• Genomics & Informatics
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• v.14 no.2
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• pp.62-68
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• 2016

Osteoporosis is a medical condition of global concern, with increasing incidence in both sexes. Bone mineral density (BMD), a highly heritable trait, has been proven a useful diagnostic factor in predicting fracture. Because medical information is lacking about male osteoporotic genetics, we conducted a genome-wide association study of BMD in Korean men. With 1,176 participants, we analyzed 4,414,664 single nucleotide polymorphisms (SNPs) after genomic imputation, and identified five SNPs and three loci correlated with bone density and strength. Multivariate linear regression models were applied to adjust for age and body mass index interference. Rs17124500 ($p=6.42{\times}10^{-7}$), rs34594869 ($p=6.53{\times}10^{-7}$) and rs17124504 ($p=6.53{\times}10^{-7}$) in 14q31.3 and rs140155614 ($p=8.64{\times}10^{-7}$) in 15q25.1 were significantly associated with lumbar spine BMD (LS-BMD), while rs111822233 ($p=6.35{\times}10^{-7}$) was linked with the femur total BMD (FT-BMD). Additionally, we analyzed the relationship between BMD and five genes previously identified in Korean men. Rs61382873 (p = 0.0009) in LRP5, rs9567003 (p = 0.0033) in TNFSF11 and rs9935828 (p = 0.0248) in FOXL1 were observed for LS-BMD. Furthermore, rs33997547 (p = 0.0057) in ZBTB and rs1664496 (p = 0.0012) in MEF2C were found to influence FT-BMD and rs61769193 (p = 0.0114) in ZBTB to influence femur neck BMD. We identified five SNPs and three genomic regions, associated with BMD. The significance of our results lies in the discovery of new loci, while also affirming a previously significant locus, as potential osteoporotic factors in the Korean male population.

• Proceedings of the KIEE Conference
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• 1993.07a
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• pp.504-506
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• 1993

The Joint Photographic Experts Group (JPEG) standard was proposed by the International Standardization Organization (ISO/SC 29/WG 10) and the CCITT SG VIII as an international standard for digital continuous-tone still image compression. The JPEG standard has been widely accepted in electronic imaging, computer graphics, and multi-media applications, however, due to the lossy character of the JPEG compression its application in the field of medical imaging has been limited. In this paper, the JPEG standard was applied to a series of head sections of magnetic resonance (MR) images (256 gray levels, $256{\times}256$ size) and its performance was investigated. For this purpose, DCT-based sequential mode of the JPEG standard was implemented using the CL550 compression chip and progressive and lossless coding was implemented by software without additional hardware. From the experiment, it appears that the compression ratio of about 10 to 20 was obtained for the MR images without noticeable distortion. It is also noted that the error signal between the reconstructed image by the JPEG and the original image was nearly random noise without causing any special-pattern-related artifact. Although the coding efficiency of the progressive and hierarchical coding is identical to that of the sequential coding in compression ratio and SNR, it has useful features In fast search of patient Image from huge image data base and in remote diagnosis through slow public communication channel.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.7
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• pp.2497-2507
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• 2010

The objectives of this study were to identify recognition, intention and practice to premarital examination of women and to define the predictors of intention and compliance to examination. The subjects for this study were 257 women at a university, college, a bank worker and health clinic visitor in Busan city. The date for this study was collected from August 25th to September 24th 2006 by structured questionaries, and were analyzed mean, standard deviations(SD), $x^2$-test, t-test and multiple Logistic regression using SPSS/WIN 12.0. The mean performance of the premarital examination was 28.4%. Thirty-five point five percent of unmarried women and 71.6 percent of married women had experience of heard premarital examination. The score of attitude toward premarital examination were that single women was 23.04 and married women was 22.55, respectively. The scores of behavioral control cognition between unmarried women and married women were statistically significant different. The predictor of premarital examination intention was necessity of premarital examination, and the predictors of examination compliance were experience of hearing examination and behavioral control cognition. Based on the results of this study, promoting recognition and behavioral control cognition by community healthcare organization and health professionals for empowering the premarital examination of women were needed.

