• Healthcare Informatics Research
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• v.24 no.4
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• pp.317-326
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• 2018

Objectives: The demand for hospice has been increasing among patients with cancer. This study examined the current hospice referral scenario for terminally ill cancer patients and created a data form to collect hospice information and a modified health information exchange (HIE) form for a more efficient referral system for terminally ill cancer patients. Methods: Surveys were conducted asking detailed information such as medical instruments and patient admission policies of hospices, and interviews were held to examine the current referral flow and any additional requirements. A task force team was organized to analyze the results of the interviews and surveys. Results: Six hospices completed the survey, and 3 physicians, 2 nurses, and 2 hospital staff from a tertiary hospital were interviewed. Seven categories were defined as essential for establishing hospice data. Ten categories and 40 data items were newly suggested for the existing HIE document form. An implementation guide for the Consolidated Clinical Document Architecture developed by Health Level 7 (HL7 CCDA) was also proposed. It is an international standard for interoperability that provides a framework for the exchange, integration, sharing, and retrieval of electronic health information. Based on these changes, a hospice referral scenario for terminally ill cancer patients was designed. Conclusions: Our findings show potential improvements that can be made to the current hospice referral system for terminally ill cancer patients. To make the referral system useful in practice, governmental efforts and investments are needed.

• BMB Reports
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• v.50 no.5
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• pp.237-246
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• 2017

Synapse is the basic structural and functional component for neural communication in the brain. The presynaptic terminal is the structural and functionally essential area that initiates communication and maintains the continuous functional neural information flow. It contains synaptic vesicles (SV) filled with neurotransmitters, an active zone for release, and numerous proteins for SV fusion and retrieval. The structural and functional synaptic plasticity is a representative characteristic; however, it is highly vulnerable to various pathological conditions. In fact, synaptic alteration is thought to be central to neural disease processes. In particular, the alteration of the structural and functional phenotype of the presynaptic terminal is a highly significant evidence for neural diseases. In this review, we specifically describe structural and functional alteration of nerve terminals in several neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD).

• Sleep Medicine and Psychophysiology
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• v.4 no.1
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• pp.29-38
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• 1997

Dementia is defined as a syndrome which is characterized by various impairments in cognitive functions, especially memory function. Most of the diagnostic criteria for dementia include memory impairment as on essential feature. Memory decline can be present as a consequence of the aging process. But it does not cause significant distress or impairment in social and occupational functionings while dementiadoes. Depression may also be associated with memory impairment. However, unlike dementia, depression dose not cause decrease in delayed verbal learning and recognition memory. In dementia, different features of memory impairment may be present depending on the involved area. Memory impairment in cortical dementia is affected by the disturbance of encoding of information and memory consolidation, while memory imparnene in subcortical denentiy is affected by the disturbance of retrieval in subcortical dementia.

• Journal of Information Management
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• v.41 no.3
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• pp.155-173
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• 2010

With the advanced learning and the diversity of topics, researchers on each area keenly feel the need of precise and a quick discovery of required information at any time. This study presents a way of constructing the automatic mapping system that can compare and analyze duplicated data and that describes the result by building an effective reference extraction method and another way of correcting the wrong form of used Chinese characters with Traditional Korean Medicine dictionary. With this innovation, data duplication on references and Chinese characters errors can be fixed. Under the situation that a number of references of newly published papers that can continuously be extracted.

• Korean Journal of Digital Imaging in Medicine
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• v.8 no.1
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• pp.21-26
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• 2006

Hospitals these days are trying to introduce the a practice has recently been generalized in the test or diagnosis process, where test results and images from different test labs are interlinked together. This process is identical to that of physical aspect in EMR process, which computerizes the paper results within the hospital. One of the prerequisites for the process of computerizing test results is the interface between clinical test devices in the test labs. However, due to the variety of prescription inputs, disparity of test result papers, complexity of job in test labs and diversify of interfaces among the different devices, interconnection with the hospital information system is a complicated job. A universal control of clinical test devices which have independent communication protocols has become possible by connecting them with an interface workstation. As for the patients, waiting time for test has been reduced, and, thanks to the synchronized result retrieval system, it has become possible to check the test results on the very day of the test. As a result, the length of hospitalization has been reduced, too. In terms of workflow, as the transfer of charts and transfer of result papers are separated, the embarrassing job of collecting result papers has disappeared. As patients' test appointment and the results processing can be made on-line, extra work for doctors have disappeared. And, thanks to the computerization of test results information management, the job of statistical processing has become convenient.

