• Genomics & Informatics
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• 제2권2호
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• pp.81-85
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• 2004

To examine whether the IL-1A (-889) polymorphism associates with a risk for Alzheimer's disease (AD) and acts interactively with the apolipoprotein (APOE) $\epsilon$4 in the development of AD, we performed genotype analyses of the IL-1A and the APOE of the 102 Korean AD patients and 200 Korean non-demented controls. We failed to detect a significant difference in genotypic and allelic frequencies of IL-1A between the AD group and control group. No overexpression of the IL-1A C/T genotype and IL-1A T allele was found when we analyzed the late-onset and early-onset patients, separately. There was no significant genetic interaction between IL-1A polymorphism and the APOE polymorphism. I n conclusion, the IL-1A polymorphism did not contribute to the development of AD independently or interactively with the APOE $\epsilon$4 allele in Koreans.

• 대한간호학회지
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• 제16권2호
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• pp.44-52
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• 1986

Maternal and child health(MCH) status is considered as an important indicator of the level of health and civilization of a community and a country. MCH services for the rural population in the remote ar deserves priority by the government, since more than half(52.9%) of the delivery was occured at home and almost half (45.5%) of the delivery was assited by family members or neighbors. The purpose of the study was to analyse the health fare behavior related to pregnancy and delivery, which can be contributed maternal health care policy mating for the rural people. Specifically, it was intended to analyze the variables which affect the health care behavior in selecting birth places and birth attendants. This study utilized the data which had been already collected for an experimental study on primary health program model in Korean rural communities, funded by the USAID. 184 sample households with women who had delivered a baby during March 1982 to February 1983 were selected. Discriminant Analysis was employed for statistical analysis by utilizing SPSS computer package program. Birth places and birth attendants were considered as dependent variables. Among 12 independent variables in 5 groups considered, 7 independent variables were found statistically significant to affect the selection of birth place. Significant variables by the order of importance are mother's age, order of baby, number of prenatal care, accessibility of emergency medical care, coverage of medical insurance, mother's membership in community organization and husband's educational level. The degree of correct classification of the grouped cases by employing a discriminant . analysis was significantly improved to 78.2％ in comparison to Cmax（56%) and Cpro(51%). Policy implications for each significant variable were discussed to improve the maternal and child health. in Korean ruralarea.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제10권2호
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• pp.99-106
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• 2004

This study attempts to provide the fundamental materials for space program in terms of planning a senior welfare center by means of examining and analyzing the present conditions of spatial arrangement of each section in senior welfare center for the aged. The results of the study are as in the following. 1) The demand for new service programs corresponding to the improved quality of the elderly and various social desires is relatively on the increase. Each program in senior welfare center for the elderly should be connected in an organic manner and the organization of space should be provided. 2) The section of counseling, the first step when using a welfare center, should be located in the entrance of the building and it has to be closely connected with other section. 3) The section of medical rehabilitation is a place mostly for the elderly in their frail physical condition; therefore, it is effective to use horizontal line. 4) It is important for the room for volunteers in the section for domiciliary welfare to be arranged flexibly with the office or the room for social education, and it is necessary to consider how easy daytime or short-term care is accessible. 5) The space where dynamic programs are progressed in the section of social education should be distinguished from the section of medical rehabilitation or the room for daytime care and the room for short-term care of the section of domiciliary welfare.

• 한국한의학연구원논문집
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• 제4권1호통권4호
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• pp.27-45
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• 1998

$\ulcorner$Euibangyoochui醫方類聚$\lrcorner$ (1445) is regarded as a treasure-house of the knowledge of traditional oriental medicine which contains over 50,000 prescriptions and enormerous amount of medical information. Despite the importance and information contained in this book, it has been rarely used since it was not convenient to use this book. In this study, therefore, the establishment of database on $\ulcorner$Euibangyoochui$\lrcorner$ was carried out. Before the database establishment of $\ulcorner$Euibangyoochui$\lrcorner$ , basic works such as correction, interpretation, proofreading and translation of original text should be done. The results obtained in this study are summaried as follows : 1) During the course of studying the original text of $\ulcorner$Euibangyoochui$\lrcorner$ , the editing process and transmission of medical books in early Chosun dynasty was figured out. 2) For better correction, interpretation, proofreading and translation of $\ulcorner$Euibangyoochui$\lrcorner$ , $\ulcorner$Euibangyoochui$\lrcorner$ microfilms which are the collection of Japanese Royal Library (宮內廳 圖書寮) were obtained in this study. Through this process, the errors in the republication were able to be corrected. 3) Analyzing the organization and compilatory method of $\ulcorner$Euibangyoochui$\lrcorner$ is one of the basic requirements of understanding the scale of the whole. book and establishing database as a result. So the analysis results were used for the basic structuring of database. 4) $\ulcorner$Euibangyoochui$\lrcorner$ CD- ROM was designed in a way that the images of microfilms, original text and Korean translation can be compared by 3-D device. In addition, the convenience and proficiency of imaging the information and prescriptions of the text is one of the remarkable features of this CD-ROM.

