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http://dx.doi.org/10.5012/bkcs.2004.25.7.1003

Alkoxybenzylcyanoguanidine Analogs as a Novel Class of Inhibitors for Restenosis  

Lee, Sun-Kyung (Medicinal Science Division, Korea Research Institute of Chemical Technology)
Yi, Kyu-Yang (Medicinal Science Division, Korea Research Institute of Chemical Technology)
Hwang, Sun-Kyung (Medicinal Science Division, Korea Research Institute of Chemical Technology)
Suh, Jee-Hee (Medicinal Science Division, Korea Research Institute of Chemical Technology)
Lee, Byung-Ho (Medicinal Science Division, Korea Research Institute of Chemical Technology)
Yoo, Sung-Eun (Medicinal Science Division, Korea Research Institute of Chemical Technology)
Publication Information
Bulletin of the Korean Chemical Society / v.25, no.7, 2004 , pp. 1003-1008 More about this Journal
Abstract
A novel class of alkoxybenzylcyanoguanidine analogs as the inhibitors of restenosis was discovered, which showed the inhibitory effects on angiotensin II-induced cell proliferation, determined by $[^3H]$thymidine incorporation method. The compound, N'-(4-nitrophenyl)guanidine analog 19, showed 62% inhibition of $[^3H]$thymidine incorporation at 1 ${\mu}M$ concentration. In addition, the compound 19 inhibited intimal thickening dose-dependently after balloon injury, which suggests the therapeutic potential for restenosis.
Keywords
Alkoxybenzylcyanoguanidine; PTCA; Restenosis; Cell proliferation; Intimal hyperplasia;
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