• BMB Reports
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• v.44 no.8
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• pp.517-522
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• 2011

Mitochondrial dynamics not only involves mitochondrial morphology but also mitochondrial biogenesis, mitochondrial distribution, and cell death. To identify specific regulators to mitochondria dynamics, we screened a chemical library and identified niclosamide as a potent inducer of mitochondria fission. Niclosamide promoted mitochondrial fragmentation but this was blocked by down-regulation of Drp1. Niclosamide treatment resulted in the disruption of mitochondria membrane potential and reduction of ATP levels. Moreover, niclosamide led to apoptotic cell death by caspase-3 activation. Interestingly, niclosamide also increased autophagic activity. Inhibition of autophagy suppressed niclosamide-induced cell death. Therefore, our findings suggest that niclosamide induces mitochondria fragmentation and may contribute to apoptotic and autophagic cell death.

• The Korean Journal of Emergency Medical Services
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• v.25 no.1
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• pp.193-203
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• 2021

Purpose: This study aimed to examine the degree of job satisfaction of emergency medical technicians and its influencing factors through systematic review of prior studies. Methods: Databases were searched including national assembly library, national digital science library, korea education research information service and korean studies information service system to conduct systematic literature review. Results: The included studies were published from 2004 to 2017. After applying the inclusion and exclusion criteria to the retrieved 92 studies, a total of 11 studies were included for the final analysis. The questionnaire developed by Slavitt, Stamps, Piedmont and Haase was the most common tool used from the included studies. In the study using 5 point Likert type scale, the average job satisfaction level of emergency medical technicians was 3.18. It was 2.86 based on 4 point scale. Conclusion: According to the study results, the satisfaction level of emergency medical technicians is around the medium level. Effective strategy should be developed to improve job satisfaction based on the findings of the influencing factors to emergency medical technicians' job satisfaction.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.30 no.4
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• pp.197-216
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• 2019

The study aimed to investigate the motivation and user satisfaction of medical school graduate students using specific academic information sites, and examines the effect of usage motivation factors on user satisfaction. This study was conducted from September 10, 2018 to September 21, 2018 by a large medical school graduate student in Seoul, and analyzed 135 valid responses. According to the analysis, the degree of reliability and interactivity of PubMed is higher than that of Google Scholar in medical school graduate students' use of academic information sites. It was found to have a significant effect on user satisfaction of academic information sites. In particular, convenience has the greatest influence on users' choice of academic information sites. The results of the study are of theoretical implications in that the discussion of academic information services through web sites is explained in terms of use and satisfaction in the context of medical information. On the other hand, specific research results provide practical implications for improving the services of medical-related academic search engines.

• Journal of Information Management
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• v.35 no.3
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• pp.75-107
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• 2004

The concept of "ubiquitous", which has been recently discussed in several industries, implies accessing a network using a computer from anywhere at anytime. The ubiquitous technology has been widely researched for distribution, construction, and medical treatments. Now, it has extended its application to libraries. The ubiquitous technology currently applied to a number of national libraries calls for a systematic study of an ubiquitous library. This thesis aims at presenting a model of introducing the ubiquitous technology to university libraries.

• Journal of the Korean Society for information Management
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• v.26 no.2
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• pp.105-126
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• 2009

In this study, research topic areas in Korean and American medical schools were analyzed to detect each nation's major research areas. CLINICAL NEUROLOGY was identified as the Korean researchers' major subject area by the total number of journals and 'RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING' was the most major area by the total number of articles. On the other hand, American researchers' top major subject area was the one same area according to all analysis, BIOCHEMISTRY & MOLECULAR BIOLOGY. In addition, Korean researchers showed publishing tendency related to journal preference in several subject areas.

