• 대한한방소아과학회지
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• 제12권1호
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• pp.145-162
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• 1998

The purpose of this study was to determine the effects of oriental medical care on growth deficiency children. These cases were collected to investigate the effects of oriental medical care on growth deficiency children. So the cases were divided into 5 groups. The growth velocity was compared to a normal growth curve, and the results are as follows: 1. Oriental medical care was efficient when the epiphysial plates were not closed. 2. In female middle school beyond 1st grade students and in male middle school 3rd grade students who had almost closed epiphysial plates, the oriental medical care was not efficient and did not promote growth velocity. endothelium were used for the experiment using organ bath. 3. In the cases where the parent were very short, the effects of the oriental medical care to promote growth velocity was not efficient. 4. when we treated children of normal height, their growth velocity was over the normal growth curve. 5. In preschool aged children, oriental medical care was very efficient to promote children's growth. 6. The principle oriental medical care was to make balanced their body and digestive organs by using herb medicines that have the capability to promote the growth of the bones, and build strong muscles.

• BMB Reports
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• 제38권1호
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• pp.28-33
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• 2005

A gene coding a novel isoform of carbamyl phosphate synthetase I (CPS1) was cloned from a human testicular library. As shown by cDNA microarray hybridization, this gene was expressed at a higher level in human adult testes than in fetal testes. The full length of its cDNA was 3831 bp, with a 3149 bp open reading frame, encoding a 1050-amino-acid protein. The cDNA sequence was deposited in the GenBank (AY317138). Sequence analysis showed that it was homologous to the human CPS1 gene. The putative protein contained functional domains composing the intact large subunit of carbamoyl phosphate synthetase, thus indicated it has the capability of arginine biosynthesis. A multiple tissue expression profile showed high expression of this gene in human testis, suggesting the novel alternative splicing form of CPS1 may be correlated with human spermatogenesis.

• 전자공학회논문지CI
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• 제49권4호
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• pp.9-15
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• 2012

인터넷과 전자상거래의 증가로 인터넷은 전보다 더 많이 이용되고, 개인이나 혹은 기업등은 그들의 업무처리나 생활의 많은 부분을 컴퓨터에 의존하고 있다. 또한 인터넷의 쉬운 접근으로 시스템을 속이고 공격하는 방법도 증가하고 있다. 따라서 웹상에서의 보안은 우리 사회에 꼭 필요한 존재이며 보안 메카니즘의 도입도 시급한 편이다. 현재 많은 보안 방법들이 사용되고 있지만 완전한 차단은 불가능한 것으로 보이고 있다. 다양한 환경에서, 또한 견고한 IDPS 솔루션은 여러개의 IDPS 기술사용 없이는 불가능하여 많은 조직들은 많은 벤더들로부터 다중의 IDPS 제품들을 구입하여 사용한다. 이들은 또한 디자인과 구현의 제약사항들 때문에 여전히 최적화 문제에 놓여있다. 본 논문에서는 IDPS의 주요기능을 설명하고 IDPS의 구성요소 및 구조, 각 기술 유형별 특징과 보안 능력과 장단점을 비교 분석하였다. 이것은 서로 다른 장단점을 가지는 IDPS 기술들을 통합하여 최적의 IDPS 솔루션을 찾는, 다중 IDPS 기술 통합의 기반을 조성할 것이다.

• 한국의학물리학회지:의학물리
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• 제25권3호
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• pp.185-192
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• 2014

이 연구의 목적은 본원이 보유하고 있는 선형가속기들의 출력 특성을 Shewhart-type Chart, EWMA Chart, 공정능력지수 $C_p$와 $C_{pk}$을 이용한 통계적 분석으로 품질보증에 대한 결과를 평가하고자 한다. 측정값은 의학물리사에 의하여 2012년 9월부터 2014년 4월까지 매월 측정된 각각 치료기들(21EX, 21EX-S, Novalis Tx)의 출력측정값을 사용하였다. 치료기들의 출력 특성은 IAEA TRS-398의 가이드라인을 따랐으며, 측정 에너지는 광자선 6 MV, 10 MV, 15 MV와 전자선 4 MeV, 6 MeV, 9 MeV, 12 MeV, 16 MeV, 20 MeV였다. 매월 측정하여 교정한 출력특성에 대한 통계학적 분석이며, 가중인자와 측정값의 관리한계의 폭은 ${\lambda}=0.10$, L=2.703로 계산되었으며, 공정능력 $C_p$와 $C_{pk}$는 모든 선형가속기(21EX, 21EX-S, Novalis Tx)의 모든 에너지에서 1이상이었다. Shewhart-type Chart를 통하여 출력선량의 측정값의 큰 변화점을 찾을 수 있었고, EWMA Chart를 통하여 출력선량의 측정값의 미세한 변화점을 알아 볼 수 있었다. 본원의 치료기의 공정능력지수 $C_p$와 $C_{pk}$를 통하여 21EX가 2.384와 2.136, 21EX-S가 1.917과 1.682, Novalis Tx가 2.895와 2.473으로 Novalis Tx가 가장 안정적이고 정확한 출력특성을 나타내고 있었다.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1998년도 추계학술대회
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• pp.197-198
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• 1998

