• 한국융합학회논문지
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• 제9권2호
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• pp.119-124
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• 2018

증강현실 기술은 사용자의 시각에 가상의 영상 정보를 결합하여 다양한 영상 정보를 동시에 취득할 수 있게 한다. 이러한 증강현실 기술은 최근 의료융합을 통해 이미지 가이드 수술(Image-Guide Operation), 수술 교육 훈련, 영상 진단 분야에서 수술 및 진단 시 환자의 장기나 조직들을 구분하여 가시화하고 가장 효과적인 수술 방법을 제시 할 수 있다. 이에 본 논문을 통해 증강현실 기술의 의료 융합을 위한 각 요소 기술의 기술적 특징과 적용 방안 등을 고찰하고자 하였다. 의료융합을 위한 증강현실 기술에서는 효율적인 의료 영상의 구현을 위해 디스플레이, 마커인식 그리고 영상합성 인터페이스 기술의 유기적인 구동이 필수적이다. 이러한 증강현실 기술은 향후, 이미지 가이드 수술, 수술 교육 및 영상 진단 등의 분야에서 현재의 의료 기술을 획기적으로 증진시킬 수 있는 방안이 될 수 있으리라 여겨진다.

• 대한의용생체공학회:의공학회지
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• 제29권2호
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• pp.164-171
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• 2008

Recently, many of hospitals have hurried to computerize the resulting data from medical devices, in order to introduce Electric Medical Record(EMR). In terms of the linkage between medical devices and hospital information systems, however, many difficulties have arisen due to some reasons such as the variety of prescription input, the format difference of the resulting data sheet, and the interface difference between medical devices from different companies. To solve these problems, many researches on standardization of the resulting data of medical devices have been performed. In this study, the linkage between hospital information systems and resulting datum in Electrocardiogram(ECG) generating biosignal waveform was tested by applying Medical waveform Format Encoding Rules(MFER) Version 1.02, which has more advantages than existing global standard. MFER viewer, in addition, was made to display the resulting data on a screen. The MFER viewer was tested and compared to the existing Scalable Vector Graphics (SVG) Viewer. The results showed that this method is more effective in the interface the data storage and application, because of simplicity and easiness in data applications. And the results show that the MFER is convenience and effective for physician. It is considered that the role of MFER as the interface in biosignal waveform including Electrocardiogram medical devices would expand in the near future.

• Journal of Microbiology and Biotechnology
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• 제30권7호
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• pp.996-1004
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• 2020

Various genetically engineered microorganisms have been developed for the removal of heavy metal contaminants. Metal biosorption by whole-cell biosorbents can be enhanced by overproduction of metal-binding proteins/peptides in the cytoplasm or on the cell surface. However, few studies have compared the biosorption capacity of whole cells expressing intracellular or surface-displayed metal-adsorbing proteins. In this study, several constructs were prepared for expressing intracellular and surface-displayed Ochrobactrum tritici 5bvl1 ChrB in Escherichia coli BL21(DE3) cells. E. coli cells expressing surface-displayed ChrB removed more Cr(VI) from aqueous solutions than cells with cytoplasmic ChrB under the same conditions. However, intracellular ChrB was less susceptible to variation in extracellular conditions (pH and ionic strength), and more effectively removed Cr(VI) from industrial wastewater than the surface-displayed ChrB at low pH (<3). An adsorption-desorption experiment demonstrated that compared with intracellular accumulation, cell-surface adsorption is reversible, which allows easy desorption of the adsorbed metal ions and regeneration of the bioadsorbent. In addition, an intrinsic ChrB protein fluorescence assay suggested that pH and salinity may influence the Cr(VI) adsorption capacity of ChrB-expressing E. coli cells by modulating the ChrB protein conformation. Although the characteristics of ChrB may not be universal for all metal-binding proteins, our study provides new insights into different engineering strategies for whole-cell biosorbents for removing heavy metals from industrial effluents.

• 반도체디스플레이기술학회지
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• 제6권1호
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• pp.49-52
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• 2007

The recent advances in digital imaging and computing technology have resulted in a rapid accumulation of digital media in the personal computing and entertainment industry. In addition, large collections of such data already exist in many scientific application domains such as the geographic information systems (GIS), digital library, trademark imaging, satellite imaging and medical imaging. Thus, the need for content-based retrieval from visual media, such as image and video data, is ever increasing rapidly in many applications.

• Molecules and Cells
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• 제27권3호
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• pp.313-319
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• 2009

The dual-vector system-II (DVS-II), which allows efficient display of Fab antibodies on phage, has been reported previously, but its practical applicability in a phage-displayed antibody library has not been verified. To resolve this issue, we created two small combinatorial human Fab antibody libraries using the DVS-II, and isolation of target-specific antibodies was attempted. Biopanning of one antibody library, termed DVFAB-1L library, which has a $1.3{\times}10^7$ combinatorial antibody complexity, against fluorescein-BSA resulted in successful isolation of human Fab clones specific for the antigen despite the presence of only a single light chain in the library. By using the unique feature of the DVS-II, an antibody library of a larger size, named DVFAB-131L, which has a $1.5{\times}10^9$ combinatorial antibody complexity, was also generated in a rapid manner by combining $1.3{\times}10^7$ heavy chains and 131 light chains and more diverse anti-fluorescein-BSA Fab antibody clones were successfully obtained. Our results demonstrate that the DVS-II can be applied readily in creating phage-displayed antibody libraries with much less effort, and target-specific antibody clones can be isolated reliably via light chain promiscuity of antibody molecules.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2007년도 하계학술대회 논문집 Vol.8
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• pp.29-29
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• 2007

