• 대한간호학회지
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• 제49권3호
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• pp.286-297
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• 2019

Purpose: To investigate the effect of nurses' emotional labor on their turnover intention that was mediated by burnout and to examine the moderated mediation effect of authentic leadership. Methods: A total of 227 nurses working at two general hospitals in Seoul were recruited from March 21 to May 6 in 2016. Emotional labor including surface acting and deep acting; burnout factors such as emotional exhaustion and personal accomplishment; and turnover intention were assessed. The data were analyzed using SPSS 22.0 and SPSS PROCESS macro. Results: Surface acting significantly increased emotional exhaustion and reduced personal accomplishment. Deep acting significantly increased personal accomplishment. Emotional exhaustion significantly increased turnover intention. Conversely, personal accomplishment significantly reduced turnover intention. Surface acting had an indirect effect on turnover intention that was mediated by emotional exhaustion. Deep acting had an indirect effect on turnover intention that was mediated by personal accomplishment. Authentic leadership had a moderated mediation effect on the relationship between surface acting and turnover intention that was mediated by emotional exhaustion. Conclusion: The findings of this study indicate that the establishment of strong authentic leadership by head nurses would help nurses reduce their burnout and turnover intention. Conducting intervention studies would be also important to promote better work environments that would enable nurses to fortify the positive aspect of emotional labor and to reduce their burnout levels.

• 한국건설관리학회논문집
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• 제19권6호
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• pp.135-143
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• 2018

건설 프로젝트를 성공하기 위해서는 핵심 이해관계자인 발주자와 시공사의 협력적 관계가 무엇보다 중요하다. 거래 상대방의 행동에 영향을 미치거나 통제 할 수 있는 권력은 건설 프로젝트에서 이해관계자간에 협력적인 행동을 유발 할 수 있는 요소로 간주될 수 있다. 또한, 거래 비용 이론에 따르면 계약은 효과적으로 거래 상대방의 행동에 영향을 미친다. 권력에 추가하여 계약 또한 시공자의 협력적 행동을 설명 할 수 있는 요소라고 할 수 있다. 건설 프로젝트에서 시공사의 협력적 행동을 유발하기 위해 발주자의 권력이 유효한 영향력을 미치는지는 매우 흥미로운 주제이다. 한편, 계약의 기능에 대한 심층적인 이해는 성공적인 건설 프로젝트 관리에 있어 필수적인 부분이다. 본 연구에서는 국내 건설 프로젝트에서 발주자의 권력 및 계약의 기능과 시공자의 행동 사이의 매커니즘을 탐색 해 보고자 한다.

• Advances in Traditional Medicine
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• 제1권2호
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• pp.29-35
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• 2000

The effect of aqueous extract of Salvia plebeia R. Br. (Labiatae) (AESP) on immunoglobulin (lgE) antibody mediated allergic reactions in rats was investigated. AESP inhibited passive cutaneous anaphylaxis (PCA) when intravenously, intraperitoneally, and orally administered. AESP dose-dependently inhibited histamine release from rat peritoneal mast cells activated by anti-DNP IgE antibody. Moreover, AESP had an inhibitory effect on anti-DNP IgE antibody induced $TNF-{\alpha}$ production from RPMC. These results suggest that AESP inhibit the IgE-mediated allergic reaction in rats.

• Journal of Dairy Science and Biotechnology
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• 제24권2호
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• pp.21-24
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• 2006

The ubiquitous presence of lactoferrin(LF) receptor in human as reported by the research group of Prof. Bo Lonnerdal, Univ. California (Suzuki, Y. A.,2001) encouraged us to search for the unknown physiological roles of Lf. Under the collaboration with Prof. Etsumori Harada, Tottori Univ., and his research group, we have found two novel biological activities of LF as the control of the lipid metabolism and the effect on the central nervous system. Relating to the lipid metabolism, LF could, in animal experiments, reduce triglyceride and total cholesterol both in blood and liver (Takeuchi, T et αl., 2003). LF increased plasms HDL-C and lowered LDL-C. In the central nervous system, LF showed anti-nociceptive activity mediated by ${\mu}$-opioid receptor in the rat spinal cord (Hayashida, K. et al., 2003). LF enhanced analgesic action of morphine synergistically via nitric oxide synthesis (Hayashida, K., et al., 2003) LF showed opioid-mediated suppressive effect on distress induced by maternal separation in rat pups (Takeuchi, T., et al., 2003).

