• Journal of Radiation Protection and Research
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• v.30 no.4
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• pp.197-208
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• 2005

Although little information is available on the underlying mechanisms, various genetic factors have been associated with tissue-specific responses to radiation. In the present study, we explored the possibility whether organ specific gene expression is associated with radiosensitivity using samples from brain, lung and spleen. We examined intrinsic expression pattern of 23 genes in the organs by semi-quantitative RT-PCR method using both male and female C57BL/6 mice. Expression of p53 and p21, well known factors for governing sensitivity to radiation or chemotherapeutic agents, was not different among the organ types. Both higher expression of sialyltransferase, delta7-sterol reductase, leptin receptor splice variant form 12.1, and Cu/Zn superoxide dismutase (SOD) and lower expression of alphaB crystalline were specific for spleen tissue. Expression level of glutathione peroxidase and APO-1 cell surface antigen gene in lung tissue was high, while that of Na, K-ATPase alpha-subunit, Cu/ZnSOD, and cyclin G was low. Brain, radioresistant organ, showed higher expressions of Na, K-ATPase-subunit, cyclin G, and nucleolar protein hNop56 and lower expression of delta7-sterol reductase. The result revealed a potential correlation between gene expression patterns and organ sensitivity, and Identified genes which might be responsible for organ sensitivity.

• Journal of Radiation Protection and Research
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• v.48 no.3
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• pp.153-161
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• 2023

Background: Fukushima Medical University (FMU) is located 57 km northwest of the Fukushima Daiichi Nuclear Power Plant. Our laboratory has been conducting environmental radiation measurements continuously before and after the nuclear accident. We aimed to report the observed behavior of radiation originating from the released radioactive materials due to the accident, predict future trends, and disseminate the results to the local residents. Materials and Methods: Measurements of the counting rate by a diameter of 76 mm and a length of 76 mm thallium-doped sodium iodide (NaI[Tl]) scintillation detector (S-1211-T; Teledyne Brown Engineering Environmental Services) in the central part of the laboratory, and the dose rate outward at the window by NaI(Tl) scintillation detector and digital processor (EMF211; EMF Japan Co. Ltd.) were conducted. Results and Discussion: Measurements by Teledyne S-1211-T showed that in the early stages, radiation from radioactive isotopes with short half-lives was dominant, while radiation from radioactive isotopes with longer half-lives became dominant as the measurement period became longer. Through nonlinear least squares regression, both short and long half-lives were successfully determined. It was also possible to predict how the radiation dose would decrease. The environmental radiation trends around FMU were measured by the EMF211. Both measurements were affected by rainfall and snow accumulation. Decontamination work on the FMU campus impacted measurements by the EMF211 especially. Conclusion: The results of two types of measurements, one at the center and the other at the window side of the laboratory, were presented. By applying a simplified model, radiation from radioactive isotopes with short and long half-lives was identified. Based on these results, future trends were predicted, and the information was used for public communication with the local residents.

• Convergence Security Journal
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• v.19 no.5
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• pp.25-36
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• 2019

With the development of information and communication technology, hospitals that electronically process and manage medical information of patients are increasing. However, if medical information is processed electronically, there is still room for infringing personal information of the patient or medical staff. Accordingly, in 2017, the International Organization for Standardization (ISO) published ISO TS 25237 Health Information - Pseudonymization[1]. In this paper, we examine the re - identification process based on ISO TS 25237, the procedure and the problems of our proposed method. In addition, we propose a new processing scheme that adds a re-identification procedure to our secure differential privacy method [2] by keeping a mapping table between de-identified data sets and original data as ciphertext. The proposed method has proved to satisfy the requirements of ISO TS 25237 trust service providers except for some policy matters.

• Proceedings of the Korea Information Processing Society Conference
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• 2021.05a
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• pp.33-36
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• 2021

Corona 19 minimizes face-to-face contact, and online untact platforms are emerging in the medical sector. However, there are potential risks of medicine expiration, medicine misuse, and responsible materials management for secure delivery. In this paper, we investigate three key functional requirements for online pharmacy, and design the blockchain based online pharmacy to meet the requirements. To protect the patient's privacy and to ensure tamper-free traceability, we incorporate the multi-level access authentication scheme for each participant (governments, medical circles, and patients). We show that our system guarantees patient's privacy without further system modification.

• Journal of Satellite, Information and Communications
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• v.6 no.2
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• pp.10-14
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• 2011

This paper suggests the method to calculate radiation limit of ISM(Industrial Scientific Medical) equipment in order to protect radio device in the situation that ISM equipment and radio device are operated in near distance. The factor for correction and protection ratio which is need for protecting radio device were considered to calculate radiation limit of ISM equipment. Also, the scenario which is required to limit radiation power of ISM equipment was referred and the S/W for calculation of radiation limit was developed by using GUI(Graphical User Interface) on Matlab. The suggested method for calculation of radiation limit of ISM equipment will be used to protect radio device from ISM equipment.

