mg melamine per kg diet for 14 days. To investigate residual melamine contents in muscle and viscera, other experimental groups were fed a melamine free diet after being fed melamine for 7 days. The residual amount of melamine was analyzed by LC-MS/MS. The melamine concentration in muscle was estimated to be 3.7 mg/kg after 6 days of feeding with a diet containing 300 mg melamine/kg. After 2 days of culture with a melamine free diet, the residual melamine was depleted and the concentration had decreased from 1.15 mg/kg to 0.19 mg/kg in the muscle of catfish fed a diet containing 300 mg melamine/kg for 7 days. The residual amount of melamine was reduced to 0.03 mg/kg in muscle after 7 days of culture with a melamine free diet and was undetectable after a prolonged culture period of 14 days. Catfish tend to excrete melamine rapidly after oral administration and changes in body color were not observed during the short dosing period.

• Journal of the Korean Wood Science and Technology
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• 제24권4호
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• pp.32-39
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• 1996

The overall purpose of this study was to investigate the dimensional changes of melamine sheet laminated medium density fiberboard(MDF) floorings by sub-heating system(Ondol). This study was also conducted to improve the properties of melamine sheet laminated MDF floorings. The effects of density, resin content, manufacturing speed of MDF and types of melamine sheet on dimensional and weight changes of floorings were investigated. The results were as followings. 1. Dimensional and weight change of melamine sheet laminated MDF flooring by heating decreased with decreasing the density of MDF. 2. Dimensional and weight change of melamine sheet laminated MDF flooring by heating decreased with increasing the resin content of MDF. 3. Dimensional and weight change of melamine sheet laminated MDF flooring by heating decreased with decreasing the manufacturing speed of MDF. 4. Dimensional change of melamine sheet laminated MDF flooring in width direction by heating was doubled than that in machine direction. 5. Dimensional change and curling of high pressure melamine laminate(HPM) laminated MDF flooring by heating was less than those of low pressure melamine laminate(LPL) flooring. 6. Weight loss of melamine sheet laminated MDF flooring by heating has linear relationship with shrinkage.

• Journal of the Korean Wood Science and Technology
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• 제47권5호
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• pp.579-586
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• 2019

This work examined effects of the synthesis method and melamine content of melamine-urea-formaldehyde (MUF) resins on the bond-line features (i.e. resin penetration and bond-line thickness) in plywood. Two synthesis methods (MUF-A and MUF-B) and three melamine contents (5, 10, and 20%) were employed to prepare MUF resins. The MUF-A resins at three melamine contents were prepared by a simultaneous reaction of melamine, urea, and formaldehyde, while the MFU-B resins were prepared by reacting melamine at the same levels with formaldehyde followed by urea. The results showed that higher melamine content increased the viscosity of MUF-A and MUF-B resins. The resin penetration of MUF-A resins decreased by 48% while those of MUF-B resins increased by 16% at 20% melamine content. As a result, the MUF-A resins had greater bond-line thickness than those of MUF-B resins as the melamine content increased. The MUF-B resins resulted in thinner bond-line and greater resin penetration compared to those of MUF-A resins. The results suggested that MUF-B resins prepared with 20% melamine content had a proper combination of resin penetration and bond-line thickness that could produce plywood panel with a better adhesion performance.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 1999년도 추계학술대회 논문집
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• pp.498-500
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• 1999

Polyacetals with melamine were investigated in terms of mechanical properties. It was found that tensile strength, impact strength and elongation were decreased with the increase of melamine content up to 30 par, flexural strength had no remarkable changes. For master-batch using polyurethane as carrier resin, in which the ratio of polyurethane to melamine was 2:1, tensile strength and flexural strength were decreased and impact strength remained unchanged with melamine me content.

• 한국동물위생학회지
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• 제32권4호
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• pp.381-383
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• 2009

From Oct. 2008 to Oct. 2009, 619 livestock products sold in Incheon were examined for melamine contamination. HPLC was used to detect the melamine concentration from various products. $C_{18}$ column $(3.9\times150mm,\;4{\mu}m)$ was applied with a phase composed of 10mM citric acid and 10mM sodium octane sulfonate : acetonitrile (in ratio 90:10) pumped isocratically at 1.0ml/min. Melamine was not detected from any of the products at the level of LOD 0.03mg/kg and LOQ 0.08mg/kg, suggesting that no melamine contamination was ascertained in livestock products in Incheon area. However, further tests should be done to detect other melamine analogues for the evaluation of toxicity and safety of melamine and cyanuric acid in the future.