• Journal of Microbiology and Biotechnology
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• 제21권5호
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• pp.525-528
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• 2011

The Raf-1 kinase inhibitory protein (RKIP) can regulate multiple key signaling pathways. Specifically, RKIP binds to Raf-1 kinase and inhibits the Ras-Raf-1-MEK1/2- ERK1/2 pathway. Additionally, Raf-1 has been shown to translocate to mitochondria and thereby protect cells from stress-mediated apoptosis. Recently, HBx was found to stimulate the mitochondrial translocation of Raf-1, contributing to the anti-apoptotic effect. We found that RKIP was downregulated during HBx-mediated hepatocarcinogenesis. In this study, we show that RKIP bound to Raf-1 and consequently inhibited the translocation of Raf-1 into mitochondria. This promoted the apoptosis of cells treated with apoptotic stimulus. Thus, the downregulation of RKIP increased the level of free Raf-1 and thereby elevated the mitochondrial translocation of Raf-1 during HBx-mediated hepatocarcinogenesis. The elevated Raf-1 mitochondrial translocation induced the increased anti-apoptotic effect and subsequently promoted HBx-mediated hepatocarcinogenesis.

• 약학회지
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• 제52권2호
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• pp.111-116
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• 2008

Diethylstilbestrol (DESB) is a synthetic estrogen not only that routinely prescribed, but also that known to be a teratogen. In this study, we found a novel pharmacological feature that DESB is able to positively modulate CD29 $({\beta}1-integrin)$ function. Thus, DESB up-regulated homotypic cell-cell adhesion of monocytic U937 cells mediated by CD29. However, DESB did not increase the surface level of CD29 and its binding activity to ligand (fibronectin), according to flow cytometric analysis and cell-fibronectin adhesion assay. Instead, the DESB-mediated up-regulation of cell-cell adhesion was blocked by several signaling enzyme inhibitors. Treatment of U0126 [an extracellular signal-regulated kinase (ERK) inhibitor], SB20358 (a p38 inhibitor) or Rp-8-pCPT-cGMP (a protein kinase G inhibitor) clearly inhibited DESB-mediated up-regulation of cell-cell adhesion induced by CD29. However, estrogen receptor antagonist ICI 182,780 failed to abrogate DESB effect. Therefore, our data suggest that DESB may up-regulate CD29-mediated cell-cell adhesion via modulating intracellular signaling enzymes such as ERK, PKG, and p38, independent of estrogen receptor function.

• 한국보육지원학회지
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• 제14권1호
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• pp.203-225
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• 2018

Objective: The aim of this study was to examine the mediated effect of teacher-infant relationships between teacher efficacy and infant's adjustment to child care centers. Methods: A total of 137 child care teachers that lived in Gwangju and Jeollanamdo participated in this study. They were asked to answer two survey questionnaires for two infants. The data were analyzed using analysis of frequency, Pearson's correlation coefficient, and hierarchical multiple regression analysis. Results: The main results are as follows. First, teacher-infant relationships partially mediated the relationship between teacher efficacy and two sub-factors (prosocial behavior and day work adjustment) of adjustment in child care centers. Unlikely as it was, several sub-factors such as positive emotion, peer adaptation, and self-strength were fully mediated by teacher-infant relationships. Conclusion: The present study suggests that it is necessary to improve teacher-infant relationships with teacher efficacy in order to improve infants' adaptation to daycare. In addition, it should be understood that the structural relationship of the influence factors is different depending on the sub-factors of the child care adjustment.