• Journal of Preventive Medicine and Public Health
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• 제46권4호
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• pp.192-200
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• 2013

Objectives: To measure the prevalence of behavioural risk factors for obesity among urban adolescent school children in Chennai, India. Methods: This study was performed as a cross-sectional study using a World Health Organization-designed Global School-based Student Health Survey questionnaire (modified for India) among adolescent school children studying in 30 randomly selected secondary and higher secondary schools in Chennai city. 1842 adolescents studying in the VIII to XII standards were randomly selected for the study. Results: In the present study, 40.7% of the students ate fruit one or more times per day and 74.5% of the students ate vegetables one or more times per day. Nearly 20% of the students ate fast food items on 4 to 7 days during the previous week. Among the students, 30.4% watched television for more than two hours per day. Nearly 68% of the girls and 22% of the boys did not participate in outdoor sports activities. When the pattern of physical activity of the students was assessed, it was observed that 15.6% were inactive, 43.4% were minimally active, and the remaining 41.0% belonged to the category of health enhancing physical activity. Among the students, 6.2% were overweight and 5.2% were obese. Conclusions: The prevalence of risk factors for obesity was quite high among the adolescents. This study also showed that a great proportion of overweight/obese adolescents had a correct perception of their body weight and they were making efforts to modify risk factors such as television viewing, computer use, a sedentary lifestyle, and unhealthy dietary habits.

• 한국화재소방학회논문지
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• 제19권4호
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• pp.47-56
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• 2005

비응급상황에 대한 제한적인 구급요청의 거절 및 환자 등의 이송거부로 인한 법적 분쟁으로부터 당해 구급대원을 보호하고 이에 대한 절차를 엄격히 하여 응급환자를 보호하기 위하여 $\ulcorner$구조대 및 구급대 편성$\cdot$운영에 관한 규칙$\lrcorner$이 개정되었다. 이에 대하여 본 논문은 구급대원의 이송거절 거부에 따라 발생할 수 있는 법적 책임으로 응급의료거부죄의 구성요건 해당성을 고찰하고 부작위에 의한 형사책임 및 환자에게 발생한 손해에 대한 국가배상책임의 발생가능성에 대하여 연구하였다. 구급대원을 법적 책임으로부터 보호하기 위해 개정된 규칙의 준수에 있어서 유의해야 할 점과 외국의 판례들을 고려하여 법원의 태도를 살펴보았다. 결론적으로는 구급대원의 법적인 보호를 위해 지도의사의 의료지도 확보 및 적법한 절차를 따라 문서화된 서식을 충실히 기록함으로써 구급대원의 의무에 대한 충실한 이행 및 환자의 동의를 확보하여 이송거절 및 거부에 대한 정당성을 확보하는 것이 중요함을 강조하였다.

• Journal of Korean Medical Science
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• 제33권48호
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• pp.312.1-312.10
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• 2018

Background: Obesity is related to several comorbidities and mortality, but its relationship with acute kidney injury (AKI) and long-term mortality remain undetermined in patients undergoing coronary artery bypass grafting. Methods: Data from 3,018 patients (age ${\geq}18$ years) who underwent coronary artery bypass graft surgery from two tertiary referral centers were retrospectively reviewed between 2004 and 2015. Obesity was defined using the body mass index, according to the World Health Organization's recommendation. The odds and hazard ratios in post-surgical, AKI, and all-cause mortality were calculated after adjustment for multiple covariates. Patients were followed for $90{\pm}40.9$ months (maximum: 13 years). Results: Among the cohort, 37.4%, 2.4%, 21.1%, 35.1%, and 4.0% of patients were classified as normal weight, underweight, overweight-at-risk, obese I, and obese II, respectively. Post-surgical AKI developed in 799 patients (26.5%). Patients in the obese groups (overweight-at-risk to obese II) had a higher risk of AKI than did those in the normal-weight group. During the follow-up period, 787 patients (26.1%) died. Underweight patients had a higher risk of mortality than did normal-weight patients, whereas overweight-at-risk, obese I, and obese II patients showed better survival rates. Conclusion: After coronary artery bypass graft surgery, obese patients encountered a high risk of AKI, and underweight patients exhibited a low chance of survival. Awareness of both obese and underweight statuses should be raised in these patients.

