• 한국의학물리학회지:의학물리
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• 제19권1호
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• pp.73-79
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• 2008

망막색소변성(retinitis pigmentosa: RP)과 연령 관련 황반변성(age-related Macular Degeneration: AMD)은 망막변성으로 인해 실명에 이르는 대표적인 질환이며 망막이식장치의 개발을 통해 치료될 수 있다고 간주되고 있다. 최근에 국내에서도 망막이식장치 개발을 위한 연구팀이 조직되었다. 성공적인 망막이식장치 개발을 위하여 여러 가지 선결요소가 필요하지만 그 중 한 가지가 이식장치에 인가할 전기자극을 최적화하는 것이다. 변성망막의 전기적 특성은 정상 망막과 다르리라 예측되므로 우리는 장차 개발될 망막 이식장치에 인가할 전기자극 최적화를 위한 가이드라인을 제공하기 위해 정상 망막과 변성 망막의 전압자극 파라미터에 관한 실험을 하였다 망막을 분리한 후 망막절편을 신경절세포 층이 다채널전극의 표면을 향하게 하여 전극에 붙인다 in-vitro 상태에서 망막 신경절세포의 전기신호를 기록하기 위해 전극 직경: $30{\mu}m$, 전극간 거리: $200{\mu}s$, 전극 임피던스 1kHz 에서 $50k{\Omega}$인 8행 8열의 다채널전극을 사용하였다. 다채널전극의 60채널 중 두 채널을 자극전극과 접지로 사용하여 단극전기자극을 인가하였고 나머지 전극을 기록전극으로 사용하였다. 가한 전기자극은 전압자극으로 전하균형을 맞춘 이상성자극을 아노딕 사각파를 먼저 주고 캐쏘딕 사각파가 나중에 나오는 형태로 두 사각파간의 지체는 없도록 하였으며 동일한 자극을 2초 간격으로 50회 반복하여 인가하였다. 다양한 전기자극을 사용하였는 바 첫째는 사각파의 크기를 달리하였다 $(0.5{\sim}3V)$. 둘째는 사각파의 시간을 달리하였다 $(100{\sim}1,200{\mu}s)$. 전하밀도는 옴의 법칙과 쿨롱의 법칙을 이용하여 계산하였다. 전기자극으로 유발된 반응은 50회 자극에 대한 평균치를 얻은 후 자극 후 히스토그램(PSTH)을 그려 분석하였다. 전압자극의 크기를 $0.5{\mu}3V$로 달리하였을 때 믿을 만한 망막신경절세포가 유발되는 자극은 1.5V이었고 이때 계산된 전하밀도의 역치는 $2.123mC/cm^2$이었다. 전압의 크기를 2V로 고정하고 자극 지속시간을 $100{\sim}1,200{\mu}s$로 달리하였을 때 믿을 만한 망막신경절세포가 유발되는 자극의 역치는 $300{\mu}s$에서 관찰되었다. 이때 계산된 전하밀도의 역치는 $1.698mC/cm^2$이었다. L-(1)-2-amino-4-phosphonobutyric acid (APB)을 사용하여 ON-경로를 차단한 후에 전기자극을 인가하였을 때도 자극에 의해 망막신경절 세포의 반응이 유발되는 것을 확인하였다. APB-변성망막에서 전압의 크기를 2V로 고정하고 자극 지속시간을 $100{\sim}1,200{\mu}s$로 달리하였을 때 믿을 만한 망막신경절세포가 유발되는 자극의 역치는 $300{\mu}s$에서 관찰되었으며 이는 정상망막의 결과와 같았다. 추후 APB-변성망막을 가지고 좀더 실험이 진행되어야 정상망막과 변성망막의 전하밀도에 관한 명료한 비교가 가능할 것이다.

• 한국정보통신학회논문지
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• 제9권5호
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• pp.1045-1051
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• 2005