TFT, LCD, OLED, PDP and FED를 비롯한 많은 디스플레이 장치가 개발, 연구되고 있으며, 이러한 디스플레이 장치에 대한 수 많은 application 연구 또한 진행되고 있다. TFT-LCD는 이미 방사선 검출기로서 연구가 오랜전에 연구되어 상용화가 되었으며, LCD는 XLV로서 적용을 위한 연구가 진행되고 있으며, 그 외 수 많은 디스플레이 장치에 대한 활발한 연구가 진행되고 있는 실정이다. PDP는 대면적, 낮은 제작 비용, 높은 contrast의 이점으로 디스플레이 장치로서 활발한 연구가 진행되고 있다. 본 논문에서는 PDP를 처음으로 방사선 검출기로 적용하기 위한 연구를 수행하였다. 제작된 7 인치 AC-PDP는 다양한 가스종류 및 압력을 가진 300um의 pixel pitch룰 가진 3 전극 구조로서, coplanar readout과 대항형 readout을 통해 신호량을 분석하였다. 결과 50-100Kvp의 진단 영역의 X-ray energy에서 줄은 민감도와 훌륭한 선형성을 보였으며, 가스 종류 및 압력, 신호 검출방식에 따라 각각 다른 특성을 보였다. 이는 PDP 내 X선과의 Interaction, R/O method. Material에 강하게 의존한다.

• 정보관리학회지
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• 제21권3호
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• pp.141-160
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• 2004

최근 의학정보 분야에서는 임상의 지식관리와 의학정보 검색의 효율화를 위한 수단으로 온톨로지의 개념 모델링을 이용한 의학용어 시스템에 관심이 모아지고 있다. 본 연구는 우리나라의 의학정보 분야에 이러한 시스템의 응용이나 새로운 시스템 개발애 기초적인 자료제공을 목적으로 , 정보 모델링과 온톨로지의 이론에 대해 고찰하였고, 외국의 의학정보 분양에서 온톨로지를 이용한 용어 시스템이 개발된 4가지 대표적인 사례를 분석하여 비교하였다. 연구결과 비형식적인 수준의 온톨로지로 파악된 MeSH의 의학용어 표준화와 UMLS의 용어 개념화, 형식적인 수준의 온톨로지인 ON9의 의학 온톨로지 통합의 이론화, 그리고 GALEN의 의학지식의 의미 모델과 형식화로 핵심적 특징을 요약할 수 있었다. 온톨로지의 응용은 목적하는 시스템에 따른 수준적 차별화가 이루어져야 하 것이고, 본 연구의 분석 결과가 참고 될 수 있을 것이다.

• 한국컴퓨터산업학회논문지
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• 제2권12호
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• pp.1505-1516
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• 2001

The goal of Medical multimedia server is to develop computer hardware and software which would enable electronic access, storage, transmission, and display of patient data and images. Since the current network only provides so called "best-effort" services, it is impossible to satisfy QoS guarantee that is required for real time application services for emergency room, operating room etc. Accordingly, world-wide research is being made for a variety of services to provide QoS. he goal of DiffServ is to offer scalable differentiated service in Internet which are made possible by traffic classification and conditioning only performed at an edge(or a boundary) node. In case DiffServ was deployed in the Medical multimedia network, it is difficult to estimate how the QoS mechanism would affect totally the network performance. Therefore, we need to verify by simulation the design of algorithm which provide a variety of differentiated services. In QoS for Medical multimedia network, a simulator is designed and implemented using OPNET to investigate the performance of DiffServ QoS support mechanism. The developed DiffServ simulator may generate packets according to random, and bursty traffic models in order to incorporate diverse traffic conditions in the Medical multimedia network environment. Based on our simulation results, we confirmed that service differentiation is possible by using the EF(Expedited Forwarding) class in DiffServ networks.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2004년도 하계학술대회 논문집 Vol.5 No.2
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• pp.1062-1065
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• 2004

The importance of display is becoming increasingly important due to the development of information and industry where it leads to diverse and abundant information in today's society. The demand and application range for FPD(Flat Panel Display), specifically represented by LCD(Liquid Crystal Display) and PDP(Plasma Display Panel), have been rapidly growing for its outstanding performance and convenience amongst many other forms of display. The current focus has been on OLED(Organic Light Emitting Diode) in the mobile form, which has just entered into mass production amid the different types of FPD. Many studies are being conducted in regards to device, vacuum evaporation, encapsulation, and drive circuits with the development of device as a matter of the utmost concern. This study develops a new type of light-emitting materials by synthesizing medical polymer organic chitosan and phosphor material CuS. Chitosan itself satisfies the Pool-Frenkel Effect, an I-V specific curve, with a thin film under $20{mu}m$, and demonstrates production possibility for a living body sensors solely with the thin film. Furthermore, it enables production possibility for EML of organic EL device(Emitting Layer) with liquid Green light emitting and Blue light emitting as a result of synthesis with phosphor material.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.121-122
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• 2002

The main principle of radiation therapy is to deliver optimum dose to tumor to increase tumor cure probability while minimizing dose to critical normal structure to reduce complications. RTP system is required for proper dose plan in radiation therapy treatment. The main goal of this research is to develop dose model for photon, electron, and brachytherapy, and to display dose distribution on patient images with optimum process. The main items developed in this research includes: (l) user requirements and quality control; analysis of user requirement in RTP, networking between RTP and relevant equipment, quality control using phantom for clinical application (2) dose model in RTP; photon, electron, brachytherapy, modifying dose model (3) image processing and 3D visualization; 2D image processing, auto contouring, image reconstruction, 3D visualization (4) object modeling and graphic user interface; development of total software structure, step-by-step planning procedure, window design and user-interface. Our final product show strong capability for routine and advance RTP planning.