DOI QR코드

DOI QR Code

Association Between Blood Pressure and Urinary Arsenic Concentration in Industrial Areas

공단지역주민의 요중 비소농도와 혈압과의 관련성에 관한 연구

  • Park, Hee-Jin (Department of Environmental Health Science, Soonchunhyang University) ;
  • Woo, Kyung-Sook (Department of Environmental Health Science, Soonchunhyang University) ;
  • Moon, Chan-Seok (Department of Industrial Health, College of Applied Science, Catholic of Pusan) ;
  • Kim, Geun-Bae (Environmental Health Research Division, National Institute of Environmental Research(NIER)) ;
  • Kang, Tack-Shin (Environmental Health Research Division, National Institute of Environmental Research(NIER)) ;
  • Chung, Eun-Kyung (School of public health, Seoul National University) ;
  • Kim, Yong-Bae (Department of Preventive medicine, Soonchunhyang University) ;
  • Son, Bu-Soon (Department of Environmental Health Science, Soonchunhyang University)
  • 박희진 (순천향대학교 환경보건학과) ;
  • 우경숙 (순천향대학교 환경보건학과) ;
  • 문찬석 (부산가톨릭대학교 산업보건학과) ;
  • 김근배 (국립환경과학원 환경보건연구과) ;
  • 강택신 (국립환경과학원 환경보건연구과) ;
  • 정은경 (서울대학교 보건대학원) ;
  • 김용배 (순천향대학교 예방의학교실) ;
  • 손부순 (순천향대학교 환경보건학과)
  • Received : 2014.05.09
  • Accepted : 2014.06.16
  • Published : 2014.06.30

Abstract

Objectives: The study examines the relation between urinary arsenic concentration and blood pressure, which is a risk factor of cardiovascular disease. Materials: In this study, the urinary arsenic concentration, history of diagnosed disease, and blood pressure of 782 local residents in Gwangyang, Yeosu, and Hadong regions from May 2007 to July 2007. Results: The urinary arsenic concentration of total participants was $9.06{\mu}g/g-ct$. The logistic regression analysis of medical diagnosed history and urinary arsenic concentration, showed statistically significance (p<0.05) of high urinary arsenic concentration in participants with diagnosed hypertension. In addition, diagnosed hypertension it was observed that the high blood pressure was related with the pulse pressure. Conclusions: The arsenic concentration level was low in this study, but the exposure to low levels of arsenic has an effect on hypertension. Also, hypertension is related to pulse pressure and mean arterial blood pressure as well as being risk factor of cardiovascular disease. Therefore, close supervision of low -level arsenic exposure is needed.