• The Journal of Internal Korean Medicine
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• v.27 no.3
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• pp.555-560
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• 2006

Objectives : The objective of this study is to analyze what quality of life(QOL) scales are frequently used in cancer patients and lay a cornerstone to develop new QOL scales adequate for oriental medical anti-cancer treatment in the future. Methods : We searched 151 articles concerned with 'QOL and scale and cancer' from PubMed and classified them according to periods. nations. cancer types and symptoms. Results: 138 articles(91%) were published after 1996. 65 articles(43%) were published in USA. For breast. lung, prostate. esophageal cancer and melanoma. European Organization for Research and Treatment of Cancer-quiality of life questionaire(EORTC-QLQ) was used most frequently to evaluate quality of life. Functional Assessment of Cancer Treatment(FACT) for bladder cancer. Hospital Anxiety and Depression Scale(HADS) for colorectal cancer and of Washington Quality of Life questionnaire(UW-QOL) for Head & Neck cancer were used repeatedly. And for the patients with the symptoms such as bone marrow depression. depression. pain. dyspnea. nausea & vomiting and voice change. the investigators used EORTC-QLQ mainly to evaluate QOL. FACT-An(anemia) for anemia. FACT-BMT(bone marrow transplant) for bone marrow depression were applicated generally. Conclusions It is anticipated that further investigations will be performed to develop adequate QOL scales for oriental medical anti-cancer therapy.

• The Journal of Korean Medical History
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• v.32 no.2
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• pp.19-27
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• 2019

For the purpose of searching examination in the connection with clinical medicine and the basic theory of Korean Medicine, we comparatively studied on the physiological system of Hyun-Gok (1912~1987) and the Hyunsang system of Ji-San (1927~2000). The results are as follows. The metabolism of Yin and Yang is connected 'Gallbladder (膽)'-'Bladder (膀胱)' and Man (男), Woman (女), Old aged (老), Young child (小) style. Man and Woman are divided in the body form chacteristic not by the sex. 'Gallbladder (膽)'-'Bladder (膀胱)' style are divided in the body form chacteristic by the terms of Yin (陰) and Yang (陽). 'Gallbladder (膽)' style represents excessive Yang and deficient Yin, 'Bladder (膀胱)' style represents excessive Yin and deficient Yang. The four composition factor of the body is connected Material basis (精) type, Vital energy (氣) type, Mental faculties (神) type and Blood (血) type. In the diagnosis of body form on the Hyungsang Medicine, there are several types of body shape and categories of people. The Material basis (精) type, Vital energy (氣) type, Mental faculties (神) type and Blood (血) type are classified by the four composition factor of the body. The structural-mechanics organization of five Internal Organs (臟) is connected five Internal Organs (臟) types and the running-animal (走), bird (鳥), fish (魚), turtle (甲) types in the Hyunsang system. The five Internal Organs (臟) types are percived on the ears, eyes, nose, mouth and facial complexion. And the running-animal, bird, fish, turtle types are accorded to the individual personalities and the most-developed part in the body trunk by the Organ picture (藏象) theory. The six atmospheric influences (六氣) is connected the six Kyung types (六經形). The six Kyung types are regulated by the shape of eyes and nose representing for the relation of Vital energy (氣) and Blood (血). By the comparative study on the physiological system of Hyun-Gok and the Hyunsang system of Ji-San, we can search the connection with clinical medicine and the basic theory of Korean Medicine.

• Journal of Fisheries and Marine Sciences Education
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• v.26 no.6
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• pp.1278-1295
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• 2014

The Sixteenth Meeting of the Conferences of Parties of the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES), which was held in March 2013 in Bangkok, Thailand, listed five shark species and one genus, and uplisted one sawfish species. All new species listings will be come into force of the eighteen months delay, on the fourteenth of September, 2014. The purpose of the delay is to support the preparation of the domestic measures on shark trade by the parties, as there has been no previous experience in trading the commercially exploited aquatic species in the CITES. The CITES Secretary-General has visited several potential shark trade countries to encourage and facilitate the implementation of the new CITES listings. The newly listed sharks have been caught as a target or non-target species by Korean distant water fisheries and introduced into Korea. So the establishment or change of the domestic laws, regulations, and measures for the implementation of the new CITES species must be prepared before the effective entry date. This paper is prepared to assess the effects of the trade of the CITES listed shark species, and to suggest effective government service measures for the management of Korean distant water fisheries. The Ministry of Environment (MOE) is the general Management Authority of the CITES, and the Ministry of Food and Drug Safety (MFDS) is in charge of the medical trade of CITES listed species in Korea. By law, all imported medicines and medical materials must be inspected by the MFDS during the customs examination; this kind of authority sharing is reasonable and effective way of providing government service. Similarly, the designation of new CITES Management Authority for the trade of commercially exploited aquatic CITES species is critical and the Ministry of Oceans and Fisheries (MOF), which is now in charge of the trade of fisheries products, is the most appropriate governing body for this purpose in Korea. The revision of the National Plan of Action for Conservation and Management of Sharks, initially submitted to the Food and Agriculture Organization (FAO) of the United Nations in 2011 as a practical guideline for shark conservation in all Korean fisheries, could be a effective measure to achieve unification of conservation of endangered species and sustainable use of fisheries stocks. The proper CITES measures for the trade of listed species, such as the establishment of the documenting system for Non-detriment Findings, domestic measures suitable for the "Introduction from the Sea" clause, species specific Harmonized System Codes for the customs service, and an effective shark catch data reporting system should be in place prior to the fourteenth of September 2014.

