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Dosimetric Plan Comparison of Accelerated Partial Breast Irradiation (APBI) Using CyberKnife

  • Lee, Chang Yeol;Kim, Woo Chul;Kim, Hun Jeong;Lee, Jeongshim;Park, Seungwoo;Huh, Hyun Do
    • Progress in Medical Physics
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    • v.29 no.2
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    • pp.73-80
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    • 2018
  • Accelerated partial breast irradiation (APBI) is a new treatment delivery technique that decreases overall treatment time by using higher fractional doses than conventional fractionation. Here, a quantitative analysis study of CyberKnife-based APBI was performed on 10 patients with left-sided breast cancer who had already finished conventional treatment at the Inha University Hospital. Dosimetric parameters for four kinds of treatment plans (3D-CRT, IMRT, VMAT, and CyberKnife) were analyzed and compared with constraints in the NSABP B39/RTOG 0413 protocol and a published CyberKnife-based APBI study. For the 10 patients recruited in this study, all the dosimetric parameters, including target coverage and doses to normal structures, met the NSABP B39/RTOG 0413 protocol. Compared with other treatment plans, a more conformal dose to the target and better dose sparing of critical structures were observed in CyberKnife plans. Accelerated partial breast irradiation via CyberKnife is a suitable treatment delivery technique for partial breast irradiation and offers improvements over external beam APBI techniques.

A Study of the Production of an Algorithm That Standardizes Descriptions of Medical Techniques Found in Ancient East Asian Medical Texts (비정형 한의약텍스트 자동정형화프로그램 알고리즘개발 - 동의보감 약재정보를 중심으로)

  • CHA Wung-seok;AHN Sang-woo
    • The Journal of Korean Medical History
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    • v.35 no.1
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    • pp.13-36
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    • 2022
  • For the past several decades, East Asian medicine has been examined in order to uncover its effectiveness in areas where biomedicine is found wanting. Although scientific approaches have been increasingly used to verify the utility of treatment techniques, countless traditional medical techniques found in ancient texts remain to be tested. Currently, about 20,000 or so ancient medical texts are recognized within the East Asian medical tradition. Although some famous texts have been translated and studied, many still exist only as original manuscripts. We are interested in the medical techniques that are listed in those manuscripts. Even before we can ascertain whether such ancient forms of medical treatment can be applied today it is important to understand the full picture of what kind of treatment technology exists. This study aims to develop a database program that automatically converts the original textual description of an East Asian medical technique into a more standardized version. First, our team analyzed the ways that medical skills were described and then designed a database algorithm that recognized the meaningful keywords of the descriptive text for a medical treatment and put it in the right cell in a structured table.

Phase II Study on Safety and Efficacy of Yadanzi® (Javanica oil emulsion injection) Combined with Chemotherapy for Patients with Gastric Cancer

  • Liu, Jin;Huang, Xin-En;Tian, Guang-Yu;Cao, Jie;Lu, Yan-Yan;Wu, Xue-Yan;Xiang, Jin
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.3
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    • pp.2009-2012
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    • 2013
  • Objective: To investigate the efficacy and safety of Yadanzi$^{(R)}$ (Javanica oil emulsion injection) combined with chemotherapy for treatment of patients with advanced gastric cancer. Methods: From January 2011 to December 2012, we recruited 75 patients with advanced gastric cancer, who received javanica oil emulsion injection together with chemotherapy. After two cycles of treatment, efficacy and safety of the combined therapies were evaluated. Results: Overall response rate of 75 patients after treatment was 85.3% (CR+PR+SD). Treatment related side effects were recorded. No treatment related death occurred. Conclusions: Javanica oil emulsion injection combined with chemotherapy could be considered as a safe and effective regimen in treating patients with advanced gastric cancer. Further randomized clinical trials should be conducted to confirm whether the addition of Yadanzi$^{(R)}$ to chemotheraphy could be associated with reduced toxicity, enhanced tolerability and improved quality of life for patients with advanced gastric cancer.

Prevention of Chemotherapy-Induced Nausea and Vomiting in Cancer Patients

  • Shankar, Abhishek;Roy, Shubham;Malik, Abhidha;Julka, PK;Rath, GK
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.15
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    • pp.6207-6213
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    • 2015
  • The supportive care of patients receiving antineoplastic treatment has dramatically improved over the past few years and development of effective measures to prevent nausea and vomiting after chemotherapy serves as one of the most important examples of this progress. A patient who starts cancer treatment with chemotherapy lists chemotherapy-induced nausea and vomiting as among their greatest fears. Inadequately controlled emesis impairs functional activity and quality of life, increases the use of health care resources, and may occasionally compromise adherence to treatment. New insights into the pathophysiology of chemotherapy-induced nausea and vomiting, a better understanding of the risk factors for these effects, and the availability of new antiemetic agents have all contributed to substantial improvements in emetic control. This review focuses on current understanding of chemotherapy-induced nausea and vomiting and the status of pharmacological interventions for their prevention and treatment.

