• Title/Summary/Keyword: MegaStudy

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Efficacy and safety of equine cartilage for rhinoplasty: a multicenter double-blind non-inferiority randomized confirmatory clinical trial

  • Chang, Yongjoon;Yun, Hyunjong;Choi, Jong Woo;Suh, Joong Min;Jeong, Woo Shik;Park, Hojin;Kang, Min Kyu;Shin, Yongho;Kim, Kuylhee;Chung, Chul Hoon
    • Archives of Craniofacial Surgery
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    • v.23 no.4
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    • pp.152-162
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    • 2022
  • Background: The efficacy and safety of equine cartilage as a competent xenograft material for rhinoplasty were evaluated and compared to the outcomes of rhinoplasty using silicone implants. Methods: We performed a multicenter, double-blind, non-inferiority, and randomized confirmatory study. Fifty-six patients were randomized 1:1 to the study group (using MegaCartilage-E) and control group (using silicone implants). The Rhinoplasty Outcome Evaluation (ROE) score, photo documentation, Global Aesthetic Improvement Scale (GAIS), and adverse event data were obtained until 12 months after surgery. The primary efficacy, which is the change in ROE score 6 months after surgery, was assessed in the modified intention-to-treat set. The secondary efficacy was evaluated in the per-protocol set by assessing the change in ROE score 6 and 12 months after surgery and nasofrontal angle, the height of the nasion, and GAIS 1, 6, and 12 months after surgery. Results: The change in ROE score of the study group was non-inferior to that of the control group; it increased by 24.26±17.24 in the study group and 18.27±17.60 in the control group (p= 0.213). In both groups, all secondary outcome measures increased, but there was no statistical difference. In the safety set, treatment-emergent adverse events occurred in 10 patients (35.71%) in the study group and six patients (21.43%) in the control group (p= 0.237). There were 13 adverse device events in the study group and six adverse device events in the control group (p= 0.515). Conclusion: Processed equine cartilage can be used effectively and safely as xenograft material for rhinoplasty.

Seismic Performance Evaluation of Concrete-filled U-shaped Mega Composite Beams (콘크리트 채움 U형 메가 합성보의 내진성능 평가)

  • Lee, Cheol Ho;Ahn, Jae Kwon;Kim, Dae Kyung;Park, Ji-Hun;Lee, Seung Hwan
    • Journal of Korean Society of Steel Construction
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    • v.29 no.2
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    • pp.111-122
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    • 2017
  • In this paper, the applicability of a 1900mm-deep concrete-filled U-shaped composite beam to composite ordinary moment frames (C-OMFs) was investigated based on existing test results from smaller-sized specimens and supplemental numerical studies since full-scale seismic testing of such a huge sized beam is practically impossible. The key issue was the web local buckling of concrete-filled U section under negative bending. Based on 13 existing test results compiled, the relationship between web slenderness and story drift capacity was obtained. From this relationship, a 1900mm-deep mega beam, fabricated with 25mm-thick plate was expected to experience the web local buckling at 2% story drift and eventually reach a story drift over 3%, thus much exceeding the requirements of C-OMFs. The limiting width to thickness ratio according to the 2010 AISC Specification was shown to be conservative for U section webs of this study. The test-validated supplemental nonlinear finite element analysis was also conducted to further investigate the effects of the horizontal stiffeners (used to tie two webs of a U section) on web local buckling and flexural strength. First, it is shown that the nominal plastic moment under negative bending can be developed without using the horizontal stiffeners, although the presence of the stiffeners can delay the occurrence of web local buckling and restrain its propagation. Considering all these, it is concluded that the 1900mm-deep concrete-filled U-shaped composite beam investigated can be conservatively applied to C-OMFs. Finally, some useful recommendations for the arrangement and design of the horizontal stiffeners are also recommended based on the numerical results.