We tested the capability of Pointwise Correlation Dimension(PD2), Approximate Entropy (ApEn) and LZ complexity, as alternative measures of a biological signal. For this purpose, we analyzed standard data and a healthy child's 24-hour heart rate variability. Our conclusion is as follows. First, PD2, ApEn and LZ complexity can be used for discerning chaotic attractor, white noise, and periodic signal. Second, these measures show different characteristics on day and night. Third, these measures can be used for detecting time-varying characteristics of biological signals.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 춘계학술대회
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• pp.143-146
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• 1996

An adaptive digital filtering of the electroencophalogram(EEG) is a successful way of suppressing mains interference, but it affects some of the frequency components of the signal, an artifact which not be acceptable in some cases of automatic EEG processing. The types of electrical artifact seen on EEG records is described. Those are the EOG and the PVC roller pump noise. And we study the method for cancelling these artifacts. The method does not need the reference channel, and are obtained by cascading the linear predictor and the noise canceller. The simulation results illustrate the performances of the presented method in terms of the capability of interferences suppression.

• BMB Reports
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• 제51권11호
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• pp.572-577
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• 2018

Recent studies showed that the PD-1/PD-L1 checkpoint blockade is a dramatic therapy for melanoma by enhancing antitumor immune activity. Currently, major strategies for the PD-1/PD-L1 blockade have mainly focused on the use of antibodies and compounds. Seeking an alternative approach, others employ endogenous proteins as blocking agents. The extracellular domain of PD-1 (ePD1) includes the binding site with PD-L1. Accordingly, we constructed a PD-1-based recombinantly tailored fusion protein (dFv-ePD1) that consists of bivalent variable fragments (dFv) of an MMP-2/9-targeted antibody and ePD1. The melanoma-binding intensity and antitumor activity were also investigated. We found the intense and selective binding capability of the protein dFv-ePD1 to human melanoma specimens was confirmed by a tissue microarray. In addition, dFv-ePD1 significantly suppressed the migration and invasion of mouse melanoma B16-F1 cells, and displayed cytotoxicity to cancer cells in vitro. Notably, dFv-ePD1 significantly inhibited the growth of mouse melanoma B16-F1 tumor cells in mice and in vivo fluorescence imaging showed that dFv-ePD was gradually accumulated into the B16-F1 tumor. Also the B16-F1 tumor fluorescence intensity at the tumor site was stronger than that of dFv. This study indicates that the recombinant protein dFv-ePD1 has an intensive melanoma-binding capability and exerts potent therapeutic efficacy against melanoma. The novel format of the PD-L1-blocked agent may play an active role in antitumor immunotherapy.

• 품질경영학회지
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• 제45권3호
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• pp.463-481
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• 2017

Purpose: This study provide the matching mechanism between startup and business incubator to enhance managerial performance of business incubator. In addition, we propose the differentiation strategy for business incubator based on the needs of startups. Methods: In order to carry out the research, we surveyed 216 startups who already have invested in venture capitals and angel investors and currently residing in business incubator and 30 venture capitals and angel investors. Based on survey results, we develop a business incubator capability table matching startup with business incubator. Results: Satisfaction and importance of the supporting programs varied depending on the startup experience and startup lifecycle. As a result, we recommended a R&D center for machinery/material, bio/medical and electric/electronics startups and individual office for ICT and knowledge service startups. In addition, we suggested a differentiation strategy to BI in university specialized for machinery/material, privately operated BI for electric/electronic, (local)government, R&D center and individual office for knowledge service respectively. Conclusion: In this study, business incubator capability table is applied to match startup with business incubator and it could be applied to evaluate the current status of business incubator. Furthermore, it will help to establish a future strategic direction for business incubator.

• Medical Lasers
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• 제10권1호
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• pp.1-6
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• 2021

Intravital microscopy is a high-resolution imaging technique based on laser-scanning two-photon and confocal microscopy, which allows dynamic 3D cellular-level imaging of various biological processes in a living animal in vivo. This unique capability allows biomedical researchers to directly verify a hypothesis in a natural in vivo microenvironment at the cellular level in a physiological setting. During the last decade, intravital microscopy has become an indispensable technique in several fields of biomedical sciences such as molecular and cell biology, immunology, neuroscience, developmental, and tumor biology. The most distinct advantage of intravital microscopy is its capability to provide a longitudinal view of disease progression at the cellular-level with repeated intravital imaging of a single animal over time by saving the images after each session.

• Imaging Science in Dentistry
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• 제42권2호
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• pp.115-119
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• 2012

Today, ultrasound imaging is being widely used to assess soft tissue lesions in the maxillofacial region. However, ultrasound investigations of intra-osseous lesions are rare, especially for tumors of the jaws. This report emphasized the capability of this useful imaging modality in identification of the characteristics of malignant conditions involving the bone. Mesenchymal chondrosarcoama, one of the unusual malignant conditions of the jaw, was presented in a young male with significant facial swelling. Different imaging modalities parallel with the histopathologic investigation confirmed the diagnosis. Interestingly, destruction of the bony cortex and new bone formation with a characteristic "sun ray appearance", highly suggestive of sarcomas, was manifested on the ultrasonograph. Thus, this report presented the ultrasonographic features of chondrosarcoma of mandible and considered the ultrasonography to be a useful imaging modality to evaluate intra-osseous jaw lesions.