• Korean Journal of Adult Nursing
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• v.20 no.3
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• pp.470-480
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• 2008

Purpose: The purpose of this study was to validate the scale of Informatics Competencies for Nurses developed by Staggers, Gassert & Curran(2001) among Korean nurses. Methods: The subjects of this study were 58 RN-BSN students and 314 nurses in Busan, Ulsan and Kyoungnam province. Data were collected by questionnaires from June to August, 2006 and from October, 2006 to August, 2007 and were analyzed by Principal Component Analysis for construct validity and Cronbach's ${\alpha}$ coefficient for reliability. Results: A factor analysis was conducted and 30 items that had a factor loading more than .40 were extracted. The explained variance from 5 factors was 55.33% of the total variance. The factors were named 'basic computer usage', 'medical informatics-related software usage', 'computer related information management', 'perception of informatics', and 'information search using internet'. The first factor consisted 10 items which explained 29.89% of the total variance and the second factor contained 7 items. The Cronbach's ${\alpha}$ coefficient was .91 among the 30 items. Conclusion: This scale, Informatics Competencies for Nurses, was proved as a proper instrument to apply to Korean nurses.

• Journal of Microbiology and Biotechnology
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• v.16 no.3
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• pp.465-468
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• 2006

Even though many pesticides are known for barley powdery mildew and wheat leaf rust, alternative controls are necessary, because of consumer rejection of chemical pesticides and the appearance of fungi resistant to fungicides. To discover biopesticides, many broths of microorganisms were screened. Of those, a culture broth of Burkholderia ambifaria showed an excellent antifungal activity against both Erysiphe graminis and Puccinia recondita, which cause barley powdery mildew and wheat leaf rust, respectively.

• Genomics & Informatics
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• v.15 no.1
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• pp.28-37
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• 2017

Obesity is a highly prevalent, chronic disorder that has been increasing in incidence in young patients. Both epigenetic and genetic aberrations may play a role in the pathogenesis of obesity. Therefore, in-depth epigenomic and genomic analyses will advance our understanding of the detailed molecular mechanisms underlying obesity and aid in the selection of potential biomarkers for obesity in youth. Here, we performed microarray-based DNA methylation and gene expression profiling of peripheral white blood cells obtained from six young, obese individuals and six healthy controls. We observed that the hierarchical clustering of DNA methylation, but not gene expression, clearly segregates the obese individuals from the controls, suggesting that the metabolic disturbance that occurs as a result of obesity at a young age may affect the DNA methylation of peripheral blood cells without accompanying transcriptional changes. To examine the genome-wide differences in the DNA methylation profiles of young obese and control individuals, we identified differentially methylated CpG sites and investigated their genomic and epigenomic contexts. The aberrant DNA methylation patterns in obese individuals can be summarized as relative gains and losses of DNA methylation in gene promoters and gene bodies, respectively. We also observed that the CpG islands of obese individuals are more susceptible to DNA methylation compared to controls. Our pilot study suggests that the genome-wide aberrant DNA methylation patterns of obese individuals may advance not only our understanding of the epigenomic pathogenesis but also early screening of obesity in youth.

• Journal of Preventive Medicine and Public Health
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• v.50 no.6
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• pp.411-414
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• 2017

Antimicrobial resistance and emerging infectious diseases, including avian influenza, Ebola virus disease, and Zika virus disease have significantly affected humankind in recent years. In the premodern era, no distinction was made between animal and human medicine. However, as medical science developed, the gap between human and animal science grew deeper. Cooperation among human, animal, and environmental sciences to combat emerging public health threats has become an important issue under the One Health Initiative. Herein, we presented the history of One Health, reviewed current public health threats, and suggested opportunities for the field of public health through better understanding of the One Health paradigm.

• Journal of the Korean Institute of Oriental Medical Informatics
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• v.14 no.2
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• pp.1-9
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• 2008

With the booming complementary medicine as a social trend of well-being, treatment by the sound waves of six kinds of syllables is believed to restore that healthy balance to the body. Sound therapy refers to a range of therapies in which sound is used to treat physical and mental conditions. Healing is done by transmitting beneficial sound to the affected area related to five viscera and six bowels. The healing sound may be produced by a voice. sound wave vibrations are to treat physical and mental conditions. In general, this therapy is based on the theory that all of life vibrates, including people's bodies. When a person's healthy resonant frequency is out of balance, physical and emotional health is affected. When a person's healthy resonant frequency is out of balance, physical and emotional health is affected. This paper focuses on the sound therapy by six syllables of 'hyu', 'huo', 'ho', 'sa', 'chi' and 'hui'.

