Browse > Article
http://dx.doi.org/10.5352/JLS.2022.32.9.734

Plant-derived Anti-HIV Natural Products: A Review of Recent Research  

Karadeniz, Fatih (Marine Biotechnology Center for Pharmaceuticals and Foods, College of Medical and Life Sciences, Silla University)
Oh, Jung Hwan (Marine Biotechnology Center for Pharmaceuticals and Foods, College of Medical and Life Sciences, Silla University)
Publication Information
Journal of Life Science / v.32, no.9, 2022 , pp. 734-741 More about this Journal
Abstract
Currently, around 40 million people worldwide are living with human immunodeficiency virus (HIV) infection making HIV a critical global health risk. Present therapies for HIV infection consist of drug cocktails that target different steps of the HIV life cycle to prevent infection, replication, and release of the virus. Due to its mutating nature, drug resistance coupled with side-effects of long-term drug use, novel strategies, and pharmaceuticals to treat and manage HIV infection are constant needs and continuously being studied. Plants allocate a major repertoire of chemical diversity and are therefore regarded as an important source of new bioactive agents that can be utilized against HIV. Since the early 1990s, upon recommendations of the World Health Organization, numerous studies reported phytochemicals from different structural classes such as flavonoids, coumarins, tannins and terpenes with strong inhibitory effects against HIV infection. The present review gathered and presented recent research (2021-present) on plant extracts and phytochemicals that exhibit anti-HIV properties with the aim of providing insights into future studies where ethnomedical and underutilized plant sources may yield important natural products against HIV. Considering the relation and importance of HIV treatment with current viral infection risks such as SARS-CoV-2, screening plants for anti-HIV agents is an important step towards the discovery of novel antivirals.
Keywords
HIV; integrase; phytochemical; protease; reverse transcriptase;
Citations & Related Records
Times Cited By KSCI : 3  (Citation Analysis)
연도 인용수 순위
1 Priyadarshini, K., Kulandhaivel, M., Sankareswaran, M. and Anbalagan, S. 2021. In-vitro screening of reverse tran- scriptase activity of selected Indian medicinal plants against human immunodeficiency virus type-1. Eur. J. Mol. Clin. Med. 7, 5168-5175.
2 Dutta, T., Baildya, N., Khan, A. A. and Ghosh, N. N. 2021. Inhibitory effect of anti-HIV compounds extracted from Indian medicinal plants to retard the replication and tran- scription process of SARS-CoV-2: an insight from molec- ular docking and MD-simulation studies. Netw. Model. Anal. Health Inform. Bioinform. 10, 1-11.   DOI
3 Wu, H. F., Morris-Natschke, S. L., Xu, X. D., Yang, M. H., Cheng, Y. Y., Yu, S. S. and Lee, K. H. 2020. Recent advances in natural anti-HIV triterpenoids and analogs. Med. Res. Rev. 40, 2339-2385.   DOI
4 Pan, B., Li, S., Xiao, J., Yang, X., Xie, S., Zhou, Y., Yang, J. and Wei, Y. 2022. Dual inhibition of HIV-1 and cathe- psin L proteases by Sarcandra glabra. Molecules 27, 5552.
5 Gulick, R. M. and Flexner, C. 2019. Long-acting HIV drugs for treatment and prevention. Annu. Rev. Med. 70, 137-150.   DOI
6 Kaur, R., Sharma, P., Gupta, G. K., Ntie-Kang, F. and Kumar, D. 2020. Structure-activity-relationship and mech- anistic insights for anti-HIV natural products. Molecules 25, 2070.
7 Yin, Z. H., Yan, H. L., Pan, Y., Zhang, D. W. and Yan, X. 2022. Evaluation of a flavonoid library for inhibition of interaction of HIV-1 integrase with human LEDGF/p75 towards a structure-activity relationship. Ann. Med. 54, 1590-1600.   DOI
8 Zubair, M. S., Khairunisa, S. Q., Widodo, A., Nasronudin. and Pitopang, R. 2021. Antiviral screening on Alpinia ere- mochlamys, Etlingera flexuosa, and Etlingera acanthoides extracts against HIV-infected MT-4 cells. Heliyon 7, e06710.