• Journal of the Korean Society for information Management
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• v.2 no.2
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• pp.71-114
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• 1985

Medical libraries in Korea consume most of their budget and efforts of staffs for acquisition and administration of foreign medical journals. Annualy the rise in prices of the journals oppress the library budget. Because of these reasons, this paper studied and analyzed the possibility of cooperative acquisition of foreign medical journals between the medical libraries in Korea and several basic informations for cooperative acquisition by citation analysis method. The 5 source medical school journals were selected from our country's medical school journals: Seoul, Yonsei, Catholic, Chonnam, Kyungbook.

• Journal of Korean Medical classics
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• v.23 no.4
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• pp.39-62
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• 2010

Background : I investigated clinical research methodology of Traditional Korean Medicine(TKM) for treatment of lung cancer with Evidence Based Medicine(EBM) approach. Methods : I conducted the internet search of National Central Library, the National Assembly Library, Korea Education & Research Information Service, Korea Institute of Science and Technology Information for Korean theses and papers, and MEDLINE for the outside articles. Conclusion : In addition to outcomes of clinical trial, abundant clinician's experience and patients' preference are also considered. Pragmatic trials and quasi-experimental trials are better than clinical trials to plan clinical design of TKM for lung cancer and appropriate endpoints includes overall survival, disease-free survival, patient reporting outcome.

• Journal of Information Management
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• v.42 no.4
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• pp.23-37
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• 2011

This study has surveyed the professors and graduate students of school of medicine at K university, to analyze the medical library users' service quality perceptions on electronic journals and their effects on the customer satisfaction. Two groups of faculty members and graduate students has statistically significant different perceptions on the service quality of electronic journals. Among four sub-dimensions of service quality, there are no statistically significant differences in the perceptions between two groups in convenience of use, accessability, and content resources, but there is significant differences in supportiveness between two groups. In the perceptions on the satisfaction and value, faculty group has significantly higher perceptions on both of them. The most influential dimension of the service quality of the electronic journal for the perception on the satisfaction is supportiveness followed by convenience of use and content resources. Moderating effect of value on service quality, its sub-dimensions, and satisfaction is not proved statistically.

• Nuclear Engineering and Technology
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• v.54 no.11
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• pp.4244-4252
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• 2022

The accuracy of Monte Carlo (MC) simulations in estimating the computed tomography radiation dose is highly dependent on the accuracy of CT scanner model. A system was developed to observe the 3D model intuitively and to calculate the X-ray energy spectrum and the bowtie (BT) filter model more accurately in Monte Carlo N-particle (MCNP). Labview's built-in Open Graphics Library (OpenGL) was used to display basic surfaces, and constructive solid geometry (CSG) method was used to realize Boolean operations. The energy spectrum was calculated by simulating the process of electronic shooting and the BT filter model was accurately modeled based on the calculated shape curve. Physical data from a study was used as an example to illustrate the accuracy of the constructed model. RMSE between the simulation and the measurement results were 0.97% and 0.74% for two filters of different shapes. It can be seen from the comparison results that to obtain an accurate CT scanner model, physical measurements should be taken as the standard. The energy spectrum library should be established based on Monte Carlo simulations with modifiable input files. It is necessary to use the three-segment splicing modeling method to construct the bowtie filter model.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.2
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• pp.947-950
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• 2013

Background: We performed this meta-analysis to assess the effectiveness and safety of axillary dissection in old women. Methods: The Cochrane Library, PubMed, EMBASE and Chinese Biomedical Literature Database were searched and all randomized controlled trials of axillary dissection in old women (at least 60 years old) were considered. Meta-analyses were completed using RevMan5.1. Results: Three eligible randomized controlled trials (RCTs) including 5,337 patients were considered. There was weak evidence in favour of axillary dissection (AD) in old women. The meta-analysis showed that the overall survival (OS) after 1, 3, 5 and 7 years and the disease free survival (DFS) after 1, 3 and 5 year were not statistically significantly different between AD and no AD groups. However, there was a difference in the 7 year DFS. Conclusions: Axillary dissection did not provide survival benefit to the old women with breast cancer analysed. Therefore, axillary dissection is not well-indicated in old women with breast cancer.