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No Evidence of Association of Interleukin 1A (-889) Genetic Polymorphism with Alzheimer's Disease in Koreans  

Jhoo, Jin Hyeong (Department of Psychiatry, Pundang Jesaeng Hospital, Daejin Medical Center)
Park, Woong Yang (Department of Biochemistry and Molecular Biology, College of Medicine, Seoul National University)
Kim, Ki Woong (Department of Neuropsychiatry, Seoul National University Bundang Hospital)
Lee, Kwang Hyuk (Department of Biochemistry and Molecular Biology, College of Medicine, Seoul National University)
Lee, Dong Young (Department of Neuropsychiatry, Seoul National University, College of Medicine and Seoul National University Hospital)
Youn, Jong Chul (Department of Neuropsychiatry, Kyunggi Provincial Hospital for Elderly)
Suh, Young Ju (Research division of Human Life Science, Seoul National University)
Seo, Jeong-Sun (Department of Biochemistry and Molecular Biology, College of Medicine, Seoul National University)
Woo, Jong Inn (Neuroscience Research Institute of the Medical Research Center, Seoul National University, and Clinical Research Institute of Seoul National University Hospital, Department of Neuropsychiatry, Seoul National University, College of Medicine and Seoul National University Hospital)
Publication Information
Genomics & Informatics / v.2, no.2, 2004 , pp. 81-85 More about this Journal
Abstract
To examine whether the IL-1A (-889) polymorphism associates with a risk for Alzheimer's disease (AD) and acts interactively with the apolipoprotein (APOE) $\epsilon$4 in the development of AD, we performed genotype analyses of the IL-1A and the APOE of the 102 Korean AD patients and 200 Korean non-demented controls. We failed to detect a significant difference in genotypic and allelic frequencies of IL-1A between the AD group and control group. No overexpression of the IL-1A C/T genotype and IL-1A T allele was found when we analyzed the late-onset and early-onset patients, separately. There was no significant genetic interaction between IL-1A polymorphism and the APOE polymorphism. I n conclusion, the IL-1A polymorphism did not contribute to the development of AD independently or interactively with the APOE $\epsilon$4 allele in Koreans.
Keywords
Alzheimer's disease (AD); Interleukin-1A (IL-1A); Koreans; association;
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