한의학적 침구치료원리에 근거한 새로운 자극방식을 통해 치료효과를 증대시킬 수 있는 구강안면 동통 진단/치료기를 개발하였다. 이 새로운 DDTS-1 치료기는 기존방식과는 달리 캐패시터를 이용하여 동통발생 원인인 인체의 과잉 이온전하를 흡수하여 치료하는 방식이다. 과도한 이온전하를 흡수하여 치료하기 위한 최적 파라미터 추출은 실험을 통해, 캐패시터의 충방전을 제어하기 위한 제어신호의 최적의 주파수는 6hz, 캐패시턴스는 $0.1\~0.33{\mu}F$으로 결정하였다. 임상실험을 통해 시스템의 검증을 위해 치성동통환자, 3차 신경통환자 등을 대상으로 정상부위와 이상부위의 전위를 측정하였다. 그 결과, 기존 자극기는 치료전과 후의 전위차가 매우 작았으며 DDTS-1은 생체전위차가 동일하거나 비슷해지는 뚜렷한 차이를 보였다. 따라서, DDTS-1의 자극방식이 기존의 전기적 자극방식보다 치료효과 측면에서 더 효과적이며 이는 캐패시터를 이용한 인체 이온전하 흡수방식의 타당성을 검증하였다. 즉, DDTS-1 치료기의 자극방식에 따른 동통조절기전의 이론적 타당성을 검증하고 성능 및 신뢰성을 검증하였다.

• 의료법학
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• 제9권2호
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• pp.11-52
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• 2008

Based on foreign examples and past debates, the minimal conditions for passive euthanasia can be suggested as following; (1) The patient is incurable by modem medical practice and his death is impending (less than 6 months), (2) Euthanasia is practiced solely to relieve physical pain of the patient, (3) If the patient can express his will, there should be a clear and sincere request or consent, (4) More than 2 doctors including doctor in charge should consent, (5) Euthanasia should be practiced in ethical way, (6) Patient family should agree(when the patient will is assumed.) It is hard to resolve issues regarding euthanasia based on past rulings and cases without concrete law. As in United States and Germany, clear and objective provisions of euthanasia and definitive method for patient's advanced directive should be legislated to resolve medical conflict and to relieve patient and family from agony. And death with dignity debate will not be able to proceed if it is only substantively approached because of unclear definition of euthanasia and benefit comparison way of thinking. Thus it is important to establish definitive process to decided legislation of euthanasia act and resolving conflicts arising from each step of the process among interested parties exchanging medical/ethical opinions.

• 대한통합의학회지
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• 제2권3호
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• pp.15-22
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• 2014

Backround : The paradigm of recent education has been shifting from existing style of professor-oriented, passive and rote teaching to learner-centered education. Rather than mere delivery of knowledge, today's idea of education uses various audiovisual media to let learners gain more problem-solving skills, judgment, cognitive thinking ability, and creativity to apply to real practice. Also, while current trends and change in policy ask for related industry to require practice-centered teaching learning model, Problem-Based Learning (PBL) is quite effective that it activates problem-solving skills as well as application of National Competency Standards (NCS). Purpose : The purpose of this study was to suggest a teaching learning model article as an approach to apply web-based PBL for patient & medical charge management practices. Discussion & Conclusion : This paper the cases on PBL and presents the teaching learning model on web-based PBL as an approach to applying web-based PBL, which fits Medical Information System Department that combines health-medical treatment and computer applications, to practical health administrative affairs.

• 한국한의학연구원논문집
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• 제13권2호통권20호
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• pp.37-45
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• 2007

Background : The 'Korean Medicine' is the traditional medicine in Korea, which has preserved its homogeneous quality in the long historic period. But since 1945 when Korea was divided, the Korean Medicine has also been independently developed in South and North Korea. As a Result, it has lost its national homogeneity. Objective : In order to illuminate the past and an actuality of the transition and medical system of traditional medicine in North Korea. Method : Overview a preceding research paper and the various data of traditional medicine in North Korea. Result : 1. The name of North Korea traditional medicine from 'East medicine' was changed history with 'Korean medicine', It with the method which combines a traditional medicine and a Western medicine is endeavoring to modernization. 2. The administrative systems which take charge of the traditional medicine of North Korea are the organization which manages the Korean medicine and the Bureau of The Korean medicine production control. Also there is relation of the Bureau of the treatment prevention. 3. There are 8 medical colleges other than P'yongyang medical college. There is 6 years 6 months and 7 years 7 month follows in curriculum. Conclusions : It evaluated the past and an actuality of the transition and medical system of traditional medicine in North Korea.

