• Genomics & Informatics
• /
• v.6 no.3
• /
• pp.153-156
• /
• 2008

Complex diseases such as stroke and cancer have two or more genetic loci and are affected by environmental factors that contribute to the diseases. Due to the complex characteristics of these diseases, identifying candidate genes requires a system-level analysis of the following: gene ontology, pathway, and interactions. A database and user interface, termed StrokeBase, was developed; StrokeBase provides queries that search for pathways, candidate genes, candidate SNPs, and gene networks. The database was developed by using in silico data mining of HGNC, ENSEMBL, STRING, RefSeq, UCSC, GO, HPRD, KEGG, GAD, and OMIM. Forty candidate genes that are associated with cerebrovascular disease were selected by human experts and public databases. The networked cerebrovascular disease gene maps also were developed; these maps describe genegene interactions and biological pathways. We identified 1127 genes, related indirectly to cerebrovascular disease but directly to the etiology of cerebrovascular disease. We found that a protein-protein interaction (PPI) network that was associated with cerebrovascular disease follows the power-law degree distribution that is evident in other biological networks. Not only was in silico data mining utilized, but also 250K Affymetrix SNP chips were utilized in the 320 control/disease association study to generate associated markers that were pertinent to the cerebrovascular disease as a genome-wide search. The associated genes and the genes that were retrieved from the in silico data mining system were compared and analyzed. We developed a well-curated cerebrovascular disease-associated gene network and provided bioinformatic resources to cerebrovascular disease researchers. This cerebrovascular disease network can be used as a frame of systematic genomic research, applicable to other complex diseases. Therefore, the ongoing database efficiently supports medical and genetic research in order to overcome cerebrovascular disease.

• Korean Journal of Oriental Medicine
• /
• v.8 no.2 s.9
• /
• pp.1-16
• /
• 2002

${\ulcorner}Gogeumdoseojipseong{\lrcorner}$, it has been compiled by Chenmenglei(1651-1723). This large encyclopedia was published in 1125 during Ohing dynasty of China in the reign of the Kangxi emperor. The medical parts of this encyclopedia was titled the name of Yibuquanlu, but it is not correct. KIOM(Korea Institute of oriental Medicine) researched the compilation and publication of the original book of this and the process of introduction to Chosun with its woodblock-printed book for making database of this book. Even more, we analyzed the structure of this book and apprehended the historical significance about medical interchange between Korea and China by this book. As the result, we found that the most part of this large encyclopedia quotedfrom ${\ulcorner}Donguibogam{\lrcorner}$ of Chosun, then it was back to Chosun and taken a part to medical books such as ${\ulcorner}Imwonkyungjaejis{\lrcorner}$, ${\ulcorner}Uijongsonikr{\lrcorner}$.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
• /
• 2000.10b
• /
• pp.187-193
• /
• 2000

An expert system for a ship medical manager is presented in this paper where it si planned to improve the medical environment of the crew. The proposed system includes a information retrieval system that is based on the knowledge database organizing important experiences of first-aiders and is intended to be used effectively by the inexpert member. Moreover, this system of which the purpose is to computerize the medical work of each ship medical manager that the third officer give an affirmative guide for the execution of their duty from the medical treatment database of the disease occurring frequently on many crews.

• Journal of Korean Public Health Nursing
• /
• v.18 no.1
• /
• pp.154-166
• /
• 2004

The purpose of this study was to design and implementation of database for school health activity. This database system was designed stand-alone application for college school health center without a hospital affiliation and the database system was made of relational database management system, Microsoft access 2000 to be made GUI (Graphic user interface) type design and made up 7 tables: patients. symptoms. departments, income and outgo. medical cures. and medicine. The construction of this database system was patient management. code management. medicine management. and statistics management. The results of the database system were as follows; 1) This database system could be used for college school health center. 2) This database system could be made correct statistic data. 3) This database system could be managed income and outgo. 4) This database system could be changed for the better activity of community health service. 5) This database system could be simply attired administrative system. This database system will be used for students and employees to protect and promote health to measure for health level and quality of health service. In conclusion. this database system can be applied for unit health center to manage the college school health activity and advanced data management can be applied for health profession to do quality improvement. cost containment. management information system. and decision support system.

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.26 no.4
• /
• pp.551-556
• /
• 2012