• International Journal of Computer Science & Network Security
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• v.23 no.6
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• pp.155-161
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• 2023

In the process of remarkable progress in the medical and technical field and activating the role of technology in health care services and applications, and since the safety of medical data and its protection from security violations plays a major role in assessing the security of health facilities and the safety of medical servers Thus, it is necessary to know the cyber vulnerabilities in health information systems and other related services to prevent and address them in addition to obtaining the best solutions and practices to reach a high level of cybersecurity against attackers, especially due to the digital transformation of health care systems and the rest of the dealings. This research is about what cyberattacks are and the purpose of them, in addition to the methods of penetration. Then challenges, solutions and some of the security issues will be discussed in general, and a special highlight will be given to obtaining a safe infrastructure to enjoy safe systems in return.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.3
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• pp.1299-1308
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• 2016

Our previous studies clearly demonstrated that a combination of WP 631 and Epo B has higher activity against ovarian cancer cells than either of these compounds used separately. In order to fully understand the exact mechanism of action in combination, we assessed effects on the cell cycle of SKOV-3 cells. We evaluated three control points essential for WP 631 and Epo B action to determine which cell cycle-regulating proteins (CDK1/cyclin B complex, EpCAM or HMGB1) mediate activity. The effects of the drug on the cell cycle were measured based on the nuclear DNA content using flow cytometry. Expression of cell cycle-regulating genes was analyzed using real-time PCR. It was discovered that WP 631, at the tested concentration, did not affect the SKOV-3 cell cycle. Epo B caused significant G2/M arrest, whereas the drug combination induced stronger apoptosis and lower mitotic arrest than Epo B alone. This is very important information from the point of view of the fight against cancer, as, while mitotic arrest in Epo B-treated cells could be overcame after DNA damage repair, apoptosis which occurs after mitotic slippage in combination-treated cells is irreversible. It clearly explains the higher activity of the drug combination in comparison to Epo B alone. Epo B acts via the CDK1/cyclin B complex and has the ability to inhibit CDK1, which may be a promising strategy for ovarian cancer treatment in the future. The drug combination diminishes EpCAM and HMGB1 expression to a greater degree than either WP 631 and Epo B alone. Owing to the fact that the high expression of these two proteins is a poor prognostic factor for ovarian cancer, a decrease in their expression, observed in our studies, may result in improved efficacy of cancer therapy. The presented findings show that the combination of WP 631 and Epo B is a better therapeutic option than either of these drugs alone.

• Journal of Veterinary Clinics
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• v.37 no.1
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• pp.15-22
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• 2020

This study investigated the effectiveness of radiation safety rules in animal hospital and the awareness and behavior of veterinary radiation workers. With the questionnaires, the data was collected from randomly selected veterinarians in animal hospitals and animal medical imaging centers. Collected data were about radiation device, shielding device, regulations, safety management, education, knowledge, behavior and awareness. Frequency, correlation and multiple regression analysis were performed. The medical devices related with radiation in animal hospital were X-ray (59%), CT (15%), fluoroscopy (12%), mobile X-ray (12%) and others (2%). The number of people using radiation shielding device is high. The answers were low on knowing radiation related regulation and receiving radiation protection education. The group with higher knowledge and awareness shows positive correlation with safety behavior. The increase of use of the radiation related medical devices in veterinary hospital causes the increase of radiation exposure risk. This study suggests that radiation safety management system and policies need to be developed to protect radiation workers and give them correct information and consciousness.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2021.10a
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• pp.47-49
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• 2021

According to the revision of the Data 3 Act in 2020, personal information of medical data can be processed anonymously for statistical purposes, research, and public interest record keeping. However, unidentified data can be re-identified using genetic information, credit information, etc., and personal health information can be abused as sensitive information. In this paper, we derive the need for homomorphic encryption to protect the privacy of personal information separated by sensitive information.

• Journal of Radiation Protection and Research
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• v.46 no.1
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• pp.1-7
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• 2021

Background: The use of computed tomography (CT) device has increased in the past few decades in Japan. Dose optimization is strongly required in pediatric CT examinations, since there is concern that an unreasonably excessive medical radiation exposure might increase the risk of brain cancer and leukemia. To accelerate the process of dose optimization, continual assessment of the dose levels in actual hospitals and medical facilities is necessary. This study presents organ dose estimation using pediatric cerebral CT scans in the Kyushu region, Japan in 2012 and the web-based calculator, WAZA-ARI (https://waza-ari.nirs.qst.go.jp). Materials and Methods: We collected actual patient information and CT scan parameters from hospitals and medical facilities with more than 200 beds that perform pediatric CT in the Kyushu region, Japan through a questionnaire survey. To estimate the actual organ dose (brain dose, bone marrow dose, thyroid dose, lens dose), we divided the pediatric population into five age groups (0, 1, 5, 10, 15) based on body size, and inputted CT scan parameters into WAZA-ARI. Results and Discussion: Organ doses for each age group were obtained using WAZA-ARI. The brain dose, thyroid dose, and lens dose were the highest in the Age 0 group among the age groups, and the bone marrow and thyroid doses tended to decrease with increasing age groups. All organ doses showed differences among facilities, and this tendency was remarkable in the young group, especially in the Age 0 group. This study confirmed a difference of more than 10-fold in organ doses depending on the facility and CT scan parameters, even when the same CT device was used in the same age group. Conclusion: This study indicated that organ doses varied widely by age group, and also suggested that CT scan parameters are not optimized for children in some hospitals and medical facilities.