The influence of intentional mobilization of implant fixtures before osseointegration (골유착전 임플란트 고정체의 의원성 동요가 골결합에 미치는 영향)

  • Cho, Jin-Hyun;Jo, Kwang-Heon;Cho, Sung-Am;Lee, Kyu-Bok;Lee, Cheong-Hee
    • The Journal of Korean Academy of Prosthodontics
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    • v.50 no.3
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    • pp.149-155
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    • 2012
  • Purpose: The purpose of this study was to investigate the influence of mobilization on bone-implant interface prior to osseointegration of fixtures. Materials and methods: The experimental implants (3.75 mm in diameter, 4.0 mm in length) were made of commercially pure (Grade IV) titanium, and were treated with RBM ($MegaGen^{(R)}$: Ca-P). The 80 implants (two in each tibia) were inserted into the monocortical tibias of 20 rabbits which each weighed more than 3.5 kg (Female, New Zealand White). According to the removal torque interval, the groups were divided into 10 groups, Group I (6 wks), Group II (4 days+6 wks), Group III (4 days+1 wk+6 wks), Group IV (1 wk+6 wks), Group V (1 wk+1 wk+6 wks), Group VI (2 wks+6 wks), Group VII (2 wks+ 1 wk+6 wk), Group VIII (3 wks+6 wks), Group IX (3 wks+1 wk+6 wks) and Group X (10 wks). The control groups were Group I and X, the removal torque was measured at 6 wks and 10 wks with a digital torque gauge (Mark-10, USA). In the experimental groups, the removal torque was given once or twice before the final removal torque and the value was measured each time. After which, the implants were put back where they had been except the control groups. All the experimental groups were given a final healing time (6 wks) before the final removal torque test, in which values were compared with the control groups and the 1st and/or 2nd removal torque values in each experimental group. Results: In the final removal torque tests, the removal torque value of Group X (10 wks) was higher than that of Group I (6 wks) in the control groups but not statistically different. There were no significant differences between the experimental groups and control groups (P>.05). In the first removal torque comparison, the experimental groups (4 days or 1 wk) values were significantly lower than the other experimental groups (2 wks or 3 wks). In the comparison of each experimental group according to healing time, the final removal torque value was significantly higher than the 1st torque test value. Conclusion: Once or twice mobilization of fixture prior to osseointegration did not deter the final bone to implant osseointegration, if sufficient healing time was given.

EFFECT OF CROSS-SECTIONAL AREA OF 6 NICKEL-TITANIUM ROTARY INSTRUMENTS ON THE FATIGUE FRACTURE UNDER CYCLIC FLEXURAL STRESS: A FRACTOGRAPHIC ANALYSIS (반복 굽힘 스트레스 하에서 전동식 니켈-티타늄 파일의 단면적의 크기가 피로파절에 미치는 영향 : 파절역학 분석)

  • Hwang, Soo-Youn;Oh, So-Ram;Lee, Yoon;Lim, Sang-Min;Kum, Kee-Yeon
    • Restorative Dentistry and Endodontics
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    • v.34 no.5
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    • pp.424-429
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    • 2009
  • This study aimed to assess the influence of different cross-sectional area on the cyclic fatigue fracture of Ni-Ti rotary files using a fatigue tester incorporating cyclical axial movement. Six brands of Ni-Ti rotary files (ISO 30 size with. 04 taper) of 10 each were tested: Alpha system (KOMET), HeroShaper (MicroMega), K3 (SybronEndo), Mtwo (VDW), NRT (Mani), and ProFile (Dentsply). A fatigue-tester (Denbotix) was designed to allow cyclic tension and compressive stress on the tip of the instrument. Each file was mounted on a torque controlled motor (Aseptico) using a 1:20 reduction contra-angle and was rotated at 300 rpm with a continuous, 6 mm axial oscillating motion inside an artificial steel canal. The canal had a $60^{\circ}$ angle and a 5 mm radius of curvature. Instrument fracture was visually detected and the time until fracture was recorded by a digital stop watch. The data were analyzed statistically. Fractographic analysis of all fractured surfaces was performed to determine the fracture modes using a scanning electron microscope. Cross-sectional area at 3 mm from the tip of 3 unused Ni-Ti instruments for each group was calculated using Image-Pro Plus (Imagej 1.34n, NIH). Results showed that NRT and ProFile had significantly longer time to fracture compared to the other groups (p < .05). The cross-sectional area was not significantly associated with fatigue resistance. Fractographycally, all fractured surfaces demonstrated a combination of ductile and brittle fracture. In conclusion, there was no significant relationship between fatigue resistance and the cross-sectional area of Ni-Ti instruments under experimental conditions.

