• The Korea Journal of Herbology
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• v.21 no.3
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• pp.35-45
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• 2006

Objectives : The plans can be used for medicinal purposes among Alismatales in korea and examined their effects and distributions. Methods : The examined herbalogical books and research papers which published at home and abroad. Results : 1. There were totaled to 15 genera and 45 species in Alismatales in Korea and among them medicinal plants are 8 genera, 17 species, some 38% in total. 2. Potamogeton genus is main kind enough that it has 14 species among 45 species in the Alismatales , of which medicinal plants are 6 species. 3. The herb is the main medicinal parts of medicinal plants in the Alismatales which is used in 14 species. 4. According to nature and flavor of medicinal plants in the Alismatales , they were classified into cool 8 species; sweet taste 10 in the order. 5. According to meridian propism of medicinal plants in the Alismatales, they were classified into liver meridian 8 species. 6. According to the properties and principal curative action, they were classified into drugs for antifebrile 12 species, drugs for detoxicant 11 , drugs for drain damp 9 in the order. 7. It was noticed that every medicinal plant in the Alismatales is nontoxic. Conclusion : There were totaled to 15 genera and 45 species in Alismatales in Korea and among them medicinal plants are 8 genera, 17 species, some 38% in total.

• Journal of Ginseng Research
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• v.20 no.4
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• pp.431-471
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• 1996

Korean ginseng has been thought and used the most very important medicinal herb among the oriental medicinal drugs for thounds of years Korean ginseng had many ingredients such as tripenoid saponins. Nitrogen compounds, polysaccharides, polyacetylenic compounds and lipid compounds. Korean ginseng has wide effects in the various systems of human such as nervous system. Vascular system. Digestive system. endocrine system, immune system. etc. Many researchess who were interested in the biological effects of Korean ginseng have concerned the tripenoid saponins among the components of ginseng and carried out to find the effects of ginseng using the various experimental system. From their results, it was unveiled many effects of Korean ginseng gractually in the experimental systems and shown that Korean ginseng has various effects in the biological system. But recent studies has been carried out to the difference ginseng components, besides ginseng saponin thought to have various effects in biological systems. Also the functional mechanism of ginseng in the biological system is limited but the basic research to elucidate the mysterious effects of ginseng has been preferred. In this review, we focus on biological effects of Korean ginseng. Especially physiological and biochemical aspects in biological systems.

• Bulletin of the Korean Chemical Society
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• v.25 no.7
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• pp.1003-1008
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• 2004

A novel class of alkoxybenzylcyanoguanidine analogs as the inhibitors of restenosis was discovered, which showed the inhibitory effects on angiotensin II-induced cell proliferation, determined by $[^3H]$thymidine incorporation method. The compound, N'-(4-nitrophenyl)guanidine analog 19, showed 62% inhibition of $[^3H]$thymidine incorporation at 1 ${\mu}M$ concentration. In addition, the compound 19 inhibited intimal thickening dose-dependently after balloon injury, which suggests the therapeutic potential for restenosis.

• Proceedings of the PSK Conference
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• 2002.10a
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• pp.251.3-252
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• 2002

The present study was performed to compare the cardiovascular adverse effects of verapamil. KR30031 and their each optical isomers, and also to measure their ability to overcome multidrug resistance (MDR). R-isomer of KR30031 (R-KR30031) was equipotent with S-isomer of KR30031 (S-KR30031) and 25 fold less potent than R-isomer of verapamil (R-verapamil) in relaxing the aorta isolated from rat (EC50: 11.8, 10.2 and 0.46 ${\mu}$M, respectively). (omitted)

• Korean Journal of Environmental Biology
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• v.22 no.1
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• pp.83-88
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• 2004

In order to investigate whether or not CCD-980sk cell line can be affected by Korean Citrus junos and medicinal herbs, we examined the MTT assay when we treated Korean Citrus junos and medicinal herbs in CCD-986sk human fibroblast cell line. The samples that added complex of grinded extracts of Korean Citrus junos and boiling-water extracts from Korean medicinal herbs were tested toy cell proliferation activity by means of a modification of the MTT assay. Among mixture of Citron 3 (Citron 3, less mellowed citron which was ripened for three months) and boiling-water extracts, the group Citron 3+Phellinus linteus showed significantly strong cell proliferation activity. And among mixture of Citron 4 (Citron 4, completely mellowed citron which was ripened for four months) and boiling-water extracts, the group Citron 4＋Cordyceps militaris and Citron 4+Phellinus linteus showed significantly strong cell proliferation activity, respectively. These results suggest that complex of Korean Citrus junos and medicinal herbs could be an excellent candidate toy protection of human skin aging.

• Journal of Nutrition and Health
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• v.45 no.5
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• pp.437-442
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• 2012

The purpose of this study was is to investigate the arthritis treatment and prevention of the effects the herbral administration to experimental animals induces arthritis 4 weeks for medicinal herbs (Scutellaria baicalensis Georgi, Acanthopanacis cortex, Achyranthis Radix). To investigate the prevention of histopathological examination and molecular biological examinations for arthritis improvement in vivo New Zealand, white rabbits were divided into a normal (Normal, n = 7), or a collagen-induced arthritis (CIA, n = 7), or a collagenase injection and medicinal herbs (SAA, n = 7). It was confirmed that induced arthritis was treated with Gross examination, and the measurement of average arthritis index (MAI) and improved arthritis by medicinal herbs. TNF-${\alpha}$ and IL-$1{\beta}$ were significantly increased in the CIA and SAA groups, compared to the normal group (p < 0.05). MMP-1 and TIMP-2 were significantly increased in the CIA, compared to the other groups (p < 0.05). MMP-1 and TIMP-2 were significantly decreased in the SAA group, compared to the CIA group (p < 0.05). As a result, Herbal administration used in this study might be able to help in the treatment of arthritis induced by inflammatory and immunosuppressive effects, that which can be expected.