9 Langarizadeh, M. A., Abiri, A., Ghasemshirazi, S., Foroutan, N., Khodadadi, A. and Faghih-Mirzaei, E. 2021. Phlor- otannins as HIV Vpu inhibitors, an in silico virtual screening study of marine natural products. Biotechnol. Appl. Biochem. 68, 918-926.   DOI
10 Maia, C. M. de A., Pasetto, S., Silva, J. P. R. e., Tavares, J. F., Costa, E. M. M. de B. and Murata, R. M. 2021. Anandenanthera colubrina (Vell.) Brenan as an inhibitor of HIV-1 BaL infection. Nat. Prod. Res. 36, 1621-1625.
11 Rotich, W., Mas-Claret, E., Sadgrove, N., Guantai, A., Padilla-Gonzalez, G. F. and Langat, M. K. 2022. HIV-1 integrase inhibitory effects of major compounds present in CareVidTM : An anti-HIV multi-herbal remedy. Life 12, 417.
12 Sanna, C., Marengo, A., Acquadro, S., Caredda, A., Lai, R., Corona, A., Tramontano, E., Rubiolo, P. and Esposito, F. 2021. In vitro anti-HIV-1 reverse transcriptase and integrase properties of Punica granatum L. leaves, bark, and peel extracts and their main compounds. Plants 10, 2124.
13 Sillapachaiyaporn, C., Rangsinth, P., Nilkhet, S., Moung- kote, N. and Chuchawankul, S. 2021. HIV-1 protease and reverse transcriptase inhibitory activities of Curcuma aeru- ginosa Roxb. rhizome extracts and the phytochemical profile analysis: In vitro and in silico screening. Pharmaceuti- cals 14, 1115.
14 Zheng, Y., Yang, X. W., Schols, D., Mori, M., Botta, B., Chevigne, A., Mulinge, M., Steinmetz, A., Schmit, J. C. and Seguin-Devaux, C. 2021. Active components from Cassia abbreviata prevent HIV-1 entry by distinct mecha- nisms of action. Int. J. Mol. Sci. 22, 5052.
15 Panvilai, S., Napaswad, C., Limthongkul, J. and Akkar- awongsapat, R. 2020. Aqueous extracts of Thai medicinal plants possess anti-HIV-1 activity. J. Herbs. Spices Med. Plants 27, 1-10.
16 Syed, I. A., Sulaiman, S. A. S., Hassali, M. A., Thiruchel- vam, K., Syed, S. H. and Lee, C. K. C. 2016. Beliefs and practices of complementary and alternative medicine (CAM) among HIV/AIDS patients: A qualitative exploration. Eur. J. Integr. Med. 8, 41-47.
17 WHO 1989. In vitro screening of traditional medicines for anti-HIV activity: memorandum from a WHO meeting. Bull. World Health Organ. 67, 613-618.
18 Olwenyi, O. A., Asingura, B., Naluyima, P., Anywar, G. U., Nalunga, J., Nakabuye, M., Semwogerere, M., Bagaya, B., Cham, F., Tindikahwa, A., Kiweewa, F., Lichter, E. Z., Podany, A. T., Fletcher, C. V., Byrareddy, S. N. and Kibuuka, H. 2021. In-vitro Immunomodulatory activity of Azadirachta indica A. Juss. ethanol: water mixture against HIV associated chronic CD4+ T-cell activation/ exhaustion. BMC Complement. Med. Ther. 21, 1-14.   DOI
19 Vora, J., Velhal, S., Sinha, S., Patel, V. and Shrivastava, N. 2021. Bioactive phytocompound mulberroside C and endophytes of Morus alba as potential inhibitors of HIV-1 replication: a mechanistic evaluation. HIV Med. 22, 690-704.   DOI
20 Terefe, E. M., Okalebo, F. A., Derese, S., Muriuki, J., Rotich, W., Mas-Claret, E., Sadgrove, N., Padilla-Gonzalez, G. F., Prescott, T. A. K., Siddique, H. and Langat, M. K. 2022. Constituents of Croton megalocarpus with potential anti-HIV activity. J. Nat. Prod. 85, 1861-1866.   DOI
21 Andersen, R. J., Ntie-Kang, F. and Tietjen, I. 2018. Natural product-derived compounds in HIV suppression, remis- sion, and eradication strategies. Antiviral Res. 158, 63-77.   DOI
22 Bertagnolio, S., Jordan, M. R., Giron, A. and Inzaule, S. 2022. Epidemiology of HIV drug resistance in low- and middle-income countries and WHO global strategy to monitor its emergence. Curr. Opin. HIV AIDS 17, 229-239.   DOI
23 Cary, D. C. and Peterlin, B. M. 2018. Natural products and HIV/AIDS. AIDS Res. Hum. Retroviruses 34, 31-38.   DOI
24 Fois, B., Corona, A., Tramontano, E., Distinto, S., Maccioni, E., Meleddu, R., Caboni, P., Floris, C. and Cottiglia, F. 2021. Flavonoids and acid-hydrolysis derivatives of neo- clerodane diterpenes from Teucrium flavum subsp. glau- cum as inhibitors of the HIV-1 reverse transcriptase-asso- ciated RNase H function. J. Enzyme Inhib. Med. Chem. 36, 749-757.   DOI
25 Tumilaar, S. G., Fatimawali, F., Niode, N. J., Effendi, Y., Idroes, R., Adam, A. A., Rakib, A., Bin Emran, T. and Tallei, T. E. 2021. The potential of leaf extract of Pangium edule Reinw as HIV-1 protease inhibitor: A computational biology approach J. Appl. Pharm. Sci. 11, 101-110.