• Journal of Korean Medical Science
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• 제33권52호
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• pp.331.1-331.17
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• 2018

Human Papillomavirus (HPV) infection is the most common sexually transmitted infection and is associated with the development of cervical cancer. The purpose of this report is to provide the literature evidences on selecting the HPV vaccine for national immunization program (NIP) in Korea. To complete these tasks, we reviewed domestic and foreign literature on the current status of HPV infection, efficacy and effectiveness of HPV vaccine, safety of vaccine and cost effectiveness analysis of vaccination business. Given that the median age of first sexual intercourse is continuing to fall, this may have serious implications for HPV infection and cervical cancer incidence at the age of 20s. The World Health Organization recommends that the HPV vaccination should be included in the NIP being implemented in each country. Both the bivalent and quadrivalent vaccines have a 90% or greater preventive efficacy on cervical intraepithelial lesion 2-3 and cervical cancer by the HPV 16 or HPV 18. In the future, if HPV vaccination rate as part of NIP increases, it is expected that the incidence of HPV infection, genital warts, and cervical precancerous lesions will be decreased in the vaccination age group. Therefore, in order to increase the HPV vaccination rate at this point in Korea, social consensus and efforts such as the introduction and promotion of HPV vaccine to the NIP according to appropriate cost-effectiveness analysis are required.

• Genomics & Informatics
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• 제18권4호
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• pp.43.1-43.13
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• 2020

The coronavirus disease 2019 is a contagious disease and had caused havoc throughout the world by creating widespread mortality and morbidity. The unavailability of vaccines and proper antiviral drugs encourages the researchers to identify potential antiviral drugs to be used against the virus. The presence of RNA binding domain in the nucleocapsid (N) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could be a potential drug target, which serves multiple critical functions during the viral life cycle, especially the viral replication. Since vaccine development might take some time, the identification of a drug compound targeting viral replication might offer a solution for treatment. The study analyzed the phylogenetic relationship of N protein sequence divergence with other 49 coronavirus species and also identified the conserved regions according to protein families through conserved domain search. Good structural binding affinities of a few natural and/or synthetic phytocompounds or drugs against N protein were determined using the molecular docking approaches. The analyzed compounds presented the higher numbers of hydrogen bonds of selected chemicals supporting the drug-ability of these compounds. Among them, the established antiviral drug glycyrrhizic acid and the phytochemical theaflavin can be considered as possible drug compounds against target N protein of SARS-CoV-2 as they showed lower binding affinities. The findings of this study might lead to the development of a drug for the SARS-CoV-2 mediated disease and offer solution to treatment of SARS-CoV-2 infection.

• Genomics & Informatics
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• 제18권4호
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• pp.44.1-44.7
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• 2020

The severity of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), greatly varies from patient to patient. In the present study, we explored and compared mutation profiles of SARS-CoV-2 isolated from mildly affected and severely affected COVID-19 patients in order to explore any relationship between mutation profile and disease severity. Genomic sequences of SARS-CoV-2 were downloaded from Global Initiative on Sharing Avian Influenza Data (GISAID) database. With the help of Genome Detective Coronavirus Typing Tool, genomic sequences were aligned with the Wuhan seafood market pneumonia virus reference sequence and all the mutations were identified. Distribution of mutant variants was then compared between mildly and severely affected groups. Among the numerous mutations detected, 14408C>T and 23403A>G mutations resulting in RNA-dependent RNA polymerase (RdRp) P323L and spike protein D614G mutations, respectively, were found predominantly in severely affected group (>82%) compared with mildly affected group (<46%, p < 0.001). The 241C>T mutation in the non-coding region of the genome was also found predominantly in severely affected group (p < 0.001). The 3037C>T, a silent mutation, also appeared in relatively high frequency in severely affected group compared with mildly affected group, but the difference was not statistically significant (p = 0.06). We concluded that spike protein D614G and RdRp P323L mutations in SARS-CoV-2 are associated with severity of COVID-19. Further studies will be required to explore whether these mutations have any impact on the severity of disease.