• Health Communication
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• v.12 no.1
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• pp.73-84
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• 2017

Purpose: As the internet use of teenagers become more common, the need for research on the relationship between the internet and youth depression has emerged. The purpose of this study is to investigate the relationship between internet use and adolescent depression. Methods: The subjects of this study were youth attending elementary($6^{th}$ grade), middle($2^{nd}$ grade), and high schools($2^{nd}$ grade) belonging to the Busan Metropolitan City Office of Education. Depression was assessed using the BDI depression scale. Internet functions were classified into 10 categories, and the degree of use by Internet functions was examined. The most frequently used Internet sites were surveyed. Univariate analysis using $X^2$ test and multivariate analysis using logistic regression analysis were conducted to find out the difference of internet and smartphone media function on depression according to elementary, middle and high school students. Results: Depression was higher of 13.2 times for students who use online transactions (goods purchase), 0.07 times for students who use 'bulletin board' activities in elementary students. Depression was higher of 1.55 times for those who use online transactions (purchasing goods), and 2.3 times for those who use adult sites for middle school students. Depression was higher of 2.1 times when using e-mail and 1.9 times when using other information retrieval for high school students. Conclusion: It is necessary to consider characteristics of internet utilizing pattern by school class in policy regulation and prevention program to reduce youth depression.

• Journal of Acupuncture Research
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• v.21 no.3
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• pp.283-302
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• 2004

Background : Angiogenesis is the proliferation of a network of blood vessels emanating from pre-existing vessels, supplying nutrients and oxygen and removing waste products. Angiogenesis occurs in a variety of normal physiologic and pathologic conditions and is regulated by a balance of stimulatory and inhibitory angiogenic factors. Excessive angiogenesis should be suppressed. However, if blood supply is insufficient, it should be encouraged. Hyul-Mek(血脈) or Hyul-Rark(血絡), known as blood vessels in western medicine, is deeply related to Chung-Ki-Hyul(精 氣 血). The goal of this study is to review the effects of herbal medicines on angiogenesis that is involved in wound healing and enhancement of blood supply. Methods : We conducted a systematic and comprehensive literature search for the identification, retrieval, and bibliographic management of independent studies to locate information on the topic. A computerized search of the published literature of Korea(KISS, RISS), China(CNKI), Japan(Kampo medicine, etc), and western countries(MEDLINE) was performed, and further supplemented with manual searches of print sources(1999 to 2003). Results : The herbal medicines with angiogenic activity were mainly found among herbs that carry replenish Shin-Cheng(補腎益精), foster Eum and improve the circulation of blood(養陰活血), or warm and circulate Kyung-Rark(溫經通絡). In particular, herbs with improve the circulation of blood and clear blood(活血化瘀) activity contain a significant amount of tannin, saponin, and pyrazine. Conclusion : Replenish Ki-Hyul(補氣血) and circulate Kyung-Rark(通經絡) could contribute to the induction of angiogenesis because various growth factors and proliferation, differentiation, and migration of vascular endothelial cells are involved in angiogenic activity.