Prevalence and Molecular Characterization of Echinococcus granulosus Sensu Stricto in Northern Xinjiang, China

  • Guo, Baoping;Zhang, Zhuangzhi;Zheng, Xueting;Guo, Yongzhong;Guo, Gang;Zhao, Li;Cai, Ren;Wang, Bingjie;Yang, Mei;Shou, Xi;Zhang, Wenbao;Jia, Bin
    • Parasites, Hosts and Diseases
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    • v.57 no.2
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    • pp.153-159
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    • 2019
  • Echinococcus granulosus is an important zoonotic parasite globally causing cystic echinococcosis (CE) in humans and animals. In this study, prevalence of CE and variation of cox1 gene sequence were analyzed with isolates E. granulosus collected from different areas in northern Xinjiang, China. The survey showed that 3.5% of sheep and 4.1% of cattle were infected with CE. Fragment of cox1 was amplified from all the positive sheep and cattle samples by PCR. In addition, 26 positive samples across the 4 areas were included. The isolates were all E. granulosus sensu stricto (s.s.) containing 15 haplotypes (Hap1-15), and clustered into 2 genotypes, G1 (90.1%, 91/101) and G3 (9.9%, 10/101). Hap1 was the most common haplotype (48.5%, 49/101). Hap9 were found in humans samples, indicating that sheep and cattle reservoir human CE. It is indicate that E. granulosus may impact on control of CE in livestock and humans in the region.

The Clinical Evaluation of East-West Medical Management for Central Poststroke Pain (뇌졸중후 중추성 통증에 대한 동서협진의 임상적 효율성 평가)

  • Cheong, Byung-Shik;Kim, Keon-Sik;Lee, Doo-Ik;Choi, Do-Young
    • Journal of Pharmacopuncture
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    • v.4 no.2
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    • pp.95-103
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    • 2001
  • Background : Central poststroke pain(CPSP) can occur as a result of lesion or dysfunction of the brain from stroke and may cause many difficulty in the social activities and daily life. In this study, we evaluate the clinical effectiveness of east-west medical management for CPSP through VAS(visual analogue scale), infrared themography, MBI(Moderfied Barthel Index) and Rankin scale. Methods : We treated thirty patients with oriental medical treatment method and western & oriental medical treatment method. Each group has fifteen patients of the CPSP. We evaluated their pain(characterizes tingling and burning sensation, aching, hyperalgesia, and allodynia) through VAS(visual analog scale) pain score, the skin temperature of pain site by infrared thermography and assessed their mobility & rehabilitation ability through MBI(Moderfied Barthel Index), Rankin scale before and after pain treatment. Results : The skin temperature of pain site was lower than non-pain site. The difference of skin temperature improved from $0.65{\pm}0.45^{\circ}C$ to $0.39{\pm}0.25^{\circ}C$ after oriental medical treatment and $0.68{\pm}0.54^{\circ}C$ to $0.27{\pm}0.24^{\circ}C$ after western & oriental medical treatment VAS scores improved from $7.9{\pm}1.4$ to $4.7{\pm}1.6$ after oriental medical treatment and $8.1{\pm}1.3$ to $4.6{\pm}1.2$ after western & oriental medical treatment. MBI scores improved from $61.40{\pm}13.58$ to $85.00{\pm}13.85$ after oriental medical treatment and $52.26{\pm}13.52$ to $77.13{\pm}12.04$ after western & oriental medical treatment. And Rankin scale scores improved from $3.33{\pm}0.72$ to $2.46{\pm}0.74$ after oriental medical treatment and $3.60{\pm}0.82$ to $2.66{\pm}0.81$ after western & oriental medical treatment Conclusion : The difference of skin temperature and Rankin scale scores more significantly improved after western & oriental medical treatment than oriental medical treatment. According to the results, we thought east-west medical management is very useful treatment for CPSP and rehabilitation of the patients with stroke.

A Study on the medical decision making for an optimum medical treatment (최적 진료를 위한 의학적 의사결정에 대한 고찰)

  • Nam, Tae-Hee
    • Journal of the Korea Computer Industry Society
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    • v.9 no.1
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    • pp.1-10
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    • 2008
  • This treatise wishes to proposal of most suitable about happened patient's disease when a doctor achieves medical treatment action about patient and decision-making methodology that decide treatment does presentation low class informer. That is, when a doctor treats patient, case that do medical examination and treatment to experience about disease at medical examination and treatment process is general. In case is like this, unexpected treatment side effect can be happened doing not consider patient's special quality or conditions. Use a medical decision-making tool to minimize these problem. Treatise that see therefore investigated validity about if arrange medical decision-making system concept, and analyze several tools(decision-making tools) that help in decision-making, and can help in medical examination and treatment decision-making of most suitable.