• Biomolecules & Therapeutics
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• 제25권5호
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• pp.471-481
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• 2017

The canonical transient receptor potential channels (TRPCs) constitute a series of nonselective cation channels with variable degrees of $Ca^{2+}$ selectivity. TRPCs consist of seven mammalian members, TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7, which are further divided into four subtypes, TRPC1, TRPC2, TRPC4/5, and TRPC3/6/7. These channels take charge of various essential cell functions such as contraction, relaxation, proliferation, and dysfunction. This review, organized into seven main sections, will provide an overview of current knowledge about the underlying pathogenesis of TRPCs in cardio/cerebro-vascular diseases, including hypertension, pulmonary arterial hypertension, cardiac hypertrophy, atherosclerosis, arrhythmia, and cerebrovascular ischemia reperfusion injury. Collectively, TRPCs could become a group of drug targets with important physiological functions for the therapy of human cardio/cerebro-vascular diseases.

• 한국통신학회논문지
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• 제32권4C호
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• pp.389-395
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• 2007

기존의 필름 X-Ray 및 CCD(Charge Coupled Device) 방식은 공간적인 제약과 진단 시간이 많이 걸리는 단점이 있다. 본 논문에서는 기존 방식들의 단점을 보완할 수 있는 TFT-DXD 방식의 digital X-ray detector (DR1000C)를 이용한 고효율 의료 영상처리시스템을 구현하였다. 본 논문에서 제안하는 DR1000C를 이용한 의료용 영상처리시스템은 기존의 X-Ray 방식에 비해 공간 효율성이 높고 진단 시간이 짧아진다는 장점이 있다. 영상처리시스템에서 획득한 영상을 고화질로 만들기 위해 1900*1200의 해상도를 가지는 LCD 컨트롤 드라이버를 개발하였고, 영상의 성능향상을 위해 enhancement unsharp masking 기법을 제안하여, 기존의 방식과 비교하였다.

• 의료법학
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• 제12권2호
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• pp.163-187
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• 2011

On March 11, 2011, the Korea National Assembly finally passed the bill on the Damage Relief on the Medical Malpractice and Mediation for Medical Dispute. One of the features of this Act is including "The Subrogation Payment System for Damage (abbreviated SPSD)". This System is that 'Korean Medical Dispute Mediation-Arbitration Board' pays the damages, instead of the health care provider, for the patient who isn't paid damages by the health care provider despite of the Mediation or ruling. The purpose of this study is to search the problems and make improvement on SPSD. This System was introduced extreamly to the patients in order to induce them to the mediation. However,there remains several problems. In this articles, I have examined thoroughly the legal issues on SPSD. There are legal issues about the methods and ratio of the financial burden. In this connection, wide discretionary authority has been granted to administrative agencies specifically. On this account, this System clearly contains elements of a violation against the Constitutional Law. Moreover, this System can be broadly applied to the case of court ruling or the Korea Consumer Agency's mediation. But these measures go against the aim of legislation that the medical dispute can be resolved through the mediation or arbitration by this Act. In the end, these problems must be revised through the additional discussion.

• 기본간호학회지
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• 제10권3호
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• pp.354-360
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• 2003

Purpose: This study was done for the purpose of identifying the relationship between work stress and job satisfaction of nurses who were evaluating medical insurance. Method: The participants in the study were 154 nurses who were in charge of evaluating medical insurance in 32 hospitals in Korea. Data were collected for 1 month from April 20 to May 20, 2001. Result: The mean total work stress score was 93.79. In comparison with work stress scores according to the work stress factors, 'work overload'(2.95) had the highest work stress score. The mean total job satisfaction score was 69.56. The total work stress scores did not show significant differences for any of the variables. The total job satisfaction score showed significant differences for the variables of age (F=3.51, p=.01), position (F=3.16, p=.02) and reason for transfer from one department to another (F=3.40, p=.003). Conclusion: The total work stress score showed a inverse correlation(v=-.36, p=.001) with the total job satisfaction score.

• The Journal of Korean Physical Therapy
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• 제14권4호
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• pp.75-86
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• 2002

The patients with a central nervous impediment and a sequela caused by a Stroke are continuously increasing, and the burden of family and society for Stroke patients are also increasing. Since Stroke patients are required to receive a long time medical treatment and care. It adds a economical burden as well as a mental and physical burden of patient's family. In addition, it is a primary factor which deepens the disparity of medical resources in social aspect. But the social concern for these patients are very insufficient and are entirely left to the patient's family The mediation of Skilled Nursing Facility for Stroke patients enable to receive more special and proper medical treatment and recuperation service in the middle of time when they return to home from hospital. It also contributes to the settlement of the charge of patient's family and the serious disparity of medical resources. Therefore, this study will summon the social understanding of the necessity of Skilled Nursing Facilities through the above debate.