• Journal of Korean Medical classics
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• v.23 no.1
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• pp.31-46
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• 2010

This research is aimed at contriving to expand to its base on the research work Military medicine in East Asia by introducing GunjungUihak(means Military medicine) and adding translations and commentaries to it and propagating to academic circles. GunjungUihak is the only technical book on GunjungUihak which was written for the purpose of treating soldiers in time of war. One of the characteristics shown in its prescription is convenience in medical treatment; the writer of GunjungUihak Wangmyeonghak(王鳴學) edited pills and a powdered medicine to be prescribed in large proportions so that they could be used urgently in the situation of battles at a viewpoint of a general while collecting knowledge of medicine. In addition, this book is compiled with a very short edition with one volume and 18 units. Including only a little amount in the book means that it was compiled by extracting only the contents needed in preparation for the wartime emergency, and such a measure was taken for military surgeons to carry it with facility during the time of war. In addition, much weight of this book was given to the diseases caused by environment with which soldiers came in contact in time of combat, not the wounds by the weapons of war as specified from the beginning of the book, which suggests that the environmental factor of the friendly forces was much more threatening than the arms of enemy troops in the situation of a combat. Like this, GunjungUihak is a material of great value in that it is showing a model of the aspects of Military medicine in East Asia at that time even in its fragmentary writings and it has been preserved by Korea.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2002.05a
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• pp.25-35
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• 2002

Transcription factor Nrf2 is essential for the antioxidant responsive element (ARE)-mediated induction of phase II detoxifying and oxidative stress enzyme genes. Detailed analysis of differential Nrf2 activity displayed in transfected cell lines ultimately led to the identification of a new protein, which we named Keap1, that suppresses Nrf2 transcriptional activity by specific binding to its evolutionarily conserved amino-terminal regulatory domain. The closest homolog of Keap1 is a Drosophila actin-binding protein called Kelch, implying that Keap1 might be a Nrf2 cytoplasmic effector. We then showed that electrophilic agents antagonize Keap1 inhibition of Nrf2 activity in vivo, allowing Nrf2 to traverse from the cytoplasm to the nucleus and potentiate the ARE response. We postulate that Keap1 and Nrf2 constitute a crucial cellular sensor for oxidative stress, and together mediate a key step in the signaling pathway that leads to transcriptional activation by this novel Nrf2 nuclear shuttling mechanism. The activation of Nrf2 leads in turn to the induction of phase II enzyme and antioxidative stress genes in response to electrophiles and reactive oxygen species.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.24 no.2
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• pp.137-145
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• 2014

Objectives: The study examines the relation between urinary arsenic concentration and blood pressure, which is a risk factor of cardiovascular disease. Materials: In this study, the urinary arsenic concentration, history of diagnosed disease, and blood pressure of 782 local residents in Gwangyang, Yeosu, and Hadong regions from May 2007 to July 2007. Results: The urinary arsenic concentration of total participants was $9.06{\mu}g/g-ct$. The logistic regression analysis of medical diagnosed history and urinary arsenic concentration, showed statistically significance (p<0.05) of high urinary arsenic concentration in participants with diagnosed hypertension. In addition, diagnosed hypertension it was observed that the high blood pressure was related with the pulse pressure. Conclusions: The arsenic concentration level was low in this study, but the exposure to low levels of arsenic has an effect on hypertension. Also, hypertension is related to pulse pressure and mean arterial blood pressure as well as being risk factor of cardiovascular disease. Therefore, close supervision of low -level arsenic exposure is needed.

• Journal of the Korean Society of School Health
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• v.3 no.2
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• pp.88-95
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• 1990

In order to promote the Generalized Health Beliefs between the medical doctors and university students for more comprehensive health control, we researched the Generalized Health Beliefs invented by Dr. Cockburn and microsystemic enviromental factors. As a result, we obtained the following conclusion from the study: 1. Analytically possible answers were given by 525 students (92.6%), and among them, 356(67.8%) male students, and 196(32.2%) female students. 2. Items for Generalized Health Beliefs, Which were divided into 4 factors: 4 items for seriousness of health, 3 items for the barrier of medical utility, 4 items for the medical motivation, and 4 item for the control over illness. 3. Cronbach's alpha constant for respective analytic factors revealed that the seriousness of health; 0.92, the barrier of medical utility; 0.94, the medical motivation; 0.44, and the control over illness; 0.76. 4. The seriousness of health was influences by gender, origin of birth, residence, and frequency of visiting a doctor during one year period (<0.05). 5. The barrier of medical utility differs from origin of birth, residence, and frequency of visiting differs from origin of birth, residence, and frequency of visiting a doctor(<0.05). 6. Gender was found to be an influencing factor in the medical motivation, and gender and religion in the control over illness(<0.05).

• Journal of Environmental Science International
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• v.28 no.12
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• pp.1111-1121
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• 2019

The purpose of this study is to analyze the effect of perceived walking environment around neighborhood on satisfaction for old adults in Daegu. The study was conducted using 407 questionnaires were collected through the survey. The walking environment was categorized into accessibility to neighborhood walking facilities and walking environment around path. Regarding perception of walking accessibility, access to 'public transit stops' and to 'medical facilities' was relatively high. For walking environment, 'pavement condition', 'continuity of sidewalk', and 'slope of sidewalk' were rated relatively high. Multiple regression analysis after factor analysis of walking environment variables showed that religious and convenient facilities, park and leisure facilities, and medical and welfare facilities had a significant effect on satisfaction in walking accessibility. For walking environment the convenience for walking, safety for walking, and amenities for walking had a significant effect on satisfaction. The findings from this study can be used for improving the walking environment for old adults.