• The Korean Journal of Nuclear Medicine
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• v.36 no.6
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• pp.317-324
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• 2002

Purpose: The use of statistical parametric mapping (SPM) program has increased for the analysis of brain PET and SPECT images. Montreal Neurological Institute (MNI) coordinate is used in SPM program as a standard anatomical framework. While the most researchers look up Talairach atlas to report the localization of the activations detected in SPM program, there is significant disparity between MNI templates and Talairach atlas. That disparity between Talairach and MNI coordinates makes the interpretation of SPM result time consuming, subjective and inaccurate. The purpose of this study was to develop a program to provide objective anatomical information of each x-y-z position in ICBM coordinate. Materials and Methods: Program was designed to provide the anatomical information for the given x-y-z position in MNI coordinate based on the Statistical Probabilistic Anatomical Map (SPAM) images of ICBM. When x-y-z position was given to the program, names of the anatomical structures with non-zero probability and the probabilities that the given position belongs to the structures were tabulated. The program was coded using IDL and JAVA language for 4he easy transplantation to any operating system or platform. Utility of this program was shown by comparing the results of this program to those of SPM program. Preliminary validation study was peformed by applying this program to the analysis of PET brain activation study of human memory in which the anatomical information on the activated areas are previously known. Results: Real time retrieval of probabilistic information with 1 mm spatial resolution was archived using the programs. Validation study showed the relevance of this program: probability that the activated area for memory belonged to hippocampal formation was more than 80%. Conclusion: These programs will be useful for the result interpretation of the image analysis peformed on MNI coordinate, as done in SPM program.

• Journal of the Korean Professional Engineers Association
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• v.24 no.6
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• pp.106-112
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• 1991

Electronics has different meanings to different people and in different countries. Hence, let me difine the term in the sense that it is used here. Electronics in the science and the technology of the passage of charged particles in a gas, in a vacumn, or in a semiconductor. The beginning of electronics came in 1895 when H. A. Lorentz postulated the existence of discrete charges called electrons. Two years later J.J. Thompson found these electrons experimentally. In the same year (1897) Braun built what was probaly the first electron tube, essentially a primitive cathode-ray tube. It was not until the start of the 20th century that electronics began to take technological shape. In 1904 Fleming invented the diode which he called a valve. This era begins with the invention of the transistor about 30 years ago. The history of this invention is interesting. M.J. Kelly, director of research(and later president of Bell Laboratories), had the foresight to realize that the telephone system needed electronic switching and better amplifiers. Vacuum tubes were not very reliable, principally because they generated a great deal of heat even when they were not being used, and, particularly, because filaments burned out and the tubes had to be replaced. In 1945 a solid-state physics group wa formed. The foregoing completes the history of electronics and electronic industries up to 1978. There is already a start toward a merging of the computer and the communication industries which might be called information manipulation. This includes storage of information, sorting, computation, information retrieval, and transmission of data. This combination of the computer and the communication fields will penetrate many disciplines. Applications will be made in the fields of law, medicine, biological sciences, engineering, library services publishing banking, reservation systems, management control, education, and defense.

• Clinical and Experimental Reproductive Medicine
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• v.48 no.2
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• pp.163-173
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• 2021

Objective: This study aimed to characterize a validated model for predicting oocyte retrieval in controlled ovarian stimulation (COS) and to construct model-based nomograms for assistance in clinical decision-making regarding the gonadotropin protocol and dose. Methods: This observational, retrospective, cohort study included 636 women with primary unexplained infertility and a normal menstrual cycle who were attempting assisted reproductive therapy for the first time. The enrolled women were split into an index group (n=497) for model building and a validation group (n=139). The primary outcome was absolute oocyte count. The dose-response relationship was tested using modified Poisson, negative binomial, hybrid Poisson-E_max, and linear models. The validation group was similarly analyzed, and its results were compared to that of the index group. Results: The Poisson model with the log-link function demonstrated superior predictive performance and precision (Akaike information criterion, 2,704; λ=8.27; relative standard error (λ)=2.02%). The covariate analysis included women's age (p<0.001), antral follicle count (p<0.001), basal follicle-stimulating hormone level (p<0.001), gonadotropin dose (p=0.042), and protocol type (p=0.002 and p<0.001 for short and antagonist protocols, respectively). The estimates from 500 bootstrap samples were close to those of the original model. The validation group showed model assessment metrics comparable to the index model. Based on the fitted model, a static nomogram was built to improve visualization. In addition, a dynamic electronic tool was created for convenience of use. Conclusion: Based on our validated model, nomograms were constructed to help clinicians individualize the stimulation protocol and gonadotropin doses in COS cycles.