• 재활복지
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• v.20 no.3
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• pp.17-43
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• 2016

This study is on understanding the reality of disabled seniors and investigation of factors that affect overall life satisfaction, making a proposal to improve their life quality. Situation data for the disabled, gathered by Korea Institute for Health and Social Affairs (KIHASA) in 2014, was used to perform the study, and the target group is 3,181 people with disability, above the age of 65. Descriptive statistics was presented for data analysis and logistic regression analysis was performed to investigate factors that affect life satisfaction. It was concluded from the analysis that gender, age, presence of spouse (demographic factors), house income, possession of house, presence of pensioner, registration to public pension plan, social discrimination (social-economical factors), level of disability, subjective health status, level of help needed for daily living, presence of care-giver, sufficiency of help, ability to go out by oneself, difficulty of using public transportations, and presence of medical checkups (disability and health factors.) make meaningful effects to life satisfaction of disabled seniors. Based on the derived results, this study suggests intensive interests and care-giving service for disabled seniors that live alone, institutional complementations to guarantee income security, including public or private pensions, improvements to social recognition and environments for discrimination of the disabled, organization of health and medical treatment service and health care system, comprehensive service provision to social welfare for both the disabled and seniors, and comprehensive service provision to both health care and social welfare.

• Korean Journal of Clinical Laboratory Science
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• v.53 no.1
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• pp.96-104
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• 2021

There will be many changes in job consciousness and job satisfaction due to changes in various job fields and social interests, and it is necessary to manage them efficiently for the organization to continue to grow. By analyzing factors influencing job satisfaction by occupation, the study intended to provide the necessary data for an efficient management plan. 400 Employees working at S tertiary hospital in Seoul from April 1st to April 15th, 2015 were targeted. An analysis of the validity and reliability of the influencing factors was conducted, and the allied health profession which showed the highest level of satisfaction in overall job satisfaction and influencing factors were identified. It was found that achievement, compensation and working environment in the medical doctor profession, achievement, compensation and job stability in the nursing profession, achievement and working environment in the allied health profession, achievement, interpersonal relationships, working environment, and job stability in the administrative profession, were the main influencing factors for job satisfaction. It can be seen that not only motivation factors but also hygiene factors affect job satisfaction. To increase the level of satisfaction, it is judged that systematic management of hygiene factors as well as motivation factors is necessary.

• Journal of Life Science
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• v.32 no.9
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• pp.734-741
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• 2022

Currently, around 40 million people worldwide are living with human immunodeficiency virus (HIV) infection making HIV a critical global health risk. Present therapies for HIV infection consist of drug cocktails that target different steps of the HIV life cycle to prevent infection, replication, and release of the virus. Due to its mutating nature, drug resistance coupled with side-effects of long-term drug use, novel strategies, and pharmaceuticals to treat and manage HIV infection are constant needs and continuously being studied. Plants allocate a major repertoire of chemical diversity and are therefore regarded as an important source of new bioactive agents that can be utilized against HIV. Since the early 1990s, upon recommendations of the World Health Organization, numerous studies reported phytochemicals from different structural classes such as flavonoids, coumarins, tannins and terpenes with strong inhibitory effects against HIV infection. The present review gathered and presented recent research (2021-present) on plant extracts and phytochemicals that exhibit anti-HIV properties with the aim of providing insights into future studies where ethnomedical and underutilized plant sources may yield important natural products against HIV. Considering the relation and importance of HIV treatment with current viral infection risks such as SARS-CoV-2, screening plants for anti-HIV agents is an important step towards the discovery of novel antivirals.

• The Journal of the Convergence on Culture Technology
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• v.8 no.6
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• pp.141-147
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• 2022

Care farm recently has been introduced as social farm and green care centered on Europe, and has been developing rapidly in the last 20 years. Although it is being introduced gradually in Korea, it is still only at the beginning level, and it does not provide a guide for systematic farm owners' model and operation of the Care farm. In Care farm, advanced countries are making it possible to operate a more common care farm by providing a systematic national guide. By reviewing the literature of these guidelines in advanced countries, the contents are organized to help compose the guidelines for domestic care farm. In Canada, Ireland, the Netherlands, Norway and Finland, the contents of the guidelines for care farm by country can be broadly divided into general matters, how to start a care farm project for farm owners, understanding of target audience, farm organization system, farm management, and farm life. As the demand for care farms increases in Korea as well, guidelines for farm owners should be disseminated to facilitate access to care farms. It is also considered a good way to make a guide by combining it with the medical field, and it seems that it is necessary for the farmer to understand the medical field to some extent.