A Study on User's Mental Model for Services and User Interface of Interactive TV -Focusing on a Comparison DCATV and IPTV (인터랙티브 의 서비스 및 인터페이스에 TV 대한 사용자의 멘탈모델에 관한 연구 -DCATV(Digital Cable TV)와 IPTV(Internet Protocol TV) 비교를 중심으로)

  • Yeoun, Myeong-Heum;Ryu, Su-Min;Han, Ah-Reum;Cheon, Jeong-Eun
    • 한국HCI학회:학술대회논문집
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    • 2009.02a
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    • pp.1038-1044
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    • 2009
  • Interests for User Interface directly influencing on usability are also growing as the competition between DCATV and IPTV come to the surface, according to getting activated Interactive TV market. Therefore, this study has the purpose to understand mental models of users for Interactive TV service & Interface. The methods for this study are as follows. First, as the step considering literature study, we compared differences between DCATV and IPTV and caught up the concepts of DCATV and IPTV among some types of Interactive TV. Second, we examinated and analysed Hello TV, C&M, Broad&TV, MegaTV, myLGtv as the step of analysis for examples for Interactive TV. Third, as the step of researches observing users we analysed usability problems caused by differences of mental models between DCATV and IPTV. As a result, we could find there are some differences for mental model of users in Interface & services between DCATV and IPTV Especially, it was found that users feel confused very much regarding perception of real time broadcasting and VOD. We regards this findings can be used as basic for concept makings of Interactive TV, when TV interface is developed in the future.

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Geo-Morphological Study of Sand Dune for Railway Project in UAE (UAE 내 철도프로젝트 수행을 위한 사막 사구의 지형학적 특성 연구)

  • Moon, Joon-Shik;Kim, Jae-Young;Lee, Seung-Bok
    • Journal of the Korean Geotechnical Society
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    • v.28 no.9
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    • pp.17-22
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    • 2012
  • Wind blown sand is expected to disrupt the operation of the railway as the presented railway project in this paper consists of large earthworks in extreme topography of the mega dune fields. For successful railway construction in sand dune area, effective mitigation measure is the most important factor to protect the track from wind blown sand. The effective mitigation measure requires an integrated consideration of the earthworks geometry and the direct control measures such as fence system. Basically there's no perfect measure protecting railway track from wind blown sand, and it would be more economical and effective to develop robust, deliberate maintenance program for track and direct control measure on the basis of geo-morphological study. The purpose of this study is to identify the large scale geo-morphological terrains and specific sand dune morphology in the project area in UAE and estimate the direction and migration rate for sand dunes with the local variations in prevailing wind directions by undertaking literature review, and aerial photographs, satellite images, and ground studies.

Estimation of Dietary Iodine Intake of Koreans through a Total Diet Study (TDS) (한국형 총식이조사에 근거한 우리 국민의 식품 기인 요오드 섭취량 추정)

  • Lee, Jeeyeon;Yeoh, Yoonjae;Seo, Min Jeong;Lee, Gae Ho;Kim, Cho-il
    • Korean Journal of Community Nutrition
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    • v.26 no.1
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    • pp.48-55
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    • 2021
  • Objectives: This study was conducted to estimate the dietary iodine intake of Koreans by a Total Diet Study (TDS) which provides 'closer-to-real' estimates of exposure to hazardous materials and nutrients through an analysis of table-ready (cooked) samples of foods. Methods: Dietary intake data from 2013-2017 Korea National Health and Nutrition Examination Survey (KNHANES) was used to select representative foods (RFs) for iodine analysis. A total of 115 RFs were selected and 158 'RF × cooking method-combination' pairs were derived by pairing each RF to corresponding cooking method(s) used more frequently. RFs were collected from 9 mega-markets in 9 metropolitan cities nationwide and mixed into composites prior to cooking preparation to a 'table ready' state for iodine analysis by inductively coupled plasma mass spectrometry. Iodine intake of Koreans was estimated based on the food intake data of the 2016-2018 KNHANES. Results: High iodine content was detected in seaweeds such as sea mustard and kelp. The mean iodine intake/capita/day was 418.4 ㎍ and the median value was 129.0 ㎍. Seaweeds contributed to 77.4% of the total iodine intake and the contribution by food item was as follows: sea mustard (44.0%), kelp (20.4%), laver (13.1%), milk (3.9%), egg (3.5%). Compared to the Dietary Reference Intakes for Koreans 2020, the proportion of people with iodine intake exceeding the tolerable upper intake level or below the estimated average requirement was high in the physiologically vulnerable groups (infants, children, pregnant women, and lactating women). Conclusions: The results, drawn from a TDS, are regarded closer to real estimates for iodine intake of Koreans compared with values in existing literature, which were based on a very limited variety of foods. On the other hand, it seems necessary to seek out solutions for the problematic iodine intake among physiologically vulnerable groups through in-depth analyses on food intake data collected with significant scale & quality.