• Proceedings of the Korea Inteligent Information System Society Conference
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• 2005.11a
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• pp.258-263
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• 2005

Haplotype-based analysis using high-density SNP markers have gained a great attention in evaluating genes in gene analysis and various clinical situations. However, there has been no research on disease diagnostic modeling based on SNPs analysis to our knowledge. The purpose of this study is to explore how knowledge discovery techniques are applied in medical informatics area and proposes a Case Based Reasoning (CBR) technique for diagnosis of gastric caner using Single Nucleotide Polymorphism(SNP).

• Biomedical Science Letters
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• v.10 no.4
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• pp.485-493
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• 2004

In the current field of Medical Informatics, the information increases, and changes fast, so we can access the various data types which are ranged from text to image type. A small number of technician digitizes these data to establish database, but it is needed a lot of money and time. Therefore digitization by many end-users confronting data and establishment of searching database is needed to manage increasing information effectively. New data and information are taken fast to provide the quality of care, diagnosis which is the basic work in the medicine. And also It is needed the medical database for purpose of private study and novice education, which is tool to make various data become knowledge. However, current medical database is used and developed only for the purpose of hospital work management. In this study, using text input, file import and object images are digitized to establish database by people who are worked at the medicine field but can not expertise to program. Data are hierarchically constructed and then knowledge is established using a tree type database establishment method. Consequently, we can get data fast and exactly through search, apply it to study as subject-oriented classification, apply it to diagnosis as time-depended reflection of data, and apply it to education and precaution through function of publishing questions and reusability of data.

• Journal of the Korean Institute of Oriental Medical Informatics
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• v.14 no.2
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• pp.59-72
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• 2008

It makes study on the medical treatment and efficacy of Colostral milk. It based on the established treatises and books, in order to studying about the literature of colostral milk. It makes a through study on the medical treatment mechanism and efficacy of colostral milk, the results as fllows. 1. Colostral milk is some special things for baby newborn, and the other men and women of course. It is low in fat, and high in carbohydrates, protein, and antibodies to help keep your body healthy. Colostral milk is easy to digest, and it is low in volume, but high in concentrated nutrition for the newborn and men and women. 2. Colostral milk provides some of living cells which will defend babies against many harmful agents. The immune factors is much higher in colostral milk than in nature milk. Colostral milk works as a vaccine. It contains some quantities of an antibody called secretory immunoglobulin A Which is a important substance to the baby and men, 3. Colostral milk has a role to play in the baby's gastrointestinal tract. A newborn's intestines are permeable. The colostral milk makes the gastrointestinal tract in general. In addition, colostral milk contains a lot of leukocytes.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.05
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• pp.471-474
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• 1997

Several selective excitation pulses are used in MRI. Because of the nonlinearity of the Block equation, the pulse problem is nonlinear generally. Recently, Shinnar & Le Roux have proposed a direct solution of this problem. In this paper, we introduce the SLR algorithm and design pulses using SLR algorithm. This SLR pulse produces a specified slice profile. For example, we demonstrate the sinc function pulse with piece wise constant duration ${\Delta}t$. Further, we will design $\pi/2$ pulse and slice profile.

• Journal of Genetic Medicine
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• v.10 no.1
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• pp.27-32
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• 2013

Post-transcriptional nucleotide sequence modification of transcripts by RNA editing is an important molecular mechanism in the regulation of protein function and is associated with a variety of human disease phenotypes. Identification of RNA editing sites is the basic step for studying RNA editing. Databases and bioinformatics resources are used to annotate and evaluate as well as identify RNA editing sites. No method is free of limitations. Correctly establishing an analytic pipeline and strategic application of both experimental and bioinformatics methods constitute the first step in investigating RNA editing. This review summarizes modern bioinformatics approaches and related resources for RNA editing research.