• The Journal of the Korea Contents Association
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• v.12 no.10
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• pp.178-194
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• 2012

Regional medical center, this country's public health researchers to activate discussion about public health nature of publicness and Regional medical center to identify actual conditions of the present analysis of previous studies based on the experience of researchers and policy factors, environmental factors, financial factors, and self-sustaining factors affecting the activation of the public health by assuming that the four provinces, Chungnam Regional Medical Center conducted the survey to target four factors through empirical analysis and 40 kinds of relationships with sub-variables hypothesis. To empirical analysis as a background element present hypotheses and research model setting, study population and method of analysis of the set, factor analysis and reliability, validity analysis conducted, and Windows 7 operating system SPSS 19.0 analysis tool for Regional Medical Center enable the public health was to investigate the relationship between factors and variables, PLS 2.0 as an analytical tool to test the hypothesis through the analysis of the model was used.

• Toxicological Research
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• v.16 no.1
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• pp.59-61
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• 2000

A single nucleotide polymorphism in the transforming growth factor-$\beta$ type II receptor (TGE$\beta$RII) gene of the rat was studied. TGF$\beta$RII is a tumor suppressor that is frequently inactivated by mutation in human colon cancers. A novel nucleotide polymorphism of G to A(or A to G), which causes a silent mutation at codon 129, was found in G:C rich sequence in the TGF$\beta$RII gene of Sprague-Dawley rats. The results suggest that genetic polymorphism occures without a strain of the laboratory animal.

• Environmental Analysis Health and Toxicology
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• v.31
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• pp.7.1-7.6
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• 2016

Objectives The aim of this study is to evaluate radiation exposure resulting from the comprehensive health examinations of selected university hospital programs and to present basic data for research and management strategies on the health effects of medical radiation exposure. Methods Radiation-based diagnostic studies of the comprehensive health examination programs of ten university hospitals in Seoul, Korea, as introduced in their websites, were analyzed. The medical radiation studies of the programs were reviewed by radiologists. Only the effective doses of the basic studies were included in the analysis. The optional studies of the programs were excluded. Results Among the 190 comprehensive health examination programs, 132 programs (69.5%) included computed tomography studies, with an average of 1.4 scans. The average effective dose of radiation by program was 3.62 mSv for an intensive program for specific diseases; 11.12 mSv for an intensive program for cancer; 18.14 mSv for a premium program; and 24.08 mSv for an overnight program. A higher cost of a programs was linked to a higher effective dose (r=0.812). The effective doses of the examination programs for the same purposes differed by as much as 2.1 times by hospital. Inclusion of positron emission tomography-computed tomography was the most critical factor in determining the level of effective dose. Conclusions It was found that radiation exposure dose from comprehensive health exam programs targeted for an asymptomatic, healthy public reached between 3.6 and 24 times the annual dose limit for the general public. Relevant management policies at the national level should be provided to minimize medical radiation exposure.

• Journal of Korean Society for Atmospheric Environment
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• v.32 no.2
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• pp.184-192
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• 2016

Recently, studies on reducing mercury have been actively conducted worldwide, which include the current status of mercury emissions and mercury control technology. Among the control technology, Sorbent Trap measurement method has been aggressively developed due to its reliability, easiness in measurement and analysis. The purpose of this study is to evaluate the applicability of the new international measurement method; Sorbent Trap. For this, the study compared the Sorbent trap method (US EPA Method 30B) and the Korean Standard Method for Examination of Air (ES 01408.1) to evaluate their reliability, and developed mercury emission factors. As the result, the relative standard deviations (% RSD) of the two methods were 3.5~13.4% at Coal-fired Power Plants (CPP), 4.0~18.4% at Cement Kilns (CK), and 3.0~11.3% at Medical Waste Incinerators (MWI). The emissions factors were developed as 14.50 kg/ton at CPP, 45.10 kg/ton at CK, and 1,290.2 kg/ton at MWI.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7303-7307
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• 2015

Background: Leukemia is a common cancer among children and adolescents. Wilms' tumor gene (WT1) is highly expressed in patients with acute leukemia. It is found as a tumor associated antigen (TAA) in various types of hematopoietic malignancies and can be employed as a useful marker for targeted immunotherapy and monitoring of minimal residual disease (MRD). In this regard, WT1 is a transcription factor that promotes gene activation or repression depending on cellular and promoter context. The purpose of this study was assessment of WT1 gene expression in patients with acute leukemia, measurement of IL-12 and C3 levels in serum and evaluation of the relationship between them. Materials and Methods: We evaluated the expression of WT1 mRNA using real-time quantitative RT-PCR and serum levels of IL-12 and C3 using ELISA and nephelometry in peripheral blood of 12 newly diagnosed patients with acute leukemia and 12 controls. Results: The results of our study showed that the average wT1 gene expression in patients was 7.7 times higher than in healthy controls (P <0.05). In addition, IL-12 (P = 0.003) and C3 (P <0.0001) were significantly decreased in the test group compared to controls. Conclusions: WT1 expression levels are significantly higher in patients compared with control subjects whereas serum levels of interleukin-12 and C3 are significantly lower in patients. Wt1 expression levels in patients are inversely related with serum levels of IL-12 and C3.