• Korean Journal of Medicinal Crop Science
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• v.5 no.2
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• pp.154-161
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• 1997

The germination inhibitory effects of American ginseng (Panax quinquefolium Linne) pulp were discussed. The germination inhibitory effects of pulp juice were decreased in a concentration dependent manner. When the pulp juice was diluted 0 (original juice), 1, 2, 5, 10, 20, 50 and 100 times, the radicle lengths of the assay plant, Chinese cabbage (Brassica chinensis Linne), showed 0, 0.32, 0.72, 3.13, 4.83, 16.07, 16.73 and 23.50 mm, respectively (CK=25.98 mm). The pulp evidently inhibited the embryo growth in natural fruit. The longer was the duration that the pulp stayed around the seed, the longer was the time course needed for embryo getting free from the inhibitory effects of pulp. When the depulping was performed on the day 0, 15, 30 and 60 after harvest, the time courses needed for embryo extricating the residual inhibitory effects from pulp were 30, 75, 135 and 135 days, respectively. Moreover, if the pulp stayed around the seed with time, that would make the seed rotten ratio increase. When the pulp stayed around the seed for 0, 15, 30, 60 and 270 days, the seed rotten ratios were 5.47, 5.71, 19.05, 27.14 and 33.33%, respectively. Therefore, we concluded that the pulp could be included in the inhibitory components which made American ginseng seed get into dormancy.

• Biomolecules & Therapeutics
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• v.29 no.4
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• pp.384-391
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• 2021

Currently, the expanding recreational use of synthetic cannabinoids (SCBs) threatens public health. SCBs produce psychoactive effects similar to those of tetrahydrocannabinol, the main component of cannabis, and additionally induce unexpected pharmacological side effects. SCBs are falsely advertised as legal and safe, but in reality, SCB abuse has been reported to cause acute intoxication and addictive disorders. However, because of the lack of scientific evidence to elucidate their dangerous pharmacological effects, SCBs are weakly regulated and continue to circulate in illegal drug markets. In the present study, the intravenous self-administration (IVSA) paradigm was used to evaluate the abuse potential of three SCBs (AM-1248, CB-13, and PB-22) in rats. All three SCBs maintained IVSA with a large number of infusions and active lever presses, demonstrating their reinforcing effects. The increase of active lever presses was particularly significant during the early IVSA sessions, indicating the reinforcement-enhancing effects of the SCBs (AM-1248 and CB-13). The number of inactive lever presses was significantly higher in the SCB groups (AM-1248 and CB-13) than that in the vehicle group, indicating their impulsive effects. In summary, these results demonstrated that SCBs have distinct pharmacological properties and abuse potential.

• The Korea Journal of Herbology
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• v.21 no.2
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• pp.27-36
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• 2006

Objectives : The plans can be used for medicinal purposes among Fagales in korea and examined their effects and distributions. Methods : The examined herbalogical books and research papers which published at home and abroad. Results : 1. Quercus genus is main kind enough that it has 32 species among 94 species in the Fagales, of which medicinal plants are 8 species. 2. Cortex is the main medicinal parts of medicinal plants in the Fagales which is used in 12 species. 3. According to nature and flavor of medicinal plants in the Fagales, they were classified into balance 23 species, cool 8 and warm 6; rough taste 25, bitter taste 21 and sweet taste 10 in the order. 4. According to meridian propism of medicinal plants in the Fagales, they were classified into large intestine meridian 11 species, spleen meridian 9, lung meridian 8, liver meridian 8 and stomach meridian 6 in the order. 5. According to the properties and principal curative action, they were classified into drugs for antifebrile and detoxicant 16 species, drugs for hemostasis 14, drugs for astriction 11, drugs to relieve cough 8 in the order. 6. It was noticed that every medicinal plant in the Fagales is nontoxic. Conclusion : There were totaled to 9 genera and 94 species in Fagales in Korea and among them medicinal plants are 6 genera, 22 species, some 23% in total.

• The Korea Journal of Herbology
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• v.21 no.2
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• pp.15-26
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• 2006

Objectives : The plans can be used for medicinal purposes among Gymnospermae in korea and examined their effects and distributions. Methods : The examined herbalogical books and research papers which published at home and abroad. Results : 1. Pinus genus is main kind enough that it has 22 species among 75 species in the Gymnospermae of which medicinal plants are 7 species. 2. Folium is the main medicinal parts of medicinal plants in the Gymnospermae which is used in 22 genera. 3. According to nature and flavor of medicinal plants in the Gymnospermae, they were classified into warm 19 genera, balance 18 ; bitter taste 25, sweet taste 21. 4. According to meridian propism of medicinal plants in the Gymnospermae, they were classified into spleen meridian 12 genera, lung meridian 11, liver meridian 9, heart meridian 7. 5. According to the properties and principal curative action, they were classified into drugs for relieve wind and moisture 37 genera, drugs for relieve pain 21, drugs for hemostasis 15, drugs to activity 14. 6. It was researched that toxic medicinal plants include toxin were 8 kinds. Conclusion : There were totaled to 21 genera and 75 species in Gymnospermae in Korea and among them medicinal plants are 14 genera, 28 species, some 37% in total.