26 Koch, M. A., Schuffenhauer, A., Scheck, M., Wetzel, S., Casaulta, M., Odermatt, A., Ertl, P. and Weldmann, H. 2005. Charting biologically relevant chemical space: A structural classification of natural products (SCONP). Proc. Natl. Acad. Sci. USA. 102, 17272-17277.   DOI
27 Guzzo, F., Russo, R., Sanna, C., Celaj, O., Caredda, A., Corona, A., Tramontano, E., Fiorentino, A., Esposito, F. and D'abrosca, B. 2021. Chemical characterization and anti-HIV-1 activity assessment of iridoids and flavonols from Scrophularia trifoliata. Molecules 26, 4777.
28 Harb, T. B. and Chow, F. 2022. Anti-HIV activity of meth- anolic and aqueous extracts of fifteen materials of beachcast macroalgae: valorization of underused waste biomass. Appl. Phycol. 3, 236-246.   DOI
29 Kharisma, V. D., Kharisma, S. D., Ansori, A. N. M., Kurniawan, H. P., Witaningrum, A. M., Fadholly, A. and Tacharina, M. R. 2021. Antiretroviral effect simulation from black tea (Camellia sinensis) via dual inhibitors mechanism in HIV-1 and ITS SOCIAL PERSPECTIVE IN Indonesia. Res. J. Pharm. Technol. 14, 455-460.   DOI
30 Li, G., Wang, Y. and De Clercq, E. 2022. Approved HIV reverse transcriptase inhibitors in the past decade. Acta Pharm. Sin. B 12, 1567-1590.   DOI
31 Lu, D. Y., Wu, H. Y., Yarla, N. S., Xu, B., Ding, J. and Lu, T. R. 2017. HAART in HIV/AIDS treatments: Future trends. Infect. Disord. Drug Targets 18, 15-22.
32 Messi, A. N., Bonnet, S. L., Owona, B. A., Wilhelm, A., Kamto, E. L. D., Ndongo, J. T., Siwe-Noundou, X., Poka, M., Demana, P. H., Krause, R. W. M., Mbing, J. N., Peg- nyemb, D. E. and Bochet, C. G. 2022. In vitro and in silico potential inhibitory effects of new biflavonoids from Ochna rhizomatosa on HIV-1 integrase and Plasmodium falciparum. Pharmaceutics 14, 1701.
33 Sierra-Aragon, S. and Walter, H. 2012. Targets for in- hibition of HIV replication: Entry, enzyme action, release and maturation. Intervirology 55, 84-97.   DOI
34 Murali, M., Gowtham, H. G., Ansari, M. A., Alomary, M. N., Alghamdi, S., Almehmadi, M., Singh, S. B., Shilpa, N., Aiyaz, M., Kalegowda, N., Ledesma, A. E. and Amruthesh, K. N. 2022. Repositioning therapeutics for SARSCoV-2: Virtual screening of plant-based anti-HIV com- pounds as possible inhibitors against COVID-19 viral RdRp. Curr. Pharm. Des. 28, 969-980.   DOI
35 Popovic-Djordjevic, J., Quispe, C., Giordo, R., Kostic, A., Katanic Stankovic, J. S., Tsouh Fokou, P. V., Carbone, K., Martorell, M., Kumar, M., Pintus, G., Sharifi-Rad, J., Docea, A. O. and Calina, D. 2022. Natural products and synthetic analogues against HIV: A perspective to develop new potential anti-HIV drugs. Eur. J. Med. Chem. 233, 114217.