The database for the oriental medicine had been existed in documentation in past times and it has been developed to the database type for random accesses in the information society. However, the aspects of the database are not so diversified and the database for the bio herbal material exists in widened type dictionary style. It is a situation that the database which handles the in-depth raw herbal medicines is not sufficient in its quantity and quality. Korean wild grape is a deciduous plant categorized into the Vitaceae and it was found experimentally that it has various medical effects. It is one of the medical materials with higher potentiality of academic study and commercialization recently because it has a bigger possibility to be applied into diverse industrial fields including the medical product for health, food and beauty. We constituted the cooperative system among the Muju cluster business group for Korean mountain wild grapes, Physiology Laboratory in Kyung Hee University Oriental Medicine and Medical Classics Laboratory in Kyung Hee University Oriental Medicine with a view to focusing on such potentiality and a database for Korean wild grapes was made a touchstone for establishing the in-depth database for the single bio medical materials. First of all, the literatures based on the North East Asia in ancient times had been categorized into the classical literature (Korean literature published by government organization, Korean classical literature, Chinese classical literature and classical literature fro Korean and Chinese oriental medicine) and modern literature (Modern literature for oriental medicine, modern literature for domestic and foreign herbal medicine) to cover the eastern and western research records and writings related to Korean wild grapes and the text-mining work has been performed through the cooperation system with the Medical Classics Laboratory in Kyung Hee University Oriental Medicine. First of all, the data for the experiment and theory for Korean wild grape were collected for the Medline database controlled by the Parliament Library of USA to arrange the domestic and foreign theses with topic for Korean wild grapes and the network hyperlink function and down load function were mounted for self-thesis searching function and active view based on the collected data. The thesis searching function provides various auxiliary functions and the searching is available according to the diverse searching/queries such as the name of sub species of Korean wild grape, the logical intersection index for the active ingredients, efficacy and elements. It was constituted for the researchers who design the Korean wild grape study to design of easier experiment. In addition, the data related to the patents for Korean wild grape which were collected from European Patent Office in response to the commercialization possibility and the system available for searching and view was established in the same viewpoint. Perl was used for the query programming and MS-SQL for database establishment and management in the designing of this database. Currently, the data is available for free use and the address is as follows. http://163.180.41.43:8011/index.html

• Journal of Digital Convergence
• /
• v.10 no.5
• /
• pp.315-320
• /
• 2012

The purpose of this study is to establish management and support system for traditional medical manuscripts using bibliographical, linguistic and traditional medical methods in order to protect disappearing and take advantage of traditional medicine. We'll translate selective traditional medical manuscripts into Korean and build a database and computerized database, which improve value of future diverse application and restore and give shape to traditional medical documents by providing methods for ontology of traditional medicine. We also arrange and analyze the old traditional medical books with diverse study system and evaluate medical usefullness. We intend to provide practical use of the prescription in based medicine as well as clinical medicine by reinterpretation from modem viewpoint.

• Journal of Korea Entertainment Industry Association
• /
• v.4 no.4
• /
• pp.72-76
• /
• 2010

Clinical nomogram is a graphical representation of numeric formula, constructed from clinical cases database of followed patients' treatment, which is used for medical predication. For a clinical nomogram to contribute patient care, it is required to accumulate as many as clinical cases and to extract medical prediction knowledge. It needs to be equipped with an effective method to build medical nomogram with high predication accuracy. It is desirable for medical nomogram to be accessible at patient care point. This paper proposes a medical nomogram service system architecture which takes into account the above-mentioned issues. The proposed system architecture includes a web-based database subsystem to maintain and keep track of clinical cases. On the periodic basis, a new clinical nomogram is reconstructed for the updated clinical database. For the convenient use of patient care practice environment, an app-based program is provided which makes prediction based on the most recent clinical nomogram constructed in the service system. The proposed method has been applied to a clinical nomogram service system development for recurrence and survival prediction in bladder cancer patients.

• The Journal of Korean Medical History
• /
• v.35 no.2
• /
• pp.45-67
• /
• 2022

Currently, there are about 20,000 or so known ancient medical texts from the East Asian medical traditions. Although the most famous texts are widely known, many texts still exist only as original manuscripts. We are interested exploring these texts to uncover the potential benefits of their therapeutic knowledge. This study aims to develop a database program that automatically converts the treatment skills described in the text version into a more structured version. In the previous study, our team analyzed patterns in the way that treatment skills are described and then tried to design a database program algorithm that identified every meaningful keyword used to describe treatment skills and put that word in the right cell of a structured table. This study continues the development of this program. East Asian medical herbal treatment information is broken down into 4 elements: the first one is the name or title of treatment skills, and the second is the symptoms to which the treatment is applied, the third is ingredients used, the fourth is how information is processed and the indications taken. This study presents the algorithm's principles on how to analyze and structure the fourth element, the processing of information and taking of indications, which is described in a form of ancient natural language.

• Proceedings of the Korea Inteligent Information System Society Conference
• /
• 2001.01a
• /
• pp.361-363
• /
• 2001

Although data mining promises a new paradigm to discover medical knowledge form a database, there are many problems to be solved before real application is feasible. We had the chance to provide a data set to be analyzed as a discovery challenge by using various data mining techniques at the PKDD conference. As data providers, we evaluated and discussed results and clarified problems.

• The Journal of Korean Medical History
• /
• v.33 no.1
• /
• pp.113-125
• /
• 2020

This paper analyzes information on Augmented Widen the Core Powder (加味普正散) (AWCP) in the Dr. Kim Young Hoon's medical record database, Cheongang Medical Records. AWCP is a prescription that is not found in the existing medical texts, yet is referred to in Dr. Kim Young Hoon's medical record database. By examining these records, this study shows that the original prescription for AWCP was Decoction for Rectifying the Qi with Cyperus and Kudzu (香葛正氣飮) and that this prescription was deeply related to Rectify the Qi Powder Worth More Than Gold (不換金正氣散) as well as Cyperus and Kudzu Decoction (香葛飮). In addition, AWCP had several names over a long period of time, and its name changed from the Powder of Relieving Lives and Rectifying the Qi (普救正氣散) to AWCP. In particular, this study shows that the term 'gami' (加味 augmented) indicates a change in prescription name, not a change in the composition of the prescription.