• 한국의류학회지
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• 제23권4호
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• pp.609-620
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• 1999

The purpose of the study were first to propose and determine the influence of sensation seeking tendency on exploratory behavior related to clothing would be mediated by consumer's clothing involvement and second to examine whether sensation seeking tendency is applicable variable on segmenting market expecially using underlying factors of sensation seeking tendency. A questionaire was developed and data were collected from 342 women ranged in age from 0 to 34 years. They were conveniently selected as a proper sample for applying and examining sensation seeking tendency. Arousal seeking tendency scale(Mehrabian & Russel 1974) was selected for operationalizing sensation seeking tendency and exploratory behavior related to clothing. As a result of regression the indirect effect mediated by clothing involvement of sensation seeking tendency on exploratory behavior was larger than the direct one. The influences of factors of sensation-seeking tendency behavior was larger than the direct one. The influences of factors of sensation-seeking tendency were also investigated. The influence of change-seeking tendency and new enviornment seeking tendency was considerably mediated by clothing involvement but that of risk-seeing tendency was not. Artistic sensation seeking tendency had little effect on clothing involvement and exploratory behavior related to clothing. As a result of regression the indirect effect mediated by clothing involvement of sensation seeking tendency on exploratory behavior was larger than influence of change-seeking tendency and new enviornment seeking tendency was considerably mediated by clothing involvement but that of risk-seeking tendency was not. Artistic sensation seeking tendency had little effect on clothing involvement and exploratory behavior related to clothing.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2019년도 추계학술대회
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• pp.91-91
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• 2019

Hibiscus syriacus L. is widely distributed throughout Eastern and Southern Asia and its root bark has been used as a traditional remedy. Recently, the extracts of H. syriacus L. exerts anti-cancerous, anti-microbial, and anti-inflammatory activities. However, the effect of anthocyanin-rich fraction of H. syriacus L. petals (PS) has not been studied under excessive oxidative stress. In this study, we evaluated the cellular protective effect of PS in HaCaT human skin keratinocytes under hydrogen peroxide ($H_2O_2$)-induced oxidative stress conditions. PS at below $400{\mu}g/ml$ did not show any cell death; however, over $800{\mu}g/ml$ of PS gradually increased cell death. PS at below $400{\mu}g/ml$ significantly inhibited $H_2O_2$-induced apoptosis in HaCaT cells concomitant with downregulation of Bax and upregulation of pro-PARP and p-Bcl-2. Additionally, PS remarkably reversed $H_2O_2$-induced excessive reactive oxygen species (ROS) production and apoptosis, and also significantly inhibited mitochondrial ROS production concomitant with suppression of $H_2O_2$-induced mitochondrial depolarization. $H_2O_2$-mediated ratio of Bax to Bcl-2, and caspase-3 activation were markedly abolished in the presence of PS. Moreover, the inhibition of HO-1 function using zinc protoporphyrin, an HO-1 inhibitor, significantly attenuated the cellular protective effects of PS against $H_2O_2$, indicating the significance of HO-1 in PS mediated cytoprotective effect, which was mediated by activating nuclear factor erythroid 2-related factor-2 (Nrf2). Taken together, our results suggest that cytoprotective effect of PS in HaCaT keratinocytes against oxidative stress-induced apoptosis is mediated by inhibiting cellular and mitochondrial ROS production, which is downregulated by activating Nrf2/HO-1 axis.

• 한국콘텐츠학회논문지
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• 제20권3호
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• pp.106-115
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• 2020

본 연구는 부모 학대·방임이 공동체의식에 미치는 영향에서 교우 및 교사관계의 매개효과검증을 목적으로 한다. 연구대상은 한국아동·청소년패널 초1패널 조사(2010년~2017년)의 2017년 중1 2,001명을 대상으로 하였다. 부모 학대·방임과 공동체의식의 관계에서 매개효과를 살펴보는 연구문제를 구조방정식으로 검증하여 다음과 같이 제시한다. 첫째, 부모 학대·방임은 공동체의식에 유의한 직접 영향은 미치지 않았다. 둘째, 부모 학대·방임(β=-.663)은 교우 및 교사관계에 유의한 부적인 영향을 미치는 것으로 나타났다. 셋째, 교우 및 교사관계(β=.664)는 공동체의식에 유의한 정적인 영향을 미치는 것으로 나타났다. 넷째 부모 학대·방임이 공동체 의식에 미치는 영향에서 교우 및 교사관계의 매개효과(β=-.440)는 유의한 부적인 영향을 미치는 것을 확인하였다. 이런 결과를 기반으로 청소년 복지실천에 대한 제언을 기술하였다.