• ETRI Journal
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• v.30 no.1
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• pp.89-100
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• 2008

We consider the feature recombination technique in a multiband approach to speaker identification and verification. To overcome the ineffectiveness of conventional feature recombination in broadband noisy environments, we propose a new subband feature recombination which uses subband likelihoods and a subband reliable-feature selection technique with an adaptive noise model. In the decision step of speaker recognition, a few very low unreliable feature likelihood scores can cause a speaker recognition system to make an incorrect decision. To overcome this problem, reliable-feature selection adjusts the likelihood scores of an unreliable feature by comparison with those of an adaptive noise model, which is estimated by the maximum a posteriori adaptation technique using noise features directly obtained from noisy test speech. To evaluate the effectiveness of the proposed methods in noisy environments, we use the TIMIT database and the NTIMIT database, which is the corresponding telephone version of TIMIT database. The proposed subband feature recombination with subband reliable-feature selection achieves better performance than the conventional feature recombination system with reliable-feature selection.

• Korean Journal of Pharmacognosy
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• v.32 no.4 s.127
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• pp.338-343
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• 2001

The extract and fractions of Rumex acetosa (Polygonaceae), a Korean medicinal plant, were examined for their cytotoxicities against five cultured human tumor cell lines, i.e. A549 (non-small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nerve system) and HCY15 (colon), using the SRB (sulforhodamine-B) method in vitro and antimutagenic activities by Ames test with Salmonella typhimurium TA98 and TA100 and SOS chromotest with E. coli PQ37. Among the tested samples, the methylene chloride fraction strongly inhibited the proliferation of each examined tumor cell line with $IC_{50}$ values ranged from 13.2 to $18.7\;{\mu}g/ml$ and showed potent antimutagenic activities with 96.1% and 96.7% at the concentration of 1 mg/plate against the mutagens, NPD and sodium azide, respectively. Its antigenotoxic activity was also very effective at the final concentration of $10\;{\mu}g/reaction$ tube against the mutagens, MNNG and NQO by SOS chromotest.

• Proceedings of the IEEK Conference
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• 2009.05a
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• pp.37-39
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• 2009

In the research of speech recognition, locating the beginning and end of a speech utterance in a background of noise is of great importance. Since the background noise presenting to record will introduce disturbance while we just want to get the stationary parameters to represent the corresponding speech section, in particular, a major source of error in automatic recognition system of isolated words is the inaccurate detection of beginning and ending boundaries of test and reference templates, thus we must find potent method to remove the unnecessary regions of a speech signal. The conventional methods for speech endpoint detection are based on two simple time-domain measurements - short-time energy, and short-time zero-crossing rate, which couldn't guarantee the precise results if in the low signal-to-noise ratio environments. This paper proposes a novel approach that finds the Lyapunov exponent of time-domain waveform. This proposed method has no use for obtaining the frequency-domain parameters for endpoint detection process, e.g. Mel-Scale Features, which have been introduced in other paper. Comparing with the conventional methods based on short-time energy and short-time zero-crossing rate, the novel approach based on time-domain Lyapunov Exponents(LEs) is low complexity and suitable for Digital Isolated Word Recognition System.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.48 no.5
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• pp.392-396
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• 2003

Maysin, a C-glycosylflavone, was isolated from the silks of maize, Zea mays L. The ESI mass spectrum indicates that molecular weight of maysin is $577\textrm{M}^+$m/z, and the ether-linked sugar is rhamnose, $431\textrm{M}^+$m/z (MW$^{+}$-146). The DPPH (1,1-Diphenyl-2-picrylhydrazyl) radical scavenging activity of maysin was higher than that of rutin. However, as compared with its aglycon luteolin, maysin showed the relatively moderate DPPH scavenging activity mainly due to the glycosylation of two sugars moieties, keto-fucose and rhamnose. In the in vitro cytotoxicity test against the five human tumor cell lines such as lung (A549), ovarian (SK-OV-3), melanoma (SK-MEL-2), central nerve system (XF-489), and colon (HCT-15), maysin exhibited the relatively weaker activities than cisplatin. The $\textrm{ED}_{50}$ values of maysin were 62.24, 43.18, 16.83, 37.22, and 32.09/$m\ell$, respectively. Result suggests that maysin is a potential cytotoxicity compound, particularly for human colon, central nerve system, and melanoma tumors.s.

• MALSORI
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• no.54
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• pp.27-43
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• 2005

Existing standard speech coders can provide speech communication of high quality while they degrade the performance of speech recognition systems that use the reconstructed speech by the coders. The main cause of the degradation is that the spectral envelope parameters in speech coding are optimized to speech quality rather than to the performance of speech recognition. For example, mel-frequency cepstral coefficient (MFCC) is generally known to provide better speech recognition performance than linear prediction coefficient (LPC) that is a typical parameter set in speech coding. In this paper, we propose a speech coder using MFCC instead of LPC to improve the performance of a server-based speech recognition system in network environments. However, the main drawback of using MFCC is to develop the efficient MFCC quantization with a low-bit rate. First, we explore the interframe correlation of MFCCs, which results in the predictive quantization of MFCC. Second, a safety-net scheme is proposed to make the MFCC-based speech coder robust to channel error. As a result, we propose a 8.7 kbps MFCC-based CELP coder. It is shown from a PESQ test that the proposed speech coder has a comparable speech quality to 8 kbps G.729 while it is shown that the performance of speech recognition using the proposed speech coder is better than that using G.729.