• Molecular & Cellular Toxicology
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• 제5권3호
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• pp.243-249
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• 2009

Melamine, which is used to produce melamine resin for various industrial applications, has a high nitrogen content by mass. For this reason, it has been illegally added to foods to increase their apparent protein content. In the present investigation, melamine-induced oxidative damage of human lymphocyte DNA was evaluated by Comet assay. The in vitro oxidative DNA damage caused by melamine increased in a dose-dependent manner. This DNA damage was significantly inhibited by treatment with ascorbate. Moreover, the traditional Korean medicinal herb, named Acanthopanax, red ginseng and green tea markedly reduced the DNA damage. Various edible plant extracts also inhibited melamine-induced oxidative DNA damage in vitro. Melamine enhanced intracellular ROS generation, and this effect was suppressed by treatment with various antioxidants.

• Food Science and Biotechnology
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• 제18권5호
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• pp.1199-1203
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• 2009

Melamine is a chemical intermediate to manufacture amino resins and plastics, which cannot be used as food additive since it can cause kidney stones. A qualitative determination method of melamine residue in powdered and liquid milk was developed using Fourier transform infrared (FTIR) spectroscopic technique. The calibration sets consisted of 21 standard melamine solutions, in which 1% trichloroacetic acid aqueous solution and acetonitrile (3:1, v/v) were used as solvent. The model was validated using 10 standard melamine solutions which were unused to build up the calibration set. Infrared (IR) absorbance peaks specific to almost all chemical groups in melamine molecule were shown in the spectral range between 1,100 and 1,800/cm. Combined partial least squares (PLS)-$2^{nd}$ derivative calibration model coupled with mean centering (MC) mathematical enhancement showed the highest correlation coefficients ($R^2$>0.99). In brief, the FTIR technique can be used for quantitative analysis of melamine in milk samples.

• Journal of the Korean Wood Science and Technology
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• 제45권4호
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• pp.409-418
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• 2017

This work attempted to manufacture glued-laminated timber (Glulam) bonded with melamine-urea-formaldehyde (MUF) resin adhesives at various melamine contents from 20% to 50% under high frequency (HF) heating for a very short time. Two preparation methods were employed to prepare MUF resin adhesives with different melamine contents: one-batch method of synthesizing MUF resins in a single batch, and two-batch method of mixing urea-formaldehyde (UF) resin with melamine-formaldehyde (MF) resin that had been synthesized separately. As the melamine content increased, the gelation time and peak temperature of MUF resins decreased. The adhesion performance of plywood showed that the one-batch MUF resin adhesive with 50% melamine content only satisfied the standard requirement of water resistance. Thus, the one-batch MUF resin adhesive with 50% melamine content was applied for bonding wood lamina from four softwood species such as Japanese larch, Korean red pine, Korean pine and Japanese cedar to manufacture Glulam under HF heating. All Glulam samples bonded with the one-batch MUF resin adhesives with 50% melamine content except those from Korean Red Pine satisfied the requirement in water soaking or boiling water delamination test as an exterior grade Glulam. The presence of rosin in Korean Red Pine was believed to be responsible for its poor adhesion. These results showed that the one-batch MUF resin adhesives with 50% melamine content provided acceptable water resistance with exterior grade Glulam manufactured under HF heating.

• Journal of Dairy Science and Biotechnology
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• 제27권1호
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• pp.1-12
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• 2009

In 2008, baby formula containing melamine was found to be responsible for a large outbreak of renal failure in infants in China. A total of 294,000 infants were hospitalized, and at least 6 babies died due to ingestion of the tainted formula. Melamine contains high levels of nitrogen (>60%), which is used as an indicator of protein content. Therefore, high levels of melamine in infant formula were thought to be the result of deliberate contamination m an attempt to increase its apparent protein content. Following inspections by China's national inspection agency, assorted products from at least 22 dairy manufacturers across China were found to have varied levels of melamine (range: 0.096196.61 mg/kg). Melamine co-exposure with cyanuric acid can induce acute melamine-cyanurate crystal nephropathy, which can lead to renal failure at much lower doses than if either compound were ingested alone. However, currently, there are very few data on melamine analogues other than cyanuric acid. At an expert meeting of the WHO and FAO held to review toxicological aspects of melamine and cyanuric acid on December 14, 2008, a new tolerable daily intake (TDI) of melamine was established that could be applied to the entire population, including infants. Therefore, a risk assessment of the various theoretical melamine contamination levels in infant formula and selected representative foods (other than infant formula and sole-source nutrition products) is urgently needed for Korean babies and children up to 7 years of age. Although the undetectable level regulation for infant formula may be low enough to guarantee the safety of babies under the age of 1 year (including premature babies), the melamine standard of 2.5 ppm for foods other than baby formula could be insufficient to protect the 95th percentile population aged 1~2 years because of this demographic's high consumption of milk, yogurt, and soy milk (hazard index = 1.79). Because TDIs are chronic values intended to protect an individual over his/her lifetime, occasional modest ingestion in excess of the TDI is not likely to be a health concern. However, children aged 1~2 years may have renal systems that are comparatively more sensitive to the crystallization of melamine and its analogues. Therefore, governmental jurisdictions may need to practice more prudent management of food items that could raise the melamine exposure for this population.