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Study for Treatment of Atopic Dermatitis in Oriental Medical Prescription (아토피 피부염 치료 처방에 대한 방제학적(方劑學的) 고찰(考察))

  • Lee, Sang-Hyun;Yun, Yong-Gab
    • The Journal of Traditional Korean Medicine
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    • v.15 no.1
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    • pp.56-69
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    • 2006
  • In Oriental Medicine, Atopic dermatitis(AD) belongs to the category of the Naesun, Taesun(胎癬), Taeryumchang(胎斂瘡), Eczema(濕疹), Seupchang(濕瘡), Samanpung(四彎風), Chimumchang(浸淫瘡). The Basic Prescriptions which have been used for treatment of Atopic dermatitis are saengryusamultang(生料四物湯), Onchungeum(溫淸飮), Seungmagalgeuntang(升麻葛根湯),Hoichunryangkyuksan(回春凉膈散), Doghengsan(導赤散), Pyungweesan(平胃散), Heungbangpaedoksan(荊防敗毒散), Goomigangharltang(九味羌活湯), Baekhotang(白虎湯), Gaegytang(桂枝湯), Yukmigihyuangtang(六味地黃湯). AD can divide three groups, Acute-Type, Semiacute-Type, Chronic-Type, according to it's condition. This study shows that it can be applicate Seungmagalgeuntang(升麻葛根湯), Hoichunryangkyuksan(回春凉膈散), Doghengsan(導赤散), Heungbangpaedoksan(荊防敗毒散), Goomigangharltang(九味羌活湯), Baekhotang(白虎湯), Gaegytang(桂枝湯) for treatment of Acute-Type, Pyungweesan(平胃散) for treatment of Semiacute-Type, and saengryusamultang(生料四物湯), Onchungeum(溫淸飮) for treatment of Chronic-Type.

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Discussion on Classical Text-based Evidence in Guidelines for the Traditional Chinese Medical Treatment of COVID-19 (COVID-19의 중의(中醫) 진료방안에 반영된 문헌 근거에 대한 고찰)

  • Kim, Sanghyun
    • Journal of Korean Medical classics
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    • v.35 no.4
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    • pp.115-125
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    • 2022
  • Objectives : This study reviews whether the traditional medical thought process reflected in the Traditional Chinese Medical Treatment Plan for COVID-19 is based on existing classical texts, and examine concerns over the quality of evidence that the plan is based on. Methods : First, terminology and basic formulas composing the compound formulas in the COVID-19 TCM Treatment Plan were collected. Next, their usage in existing classical texts were searched in the medical classics database. Results : Infectious diseases similar to COVID-19 were understood as external disease due to Six Qi in the texts. Basic formulas used for treatment were those applied in Shanghan and Wenbing, among which cases where such formulas were applied in infectious diseases could be found in the classics. Conclusions : The level of evidence of the Treatment Plan suggested by various specialists could be evaluated as insufficient if we consider the literature. However, if application of such a plan could be supported institutionally, it could become a starting point for evidence generation.

Retrospective Observational Study for Effectiveness of Inmok-tang on Dry Eye Syndrome (건성안 증후군 환자에서 인목탕의 유효성 평가를 위한 후향적 관찰연구)

  • Kim, Young-Sam;Park, Beom-Chan;Kim, Hee-Yeon;Choi, Jun-Yong;Moon, Jin-Bok;Oh, Tae-woo;Ma, Jin-Yeul;Kim, Kibong
    • Herbal Formula Science
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    • v.27 no.4
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    • pp.285-297
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    • 2019
  • Objectives : The purpose of this study is to analyze effectiveness of herbal medicine treatment on Dry Eye Syndrome. Methods : We analyze medical records of 114 patients who visited Indara oriental medical clinic for dry eye syndrome. Patients were treated with acupuncture and Inmok-tang, and the ocular surface disease index was evaluated before and after treatment. Results : Analysis of 114 medical records showed a significant decrease in the pre-treatment and post-treatment ocular surface disease index, and a statistically significant positive correlation between the duration of Inmok-tang administration and the change in the ocular surface disease index. Conclusions : Herbal medicine treatment with Inmok-tang reduces the Ocular Surface Disease Index, an indicator of subjective symptoms of dry eye syndrome.