• The Journal of the Acoustical Society of Korea
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• v.29 no.4
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• pp.265-269
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• 2010

This paper proposes a novel spectral audio feature, spectral contrast MFCC (SCMFCC), and studies its performance on the musical genre classification. For a successful musical genre classifier, extracting features that allow direct access to the relevant genre-specific information is crucial. In this regard, the features based on the spectral contrast, which represents the relative distribution of the harmonic and non-harmonic components, have received increased attention. The proposed SCMFCC feature utilizes the spectral contrst on the mel-frequency cepstrum and thus conforms the conventional MFCC in a way more relevant for musical genre classification. By performing classification test on the widely used music DB, we compare the performance of the proposed feature with that of the previous ones.

• Applied Biological Chemistry
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• v.41 no.2
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• pp.187-190
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• 1998

The cytotoxic activity of MeOH extracts of the freeze-dried silkworm (Bombyx mori)-derived materials (4th instar larvae, female and mate pupae, virgin female and male adult), dried Beauveria bassiana-infected silkworm larvae, dried feces from the 4th instar larvae B. mori, and dried mulberry (Morus alba)-derived materials (leaves, fruits, root barks) in vitro was evaluated by sulforhodamine B assay, using the five human solid A 549 lung, SK-OV-2 ovarian, SK-MEL-2 melanoma, XF-498 CNS and HCT-15 colon tumor cell lines. The responses varied with both cell line and material used. The 70% hot MeOH extract of B. mori feces (BFH) revealed potent cytotoxic activity against model tumor cell lines whereas moderate activity was observed from the MeOH extract of B. mori feces. M. alba root barks, and M. alba fruits. The other test materials were ineffective. Because of its potent cytotoxic activity, the activity of each solvent fraction from the BFH was determined. Chloroform and ethyl acetate fractions showed the most potent cytotoxic activity. In conclusion, our results may be an indication of at least one of the pharmacological actions of B. mori feces. M. alba root barks, and M. alba fruits.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.28 no.3
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• pp.30-47
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• 2015

Objective : Melanoma is a very critical and devastating disease. Although many people have depended on surgical operation in melanoma treatment, they have placed importance on non-invasive methods constantly. So we planned to establish a research methodology by analysing existing articles containing conservative melanoma treatments in Journals of Korean Medicine published in Korea.Methods : Using search words of anti-cancer, B16, cancer, lung metastasis, melanoma, metastasis, S-100, SK-MEL, tumor, tyrosinase, we collected 26 articles by searching internet portal sites as following;Using search words of anti-cancer, B16, cancer, lung metastasis, melanoma, metastasis, S-100, SK-MEL, tumor, tyrosinase, we collected 26 articles by searching internet portal sites as followinghttp://oasis.kiom.re.kr,http://www.koreantk.com,http://www.riss.kr,http://www.dbpia.co.kr,http://www.ndsl.kr,http://kiss.kstudy.com,http://www.naver.com,http://www.google.com.Result : The number of articles is 26 and in the year of 2003, 2004 is ranked the highest number in publication. The journal of acupuncture & moxibustion society ranked the highest(30.8%). 2 and 4 authors ranked the highest(26.9%) in number of authors. T-test ranked the highest(58.1%) in statistics methods. P.O. med indicated in 11 articles and Pharmacopuncture in 15 articles. B16 murine melanoma cell was indicated in 25 articles by cancer-induced methods. In measurement, T cell activity was indicated in 14 articles, NK activity in 4 articles, IL-2 in 6 articles, apoptosis in 1 article, lung metastasis in 14 articles.Conclusion : Considering overall results, it is necessary to diversify cancer-induced methods and measurement methods in experimental melanoma research.

• Journal of the Institute of Convergence Signal Processing
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• v.10 no.3
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• pp.170-175
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• 2009

In this paper, we propose real time automatic speaker verification (ASV) system to protect personal information on personal digital assistant (PDA) device. Recently, the capacity of PDA has extended and been popular, especially for mobile environment such as mobile commerce (M-commerce). However, there still exist lots of difficulties for practical application of ASV utility to PDA device because it requires too much computational complexity. To solve this problem, we apply the method to relieve the computational burden by performing the preprocessing such as spectral subtraction and speech detection during the speech utterance. Also by applying the hidden Markov model (HMM) optimal state alignment and the sequential probability ratio test (SPRT), we can get much faster processing results. The whole system implementation is simple and compact enough to fit well with PDA device's limited memory and low CPU speed.

• The Korea Journal of Herbology
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• v.21 no.2
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• pp.151-158
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• 2006

Objectives : The purpose of the present study is to observe the neuroprotective effect of the $NeuBo153^{\circledR}$ on transient focal cerebral ischemia in rats. Methods : $NeuBo153^{\circledR}$ was made by mixing the herbs, mainly the root of Panax ginseng, the root of Rehmannia glutinosa and Poria cocos, the stem bark of Acanthopanax senticosus, the root of Scutellaria baicalensis and Mel, and heating for 96 hours. Transient Focal cerebral ischemia (2 h of ischemia, 22 h of reperfusion) was induced by intraluminal suture method with SD rats. Sensory motor function was tested by rotarod test, prehensile traction test, beam balance test and foot fault test at 24 h after ischemia. The brain slices were stained by 2% 2, 3, 5-triphenyltetrazolium chloride and the infarct volume was measured by graphic analyzer at 24 h after ischemia. Results : $NeuBo153^{\circledR}$ treated group did not show significant differences compared with vehicle treated group in body temperature. Oral administration of $NeuBo153^{\circledR}$ reduced brain infarct volume by 29.7% compared with vehicle treated group. $NeuBo153^{\circledR}$ also showed protective effects on sensory motor functional deficits. Conclusion : $NeuBo153^{\circledR}$ treatment reduced brain damage and improved functional deficits induced by MCAo. It showed neuroprotective effects even when treatment was relayed 2 h after injury. Further research is required to evaluating long term functional recovery am accurate therapeutic range and mechanisms.