Keywords

References

  1. Agency for Toxic Substabces and Disease Registry (ATSDR). Toxicological Profile for Arsenic. 2007
  2. Balakumar P, Kaur J. Arsenic exposure and cardiovascular disorders: An overview. Cardiovasc Toxicol. 2009;9(4):169-176 https://doi.org/10.1007/s12012-009-9050-6
  3. Bosnjak Z, Cavar S, Klapec T, Milic M, Klapec-Basar M, Toman M. Selected markers of cardiovascular disease in a population exposed to arsenic from drinking water. Environmental Toxicology and Pharmacology. 2008;26(2):181-186 https://doi.org/10.1016/j.etap.2008.03.005
  4. Caceres DD, Pino P, Montesinos N, Atalah E, Amigo H, Loomis D. Exposure to inorganic arsenic in drinking water and total urinary arsenic concentration in a Chilean population. Environmental Research. 2005;98(2):151-159 https://doi.org/10.1016/j.envres.2005.02.007
  5. Calderon RL, Hudgens EE, Carty C, He B, Le XC, Rogers J, Thomas DJ. Biological and behavioral factors modify biomarkers of arsenic exposure in a U.S. population. Environmental Research. 2013;126:134-144 https://doi.org/10.1016/j.envres.2013.04.004
  6. Centers for Disease Control and Prevention(CDC). Fourth National Report on Human Exposure to Environmental Chemicals. Department of Health and Human Services Centers for Disease Control and Prevention. http://www.cdc.gov/exposurerport/pdf/fourthreport.pdf [accessed 1 February 2009]
  7. Domanski MJ, Norman J, Wolz M, Mitchell G, Pfeffer M. Cardiovascular risk assessment using pulse pressure in the first national health and nutrition examination survey(NHANES I). Hypertension. 2001;38(4):793-797 https://doi.org/10.1161/hy1001.092966
  8. Federal Environment Agency(Umweltbundesamt). German Environmental Survey 1998, Vol. VII: Arsenic, Lead, Cadmium, Mercury and Precious Metals in Blood and Urine. Environmental Research of The Federal Ministry of The Environment. 2004.
  9. Frumkin H. Environmental health: from global to local. San Francisco, CA: Jossey-Bass. 2005
  10. Harrison DG, Kurz MA, Quillen JE, Sellke FW, Mugge A. Normal and pathophysiologic considerations of endothelial regulation of vascular tone and their relevance to nitrate therapy. Am. J. Cardiology. 1992;70(8):11B-17B https://doi.org/10.1016/0002-9149(92)90589-Q
  11. Health Canada. Report on human biomonitoring of environmental chemicals in Canada: results of the Canadian Health Measures Survey Cycle 1 (2007-2009). (Catalogue No. H128-1/10-601E). Minister of Health, Ottawa. 2010
  12. Hsueh YM, Ko YF, Huang YK, Chen HW, Chiou HY, Huang YL, et al. Determinants of inorganic arsenic methylation capability among residents of the lanyang basin, Taiwan: arsenic and selenium exposure and alcohol consumption. Toxicology Letters. 2003;137(1-2):49-63 https://doi.org/10.1016/S0378-4274(02)00380-6
  13. Hsueh YM, Chung CJ, Shiue HS, Chen JB, Chiang SS, Yang MH, et al. Urinary arsenic species and CKD in a Taiwanese population: a case control study. American Journal of Kidney Disease. 2009;54(5):859-870 https://doi.org/10.1053/j.ajkd.2009.06.016
  14. Huang CH, Chen YW, Yang CY, Tsai KS, Yang RS, Liu SH. Arsenic anc diabetes: Current perspectives. Medical Science. 2011;27:402-410.
  15. Hughes MF, Beck BD, Chen Y, Lewis AS, Thomas DJ. Arsenic exposure and toxicology: a historical perspective. Toxicological sciences. 2011;123(2):305-332 https://doi.org/10.1093/toxsci/kfr184
  16. Im R, Yeum HC, Kim DW, Bae HS, Ahn SJ, Ryu D Y. Dietary exposure assessment of arsenic in Korean adult. Environmental Health and Toxicology. 2010;25(4): 307-314
  17. James KA, Marshall JA, Hokanson JE, Meliker JR, Zerbe GO, Byers TE. A case-cohort study examining lifetime exposure to inorganic arsenic in drinking water and diabetes mellitus. Enviornmental Research. 2013;123:33-38 https://doi.org/10.1016/j.envres.2013.02.005
  18. Lawes CMM, Hoom SV, Rodgers A. Global burden of blood-pressure-related disease, 2001. Lancet. 2008;371(9623):1513-1518 https://doi.org/10.1016/S0140-6736(08)60655-8
  19. Lee MY. Functional alteration of blood vessels and platelets by Arsenic : a contributing factor to cardiovascular disease. [dissertation]. [Seoul]: Seoul University; 2002
  20. National Heart, Lung, and Blood Institute(US). The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. Washington: Department of Health and Human Services, National Institute of Health. 2003
  21. Navas-Acien N, Umans JG, Howard BV, Goessler W, Francesconi KA, Crainiceanu CM, et al. Urine arsenic concentrations and species excretion patterns in American Indian communities over a 10-year period: the strong heart study. Environmental Health Perspectives. 2009;117(9):1428-1433 https://doi.org/10.1289/ehp.0800509
  22. Nuntharatanapong N, Chen K, Sinhaseni P, Keaney JF. EGR receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis. Am J Physiol Heart Circ Physiol. 2005;289(1):H99-H107 https://doi.org/10.1152/ajpheart.00901.2004
  23. Rivera-Nunez Z, Meliker JR, Linder AM, Nriagu JO. Reliability of spot urine samples in assessing arsenic exposure. International Journal of Hygiene and Environmental Health. 2010;213(4):259-264 https://doi.org/10.1016/j.ijheh.2010.03.003
  24. Sipahi I, Tuzcu EM, Schoenhagen P, Wolski KE, Nicholls SJ, Balog C, et al. Effects of normal, prehypertensive, and hypertensive blood pressure levels on progression of coronary atherosclerosis. American College of Cardiology. 2006;48(4):833-838 https://doi.org/10.1016/j.jacc.2006.05.045
  25. Shin JY, Kim JM, Kim YR. The association of heavy metals in blood, fish consumption frequency, and risk of cardiovascular diseases among Korean adults: The Korean National Health and Nutrition Examination Survey (2008-2010). Korean J Nutrition. 2012;45(4):347-361 https://doi.org/10.4163/kjn.2012.45.4.347
  26. Statistics Korea, Cause of Death Statistics, 2012. 2013.
  27. Valko M, Leibfritz D, Monocol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39(1):44-84 https://doi.org/10.1016/j.biocel.2006.07.001
  28. Zhang C, Mao G, He S, Yang Z, Yang W, Zhang X, et al. Relationship between long-term exposure to low-level arsenic in drinking water and the prevalence of abnormal blood pressure. Journal of Hazardous Materials. 2013;262:1154-1158 https://doi.org/10.1016/j.jhazmat.2012.09.045

Cited by

  1. A Time-Series Study of Ambient Air Pollution in Relation to Daily Mortality Count in Yeosu vol.24, pp.1, 2015, https://doi.org/10.14249/eia.2015.24.1.66
  2. Evaluation of VOCs exposure concentration and health effects assessment regarding respiratory diseases vol.17, pp.2, 2018, https://doi.org/10.15250/joie.2018.17.2.151