Evaluation on Geological Structures to Secure Long-term Safety of Nuclear Facility Sites (원자력시설물 부지의 장기적 안전성 확보를 위한 지질구조 평가)

  • Jin, Kwangmin;Kim, Young-Seog
    • Economic and Environmental Geology
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    • v.51 no.2
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    • pp.149-166
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    • 2018
  • Many large earthquakes have continuously been reported and resulted in significant human casualties and extensive damages to properties globally. The accident of Fukushima nuclear power plant in Japan was caused by a mega-tsunami, which is a secondary effect associated with the Tohoku large earthquake (M=9.0, 2011. 3. 11.). Most earthquakes occur by reactivation of pre-existing active faults. Therefore, the importance of paleoseismological study have greatly been increased. The Korean peninsula has generally been considered to be a tectonically stable region compared with neighboring countries such as Japan and Taiwan, because it is located on the margin of the Eurasian intra-continental region. However, the recent earthquakes in Gyeongju and Pohang have brought considerable insecurity on earthquake hazard. In particular, this region should be secure against earthquake, because many nuclear facilties and large industrial facilities are located in this area. However, some large earthquakes have been reported in historic documents and also several active faults have been reported in southeast Korea. This study explains the evaluation methods of geological structures on active fault, fault damage zone, the relationship between earthquake and active fault, and respect distance. This study can contribute to selection of safe locations for nuclear facilities and to earthquake hazards and disaster prevention.

Image Processing Algorithm for Crack Detection of Sewer with low resolution (저해상도 하수관거의 균열 탐지를 위한 영상처리 알고리즘)

  • Son, Byung Jik;Jeon, Joon Ryong;Heo, Gwang Hee
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.2
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    • pp.590-599
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    • 2017
  • In South Korea, sewage pipeline exploration devices have been developed using high resolution digital cameras of 2 mega-pixels or more. On the other hand, most devices are less than 300 kilo-pixels. Moreover, because 100 kilo-pixels devices are used widely, the environment for image processing is very poor. In this study, very low resolution ($240{\times}320$ = 76,800 pixels) images were adapted when it is difficult to detect cracks. Considering that the images of sewers in South Korea have very low resolution, this study selected low resolution images to be investigated. An automatic crack detection technique was studied using digital image processing technology for low resolution images of sewage pipelines. The authors developed a program to automatically detect cracks as 6 steps based on the MATLAB functions. In this study, the second step covers an algorithm developed to find the optimal threshold value, and the fifth step deals with an algorithm to determine cracks. In step 2, Otsu's threshold for images with a white caption was higher than that for an image without caption. Therefore, the optimal threshold was found by decreasing the Otsu threshold by 0.01 from the beginning. Step 5 presents an algorithm that detects cracks by judging that the length is 10 mm (40 pixels) or more and the width is 1 mm (4 pixels) or more. As a result, the crack detection performance was good despite the very low-resolution images.

An Empirical Study on Improving Competitiveness of Korean Shipping Industry (한국 해운산업의 경쟁력강화 정책방안에 관한 실증연구)

  • Lee, Choong-Bae;Noh, Jin-Ho
    • Journal of Korea Port Economic Association
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    • v.26 no.3
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    • pp.259-278
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    • 2010
  • This study analyzes the achievement of the shipping policies and the priority for the promotion of such policies, in order to consider the features of the shipping industries in Korea and other advanced shipping countries and manage the rapidly changing shipping environment actively. Based on such analysis, this study also discusses the promotional strategy to strengthen the international competitiveness of the shipping industry. Regarding the promotion of the related policies, it is necessary to establish a base for growth, strengthen a capacity of leading the market, and create an opportunity in the market. By considering such three factors, it has become known that the establishment of the market order is important for the establishment of a base for growth. It is important to consider the advancement of the shipping tax system. Also, the information-orientation and the knowledge-industrialization of the shipping industry need to be considered. In order to strengthen a capacity of leading the market, the stable security of the labor force in the shipping industry is the most important factor. Also, it is important to consider the development and the upbringing of the global mega career and the shipping business. Regarding the creation of an opportunity in the market, it is important to expand the range of the shipping exchange between South Korea and North Korea, which will influence the administrative and the operative results related with the promotion of the related policies.